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B2RSN1

- B2RSN1_MOUSE

UniProt

B2RSN1 - B2RSN1_MOUSE

Protein
Submitted name:

Myelocytomatosis oncogene

Gene

Myc

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. core promoter proximal region sequence-specific DNA binding Source: MGI
    2. DNA binding Source: MGI
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
    2. B cell apoptotic process Source: MGI
    3. canonical Wnt signaling pathway involved in negative regulation of apoptotic process Source: MGI
    4. canonical Wnt signaling pathway involved in positive regulation of apoptotic process Source: MGI
    5. cellular response to DNA damage stimulus Source: MGI
    6. detection of mechanical stimulus involved in sensory perception of sound Source: MGI
    7. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
    8. middle ear morphogenesis Source: MGI
    9. negative regulation of protein binding Source: MGI
    10. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    11. pigmentation Source: MGI
    12. positive regulation of apoptotic signaling pathway Source: MGI
    13. positive regulation of B cell apoptotic process Source: MGI
    14. positive regulation of catalytic activity Source: MGI
    15. positive regulation of cell proliferation Source: MGI
    16. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    17. protein processing Source: MGI
    18. regulation of apoptotic process Source: MGI
    19. regulation of gene expression Source: MGI
    20. regulation of transcription, DNA-templated Source: MGI
    21. response to alkaloid Source: MGI
    22. response to radiation Source: MGI
    23. skeletal muscle cell differentiation Source: MGI
    24. skeletal system morphogenesis Source: MGI
    25. Wnt signaling pathway Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Myelocytomatosis oncogeneImported
    Gene namesi
    Name:MycImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:97250. Myc.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: MGI
    2. nuclear body Source: MGI
    3. nucleus Source: MGI
    4. spindle Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriB2RSN1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000022971.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000043075.
    HOVERGENiHBG000472.
    InParanoidiB2RSN1.
    KOiK04377.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    IPR003327. Myc-LZ.
    IPR002418. Tscrpt_reg_Myc.
    IPR012682. Tscrpt_reg_Myc_N.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    PF02344. Myc-LZ. 1 hit.
    PF01056. Myc_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001705. Myc_protein. 1 hit.
    PRINTSiPR00044. LEUZIPPRMYC.
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2RSN1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFLWALETP QTATTMPLNV NFTNRNYDLD YDSVQPYFIC DEEENFYHQQ    50
    QQSELQPPAP SEDIWKKFEL LPTPPLSPSR RSGLCSPSYV AVATSFSPRE 100
    DDDGGGGNFS TADQLEMMTE LLGGDMVNQS FICDPDDETF IKNIIIQDCM 150
    WSGFSAAAKL VSEKLASYQA ARKDSTSLSP ARGHSVCSTS SLYLQDLTAA 200
    ASECIDPSVV FPYPLNDSSS PKSCTSSDST AFSPSSDSLL SSESSPRASP 250
    EPLVLHEETP PTTSSDSEEE QEDEEEIDVV SVEKRQTPAK RSESGSSPSR 300
    GHSKPPHSPL VLKRCHVSTH QHNYAAPPST RKDYPAAKRA KLDSGRVLKQ 350
    ISNNRKCSSP RSSDTEENDK RRTHNVLERQ RRNELKRSFF ALRDQIPELE 400
    NNEKAPKVVI LKKATAYILS IQADEHKLTS EKDLLRKRRE QLKHKLEQLR 450
    NSGA 454
    Length:454
    Mass (Da):50,678
    Last modified:July 1, 2008 - v1
    Checksum:i1CE6F658565FF720
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC138931 mRNA. Translation: AAI38932.1.
    BC138932 mRNA. Translation: AAI38933.1.
    RefSeqiNP_001170823.1. NM_001177352.1.
    NP_034979.3. NM_010849.4.
    UniGeneiMm.2444.

    Genome annotation databases

    GeneIDi17869.
    KEGGimmu:17869.
    UCSCiuc007vyg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC138931 mRNA. Translation: AAI38932.1 .
    BC138932 mRNA. Translation: AAI38933.1 .
    RefSeqi NP_001170823.1. NM_001177352.1.
    NP_034979.3. NM_010849.4.
    UniGenei Mm.2444.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000022971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 17869.
    KEGGi mmu:17869.
    UCSCi uc007vyg.1. mouse.

    Organism-specific databases

    CTDi 4609.
    MGIi MGI:97250. Myc.

    Phylogenomic databases

    HOGENOMi HOG000043075.
    HOVERGENi HBG000472.
    InParanoidi B2RSN1.
    KOi K04377.

    Miscellaneous databases

    ChiTaRSi MYC. mouse.
    NextBioi 292641.
    PROi B2RSN1.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori B2RSN1.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    IPR003327. Myc-LZ.
    IPR002418. Tscrpt_reg_Myc.
    IPR012682. Tscrpt_reg_Myc_N.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    PF02344. Myc-LZ. 1 hit.
    PF01056. Myc_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001705. Myc_protein. 1 hit.
    PRINTSi PR00044. LEUZIPPRMYC.
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.

    Entry informationi

    Entry nameiB2RSN1_MOUSE
    AccessioniPrimary (citable) accession number: B2RSN1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)