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B2RSC8 (B2RSC8_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
E3 ubiquitin-protein ligase PIRNR PIRNR001569

EC=6.3.2.- PIRNR PIRNR001569
Gene names
Name:Nedd4 MGI 97297 EMBL AAI38814.1
ORF Names:mCG_8038 EMBL EDL26269.1
OrganismMus musculus (Mouse) EMBL AAI38814.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length887 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Pathway

Protein modification; protein ubiquitination. PIRNR PIRNR001569

Sequence similarities

Contains 1 C2 domain. RuleBase RU003412

Contains HECT (E6AP-type E3 ubiquitin-protein ligase) domain. SAAS SAAS000569

Ontologies

Keywords
   Biological processUbl conjugation pathway SAAS SAAS000569 PIRNR PIRNR001569
   Molecular functionLigase SAAS SAAS000569 PIRNR PIRNR001569
Gene Ontology (GO)
   Biological_processT cell activation

Inferred from mutant phenotype PubMed 18931680. Source: MGI

adaptive immune response

Inferred from mutant phenotype PubMed 18931680. Source: MGI

blood vessel morphogenesis

Inferred from mutant phenotype PubMed 20026598. Source: MGI

development involved in symbiotic interaction

Inferred from electronic annotation. Source: Ensembl

endocardial cushion development

Inferred from mutant phenotype PubMed 20026598. Source: MGI

glucocorticoid receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of sodium ion transport

Inferred from direct assay PubMed 10212229. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 20026598. Source: MGI

negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage

Inferred from electronic annotation. Source: Ensembl

neuromuscular junction development

Inferred from mutant phenotype PubMed 19345204. Source: MGI

neuron projection development

Inferred from electronic annotation. Source: Ensembl

outflow tract morphogenesis

Inferred from mutant phenotype PubMed 20026598. Source: MGI

positive regulation of nucleocytoplasmic transport

Inferred from electronic annotation. Source: Ensembl

positive regulation of phosphatidylinositol 3-kinase signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein catabolic process

Inferred from direct assay PubMed 11748237. Source: MGI

progesterone receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

protein monoubiquitination

Inferred from direct assay PubMed 21920314. Source: MGI

protein targeting to lysosome

Inferred from electronic annotation. Source: Ensembl

protein ubiquitination

Inferred from direct assay PubMed 9182527. Source: MGI

protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Inferred from mutant phenotype PubMed 18931680. Source: MGI

receptor catabolic process

Inferred from electronic annotation. Source: Ensembl

receptor internalization

Inferred from electronic annotation. Source: Ensembl

regulation of membrane potential

Inferred from electronic annotation. Source: Ensembl

regulation of potassium ion transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

regulation of synapse organization

Inferred from mutant phenotype PubMed 19345204. Source: MGI

transmission of virus

Inferred from electronic annotation. Source: Ensembl

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

cell cortex

Inferred from electronic annotation. Source: Ensembl

chromatin

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay PubMed 14973438. Source: MGI

cytosol

Inferred from direct assay PubMed 19794060PubMed 9182527. Source: MGI

membrane

Inferred from direct assay PubMed 14973438. Source: MGI

nucleus

Inferred from Biological aspect of Ancestor. Source: RefGenome

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: Ensembl

ubiquitin ligase complex

Inferred from physical interaction PubMed 11042109. Source: MGI

   Molecular_functionproline-rich region binding

Inferred from physical interaction PubMed 11748237PubMed 9305852. Source: MGI

sodium channel inhibitor activity

Inferred from direct assay PubMed 10212229. Source: MGI

ubiquitin-protein ligase activity

Inferred from direct assay PubMed 11717310PubMed 9182527. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site8541Glycyl thioester intermediate By similarity PIRSR PIRSR001569-1

Sequences

Sequence LengthMass (Da)Tools
B2RSC8 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: AE7DD3ED63986C50

FASTA887102,706
        10         20         30         40         50         60 
MSSDMAADES EAPVLSEDEV WEFCLDKTED GGGSPGSDVT DTCEPPCGCW ELNPNSLEEE 

        70         80         90        100        110        120 
HVLFTADPYL ELHNDDTRVV RVKVIAGIGL AKKDILGASD PYVRVTLYDP MSGILTSVQT 

       130        140        150        160        170        180 
KTIKKSLNPK WNEEILFRVL PQRHRILFEV FDENRLTRDD FLGQVDVPLY PLPTENPRME 

       190        200        210        220        230        240 
RPYTFKDFVL HPRSHKSRVK GYLRLKMTYL PKNGSEDENA DQAEELEPGW VVLDQPDAAT 

       250        260        270        280        290        300 
HLPHPPEPSP LPPGWEERQD VLGRTYYVNH ESRRTQWKRP SPDDDLTDED NDDMQLQAQR 

       310        320        330        340        350        360 
AFTTRRQISE DVDGPDNRES PENWEIVRED ENTEYSGQAV QSPPSGHIDV QTHLAEEFNT 

       370        380        390        400        410        420 
RLAVCGNPAT SQPVTSSNHS SRGGSLQTCI FEEQPTLPVL LPTSSGLPPG WEEKQDDRGR 

       430        440        450        460        470        480 
SYYVDHNSKT TTWSKPTMQD DPRSKIPAHL RGKTDSNDLG PLPPGWEERT HTDGRVFFIN 

       490        500        510        520        530        540 
HNIKKTQWED PRLQNVAITG PAVPYSRDYK RKYEFFRRKL KKQTDIPNKF EMKLRRANIL 

       550        560        570        580        590        600 
EDSYRRIMGV KRADLLKARL WIEFDGEKGL DYGGVAREWF FLISKEMFNP YYGLFEYSAT 

       610        620        630        640        650        660 
DNYTLQINPN SGLCNEDHLS YFKFIGRVAG MAVYHGKLLD GFFIRPFYKM MLQKLITLHD 

       670        680        690        700        710        720 
MESVDSEYYS SLRWILENDP TELDLRFIID EELFGQTHQH ELKTGGSEIV VTNKNKKEYI 

       730        740        750        760        770        780 
YLVIQWRFVN RIQKQMAAFK EGFFELIPQD LIKIFDENEL ELLMCGLGDV DVNDWREHTK 

       790        800        810        820        830        840 
YKNGYSMNHQ VIHWFWKAVW MMDSEKRIRL LQFVTGTSRV PMNGFAELYG SNGPQSFTVE 

       850        860        870        880 
QWGTPDKLPR AHTCFNRLDL PPYESFDELW DKLQMAIENT QGFDGVD 

« Hide

References

« Hide 'large scale' references
[1]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL26269.1.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo EMBL AAI38814.1.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL26269.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC138813 mRNA. Translation: AAI38814.1.
CH466522 Genomic DNA. Translation: EDL26269.1.
RefSeqNP_035020.2. NM_010890.3.
UniGeneMm.279923.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID17999.
KEGGmmu:17999.

Organism-specific databases

CTD4734.
MGIMGI:97297. Nedd4.

Phylogenomic databases

HOVERGENHBG004134.
InParanoidB2RSC8.
KOK10591.
OMAYRRILSV.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

GenevestigatorB2RSC8.

Family and domain databases

Gene3D2.60.40.150. 1 hit.
InterProIPR000008. C2_dom.
IPR024928. E3_ub_ligase_SMURF1.
IPR000569. HECT.
IPR001202. WW_dom.
[Graphical view]
PfamPF00168. C2. 1 hit.
PF00632. HECT. 1 hit.
PF00397. WW. 3 hits.
[Graphical view]
PIRSFPIRSF001569. E3_ub_ligase_SMURF1. 1 hit.
SMARTSM00239. C2. 1 hit.
SM00119. HECTc. 1 hit.
SM00456. WW. 3 hits.
[Graphical view]
SUPFAMSSF49562. SSF49562. 1 hit.
SSF51045. SSF51045. 3 hits.
SSF56204. SSF56204. 1 hit.
PROSITEPS50004. C2. 1 hit.
PS50237. HECT. 1 hit.
PS01159. WW_DOMAIN_1. 3 hits.
PS50020. WW_DOMAIN_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNEDD4. mouse.
NextBio292995.
SOURCESearch...

Entry information

Entry nameB2RSC8_MOUSE
AccessionPrimary (citable) accession number: B2RSC8
Entry history
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)