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Protein
Submitted name:

Myelocytomatosis oncogene

Gene

Myc

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • B cell apoptotic process Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • canonical Wnt signaling pathway involved in negative regulation of apoptotic process Source: MGI
  • canonical Wnt signaling pathway involved in positive regulation of apoptotic process Source: MGI
  • cell cycle arrest Source: MGI
  • cellular iron ion homeostasis Source: MGI
  • cellular response to DNA damage stimulus Source: MGI
  • cellular response to drug Source: MGI
  • chromatin remodeling Source: MGI
  • chromosome organization Source: MGI
  • detection of mechanical stimulus involved in sensory perception of sound Source: MGI
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  • MAPK cascade Source: MGI
  • middle ear morphogenesis Source: MGI
  • negative regulation of cell division Source: MGI
  • negative regulation of fibroblast proliferation Source: MGI
  • negative regulation of monocyte differentiation Source: MGI
  • negative regulation of protein binding Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • pigmentation Source: MGI
  • positive regulation of apoptotic signaling pathway Source: MGI
  • positive regulation of B cell apoptotic process Source: MGI
  • positive regulation of catalytic activity Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • positive regulation of DNA biosynthetic process Source: MGI
  • positive regulation of epithelial cell proliferation Source: MGI
  • positive regulation of fibroblast proliferation Source: MGI
  • positive regulation of response to DNA damage stimulus Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • protein processing Source: MGI
  • regulation of apoptotic process Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of telomere maintenance Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • response to alkaloid Source: MGI
  • response to gamma radiation Source: MGI
  • response to radiation Source: MGI
  • skeletal muscle cell differentiation Source: MGI
  • skeletal system morphogenesis Source: MGI
  • Wnt signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Myelocytomatosis oncogeneImported
Gene namesi
Name:MycImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97250. Myc.

Subcellular locationi

GO - Cellular componenti

  • axon Source: MGI
  • nuclear body Source: MGI
  • nucleolus Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • protein complex Source: MGI
  • spindle Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriB2RSN1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022971.

Structurei

3D structure databases

ProteinModelPortaliB2RSN1.
SMRiB2RSN1. Positions 368-449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000043075.
HOVERGENiHBG000472.
KOiK04377.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR003327. Myc-LZ.
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF02344. Myc-LZ. 1 hit.
PF01056. Myc_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001705. Myc_protein. 1 hit.
PRINTSiPR00044. LEUZIPPRMYC.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RSN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLWALETP QTATTMPLNV NFTNRNYDLD YDSVQPYFIC DEEENFYHQQ
60 70 80 90 100
QQSELQPPAP SEDIWKKFEL LPTPPLSPSR RSGLCSPSYV AVATSFSPRE
110 120 130 140 150
DDDGGGGNFS TADQLEMMTE LLGGDMVNQS FICDPDDETF IKNIIIQDCM
160 170 180 190 200
WSGFSAAAKL VSEKLASYQA ARKDSTSLSP ARGHSVCSTS SLYLQDLTAA
210 220 230 240 250
ASECIDPSVV FPYPLNDSSS PKSCTSSDST AFSPSSDSLL SSESSPRASP
260 270 280 290 300
EPLVLHEETP PTTSSDSEEE QEDEEEIDVV SVEKRQTPAK RSESGSSPSR
310 320 330 340 350
GHSKPPHSPL VLKRCHVSTH QHNYAAPPST RKDYPAAKRA KLDSGRVLKQ
360 370 380 390 400
ISNNRKCSSP RSSDTEENDK RRTHNVLERQ RRNELKRSFF ALRDQIPELE
410 420 430 440 450
NNEKAPKVVI LKKATAYILS IQADEHKLTS EKDLLRKRRE QLKHKLEQLR

NSGA
Length:454
Mass (Da):50,678
Last modified:July 1, 2008 - v1
Checksum:i1CE6F658565FF720
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC138931 mRNA. Translation: AAI38932.1.
BC138932 mRNA. Translation: AAI38933.1.
RefSeqiNP_001170823.1. NM_001177352.1.
NP_034979.3. NM_010849.4.
UniGeneiMm.2444.

Genome annotation databases

GeneIDi17869.
KEGGimmu:17869.
UCSCiuc007vyg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC138931 mRNA. Translation: AAI38932.1.
BC138932 mRNA. Translation: AAI38933.1.
RefSeqiNP_001170823.1. NM_001177352.1.
NP_034979.3. NM_010849.4.
UniGeneiMm.2444.

3D structure databases

ProteinModelPortaliB2RSN1.
SMRiB2RSN1. Positions 368-449.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17869.
KEGGimmu:17869.
UCSCiuc007vyg.1. mouse.

Organism-specific databases

CTDi4609.
MGIiMGI:97250. Myc.

Phylogenomic databases

HOGENOMiHOG000043075.
HOVERGENiHBG000472.
KOiK04377.

Miscellaneous databases

ChiTaRSiMyc. mouse.
NextBioi292641.
SOURCEiSearch...

Gene expression databases

GenevestigatoriB2RSN1.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR003327. Myc-LZ.
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF02344. Myc-LZ. 1 hit.
PF01056. Myc_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001705. Myc_protein. 1 hit.
PRINTSiPR00044. LEUZIPPRMYC.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.

Entry informationi

Entry nameiB2RSN1_MOUSE
AccessioniPrimary (citable) accession number: B2RSN1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: May 27, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.