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Protein
Submitted name:

Occludin

Gene

Ocln

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
OccludinImported
Submitted name:
Occludin, isoform CRA_aImported
Submitted name:
Ocln proteinImported
Gene namesi
Name:OclnImported
ORF Names:mCG_116163Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:106183 Ocln

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei67 – 89HelicalSequence analysisAdd BLAST23
Transmembranei138 – 159HelicalSequence analysisAdd BLAST22
Transmembranei171 – 193HelicalSequence analysisAdd BLAST23
Transmembranei242 – 263HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000021638
ExpressionAtlasiB2RS24 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiB2RS24
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 267MARVELInterPro annotationAdd BLAST208

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili435 – 486Sequence analysisAdd BLAST52

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IGK8 Eukaryota
ENOG4110E0E LUCA
HOGENOMiHOG000233490
HOVERGENiHBG004523
KOiK06088
OMAiYAPSNDM
OrthoDBiEOG091G0BWN

Family and domain databases

InterProiView protein in InterPro
IPR031176 ELL/occludin
IPR008253 Marvel
IPR002958 Occludin
IPR010844 Occludin_ELL
PANTHERiPTHR23288 PTHR23288, 1 hit
PTHR23288:SF4 PTHR23288:SF4, 1 hit
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PF07303 Occludin_ELL, 1 hit
PIRSFiPIRSF005993 Occludin, 1 hit
PRINTSiPR01258 OCCLUDIN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

Sequencei

Sequence statusi: Complete.

B2RS24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRPFESPP PYRPDEFKPN HYAPSNDMYG GEMHVRPMLS QPAYSFYPED
60 70 80 90 100
EILHFYKWTS PPGVIRILSM LIIVMCIAIF ACVASTLAWD RGYGTGLFGG
110 120 130 140 150
SLNYPYSGFG YGGGYGGGYG GYGYGYGGYT DPRAAKGFLL AMAAFCFIAS
160 170 180 190 200
LVIFVTSVIR SGMSRTRRYY LIVIIVSAIL GIMVFIATIV YIMGVNPTAQ
210 220 230 240 250
ASGSMYGSQI YMICNQFYTP GGTGLYVDQY LYHYCVVDPQ EAIAIVLGFM
260 270 280 290 300
IIVAFALIIF FAVKTRRKMD RYDKSNILWD KEHIYDEQPP NVEEWVKNVS
310 320 330 340 350
AGTQDMPPPP SDYAERVDSP MAYSSNGKVN GKRSYPESFY KSTPLVPEVA
360 370 380 390 400
QEIPLTLSVD DFRQPRYSSN GNLETPSKRA PTKGKAGKGK RTDPDHYETD
410 420 430 440 450
YTTGGESCEE LEEDWVREYP PITSDQQRQL YKRNFDAGLQ EYKSLQAELD
460 470 480 490 500
DVNKELSRLD KELDDYREES EEYMAAADEY NRLKQVKGSA DYKSKRNYCK
510 520
QLKSKLSHIK RMVGDYDRRK P
Length:521
Mass (Da):59,000
Last modified:July 1, 2008 - v1
Checksum:i21D62F370EB33E7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC138679 mRNA Translation: AAI38680.1
BC138680 mRNA Translation: AAI38681.1
BC145371 mRNA Translation: AAI45372.1
CH466567 Genomic DNA Translation: EDL00804.1
RefSeqiNP_032782.1, NM_008756.2
XP_006517626.1, XM_006517563.3
XP_006517627.1, XM_006517564.3
XP_006517629.1, XM_006517566.2
XP_011242936.1, XM_011244634.2
UniGeneiMm.4807

Genome annotation databases

GeneIDi18260
KEGGimmu:18260

Similar proteinsi

Entry informationi

Entry nameiB2RS24_MOUSE
AccessioniPrimary (citable) accession number: B2RS24
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health