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B2RS85

- B2RS85_MOUSE

UniProt

B2RS85 - B2RS85_MOUSE

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Protein
Submitted name: Sprouty homolog 2 (Drosophila)
Gene
Spry2, mCG_121239
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: MGI
  2. protein serine/threonine kinase activator activity Source: Ensembl

GO - Biological processi

  1. branching morphogenesis of an epithelial tube Source: MGI
  2. bud elongation involved in lung branching Source: MGI
  3. cell fate commitment Source: MGI
  4. establishment of mitotic spindle orientation Source: MGI
  5. inner ear morphogenesis Source: MGI
  6. lung development Source: MGI
  7. lung growth Source: MGI
  8. lung morphogenesis Source: MGI
  9. negative regulation of ERK1 and ERK2 cascade Source: MGI
  10. negative regulation of MAP kinase activity Source: MGI
  11. negative regulation of Ras GTPase activity Source: MGI
  12. negative regulation of Ras protein signal transduction Source: MGI
  13. negative regulation of apoptotic process Source: Ensembl
  14. negative regulation of cell proliferation Source: MGI
  15. negative regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  16. negative regulation of neurotrophin TRK receptor signaling pathway Source: MGI
  17. negative regulation of peptidyl-threonine phosphorylation Source: Ensembl
  18. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  19. positive regulation of gene expression Source: Ensembl
  20. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  21. positive regulation of protein kinase B signaling Source: Ensembl
  22. respiratory system development Source: MGI
  23. sensory perception of sound Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Sprouty homolog 2 (Drosophila)Imported
Gene namesi
Name:Spry2Imported
ORF Names:mCG_121239Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1345138. Spry2.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriB2RS85.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG003544.
InParanoidiB2RS85.
KOiK17383.
OMAiPHGEPDL.

Family and domain databases

InterProiIPR007875. Sprouty.
[Graphical view]
PfamiPF05210. Sprouty. 1 hit.
[Graphical view]
PROSITEiPS51227. SPR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RS85-1 [UniParc]FASTAAdd to Basket

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MEARAQSGNG SQPLLQTAHD SGRQRGEPDP RDALTQQVHV LSLDQIRAIR    50
NTNEYTEGPT VVPRPGLKPA PRPSTQHKHE RLHGLPEHRQ PPRLQPSQVH 100
SSRAPLSRSI STVSSGSRSS TRTSTSSSSS EQRLLGPSFS HGPAAADGII 150
RVQPKSELKP GDVKPLSKDD LGLHAYRCED CGKCKCKECT YPRPLPSDWI 200
CDKQCLCSAQ NVIDYGTCVC CVKGLFYHCS NDDEDNCADN PCSCSQSHCC 250
TRWSAMGVMS LFLPCLWCYL PAKGCLKLCQ GCYDRVNRPG CRCKNSNTVC 300
CKVPTVPPRN FEKPT 315
Length:315
Mass (Da):34,623
Last modified:July 1, 2008 - v1
Checksum:i81514698EAD809A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC138768 mRNA. Translation: AAI38769.1.
BC138771 mRNA. Translation: AAI38772.1.
CH466544 Genomic DNA. Translation: EDL00523.1.
RefSeqiNP_036027.1. NM_011897.3.
XP_006519079.1. XM_006519016.1.
UniGeneiMm.489870.
Mm.89982.

Genome annotation databases

GeneIDi24064.
KEGGimmu:24064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC138768 mRNA. Translation: AAI38769.1 .
BC138771 mRNA. Translation: AAI38772.1 .
CH466544 Genomic DNA. Translation: EDL00523.1 .
RefSeqi NP_036027.1. NM_011897.3.
XP_006519079.1. XM_006519016.1.
UniGenei Mm.489870.
Mm.89982.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 24064.
KEGGi mmu:24064.

Organism-specific databases

CTDi 10253.
MGIi MGI:1345138. Spry2.

Phylogenomic databases

HOVERGENi HBG003544.
InParanoidi B2RS85.
KOi K17383.
OMAi PHGEPDL.

Miscellaneous databases

NextBioi 304033.
SOURCEi Search...

Gene expression databases

Genevestigatori B2RS85.

Family and domain databases

InterProi IPR007875. Sprouty.
[Graphical view ]
Pfami PF05210. Sprouty. 1 hit.
[Graphical view ]
PROSITEi PS51227. SPR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LungImported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiB2RS85_MOUSE
AccessioniPrimary (citable) accession number: B2RS85
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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