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B2RRE7

- OTUD4_MOUSE

UniProt

B2RRE7 - OTUD4_MOUSE

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Protein

OTU domain-containing protein 4

Gene
Otud4, Kiaa1046
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Deubiquitinating enzyme that specifically hydrolyzes 'Lys-48'-linked polyubiquitin By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei42 – 421 By similarity
Active sitei45 – 451Nucleophile By similarity
Active sitei148 – 1481 By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. protein K48-linked deubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC85.002.

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 4 (EC:3.4.19.12)
Gene namesi
Name:Otud4
Synonyms:Kiaa1046
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1098801. Otud4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11071107OTU domain-containing protein 4PRO_0000394458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarityBy similarity
Modified residuei438 – 4381Phosphotyrosine1 Publication
Modified residuei442 – 4421Phosphoserine By similarityBy similarity
Modified residuei459 – 4591Phosphotyrosine By similarity
Modified residuei895 – 8951Phosphoserine By similarity
Modified residuei1000 – 10001Phosphoserine1 Publication
Modified residuei1005 – 10051Phosphoserine1 Publication
Modified residuei1016 – 10161Phosphoserine3 Publications
Modified residuei1017 – 10171Phosphoserine3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiB2RRE7.
PaxDbiB2RRE7.
PRIDEiB2RRE7.

PTM databases

PhosphoSiteiB2RRE7.

Expressioni

Gene expression databases

BgeeiB2RRE7.
GenevestigatoriB2RRE7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035541.

Structurei

3D structure databases

ProteinModelPortaliB2RRE7.
SMRiB2RRE7. Positions 2-152.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 155122OTUAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni39 – 457Cys-loop By similarity
Regioni94 – 10411Variable-loop By similarityAdd
BLAST
Regioni143 – 1486His-loop By similarity

Sequence similaritiesi

Contains 1 OTU domain.

Phylogenomic databases

eggNOGiNOG81083.
GeneTreeiENSGT00530000063508.
HOGENOMiHOG000168383.
HOVERGENiHBG082091.
InParanoidiQ9CUN2.
KOiK13718.
OMAiNPWFQEA.
OrthoDBiEOG7H791H.
PhylomeDBiB2RRE7.
TreeFamiTF326812.

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RRE7-1 [UniParc]FASTAAdd to Basket

« Hide

MEAAVGAPDG VDQGGVGPLE DETPMDAYLR KLGLYRKLVA KDGSCLFRAV     50
AEQVLHSQSR HVEVRMACIR YLRENREKFE AFIEGSFEEY LKRLENPQEW 100
VGQVEISALS LMYRKDFVIY QEPNVSPSHV TENNFPEKVL LCFSNGNHYD 150
IVYPITYKDS SAMCQSLLYE LLYEKVFKTD VSKIMMGLEA SEVAEESNSE 200
ISDSEDDSCK SKSTAATDVN GFKPSGSENP KNNGNSADLP LSRKVLKSLN 250
PAVYRNVEYE IWLKSKQAQQ KRDYSIAAGL QYEVGDKCHQ VRLDHNGKLS 300
NADIHGVHSE NGLVLSEELG KKHTPKNLKP PPPESWNTVS GKKMKKPNSG 350
QNFHSDTDYR GPKNLNKPIK APSALPPRLQ HPSSGVRQHA FSSHSTGSQS 400
QKSSSEHKNL SRMPSQITRK PDRERAEDFD HVSRESYYFG LSPEERREKQ 450
AIEESRLLYE IQNRDEQAFP ALSSSSVSQS PSQNSNACVP RKSSHARDRK 500
GSMRRADAEE RKDKDSLRGH THVDKKPEPS TLEISDDKCT RVSSPSKSKK 550
ECPSPVEQKP AEHIPLSNPA PLLVSPEVHL TPAVPSLPAT VPAWPSEPTT 600
FGPTGVPAQI PILSVTQTTG PDAAVSQAHL TPSPVPVSIQ AVNQPLMPLP 650
QTMSLYQDPL YPGFPCSEKG DRAIAPPYSL CQTGEDLPKD KNILRFFFNL 700
GVKAYSCPMW APHSYLYPLH QAYMAACRMY PKVPVPVYPQ NTWFQEAPPA 750
QSESDCPCTD AHYSLHPEAS VNGQMPQAEM GPPAFASPLV IPPSQVSEGH 800
GQLSYQPELE SENPGQLLHA EYEESLSGKN MYPQQSFGPN PFLGPVPIAP 850
PFFPHVWYGY PFQGFVENPV MRQNIVLPPD DKGELDLPLE NLDLSKECDS 900
VSAVDEFPDA RVEGAHSLSA ASVSSKHEGR VEQSSQTRKA DIDLASGSSA 950
VEGKGHPPTQ ILNREREPGS AEPEPKRTIQ SLKEKPEKVK DPKTAADVVS 1000
PGANSVDRLQ RPKEESSEDE NEVSNILRSG RSKQFYNQTY GSRKYKSDWG 1050
SSGRGGYQHV RGEESWKGQP NRSRDEGYQY HRHVRGRPYR GDRRRSGMGD 1100
GHRGQHT 1107
Length:1,107
Mass (Da):123,055
Last modified:July 1, 2008 - v1
Checksum:i746B6BC8589FA672
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti290 – 2901Missing in AAI45260. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC138373 mRNA. Translation: AAI38374.1.
BC145259 mRNA. Translation: AAI45260.1.
AK122429 mRNA. Translation: BAC65711.1.
AK015275 mRNA. Translation: BAB29777.1.
CCDSiCCDS57625.1.
RefSeqiNP_001074633.1. NM_001081164.1.
NP_001242962.1. NM_001256033.1.
UniGeneiMm.34348.

Genome annotation databases

EnsembliENSMUST00000173078; ENSMUSP00000133939; ENSMUSG00000036990.
ENSMUST00000173286; ENSMUSP00000134097; ENSMUSG00000036990.
GeneIDi73945.
KEGGimmu:73945.
UCSCiuc009mir.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC138373 mRNA. Translation: AAI38374.1 .
BC145259 mRNA. Translation: AAI45260.1 .
AK122429 mRNA. Translation: BAC65711.1 .
AK015275 mRNA. Translation: BAB29777.1 .
CCDSi CCDS57625.1.
RefSeqi NP_001074633.1. NM_001081164.1.
NP_001242962.1. NM_001256033.1.
UniGenei Mm.34348.

3D structure databases

ProteinModelPortali B2RRE7.
SMRi B2RRE7. Positions 2-152.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000035541.

Protein family/group databases

MEROPSi C85.002.

PTM databases

PhosphoSitei B2RRE7.

Proteomic databases

MaxQBi B2RRE7.
PaxDbi B2RRE7.
PRIDEi B2RRE7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000173078 ; ENSMUSP00000133939 ; ENSMUSG00000036990 .
ENSMUST00000173286 ; ENSMUSP00000134097 ; ENSMUSG00000036990 .
GeneIDi 73945.
KEGGi mmu:73945.
UCSCi uc009mir.1. mouse.

Organism-specific databases

CTDi 54726.
MGIi MGI:1098801. Otud4.
Rougei Search...

Phylogenomic databases

eggNOGi NOG81083.
GeneTreei ENSGT00530000063508.
HOGENOMi HOG000168383.
HOVERGENi HBG082091.
InParanoidi Q9CUN2.
KOi K13718.
OMAi NPWFQEA.
OrthoDBi EOG7H791H.
PhylomeDBi B2RRE7.
TreeFami TF326812.

Miscellaneous databases

ChiTaRSi OTUD4. mouse.
NextBioi 339402.
PROi B2RRE7.
SOURCEi Search...

Gene expression databases

Bgeei B2RRE7.
Genevestigatori B2RRE7.

Family and domain databases

InterProi IPR003323. OTU.
[Graphical view ]
Pfami PF02338. OTU. 1 hit.
[Graphical view ]
PROSITEi PS50802. OTU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 161-1107.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 930-1107.
    Strain: C57BL/6J.
    Tissue: Testis.
  4. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-438, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mast cell.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1000; SER-1005; SER-1016 AND SER-1017, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1016 AND SER-1017, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiOTUD4_MOUSE
AccessioniPrimary (citable) accession number: B2RRE7
Secondary accession number(s): B7ZNI5, Q80TL3, Q9CUN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 1, 2008
Last modified: July 9, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi