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Protein
Submitted name:

Thrombospondin 4

Gene

Thbs4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Thrombospondin 4Imported
Gene namesi
Name:Thbs4Imported
ORF Names:mCG_114974Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1101779. Thbs4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_501108710427 – 963Sequence analysisAdd BLAST937

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000021702.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiB2RTL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini288 – 327EGF-likeInterPro annotationAdd BLAST40
Domaini328 – 365EGF-likeInterPro annotationAdd BLAST38
Domaini381 – 418EGF-likeInterPro annotationAdd BLAST38
Domaini422 – 464EGF-likeInterPro annotationAdd BLAST43
Repeati465 – 497TSP type-3PROSITE-ProRule annotationAdd BLAST33
Repeati498 – 533TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati534 – 556TSP type-3PROSITE-ProRule annotationAdd BLAST23
Repeati557 – 592TSP type-3PROSITE-ProRule annotationAdd BLAST36
Repeati593 – 615TSP type-3PROSITE-ProRule annotationAdd BLAST23
Repeati616 – 653TSP type-3PROSITE-ProRule annotationAdd BLAST38
Repeati654 – 693TSP type-3PROSITE-ProRule annotationAdd BLAST40
Repeati694 – 729TSP type-3PROSITE-ProRule annotationAdd BLAST36
Domaini733 – 947TSP C-terminalInterPro annotationAdd BLAST215

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IFQQ. Eukaryota.
ENOG410XQKE. LUCA.
HOVERGENiHBG000636.
KOiK04659.
OMAiAECQACG.
OrthoDBiEOG091G00TV.

Family and domain databases

Gene3Di4.10.1080.10. 3 hits.
InterProiView protein in InterPro
IPR013320. ConA-like_dom_sf.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
IPR024665. Thbs/COMP_coiled-coil.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
PfamiView protein in Pfam
PF11598. COMP. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02412. TSP_3. 5 hits.
PF05735. TSP_C. 1 hit.
SMARTiView protein in SMART
SM00181. EGF. 4 hits.
SM00179. EGF_CA. 3 hits.
SM00210. TSPN. 1 hit.
SUPFAMiSSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
PROSITEiView protein in PROSITE
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 1 hit.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

B2RTL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPRAAAAA FLLLHLVLQP WQRTSAQATP QVFDLLPSSS QRLNPSALQP
60 70 80 90 100
VLTDPTLHEV YLISTFKLQS KSSATIFGLY SSSDNSKYFE FTVMGRLNKA
110 120 130 140 150
ILRYLKNDGK IHLVVFNNLQ LADGRRHRVL LRLSNLQRGD GSVELYLDCA
160 170 180 190 200
QADSVRNLPR AFSGLTQNPE SIELRTFQRK PQDFLEELKL VVRGSLFQVA
210 220 230 240 250
SLQDCFLQQS EPLAATSTGD FNRQFLGQMT QLNQLLGEVK DLLRQQVKET
260 270 280 290 300
SFLRNTIAEC QACGPLSFQS PTPNTLVPIA PPAPPTRPTR HCDSSPCFRG
310 320 330 340 350
VRCTDTRDGF QCGPCPDGYT GNGITCSDVD ECKYHPCYPG VRCVNLAPGF
360 370 380 390 400
RCDACPVGFT GPMVQGVGIN FAKTNKQVCT DVDECQNGAC VLNSICINTL
410 420 430 440 450
GSYRCGPCKP GYTGDQTRGC KTERSCRNPE QNPCSVHAQC IEERQGDVTC
460 470 480 490 500
VCGVGWAGDG YVCGKDVDID SYPDEELPCS ARNCKKDNCK YVPNSGQEDA
510 520 530 540 550
DRDGIGDACD EDADGDGILN EQDNCVLTHN IDQRNSDKDI FGDACDNCRM
560 570 580 590 600
VLNNDQKDTD GDGRGDACDD DMDGDGIKNI LDNCPRVPNR DQQDRDGDDV
610 620 630 640 650
GDACDSCPDV SNPNQSDVDN DLVGDSCDTN QDSDGDGHQD STDNCPTVIN
660 670 680 690 700
SSQLDTDKDG IGDECDDDDD NDGIPDLVPP GPDNCRLVPN PAQEDSNNDG
710 720 730 740 750
VGDICEADFD QDQVIDHIDV CPENAEITLT DFRAYQTVVL DPEGDAQIDP
760 770 780 790 800
NWVVLNQGME IVQTMNSDPG LAVGYTAFNG VDFEGTFHVN TQTDDDYAGF
810 820 830 840 850
IFGYQDSSSF YVVMWKQTEQ TYWQATPFRA VAEPGIQLKA VKSKTGPGEH
860 870 880 890 900
LRNSLWHTGD TSDQVRLLWK DSRNVGWKDK VSYRWFLQHR PQVGYIRVRF
910 920 930 940 950
YEGSELVADS GVTIDTTMRG GRLGVFCFSQ ENIIWSNLKY RCNDTIPEDF
960
QEFQTQSFDR LDN
Length:963
Mass (Da):106,366
Last modified:July 1, 2008 - v1
Checksum:iB8BA83B84F489FB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC139414 mRNA. Translation: AAI39415.1.
CH466567 Genomic DNA. Translation: EDL00951.1.
RefSeqiNP_035712.1. NM_011582.3.
UniGeneiMm.20865.

Genome annotation databases

GeneIDi21828.
KEGGimmu:21828.

Similar proteinsi

Entry informationi

Entry nameiB2RTL6_MOUSE
AccessioniPrimary (citable) accession number: B2RTL6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: November 22, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation