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Protein
Submitted name:

Myo18a protein

Gene

Myo18a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, MyosinSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Myo18a proteinImported
Submitted name:
Unconventional myosin-XVIIIaImported
Gene namesi
Name:Myo18aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2667185. Myo18a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSMUSG00000000631.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090563.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini220 – 31192PDZ (DHR)InterPro annotationAdd
BLAST
Domaini417 – 1193777Myosin motorInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1257 – 131256Sequence analysisAdd
BLAST
Coiled coili1320 – 136142Sequence analysisAdd
BLAST
Coiled coili1383 – 1509127Sequence analysisAdd
BLAST
Coiled coili1517 – 159680Sequence analysisAdd
BLAST
Coiled coili1602 – 165049Sequence analysisAdd
BLAST
Coiled coili1721 – 181898Sequence analysisAdd
BLAST
Coiled coili1825 – 1936112Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.SAAS annotation
Contains 1 PDZ (DHR) domain.UniRule annotation
Contains IQ domain.SAAS annotation
Contains myosin motor domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129849.
HOVERGENiHBG052543.
KOiK10362.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 1 hit.
4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR031244. MYO18A.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
[Graphical view]
PANTHERiPTHR13140:SF421. PTHR13140:SF421. 4 hits.
PfamiPF00063. Myosin_head. 2 hits.
PF01576. Myosin_tail_1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RRE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS MRRGFFNLNR
60 70 80 90 100
SSKRESKTRL EISNPIPIKV ASGSDLHLTD IDSDSNRGSI ILDSGHLSTA
110 120 130 140 150
SSSDDLKGEE GSFRGSVLQR AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA
160 170 180 190 200
SETSTPSEHS AAPSPQVEVR TLEGQLMQHP GLGIPRPGPR SRVPELVTKR
210 220 230 240 250
FPADLRLPAL VPPPPPALRE LELQRRPTGD FGFSLRRTTM LDRAPEGQAY
260 270 280 290 300
RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GQNVENKSRD EIVEMIRQSG
310 320 330 340 350
DSVRLKVQPI PELSELSRSW LRTGEGHRRE PADLDPEAAS PAYSQAKTEE
360 370 380 390 400
QIAAEEAWYE TEKVWLVHRD GFSLASQLKS EELSLPEGKA RVKLDHDGAI
410 420 430 440 450
LDVDEDDIEK ANAPSCDRLE DLASLVYLNE SSVLHTLRQR YGASLLHTYA
460 470 480 490 500
GPSLLVLSTR GAPAVYSEKV MHMFKGCRRE DMAPHIYAVA QTAYRAMLMS
510 520 530 540 550
RQDQSIVLLG SSGSGKTTSF QHLVQYLATI AGTSGTKVFS VEKWQALSTL
560 570 580 590 600
LEAFGNSPTI MNGSATRFSQ ILSLDFDQAG QVASASIQTM LLEKLRVARR
610 620 630 640 650
PASEATFNVF YYLLACGDAT LRTELHLNHL AENNVFGIVP LSKPEEKQKA
660 670 680 690 700
AQQFSKLQAA MKVLAISPEE QKTCWLILAS IYHLGAAGAT KEAAEAGRKQ
710 720 730 740 750
FARHEWAQKA AYLLGCSLEE LSSAIFKHQL KGGTLQRSTS FRQGPEESGL
760 770 780 790 800
GEGTKLSALE CLEGMASGLY SELFTLLISL VNRALKSSQH SLCSMMIVDT
810 820 830 840 850
PGFQNPEWGG SARGASFEEL CHNYAQDRLQ RLFHERTFLQ ELERYKEDNI
860 870 880 890 900
ELAFDDLEPV ADDSVAAVDQ ASHLVRSLAH ADEARGLLWL LEEEALVPGA
910 920 930 940 950
TEDALLDRLF SYYGPQEGDK KGQSPLLRSS KPRHFLLGHS HGTNWVEYNV
960 970 980 990 1000
AGWLNYTKQN PATQNAPRLL QDSQKKIISN LFLGRAGSAT VLSGSIAGLE
1010 1020 1030 1040 1050
GGSQLALRRA TSMRKTFTTG MAAVKKKSLC IQIKLQVDAL IDTIKRSKMH
1060 1070 1080 1090 1100
FVHCFLPVAE GWPGEPRSAS SRRVSSSSEL DLPPGDPCEA GLLQLDVSLL
1110 1120 1130 1140 1150
RAQLRGSRLL DAMRMYRQGY PDHMVFSEFR RRFDVLAPHL TKKHGRNYIV
1160 1170 1180 1190 1200
VDEKRAVEEL LESLDLEKSS CCLGLSRVFF RAGTLARLEE QRDEQTSRHL
1210 1220 1230 1240 1250
TLFQAACRGY LARQHFKKRK IQDLAIRCVQ KNIKKNKGVK DWPWWKLFTT
1260 1270 1280 1290 1300
VRPLIQVQLS EEQIRNKDEE IQQLRSKLEK VEKERNELRL SSDRLETRIS
1310 1320 1330 1340 1350
ELTSELTDER NTGESASQLL DAETAERLRT EKEMKELQTQ YDALKKQMEV
1360 1370 1380 1390 1400
MEMEVMEARL IRAAEINGEV DDDDAGGEWR LKYERAVREV DFTKKRLQQE
1410 1420 1430 1440 1450
LEDKMEVEQQ SRRQLERRLG DLQADSDESQ RALQQLKKKC QRLTAELQDT
1460 1470 1480 1490 1500
KLHLEGQQVR NHELEKKQRR FDSELSQAHE ETQREKLQRE KLQREKDMLL
1510 1520 1530 1540 1550
AEAFSLKQQM EEKDLDIAGF TQKVVSLEAE LQDISSQESK DEASLAKVKK
1560 1570 1580 1590 1600
QLRDLEAKVK DQEEELDEQA GSIQMLEQAK LRLEMEMERM RQTHSKEMES
1610 1620 1630 1640 1650
RDEEVEEARQ SCQKKLKQME VQLEEEYEDK QKALREKREL ESKLSTLSDQ
1660 1670 1680 1690 1700
VNQRDFESEK RLRKDLKRTK ALLADAQIML DHLKNNAPSK REIAQLKNQL
1710 1720 1730 1740 1750
EESEFTCAAA VKARKAMEVE MEDLHLQIDD IAKAKTALEE QLSRLQREKN
1760 1770 1780 1790 1800
EIQNRLEEDQ EDMNELMKKH KAAVAQASRD MAQMNDLQAQ IEESNKEKQE
1810 1820 1830 1840 1850
LQEKLQALQS QVEFLEQSMV DKSLVSRQEA KIRELETRLE FEKTQVKRLE
1860 1870 1880 1890 1900
NLASRLKETM EKLTEERDQR AAAENREKEQ NKRLQRQLRD TKEEMSELAR
1910 1920 1930 1940 1950
KEAEASRKKH ELEMDLESLE AANQSLQADL KLAFKRIGDL QAAIEDEMES
1960 1970 1980 1990 2000
DENEDLINSE GDSDVDSELE DRVDGVKSWL SKNKGPSKAP SDDGSLKSSS
2010 2020 2030 2040
PTSHWKPLAP DPSDDEHDPV DSISRPRFSH SYLSDSDTEA KLTETSA
Length:2,047
Mass (Da):232,138
Last modified:July 1, 2008 - v1
Checksum:iBDB665AF95B5A54C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591065 Genomic DNA. No translation available.
BC138366 mRNA. Translation: AAI38367.1.
RefSeqiNP_001278141.1. NM_001291212.1.
NP_001278142.1. NM_001291213.1.
NP_001278143.1. NM_001291214.1.
XP_011247394.1. XM_011249092.1.
UniGeneiMm.341248.
Mm.476162.

Genome annotation databases

EnsembliENSMUST00000169105; ENSMUSP00000132149; ENSMUSG00000000631.
GeneIDi360013.
KEGGimmu:360013.
UCSCiuc011xzx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591065 Genomic DNA. No translation available.
BC138366 mRNA. Translation: AAI38367.1.
RefSeqiNP_001278141.1. NM_001291212.1.
NP_001278142.1. NM_001291213.1.
NP_001278143.1. NM_001291214.1.
XP_011247394.1. XM_011249092.1.
UniGeneiMm.341248.
Mm.476162.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090563.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000169105; ENSMUSP00000132149; ENSMUSG00000000631.
GeneIDi360013.
KEGGimmu:360013.
UCSCiuc011xzx.2. mouse.

Organism-specific databases

CTDi399687.
MGIiMGI:2667185. Myo18a.

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129849.
HOVERGENiHBG052543.
KOiK10362.

Miscellaneous databases

ChiTaRSiMyo18a. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000631.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 1 hit.
4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR031244. MYO18A.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
[Graphical view]
PANTHERiPTHR13140:SF421. PTHR13140:SF421. 4 hits.
PfamiPF00063. Myosin_head. 2 hits.
PF01576. Myosin_tail_1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB2RRE2_MOUSE
AccessioniPrimary (citable) accession number: B2RRE2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.