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Protein

RNA polymerase I-specific transcription initiation factor RRN3

Gene

Rrn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction.2 Publications

GO - Molecular functioni

GO - Biological processi

  • cell proliferation Source: MGI
  • cytoplasm organization Source: MGI
  • DNA-templated transcription, initiation Source: MGI
  • homeostasis of number of cells Source: MGI
  • in utero embryonic development Source: MGI
  • negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator Source: MGI
  • nucleolus organization Source: MGI
  • positive regulation of neuron projection development Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: MGI
  • regulation of DNA-templated transcription, initiation Source: MGI
  • ribosome biogenesis Source: MGI
  • transcription initiation from RNA polymerase I promoter Source: MGI

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-73762 RNA Polymerase I Transcription Initiation
R-MMU-73772 RNA Polymerase I Promoter Escape

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase I-specific transcription initiation factor RRN3
Gene namesi
Name:Rrn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1925255 Rrn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003849051 – 656RNA polymerase I-specific transcription initiation factor RRN3Add BLAST656

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei168PhosphoserineCombined sources1
Modified residuei170PhosphoserineCombined sources1
Modified residuei198Phosphothreonine; by MAPK9By similarity1
Modified residuei638PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated at Thr-198 by MAPK9/JNK2, which abrogates initiation complex formation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiB2RS91
PaxDbiB2RS91
PeptideAtlasiB2RS91
PRIDEiB2RS91

PTM databases

iPTMnetiB2RS91
PhosphoSitePlusiB2RS91

Expressioni

Gene expression databases

BgeeiENSMUSG00000022682
GenevisibleiB2RS91 MM

Interactioni

Subunit structurei

Interacts with TAF1B. Interacts with TWISTNB, EIF3L and TAF1C (By similarity).By similarity

GO - Molecular functioni

  • RNA polymerase binding Source: MGI
  • RNA polymerase I core binding Source: GO_Central

Protein-protein interaction databases

BioGridi223022, 3 interactors
CORUMiB2RS91
STRINGi10090.ENSMUSP00000023363

Structurei

3D structure databases

ProteinModelPortaliB2RS91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni498 – 650Interaction with TWISTNBBy similarityAdd BLAST153
Regioni555 – 650Interaction with EIF3LBy similarityAdd BLAST96

Sequence similaritiesi

Belongs to the RRN3 family.Curated

Phylogenomic databases

eggNOGiKOG2434 Eukaryota
ENOG410XRJJ LUCA
GeneTreeiENSGT00390000001488
HOGENOMiHOG000236344
InParanoidiB2RS91
KOiK15216
OMAiPLKVCSP
OrthoDBiEOG091G089T
PhylomeDBiB2RS91
TreeFamiTF312979

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR007991 RNA_pol_I_trans_ini_fac_RRN3
PANTHERiPTHR12790 PTHR12790, 1 hit
PfamiView protein in Pfam
PF05327 RRN3, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

Sequencei

Sequence statusi: Complete.

B2RS91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPLLHTRL SGDVTAAASA TLSASRTGLS DMLALESDFF NSPPKKTVRF
60 70 80 90 100
GGTVTEVLLK YKKGETNDLE LLKNQLSDPD IKDDQIINWL LEFRSSVMYL
110 120 130 140 150
TKDFEQLINI ILRLPWLNRS QRVVEEYLAF LGNLVSAQTV FLRPCLSMIA
160 170 180 190 200
SHFVPPRVIV KEGGIDVSDS DDEDDNLPAI FDTCHRALQI ITRYVPSTPW
210 220 230 240 250
FLMPILVEKF PFVRKSERTL ECYVHNLLRI SLYFPTLRRE ILELVIEKLL
260 270 280 290 300
KLDVSVSRQD IEDAEEKAAQ TCGGTDTTEG LFNMDEDEDT DPEKKADQEQ
310 320 330 340 350
PNQMAHPTAE RLDVLLCLLL SYIEDVCRVH GKIDNNKTKD LYRDLISIFD
360 370 380 390 400
KLLLPTHASC HVQFFMFFLC SFKLGFAEAF LEHLWKKLQD PNNPAIIRQA
410 420 430 440 450
AANYIGSFLA RAKFIPLITV KTCLDLLVNW LHMYLTNQDS GTKAFCDVAL
460 470 480 490 500
HGPFYSACQA VFYTVVFRHK QLLSGNLKQG LQYLQSLNFE RIVLSQLNPL
510 520 530 540 550
KICLPQVVNF FAAITNKYQL VFCYTIMERN SRQMLPVIRS TAGGDSVQTC
560 570 580 590 600
TNPLDTFFPF DPCVLKRSKK FIDPIYQIWE DGSAEELQEF KKSTKKEVVE
610 620 630 640 650
DEDDDFLKGE VPQSDTVTGL TPSSFDTHFQ SPSSSVGSPP VLYIPGQSPL

LTRIYD
Length:656
Mass (Da):74,518
Last modified:July 1, 2008 - v1
Checksum:i8C83C4893E2C2257
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti597E → Q in AAH55781 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055781 mRNA Translation: AAH55781.1
BC034110 mRNA Translation: AAH34110.1
BC138774 mRNA Translation: AAI38775.1
BC138776 mRNA Translation: AAI38777.1
CCDSiCCDS27968.1
RefSeqiNP_001034610.1, NM_001039521.1
UniGeneiMm.288606
Mm.490362

Genome annotation databases

EnsembliENSMUST00000023363; ENSMUSP00000023363; ENSMUSG00000022682
GeneIDi106298
KEGGimmu:106298
UCSCiuc007ygj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRRN3_MOUSE
AccessioniPrimary (citable) accession number: B2RS91
Secondary accession number(s): Q7TNE7, Q8K052
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 1, 2008
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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