UniProtKB - B2RT14 (B2RT14_MOUSE)
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Protein
UDP-glucuronosyltransferase
Gene
Ugt1a5
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.UniRule annotation
GO - Molecular functioni
- enzyme binding Source: MGI
- glucuronosyltransferase activity Source: MGI
- protein heterodimerization activity Source: MGI
- protein homodimerization activity Source: MGI
GO - Biological processi
- cellular glucuronidation Source: MGI
- flavonoid glucuronidation Source: GO_Central
- xenobiotic glucuronidation Source: GO_Central
Keywordsi
Molecular function | GlycosyltransferaseUniRule annotation, Transferase |
Enzyme and pathway databases
Reactomei | R-MMU-156588. Glucuronidation. R-MMU-189483. Heme degradation. |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Ugt1a5Imported ORF Names:mCG_14318Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3032634. Ugt1a5. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 487 – 510 | HelicalUniRule annotationAdd BLAST | 24 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | UniRule annotationAdd BLAST | 24 | |
ChainiPRO_5013982016 | 25 – 529 | UDP-glucuronosyltransferaseUniRule annotationAdd BLAST | 505 |
Interactioni
GO - Molecular functioni
- enzyme binding Source: MGI
- protein heterodimerization activity Source: MGI
- protein homodimerization activity Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000095263. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 350 – 393 | UDPGTInterPro annotationAdd BLAST | 44 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 409 – 429 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationPhylogenomic databases
eggNOGi | KOG1192. Eukaryota. COG1819. LUCA. |
GeneTreei | ENSGT00760000118949. |
HOGENOMi | HOG000220832. |
HOVERGENi | HBG004033. |
KOi | K00699. |
OMAi | IHRSCVE. |
OrthoDBi | EOG091G03YY. |
TreeFami | TF315472. |
Family and domain databases
InterProi | View protein in InterPro IPR002213. UDP_glucos_trans. IPR035595. UDP_glycos_trans_CS. |
Pfami | View protein in Pfam PF00201. UDPGT. 1 hit. |
PROSITEi | View protein in PROSITE PS00375. UDPGT. 1 hit. |
i Sequence
Sequence statusi: Complete.
B2RT14-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLRMPLQGL VGLLLLCALP WTEGEKVLVF PVGGSHWLSM RDVVRELHAQ
60 70 80 90 100
GHQTVVLAPE VNMRIKEEDF FTFKVYAVPY TRQELEEMME NLKVFFDTGN
110 120 130 140 150
YMKKIFKTSE ALRNMSTVLL KTCTNILHNE SLLHHLNSSS FDVVFTDPVF
160 170 180 190 200
PCGALLAKYL GIPAVFFLRY IPCGIEYEAT QCPSPSSYIP NLFTRLSDHM
210 220 230 240 250
DFLQRVQNML YHLVLKYICH LLITPYESLA SELFQREVSS VELFSYASVW
260 270 280 290 300
LFRGDFVLDY PRPIMPNMVF IGGINCVTKK PLSQEFEAYV NASGEHGIVV
310 320 330 340 350
FSLGSMVSEI PEKKAMEIAE ALGRIPQTVL WRYTGTRPSN LAKNTILVKW
360 370 380 390 400
LPQNDLLGHP KTRAFITHSG SHGIYEGICN GVPMVMMPLF GDQMDNAKRM
410 420 430 440 450
ETRGAGVTLN VLEMTADDLE NALKTVINNK SYKENIMRLS SLHKDRPIEP
460 470 480 490 500
LDLAVFWVEY VMRHKGAPHL RPAAHDLTWY QYHSLDVIGF LLAIVLTVVF
510 520
IVFKCCAYGC RKCFGGKGRV KKSHKSKTH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC087780 Genomic DNA. No translation available. AC087801 Genomic DNA. No translation available. BC139093 mRNA. Translation: AAI39094.1. BC139094 mRNA. Translation: AAI39095.1. CH466520 Genomic DNA. Translation: EDL40128.1. |
RefSeqi | NP_964005.2. NM_201643.2. |
UniGenei | Mm.300095. |
Genome annotation databases
Ensembli | ENSMUST00000097659; ENSMUSP00000095263; ENSMUSG00000089943. |
GeneIDi | 394433. |
KEGGi | mmu:394433. |
UCSCi | uc007byh.1. mouse. |
Similar proteinsi
Entry informationi
Entry namei | B2RT14_MOUSE | |
Accessioni | B2RT14Primary (citable) accession number: B2RT14 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 1, 2008 |
Last sequence update: | July 1, 2008 | |
Last modified: | March 28, 2018 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |