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B2RSN1

- B2RSN1_MOUSE

UniProt

B2RSN1 - B2RSN1_MOUSE

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Protein
Submitted name:

Myelocytomatosis oncogene

Gene

Myc

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. core promoter proximal region sequence-specific DNA binding Source: MGI
  2. DNA binding Source: MGI
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  2. B cell apoptotic process Source: MGI
  3. canonical Wnt signaling pathway involved in negative regulation of apoptotic process Source: MGI
  4. canonical Wnt signaling pathway involved in positive regulation of apoptotic process Source: MGI
  5. cellular response to DNA damage stimulus Source: MGI
  6. detection of mechanical stimulus involved in sensory perception of sound Source: MGI
  7. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  8. middle ear morphogenesis Source: MGI
  9. negative regulation of protein binding Source: MGI
  10. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  11. pigmentation Source: MGI
  12. positive regulation of apoptotic signaling pathway Source: MGI
  13. positive regulation of B cell apoptotic process Source: MGI
  14. positive regulation of catalytic activity Source: MGI
  15. positive regulation of cell proliferation Source: MGI
  16. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  17. protein processing Source: MGI
  18. regulation of apoptotic process Source: MGI
  19. regulation of gene expression Source: MGI
  20. regulation of transcription, DNA-templated Source: MGI
  21. response to alkaloid Source: MGI
  22. response to radiation Source: MGI
  23. skeletal muscle cell differentiation Source: MGI
  24. skeletal system morphogenesis Source: MGI
  25. Wnt signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Myelocytomatosis oncogeneImported
Gene namesi
Name:MycImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97250. Myc.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: MGI
  2. nuclear body Source: MGI
  3. nucleus Source: MGI
  4. spindle Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriB2RSN1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022971.

Family & Domainsi

Sequence similaritiesi

Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000043075.
HOVERGENiHBG000472.
KOiK04377.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR003327. Myc-LZ.
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF02344. Myc-LZ. 1 hit.
PF01056. Myc_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001705. Myc_protein. 1 hit.
PRINTSiPR00044. LEUZIPPRMYC.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RSN1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFLWALETP QTATTMPLNV NFTNRNYDLD YDSVQPYFIC DEEENFYHQQ
60 70 80 90 100
QQSELQPPAP SEDIWKKFEL LPTPPLSPSR RSGLCSPSYV AVATSFSPRE
110 120 130 140 150
DDDGGGGNFS TADQLEMMTE LLGGDMVNQS FICDPDDETF IKNIIIQDCM
160 170 180 190 200
WSGFSAAAKL VSEKLASYQA ARKDSTSLSP ARGHSVCSTS SLYLQDLTAA
210 220 230 240 250
ASECIDPSVV FPYPLNDSSS PKSCTSSDST AFSPSSDSLL SSESSPRASP
260 270 280 290 300
EPLVLHEETP PTTSSDSEEE QEDEEEIDVV SVEKRQTPAK RSESGSSPSR
310 320 330 340 350
GHSKPPHSPL VLKRCHVSTH QHNYAAPPST RKDYPAAKRA KLDSGRVLKQ
360 370 380 390 400
ISNNRKCSSP RSSDTEENDK RRTHNVLERQ RRNELKRSFF ALRDQIPELE
410 420 430 440 450
NNEKAPKVVI LKKATAYILS IQADEHKLTS EKDLLRKRRE QLKHKLEQLR

NSGA
Length:454
Mass (Da):50,678
Last modified:July 1, 2008 - v1
Checksum:i1CE6F658565FF720
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC138931 mRNA. Translation: AAI38932.1.
BC138932 mRNA. Translation: AAI38933.1.
RefSeqiNP_001170823.1. NM_001177352.1.
NP_034979.3. NM_010849.4.
UniGeneiMm.2444.

Genome annotation databases

GeneIDi17869.
KEGGimmu:17869.
UCSCiuc007vyg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC138931 mRNA. Translation: AAI38932.1 .
BC138932 mRNA. Translation: AAI38933.1 .
RefSeqi NP_001170823.1. NM_001177352.1.
NP_034979.3. NM_010849.4.
UniGenei Mm.2444.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000022971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 17869.
KEGGi mmu:17869.
UCSCi uc007vyg.1. mouse.

Organism-specific databases

CTDi 4609.
MGIi MGI:97250. Myc.

Phylogenomic databases

HOGENOMi HOG000043075.
HOVERGENi HBG000472.
KOi K04377.

Miscellaneous databases

ChiTaRSi MYC. mouse.
NextBioi 292641.
PROi B2RSN1.
SOURCEi Search...

Gene expression databases

Genevestigatori B2RSN1.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
IPR003327. Myc-LZ.
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
PF02344. Myc-LZ. 1 hit.
PF01056. Myc_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001705. Myc_protein. 1 hit.
PRINTSi PR00044. LEUZIPPRMYC.
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.

Entry informationi

Entry nameiB2RSN1_MOUSE
AccessioniPrimary (citable) accession number: B2RSN1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)