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B2RSN1 (B2RSN1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Myelocytomatosis oncogene EMBL AAI38932.1
Gene names
Name:Myc EMBL AAI38932.1 MGI 97250
OrganismMus musculus (Mouse) EMBL AAI38932.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length454 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 basic helix-loop-helix (bHLH) domain. RuleBase RU000367

Ontologies

Gene Ontology (GO)
   Biological_processB cell apoptotic process

Inferred from mutant phenotype PubMed 12970677. Source: MGI

Wnt receptor signaling pathway

Inferred from direct assay PubMed 19056892. Source: MGI

activation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from direct assay PubMed 14517295. Source: MGI

apoptotic DNA fragmentation

Inferred from direct assay PubMed 14517295. Source: MGI

detection of mechanical stimulus involved in sensory perception of sound

Inferred from mutant phenotype PubMed 17523175. Source: MGI

intrinsic apoptotic signaling pathway

Inferred from direct assay PubMed 14517295. Source: MGI

middle ear morphogenesis

Inferred from mutant phenotype PubMed 17523175. Source: MGI

negative regulation of protein binding

Inferred from direct assay PubMed 18045875. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 12196193. Source: MGI

pigmentation

Inferred from mutant phenotype PubMed 17523175. Source: MGI

positive regulation of B cell apoptotic process

Inferred from genetic interaction PubMed 11604501. Source: MGI

positive regulation of apoptotic signaling pathway

Inferred from direct assay PubMed 14517295. Source: MGI

positive regulation of cell proliferation

Inferred from direct assay PubMed 12235125PubMed 14517295. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 17382917. Source: MGI

protein processing

Inferred from mutant phenotype PubMed 12970677. Source: MGI

release of cytochrome c from mitochondria

Inferred from direct assay PubMed 14517295. Source: MGI

response to DNA damage stimulus

Inferred from direct assay PubMed 20212154. Source: MGI

response to alkaloid

Inferred from mutant phenotype PubMed 12970677. Source: MGI

response to radiation

Inferred from direct assay PubMed 14517295. Source: MGI

skeletal muscle cell differentiation

Inferred from mutant phenotype PubMed 22147266. Source: MGI

skeletal system morphogenesis

Inferred from mutant phenotype PubMed 17523175. Source: MGI

   Cellular_componentaxon

Inferred from direct assay PubMed 10482234. Source: MGI

nuclear body

Inferred from direct assay PubMed 15735755. Source: MGI

spindle

Inferred from direct assay PubMed 15509711. Source: MGI

   Molecular_functioncore promoter proximal region sequence-specific DNA binding

Inferred from direct assay PubMed 15511642. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
B2RSN1 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 1CE6F658565FF720

FASTA45450,678
        10         20         30         40         50         60 
MDFLWALETP QTATTMPLNV NFTNRNYDLD YDSVQPYFIC DEEENFYHQQ QQSELQPPAP 

        70         80         90        100        110        120 
SEDIWKKFEL LPTPPLSPSR RSGLCSPSYV AVATSFSPRE DDDGGGGNFS TADQLEMMTE 

       130        140        150        160        170        180 
LLGGDMVNQS FICDPDDETF IKNIIIQDCM WSGFSAAAKL VSEKLASYQA ARKDSTSLSP 

       190        200        210        220        230        240 
ARGHSVCSTS SLYLQDLTAA ASECIDPSVV FPYPLNDSSS PKSCTSSDST AFSPSSDSLL 

       250        260        270        280        290        300 
SSESSPRASP EPLVLHEETP PTTSSDSEEE QEDEEEIDVV SVEKRQTPAK RSESGSSPSR 

       310        320        330        340        350        360 
GHSKPPHSPL VLKRCHVSTH QHNYAAPPST RKDYPAAKRA KLDSGRVLKQ ISNNRKCSSP 

       370        380        390        400        410        420 
RSSDTEENDK RRTHNVLERQ RRNELKRSFF ALRDQIPELE NNEKAPKVVI LKKATAYILS 

       430        440        450 
IQADEHKLTS EKDLLRKRRE QLKHKLEQLR NSGA

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain EMBL AAI38932.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC138931 mRNA. Translation: AAI38932.1.
BC138932 mRNA. Translation: AAI38933.1.
IPIIPI00131999.
RefSeqNP_001170823.1. NM_001177352.1.
NP_034979.3. NM_010849.4.
UniGeneMm.2444.

3D structure databases

SMRB2RSN1. Positions 368-449.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000022971.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID17869.
KEGGmmu:17869.
UCSCuc007vyg.1. mouse.

Organism-specific databases

CTD4609.
MGIMGI:97250. Myc.

Phylogenomic databases

HOGENOMHOG000043075.
HOVERGENHBG000472.
InParanoidB2RSN1.
KOK04377.

Gene expression databases

GenevestigatorB2RSN1.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
IPR003327. Myc-LZ.
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
[Graphical view]
PfamPF00010. HLH. 1 hit.
PF02344. Myc-LZ. 1 hit.
PF01056. Myc_N. 1 hit.
[Graphical view]
PIRSFPIRSF001705. Myc_protein. 1 hit.
PRINTSPR00044. LEUZIPPRMYC.
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. HLH_basic. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMYC. mouse.
NextBio292641.
SOURCESearch...

Entry information

Entry nameB2RSN1_MOUSE
AccessionPrimary (citable) accession number: B2RSN1
Entry history
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info