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B2RSC8

- B2RSC8_MOUSE

UniProt

B2RSC8 - B2RSC8_MOUSE

Protein

E3 ubiquitin-protein ligase

Gene

Nedd4

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei854 – 8541Glycyl thioester intermediateUniRule annotation

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. proline-rich region binding Source: MGI
    3. protein binding Source: MGI
    4. sodium channel inhibitor activity Source: MGI
    5. ubiquitin-protein transferase activity Source: MGI

    GO - Biological processi

    1. adaptive immune response Source: MGI
    2. blood vessel morphogenesis Source: MGI
    3. development involved in symbiotic interaction Source: Ensembl
    4. endocardial cushion development Source: MGI
    5. glucocorticoid receptor signaling pathway Source: Ensembl
    6. negative regulation of sodium ion transport Source: MGI
    7. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    8. negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage Source: Ensembl
    9. neuromuscular junction development Source: MGI
    10. neuron projection development Source: Ensembl
    11. outflow tract morphogenesis Source: MGI
    12. positive regulation of nucleocytoplasmic transport Source: Ensembl
    13. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
    14. positive regulation of protein catabolic process Source: MGI
    15. progesterone receptor signaling pathway Source: Ensembl
    16. protein monoubiquitination Source: MGI
    17. protein targeting to lysosome Source: Ensembl
    18. protein ubiquitination Source: MGI
    19. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: MGI
    20. receptor catabolic process Source: Ensembl
    21. receptor internalization Source: Ensembl
    22. regulation of membrane potential Source: Ensembl
    23. regulation of potassium ion transmembrane transporter activity Source: Ensembl
    24. regulation of synapse organization Source: MGI
    25. T cell activation Source: MGI
    26. transmission of virus Source: Ensembl
    27. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: Ensembl

    Keywords - Molecular functioni

    LigaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Ubl conjugation pathwayUniRule annotationSAAS annotation

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligaseUniRule annotation (EC:6.3.2.-UniRule annotation)
    Gene namesi
    Name:Nedd4Imported
    ORF Names:mCG_8038Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:97297. Nedd4.

    Subcellular locationi

    GO - Cellular componenti

    1. cell cortex Source: Ensembl
    2. chromatin Source: Ensembl
    3. cytoplasm Source: MGI
    4. cytosol Source: MGI
    5. Golgi apparatus Source: Ensembl
    6. membrane Source: MGI
    7. nucleus Source: RefGenome
    8. perinuclear region of cytoplasm Source: Ensembl
    9. plasma membrane Source: Ensembl
    10. ubiquitin ligase complex Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriB2RSC8.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 C2 domain.UniRule annotation
    Contains HECT (E6AP-type E3 ubiquitin-protein ligase) domain.SAAS annotation

    Phylogenomic databases

    HOVERGENiHBG004134.
    InParanoidiB2RSC8.
    KOiK10591.
    OMAiYRRILSV.

    Family and domain databases

    Gene3Di2.60.40.150. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR024928. E3_ub_ligase_SMURF1.
    IPR000569. HECT.
    IPR001202. WW_dom.
    [Graphical view]
    PfamiPF00168. C2. 1 hit.
    PF00632. HECT. 1 hit.
    PF00397. WW. 3 hits.
    [Graphical view]
    PIRSFiPIRSF001569. E3_ub_ligase_SMURF1. 1 hit.
    SMARTiSM00239. C2. 1 hit.
    SM00119. HECTc. 1 hit.
    SM00456. WW. 3 hits.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF51045. SSF51045. 3 hits.
    SSF56204. SSF56204. 1 hit.
    PROSITEiPS50004. C2. 1 hit.
    PS50237. HECT. 1 hit.
    PS01159. WW_DOMAIN_1. 3 hits.
    PS50020. WW_DOMAIN_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2RSC8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSDMAADES EAPVLSEDEV WEFCLDKTED GGGSPGSDVT DTCEPPCGCW    50
    ELNPNSLEEE HVLFTADPYL ELHNDDTRVV RVKVIAGIGL AKKDILGASD 100
    PYVRVTLYDP MSGILTSVQT KTIKKSLNPK WNEEILFRVL PQRHRILFEV 150
    FDENRLTRDD FLGQVDVPLY PLPTENPRME RPYTFKDFVL HPRSHKSRVK 200
    GYLRLKMTYL PKNGSEDENA DQAEELEPGW VVLDQPDAAT HLPHPPEPSP 250
    LPPGWEERQD VLGRTYYVNH ESRRTQWKRP SPDDDLTDED NDDMQLQAQR 300
    AFTTRRQISE DVDGPDNRES PENWEIVRED ENTEYSGQAV QSPPSGHIDV 350
    QTHLAEEFNT RLAVCGNPAT SQPVTSSNHS SRGGSLQTCI FEEQPTLPVL 400
    LPTSSGLPPG WEEKQDDRGR SYYVDHNSKT TTWSKPTMQD DPRSKIPAHL 450
    RGKTDSNDLG PLPPGWEERT HTDGRVFFIN HNIKKTQWED PRLQNVAITG 500
    PAVPYSRDYK RKYEFFRRKL KKQTDIPNKF EMKLRRANIL EDSYRRIMGV 550
    KRADLLKARL WIEFDGEKGL DYGGVAREWF FLISKEMFNP YYGLFEYSAT 600
    DNYTLQINPN SGLCNEDHLS YFKFIGRVAG MAVYHGKLLD GFFIRPFYKM 650
    MLQKLITLHD MESVDSEYYS SLRWILENDP TELDLRFIID EELFGQTHQH 700
    ELKTGGSEIV VTNKNKKEYI YLVIQWRFVN RIQKQMAAFK EGFFELIPQD 750
    LIKIFDENEL ELLMCGLGDV DVNDWREHTK YKNGYSMNHQ VIHWFWKAVW 800
    MMDSEKRIRL LQFVTGTSRV PMNGFAELYG SNGPQSFTVE QWGTPDKLPR 850
    AHTCFNRLDL PPYESFDELW DKLQMAIENT QGFDGVD 887
    Length:887
    Mass (Da):102,706
    Last modified:July 1, 2008 - v1
    Checksum:iAE7DD3ED63986C50
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC138813 mRNA. Translation: AAI38814.1.
    CH466522 Genomic DNA. Translation: EDL26269.1.
    RefSeqiNP_035020.2. NM_010890.3.
    UniGeneiMm.279923.

    Genome annotation databases

    GeneIDi17999.
    KEGGimmu:17999.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC138813 mRNA. Translation: AAI38814.1 .
    CH466522 Genomic DNA. Translation: EDL26269.1 .
    RefSeqi NP_035020.2. NM_010890.3.
    UniGenei Mm.279923.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 17999.
    KEGGi mmu:17999.

    Organism-specific databases

    CTDi 4734.
    MGIi MGI:97297. Nedd4.

    Phylogenomic databases

    HOVERGENi HBG004134.
    InParanoidi B2RSC8.
    KOi K10591.
    OMAi YRRILSV.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    ChiTaRSi NEDD4. mouse.
    NextBioi 292995.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori B2RSC8.

    Family and domain databases

    Gene3Di 2.60.40.150. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR024928. E3_ub_ligase_SMURF1.
    IPR000569. HECT.
    IPR001202. WW_dom.
    [Graphical view ]
    Pfami PF00168. C2. 1 hit.
    PF00632. HECT. 1 hit.
    PF00397. WW. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF001569. E3_ub_ligase_SMURF1. 1 hit.
    SMARTi SM00239. C2. 1 hit.
    SM00119. HECTc. 1 hit.
    SM00456. WW. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF51045. SSF51045. 3 hits.
    SSF56204. SSF56204. 1 hit.
    PROSITEi PS50004. C2. 1 hit.
    PS50237. HECT. 1 hit.
    PS01159. WW_DOMAIN_1. 3 hits.
    PS50020. WW_DOMAIN_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: EmbryoImported.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.

    Entry informationi

    Entry nameiB2RSC8_MOUSE
    AccessioniPrimary (citable) accession number: B2RSC8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)