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Protein
Submitted name:

Occludin

Gene

Ocln

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
OccludinImported
Submitted name:
Occludin, isoform CRA_aImported
Submitted name:
Ocln proteinImported
Gene namesi
Name:OclnImported
ORF Names:mCG_116163Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:106183. Ocln.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei67 – 8923HelicalSequence analysisAdd
BLAST
Transmembranei138 – 15922HelicalSequence analysisAdd
BLAST
Transmembranei171 – 19323HelicalSequence analysisAdd
BLAST
Transmembranei242 – 26322HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022140.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 267208MARVELInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili435 – 48652Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IGK8. Eukaryota.
ENOG4110E0E. LUCA.
HOGENOMiHOG000233490.
HOVERGENiHBG004523.
KOiK06088.
OMAiYAPSNDV.

Family and domain databases

InterProiIPR031176. ELL/occludin.
IPR008253. Marvel.
IPR002958. Occludin.
IPR010844. Occludin_ELL.
[Graphical view]
PANTHERiPTHR23288. PTHR23288. 1 hit.
PTHR23288:SF4. PTHR23288:SF4. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
PF07303. Occludin_ELL. 1 hit.
[Graphical view]
PIRSFiPIRSF005993. Occludin. 1 hit.
PRINTSiPR01258. OCCLUDIN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RS24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRPFESPP PYRPDEFKPN HYAPSNDMYG GEMHVRPMLS QPAYSFYPED
60 70 80 90 100
EILHFYKWTS PPGVIRILSM LIIVMCIAIF ACVASTLAWD RGYGTGLFGG
110 120 130 140 150
SLNYPYSGFG YGGGYGGGYG GYGYGYGGYT DPRAAKGFLL AMAAFCFIAS
160 170 180 190 200
LVIFVTSVIR SGMSRTRRYY LIVIIVSAIL GIMVFIATIV YIMGVNPTAQ
210 220 230 240 250
ASGSMYGSQI YMICNQFYTP GGTGLYVDQY LYHYCVVDPQ EAIAIVLGFM
260 270 280 290 300
IIVAFALIIF FAVKTRRKMD RYDKSNILWD KEHIYDEQPP NVEEWVKNVS
310 320 330 340 350
AGTQDMPPPP SDYAERVDSP MAYSSNGKVN GKRSYPESFY KSTPLVPEVA
360 370 380 390 400
QEIPLTLSVD DFRQPRYSSN GNLETPSKRA PTKGKAGKGK RTDPDHYETD
410 420 430 440 450
YTTGGESCEE LEEDWVREYP PITSDQQRQL YKRNFDAGLQ EYKSLQAELD
460 470 480 490 500
DVNKELSRLD KELDDYREES EEYMAAADEY NRLKQVKGSA DYKSKRNYCK
510 520
QLKSKLSHIK RMVGDYDRRK P
Length:521
Mass (Da):59,000
Last modified:July 1, 2008 - v1
Checksum:i21D62F370EB33E7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158536 Genomic DNA. No translation available.
BC138679 mRNA. Translation: AAI38680.1.
BC138680 mRNA. Translation: AAI38681.1.
BC145371 mRNA. Translation: AAI45372.1.
CH466567 Genomic DNA. Translation: EDL00804.1.
RefSeqiNP_032782.1. NM_008756.2.
XP_006517626.1. XM_006517563.2.
XP_006517627.1. XM_006517564.2.
XP_006517629.1. XM_006517566.2.
XP_011242936.1. XM_011244634.1.
UniGeneiMm.4807.

Genome annotation databases

EnsembliENSMUST00000022140; ENSMUSP00000022140; ENSMUSG00000021638.
ENSMUST00000069756; ENSMUSP00000065284; ENSMUSG00000021638.
ENSMUST00000160859; ENSMUSP00000124849; ENSMUSG00000021638.
GeneIDi18260.
KEGGimmu:18260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158536 Genomic DNA. No translation available.
BC138679 mRNA. Translation: AAI38680.1.
BC138680 mRNA. Translation: AAI38681.1.
BC145371 mRNA. Translation: AAI45372.1.
CH466567 Genomic DNA. Translation: EDL00804.1.
RefSeqiNP_032782.1. NM_008756.2.
XP_006517626.1. XM_006517563.2.
XP_006517627.1. XM_006517564.2.
XP_006517629.1. XM_006517566.2.
XP_011242936.1. XM_011244634.1.
UniGeneiMm.4807.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022140.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022140; ENSMUSP00000022140; ENSMUSG00000021638.
ENSMUST00000069756; ENSMUSP00000065284; ENSMUSG00000021638.
ENSMUST00000160859; ENSMUSP00000124849; ENSMUSG00000021638.
GeneIDi18260.
KEGGimmu:18260.

Organism-specific databases

CTDi100506658.
MGIiMGI:106183. Ocln.

Phylogenomic databases

eggNOGiENOG410IGK8. Eukaryota.
ENOG4110E0E. LUCA.
HOGENOMiHOG000233490.
HOVERGENiHBG004523.
KOiK06088.
OMAiYAPSNDV.

Miscellaneous databases

NextBioi293704.
SOURCEiSearch...

Family and domain databases

InterProiIPR031176. ELL/occludin.
IPR008253. Marvel.
IPR002958. Occludin.
IPR010844. Occludin_ELL.
[Graphical view]
PANTHERiPTHR23288. PTHR23288. 1 hit.
PTHR23288:SF4. PTHR23288:SF4. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
PF07303. Occludin_ELL. 1 hit.
[Graphical view]
PIRSFiPIRSF005993. Occludin. 1 hit.
PRINTSiPR01258. OCCLUDIN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (AUG-2015) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB2RS24_MOUSE
AccessioniPrimary (citable) accession number: B2RS24
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: May 11, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.