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B2RRE7

- OTUD4_MOUSE

UniProt

B2RRE7 - OTUD4_MOUSE

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Protein

OTU domain-containing protein 4

Gene

Otud4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Deubiquitinating enzyme that specifically hydrolyzes 'Lys-48'-linked polyubiquitin.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei42 – 421By similarity
Active sitei45 – 451NucleophileBy similarity
Active sitei148 – 1481By similarity

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl
  2. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. protein K48-linked deubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC85.002.

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 4By similarity (EC:3.4.19.12)
Gene namesi
Name:Otud4Imported
Synonyms:Kiaa1046Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1098801. Otud4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11071107OTU domain-containing protein 4PRO_0000394458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei438 – 4381Phosphotyrosine1 Publication
Modified residuei442 – 4421PhosphoserineBy similarity
Modified residuei459 – 4591PhosphotyrosineBy similarity
Modified residuei895 – 8951PhosphoserineBy similarity
Modified residuei1000 – 10001Phosphoserine1 Publication
Modified residuei1005 – 10051Phosphoserine1 Publication
Modified residuei1016 – 10161Phosphoserine2 Publications
Modified residuei1017 – 10171Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiB2RRE7.
PaxDbiB2RRE7.
PRIDEiB2RRE7.

PTM databases

PhosphoSiteiB2RRE7.

Expressioni

Gene expression databases

BgeeiB2RRE7.
GenevestigatoriB2RRE7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035541.

Structurei

3D structure databases

ProteinModelPortaliB2RRE7.
SMRiB2RRE7. Positions 2-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 155122OTUPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni39 – 457Cys-loopBy similarity
Regioni94 – 10411Variable-loopBy similarityAdd
BLAST
Regioni143 – 1486His-loopBy similarity

Sequence similaritiesi

Contains 1 OTU domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG81083.
GeneTreeiENSGT00530000063508.
HOGENOMiHOG000168383.
HOVERGENiHBG082091.
InParanoidiB2RRE7.
KOiK13718.
OMAiNPWFQEA.
OrthoDBiEOG7H791H.
PhylomeDBiB2RRE7.
TreeFamiTF326812.

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RRE7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEAAVGAPDG VDQGGVGPLE DETPMDAYLR KLGLYRKLVA KDGSCLFRAV
60 70 80 90 100
AEQVLHSQSR HVEVRMACIR YLRENREKFE AFIEGSFEEY LKRLENPQEW
110 120 130 140 150
VGQVEISALS LMYRKDFVIY QEPNVSPSHV TENNFPEKVL LCFSNGNHYD
160 170 180 190 200
IVYPITYKDS SAMCQSLLYE LLYEKVFKTD VSKIMMGLEA SEVAEESNSE
210 220 230 240 250
ISDSEDDSCK SKSTAATDVN GFKPSGSENP KNNGNSADLP LSRKVLKSLN
260 270 280 290 300
PAVYRNVEYE IWLKSKQAQQ KRDYSIAAGL QYEVGDKCHQ VRLDHNGKLS
310 320 330 340 350
NADIHGVHSE NGLVLSEELG KKHTPKNLKP PPPESWNTVS GKKMKKPNSG
360 370 380 390 400
QNFHSDTDYR GPKNLNKPIK APSALPPRLQ HPSSGVRQHA FSSHSTGSQS
410 420 430 440 450
QKSSSEHKNL SRMPSQITRK PDRERAEDFD HVSRESYYFG LSPEERREKQ
460 470 480 490 500
AIEESRLLYE IQNRDEQAFP ALSSSSVSQS PSQNSNACVP RKSSHARDRK
510 520 530 540 550
GSMRRADAEE RKDKDSLRGH THVDKKPEPS TLEISDDKCT RVSSPSKSKK
560 570 580 590 600
ECPSPVEQKP AEHIPLSNPA PLLVSPEVHL TPAVPSLPAT VPAWPSEPTT
610 620 630 640 650
FGPTGVPAQI PILSVTQTTG PDAAVSQAHL TPSPVPVSIQ AVNQPLMPLP
660 670 680 690 700
QTMSLYQDPL YPGFPCSEKG DRAIAPPYSL CQTGEDLPKD KNILRFFFNL
710 720 730 740 750
GVKAYSCPMW APHSYLYPLH QAYMAACRMY PKVPVPVYPQ NTWFQEAPPA
760 770 780 790 800
QSESDCPCTD AHYSLHPEAS VNGQMPQAEM GPPAFASPLV IPPSQVSEGH
810 820 830 840 850
GQLSYQPELE SENPGQLLHA EYEESLSGKN MYPQQSFGPN PFLGPVPIAP
860 870 880 890 900
PFFPHVWYGY PFQGFVENPV MRQNIVLPPD DKGELDLPLE NLDLSKECDS
910 920 930 940 950
VSAVDEFPDA RVEGAHSLSA ASVSSKHEGR VEQSSQTRKA DIDLASGSSA
960 970 980 990 1000
VEGKGHPPTQ ILNREREPGS AEPEPKRTIQ SLKEKPEKVK DPKTAADVVS
1010 1020 1030 1040 1050
PGANSVDRLQ RPKEESSEDE NEVSNILRSG RSKQFYNQTY GSRKYKSDWG
1060 1070 1080 1090 1100
SSGRGGYQHV RGEESWKGQP NRSRDEGYQY HRHVRGRPYR GDRRRSGMGD

GHRGQHT
Length:1,107
Mass (Da):123,055
Last modified:July 1, 2008 - v1
Checksum:i746B6BC8589FA672
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti290 – 2901Missing in AAI45260. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC138373 mRNA. Translation: AAI38374.1.
BC145259 mRNA. Translation: AAI45260.1.
AK122429 mRNA. Translation: BAC65711.1.
AK015275 mRNA. Translation: BAB29777.1.
CCDSiCCDS57625.1.
RefSeqiNP_001074633.1. NM_001081164.1.
NP_001242962.1. NM_001256033.1.
UniGeneiMm.34348.

Genome annotation databases

EnsembliENSMUST00000173078; ENSMUSP00000133939; ENSMUSG00000036990.
ENSMUST00000173286; ENSMUSP00000134097; ENSMUSG00000036990.
GeneIDi73945.
KEGGimmu:73945.
UCSCiuc009mir.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC138373 mRNA. Translation: AAI38374.1 .
BC145259 mRNA. Translation: AAI45260.1 .
AK122429 mRNA. Translation: BAC65711.1 .
AK015275 mRNA. Translation: BAB29777.1 .
CCDSi CCDS57625.1.
RefSeqi NP_001074633.1. NM_001081164.1.
NP_001242962.1. NM_001256033.1.
UniGenei Mm.34348.

3D structure databases

ProteinModelPortali B2RRE7.
SMRi B2RRE7. Positions 2-152.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000035541.

Protein family/group databases

MEROPSi C85.002.

PTM databases

PhosphoSitei B2RRE7.

Proteomic databases

MaxQBi B2RRE7.
PaxDbi B2RRE7.
PRIDEi B2RRE7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000173078 ; ENSMUSP00000133939 ; ENSMUSG00000036990 .
ENSMUST00000173286 ; ENSMUSP00000134097 ; ENSMUSG00000036990 .
GeneIDi 73945.
KEGGi mmu:73945.
UCSCi uc009mir.1. mouse.

Organism-specific databases

CTDi 54726.
MGIi MGI:1098801. Otud4.
Rougei Search...

Phylogenomic databases

eggNOGi NOG81083.
GeneTreei ENSGT00530000063508.
HOGENOMi HOG000168383.
HOVERGENi HBG082091.
InParanoidi B2RRE7.
KOi K13718.
OMAi NPWFQEA.
OrthoDBi EOG7H791H.
PhylomeDBi B2RRE7.
TreeFami TF326812.

Miscellaneous databases

ChiTaRSi Otud4. mouse.
NextBioi 339402.
PROi B2RRE7.
SOURCEi Search...

Gene expression databases

Bgeei B2RRE7.
Genevestigatori B2RRE7.

Family and domain databases

InterProi IPR003323. OTU.
[Graphical view ]
Pfami PF02338. OTU. 1 hit.
[Graphical view ]
PROSITEi PS50802. OTU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 161-1107.
    Tissue: BrainImported.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 930-1107.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  4. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-438, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mast cell1 Publication.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1000; SER-1005; SER-1016 AND SER-1017, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver1 Publication.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1016 AND SER-1017, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiOTUD4_MOUSE
AccessioniPrimary (citable) accession number: B2RRE7
Secondary accession number(s): B7ZNI5, Q80TL3, Q9CUN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 1, 2008
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3