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Protein

Zinc finger protein 518A

Gene

Znf518a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri152 – 17423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri209 – 23123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri236 – 25823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri264 – 28724C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1444 – 146623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 518A
Gene namesi
Name:Znf518a
Synonyms:Kiaa0335, Zfp518, Zfp518a, Znf518
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1919922. Zfp518a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14781478Zinc finger protein 518APRO_0000349265Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki359 – 359Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei653 – 6531PhosphoserineBy similarity
Cross-linki709 – 709Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki989 – 989Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1441 – 1441Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiB2RRF6.
PeptideAtlasiB2RRF6.
PRIDEiB2RRF6.

PTM databases

iPTMnetiB2RRF6.
PhosphoSiteiB2RRF6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000049164.
GenevisibleiB2RRF6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055956.

Structurei

3D structure databases

ProteinModelPortaliB2RRF6.
SMRiB2RRF6. Positions 143-182, 232-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi309 – 3124Poly-Thr

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri152 – 17423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri209 – 23123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri236 – 25823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri264 – 28724C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1444 – 146623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000064040.
HOGENOMiHOG000155775.
HOVERGENiHBG098619.
InParanoidiB2RRF6.
OMAiVDGKQHI.
OrthoDBiEOG091G00JQ.
PhylomeDBiB2RRF6.
TreeFamiTF332842.

Family and domain databases

InterProiIPR027775. C2H2_Znf_fam.
IPR027760. ZNF518A.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 3 hits.
PTHR10032:SF198. PTHR10032:SF198. 3 hits.
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RRF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFEQTQLFC DEKPTILKKL DTRNEIADTI RSVSTSKISE TSFQYVLKDV
60 70 80 90 100
NICLPKINIP NEILMKHEVE KYRLLFQSKP QTARKSISVK TVSCAEECVL
110 120 130 140 150
LCKSERAEDE TVNMSAKILN FSCSKCQDST QYSPNDLQKH FEMWHHGELP
160 170 180 190 200
SFPCEMCSFS ASDFQIFKQH RKTHRNTFVK CDICNSERSY TLLDLTKHFT
210 220 230 240 250
SKHCVNGNFQ CEECRFFTQD VGTFVQHIHR HKEVHYKCGK CHHLCFTKGE
260 270 280 290 300
LQKHLRVHSG TLPFTCHYCS YGAIHKDQLI RHVITLHKEH LYAKEKLERD
310 320 330 340 350
QYDKRVAKTT TTGLKLILKR YKIGPTKTFW KRKTITSGND ESIGKNAQAF
360 370 380 390 400
NIVSKTQTKS EDQSQEQVNG EKGEKQHCEN GDKPVESESE KATVLSTGQY
410 420 430 440 450
NKADEGASTT SSSVLSAVQG PTVLLVRNNK ITIPANYSAK FMGFKMVDGR
460 470 480 490 500
QHIVIKLLPA NKQILPSPVL QSNTEKNSTA NLSPQAVANT GFATGLTTKV
510 520 530 540 550
NDTDFVKAAP PACSSPVLAR KVISEKEAAF ISEKNNTLQM VDDSKSLSSL
560 570 580 590 600
PTTSTTSVRV TTKVEARDNV DLWENDSPQS HPDASDTSIS SPDKVSLTPK
610 620 630 640 650
PNAYSSGDMH NYCINYVNSE LPAESSNSFE FSNQGSLPFH NYSKVNNKRR
660 670 680 690 700
RFSRATLCEN LQKESPNKTV TQQSTSDSDT ASPLLRKESS NSDNLFASIN
710 720 730 740 750
PLNGTLKIKT EIEEPYNLEE TQNFNEQSLF TNENQNLLNV TEEPKWNDIP
760 770 780 790 800
SAGSPMMPRI TSVFSLQSEQ ASEFLTPEVN QLLQDTLKPK SDIKEDSNNI
810 820 830 840 850
PSKNLPFDCD QTLKKSEEVV IKSSKDFQMQ DDIPVPSASV GVNVPANDLN
860 870 880 890 900
SKCNGQEKQG LSVLQDVRDS EVTTKIPNII TLLKTQSDAI ITQQLVKDKL
910 920 930 940 950
RTTTQNSGPV YVQNPFLTSE QKNPVFVQTP KGFIIPLHVA NKPGLHVFSG
960 970 980 990 1000
RPVPLVNTRS VPATLLVNKK PGMLLATNNG KPESVPTVKT ENVHSYGTVT
1010 1020 1030 1040 1050
KEPCKTPFLK AEHNNSCLTP GLCSSIGNCV NMKTCSENTL PLKGSYIIKT
1060 1070 1080 1090 1100
SVNSSVKAVP NILPEQQGPK MNILDTVKQQ NENLPKASLY TLMPDGKQAV
1110 1120 1130 1140 1150
FFKCVMPNNT KLLKPKLVQS STYQHIQPKR PAGAPQKILV KIFNPVLSMS
1160 1170 1180 1190 1200
AFNNLSASNS ASSFQKEIVP SKPTVHGEQK EPETSRNALP VLVHGLMPAN
1210 1220 1230 1240 1250
ETVHSSTTAC PGSSEEPVYI SERSETRVLR GKANCAVERN FNKRKTCKNK
1260 1270 1280 1290 1300
FAKIKTRIDQ DSETAFVSRN RSCKRKYIDN YQEPPRKKST LNRKGKERAS
1310 1320 1330 1340 1350
AEDVQEAFGF SRPRLPKDSS RTLRLFPFSS KQLVKCPRRN QPVVVLNHPD
1360 1370 1380 1390 1400
ADTPEVERVM KTIAKFNGHV LKVSLSQTTI NALLKPVSNT SETTYNDFSK
1410 1420 1430 1440 1450
RQKMLKPVNS VKERFVLKLT LKKTSKNNYQ IVKTTSEDVL KSQFNCWFCG
1460 1470
RVFDNQDVWA GHGQRHLVEA TRDWNMLE
Length:1,478
Mass (Da):165,604
Last modified:July 1, 2008 - v1
Checksum:i3C993056631ADB00
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti350 – 3501F → L in BAB28569 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC138382 mRNA. Translation: AAI38383.1.
BC138383 mRNA. Translation: AAI38384.1.
AK012959 mRNA. Translation: BAB28569.3.
CCDSiCCDS37982.1.
RefSeqiNP_082595.1. NM_028319.1.
XP_006527431.1. XM_006527368.2.
XP_011245661.1. XM_011247359.1.
XP_011245662.1. XM_011247360.1.
XP_011245663.1. XM_011247361.1.
XP_011245664.1. XM_011247362.1.
XP_011245665.1. XM_011247363.1.
XP_011245666.1. XM_011247364.1.
XP_011245667.1. XM_011247365.1.
UniGeneiMm.313523.

Genome annotation databases

EnsembliENSMUST00000050092; ENSMUSP00000055956; ENSMUSG00000049164.
GeneIDi72672.
KEGGimmu:72672.
UCSCiuc008hlk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC138382 mRNA. Translation: AAI38383.1.
BC138383 mRNA. Translation: AAI38384.1.
AK012959 mRNA. Translation: BAB28569.3.
CCDSiCCDS37982.1.
RefSeqiNP_082595.1. NM_028319.1.
XP_006527431.1. XM_006527368.2.
XP_011245661.1. XM_011247359.1.
XP_011245662.1. XM_011247360.1.
XP_011245663.1. XM_011247361.1.
XP_011245664.1. XM_011247362.1.
XP_011245665.1. XM_011247363.1.
XP_011245666.1. XM_011247364.1.
XP_011245667.1. XM_011247365.1.
UniGeneiMm.313523.

3D structure databases

ProteinModelPortaliB2RRF6.
SMRiB2RRF6. Positions 143-182, 232-267.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055956.

PTM databases

iPTMnetiB2RRF6.
PhosphoSiteiB2RRF6.

Proteomic databases

PaxDbiB2RRF6.
PeptideAtlasiB2RRF6.
PRIDEiB2RRF6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050092; ENSMUSP00000055956; ENSMUSG00000049164.
GeneIDi72672.
KEGGimmu:72672.
UCSCiuc008hlk.1. mouse.

Organism-specific databases

CTDi72672.
MGIiMGI:1919922. Zfp518a.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000064040.
HOGENOMiHOG000155775.
HOVERGENiHBG098619.
InParanoidiB2RRF6.
OMAiVDGKQHI.
OrthoDBiEOG091G00JQ.
PhylomeDBiB2RRF6.
TreeFamiTF332842.

Miscellaneous databases

PROiB2RRF6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049164.
GenevisibleiB2RRF6. MM.

Family and domain databases

InterProiIPR027775. C2H2_Znf_fam.
IPR027760. ZNF518A.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 3 hits.
PTHR10032:SF198. PTHR10032:SF198. 3 hits.
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZ518A_MOUSE
AccessioniPrimary (citable) accession number: B2RRF6
Secondary accession number(s): Q9CSF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 1, 2008
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.