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Protein

UDP-glucuronosyltransferase

Gene

Ugt1a5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-156588. Glucuronidation.
R-MMU-189483. Heme degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferaseUniRule annotation (EC:2.4.1.17UniRule annotation)
Gene namesi
Name:Ugt1a5Imported
ORF Names:mCG_14318Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3032634. Ugt1a5.

Subcellular locationi

  • Membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei487 – 510HelicalUniRule annotationAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24UniRule annotationAdd BLAST24
ChainiPRO_500845014625 – 529UDP-glucuronosyltransferaseUniRule annotationAdd BLAST505

Expressioni

Gene expression databases

BgeeiENSMUSG00000089943.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095263.

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220832.
HOVERGENiHBG004033.
KOiK00699.
OMAiFFRSMAM.
OrthoDBiEOG091G03YY.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RT14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLRMPLQGL VGLLLLCALP WTEGEKVLVF PVGGSHWLSM RDVVRELHAQ
60 70 80 90 100
GHQTVVLAPE VNMRIKEEDF FTFKVYAVPY TRQELEEMME NLKVFFDTGN
110 120 130 140 150
YMKKIFKTSE ALRNMSTVLL KTCTNILHNE SLLHHLNSSS FDVVFTDPVF
160 170 180 190 200
PCGALLAKYL GIPAVFFLRY IPCGIEYEAT QCPSPSSYIP NLFTRLSDHM
210 220 230 240 250
DFLQRVQNML YHLVLKYICH LLITPYESLA SELFQREVSS VELFSYASVW
260 270 280 290 300
LFRGDFVLDY PRPIMPNMVF IGGINCVTKK PLSQEFEAYV NASGEHGIVV
310 320 330 340 350
FSLGSMVSEI PEKKAMEIAE ALGRIPQTVL WRYTGTRPSN LAKNTILVKW
360 370 380 390 400
LPQNDLLGHP KTRAFITHSG SHGIYEGICN GVPMVMMPLF GDQMDNAKRM
410 420 430 440 450
ETRGAGVTLN VLEMTADDLE NALKTVINNK SYKENIMRLS SLHKDRPIEP
460 470 480 490 500
LDLAVFWVEY VMRHKGAPHL RPAAHDLTWY QYHSLDVIGF LLAIVLTVVF
510 520
IVFKCCAYGC RKCFGGKGRV KKSHKSKTH
Length:529
Mass (Da):60,073
Last modified:July 1, 2008 - v1
Checksum:iACA1EADA382CCE4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087780 Genomic DNA. No translation available.
AC087801 Genomic DNA. No translation available.
BC139093 mRNA. Translation: AAI39094.1.
BC139094 mRNA. Translation: AAI39095.1.
CH466520 Genomic DNA. Translation: EDL40128.1.
RefSeqiNP_964005.2. NM_201643.2.
UniGeneiMm.300095.

Genome annotation databases

EnsembliENSMUST00000097659; ENSMUSP00000095263; ENSMUSG00000089943.
GeneIDi394433.
KEGGimmu:394433.
UCSCiuc007byh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087780 Genomic DNA. No translation available.
AC087801 Genomic DNA. No translation available.
BC139093 mRNA. Translation: AAI39094.1.
BC139094 mRNA. Translation: AAI39095.1.
CH466520 Genomic DNA. Translation: EDL40128.1.
RefSeqiNP_964005.2. NM_201643.2.
UniGeneiMm.300095.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095263.

Protocols and materials databases

DNASUi394433.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097659; ENSMUSP00000095263; ENSMUSG00000089943.
GeneIDi394433.
KEGGimmu:394433.
UCSCiuc007byh.1. mouse.

Organism-specific databases

CTDi54579.
MGIiMGI:3032634. Ugt1a5.

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220832.
HOVERGENiHBG004033.
KOiK00699.
OMAiFFRSMAM.
OrthoDBiEOG091G03YY.
TreeFamiTF315472.

Enzyme and pathway databases

ReactomeiR-MMU-156588. Glucuronidation.
R-MMU-189483. Heme degradation.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000089943.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB2RT14_MOUSE
AccessioniPrimary (citable) accession number: B2RT14
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.