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B2RRE7

- OTUD4_MOUSE

UniProt

B2RRE7 - OTUD4_MOUSE

Protein

OTU domain-containing protein 4

Gene

Otud4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme that specifically hydrolyzes 'Lys-48'-linked polyubiquitin.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei42 – 421By similarity
    Active sitei45 – 451NucleophileBy similarity
    Active sitei148 – 1481By similarity

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: UniProtKB

    GO - Biological processi

    1. protein K48-linked deubiquitination Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC85.002.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    OTU domain-containing protein 4By similarity (EC:3.4.19.12)
    Gene namesi
    Name:Otud4Imported
    Synonyms:Kiaa1046Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1098801. Otud4.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11071107OTU domain-containing protein 4PRO_0000394458Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei438 – 4381Phosphotyrosine1 Publication
    Modified residuei442 – 4421PhosphoserineBy similarity
    Modified residuei459 – 4591PhosphotyrosineBy similarity
    Modified residuei895 – 8951PhosphoserineBy similarity
    Modified residuei1000 – 10001Phosphoserine1 Publication
    Modified residuei1005 – 10051Phosphoserine1 Publication
    Modified residuei1016 – 10161Phosphoserine2 Publications
    Modified residuei1017 – 10171Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiB2RRE7.
    PaxDbiB2RRE7.
    PRIDEiB2RRE7.

    PTM databases

    PhosphoSiteiB2RRE7.

    Expressioni

    Gene expression databases

    BgeeiB2RRE7.
    GenevestigatoriB2RRE7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000035541.

    Structurei

    3D structure databases

    ProteinModelPortaliB2RRE7.
    SMRiB2RRE7. Positions 2-152.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 155122OTUPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni39 – 457Cys-loopBy similarity
    Regioni94 – 10411Variable-loopBy similarityAdd
    BLAST
    Regioni143 – 1486His-loopBy similarity

    Sequence similaritiesi

    Contains 1 OTU domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG81083.
    GeneTreeiENSGT00530000063508.
    HOGENOMiHOG000168383.
    HOVERGENiHBG082091.
    InParanoidiQ9CUN2.
    KOiK13718.
    OMAiNPWFQEA.
    OrthoDBiEOG7H791H.
    PhylomeDBiB2RRE7.
    TreeFamiTF326812.

    Family and domain databases

    InterProiIPR003323. OTU.
    [Graphical view]
    PfamiPF02338. OTU. 1 hit.
    [Graphical view]
    PROSITEiPS50802. OTU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2RRE7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAAVGAPDG VDQGGVGPLE DETPMDAYLR KLGLYRKLVA KDGSCLFRAV     50
    AEQVLHSQSR HVEVRMACIR YLRENREKFE AFIEGSFEEY LKRLENPQEW 100
    VGQVEISALS LMYRKDFVIY QEPNVSPSHV TENNFPEKVL LCFSNGNHYD 150
    IVYPITYKDS SAMCQSLLYE LLYEKVFKTD VSKIMMGLEA SEVAEESNSE 200
    ISDSEDDSCK SKSTAATDVN GFKPSGSENP KNNGNSADLP LSRKVLKSLN 250
    PAVYRNVEYE IWLKSKQAQQ KRDYSIAAGL QYEVGDKCHQ VRLDHNGKLS 300
    NADIHGVHSE NGLVLSEELG KKHTPKNLKP PPPESWNTVS GKKMKKPNSG 350
    QNFHSDTDYR GPKNLNKPIK APSALPPRLQ HPSSGVRQHA FSSHSTGSQS 400
    QKSSSEHKNL SRMPSQITRK PDRERAEDFD HVSRESYYFG LSPEERREKQ 450
    AIEESRLLYE IQNRDEQAFP ALSSSSVSQS PSQNSNACVP RKSSHARDRK 500
    GSMRRADAEE RKDKDSLRGH THVDKKPEPS TLEISDDKCT RVSSPSKSKK 550
    ECPSPVEQKP AEHIPLSNPA PLLVSPEVHL TPAVPSLPAT VPAWPSEPTT 600
    FGPTGVPAQI PILSVTQTTG PDAAVSQAHL TPSPVPVSIQ AVNQPLMPLP 650
    QTMSLYQDPL YPGFPCSEKG DRAIAPPYSL CQTGEDLPKD KNILRFFFNL 700
    GVKAYSCPMW APHSYLYPLH QAYMAACRMY PKVPVPVYPQ NTWFQEAPPA 750
    QSESDCPCTD AHYSLHPEAS VNGQMPQAEM GPPAFASPLV IPPSQVSEGH 800
    GQLSYQPELE SENPGQLLHA EYEESLSGKN MYPQQSFGPN PFLGPVPIAP 850
    PFFPHVWYGY PFQGFVENPV MRQNIVLPPD DKGELDLPLE NLDLSKECDS 900
    VSAVDEFPDA RVEGAHSLSA ASVSSKHEGR VEQSSQTRKA DIDLASGSSA 950
    VEGKGHPPTQ ILNREREPGS AEPEPKRTIQ SLKEKPEKVK DPKTAADVVS 1000
    PGANSVDRLQ RPKEESSEDE NEVSNILRSG RSKQFYNQTY GSRKYKSDWG 1050
    SSGRGGYQHV RGEESWKGQP NRSRDEGYQY HRHVRGRPYR GDRRRSGMGD 1100
    GHRGQHT 1107
    Length:1,107
    Mass (Da):123,055
    Last modified:July 1, 2008 - v1
    Checksum:i746B6BC8589FA672
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti290 – 2901Missing in AAI45260. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC138373 mRNA. Translation: AAI38374.1.
    BC145259 mRNA. Translation: AAI45260.1.
    AK122429 mRNA. Translation: BAC65711.1.
    AK015275 mRNA. Translation: BAB29777.1.
    CCDSiCCDS57625.1.
    RefSeqiNP_001074633.1. NM_001081164.1.
    NP_001242962.1. NM_001256033.1.
    UniGeneiMm.34348.

    Genome annotation databases

    EnsembliENSMUST00000173078; ENSMUSP00000133939; ENSMUSG00000036990.
    ENSMUST00000173286; ENSMUSP00000134097; ENSMUSG00000036990.
    GeneIDi73945.
    KEGGimmu:73945.
    UCSCiuc009mir.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC138373 mRNA. Translation: AAI38374.1 .
    BC145259 mRNA. Translation: AAI45260.1 .
    AK122429 mRNA. Translation: BAC65711.1 .
    AK015275 mRNA. Translation: BAB29777.1 .
    CCDSi CCDS57625.1.
    RefSeqi NP_001074633.1. NM_001081164.1.
    NP_001242962.1. NM_001256033.1.
    UniGenei Mm.34348.

    3D structure databases

    ProteinModelPortali B2RRE7.
    SMRi B2RRE7. Positions 2-152.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000035541.

    Protein family/group databases

    MEROPSi C85.002.

    PTM databases

    PhosphoSitei B2RRE7.

    Proteomic databases

    MaxQBi B2RRE7.
    PaxDbi B2RRE7.
    PRIDEi B2RRE7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000173078 ; ENSMUSP00000133939 ; ENSMUSG00000036990 .
    ENSMUST00000173286 ; ENSMUSP00000134097 ; ENSMUSG00000036990 .
    GeneIDi 73945.
    KEGGi mmu:73945.
    UCSCi uc009mir.1. mouse.

    Organism-specific databases

    CTDi 54726.
    MGIi MGI:1098801. Otud4.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG81083.
    GeneTreei ENSGT00530000063508.
    HOGENOMi HOG000168383.
    HOVERGENi HBG082091.
    InParanoidi Q9CUN2.
    KOi K13718.
    OMAi NPWFQEA.
    OrthoDBi EOG7H791H.
    PhylomeDBi B2RRE7.
    TreeFami TF326812.

    Miscellaneous databases

    ChiTaRSi OTUD4. mouse.
    NextBioi 339402.
    PROi B2RRE7.
    SOURCEi Search...

    Gene expression databases

    Bgeei B2RRE7.
    Genevestigatori B2RRE7.

    Family and domain databases

    InterProi IPR003323. OTU.
    [Graphical view ]
    Pfami PF02338. OTU. 1 hit.
    [Graphical view ]
    PROSITEi PS50802. OTU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 161-1107.
      Tissue: BrainImported.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 930-1107.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    4. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
      J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-438, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Mast cell1 Publication.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1000; SER-1005; SER-1016 AND SER-1017, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver1 Publication.
    6. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1016 AND SER-1017, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiOTUD4_MOUSE
    AccessioniPrimary (citable) accession number: B2RRE7
    Secondary accession number(s): B7ZNI5, Q80TL3, Q9CUN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3