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Protein
Submitted name:

Hcn3 protein

Gene

Hcn3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation, Voltage-gated channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Submitted name:
Hcn3 proteinImported
Submitted name:
Hyperpolarization-activated, cyclic nucleotide-gated K+ 3Imported
Gene namesi
Name:Hcn3Imported
ORF Names:mCG_17563Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1298211 Hcn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei93 – 117HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000028051

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini427 – 533Cyclic nucleotide-bindingInterPro annotationAdd BLAST107

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0498 Eukaryota
ENOG410XPSE LUCA
HOVERGENiHBG039489
KOiK04956
OMAiVMEQHLV
OrthoDBiEOG091G0JQU

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR005821 Ion_trans_dom
IPR013621 Ion_trans_N
IPR003938 K_chnl_volt-dep_EAG/ELK/ERG
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00520 Ion_trans, 1 hit
PF08412 Ion_trans_N, 1 hit
PRINTSiPR01463 EAGCHANLFMLY
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit

Sequencei

Sequence statusi: Complete.

B2RRB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEEARPAAG AGEAATPARE TPPAAPAQAR AASGGVPESA PEPKRRQLGT
60 70 80 90 100
LLQPTVNKFS LRVFGSHKAV EIEQERVKSA GAWIIHPYSD FRFYWDLIML
110 120 130 140 150
LLMVGNLIVL PVGITFFKEE NSPPWIVFNV LSDTFFLLDL VLNFRTGIVV
160 170 180 190 200
EEGAEILLAP RAIRTRYLRT WFLVDLISSI PVDYIFLVVE LEPRLDAEVY
210 220 230 240 250
KTARALRIVR FTKILSLLRL LRLSRLIRYI HQWEEIFHMT YDLASAVVRI
260 270 280 290 300
FNLIGMMLLL CHWDGCLQFL VPMLQDFPSD CWVSMNRMVN HSWGRQYSHA
310 320 330 340 350
LFKAMSHMLC IGYGQQAPVG MPDVWLTMLS MIVGATCYAM FIGHATALIQ
360 370 380 390 400
SLDSSRRQYQ EKYKQVEQYM SFHKLPADTR QRIHEYYEHR YQGKMFDEES
410 420 430 440 450
ILGELSEPLR EEIINFTCRG LVAHMPLFAH ADPSFVTAVL TKLRFEVFQP
460 470 480 490 500
GDLVVREGSV GRKMYFIQHG LLSVLARGAR DTRLTDGSYF GEICLLTRGR
510 520 530 540 550
RTASVRADTY CRLYSLSVDH FNAVLEEFPM MRRAFETVAM DRLRRIGKKN
560 570 580 590 600
SILQRKRSEP SPGSSGGVME QHLVQHDRDM ARGVRGLAPG TGARLSGKPV
610 620 630 640 650
LWEPLVHAPL QAAAVTSNVA IALTHQRGPL PLSPDSPATL LARSARRSAG
660 670 680 690 700
SPASPLVPVR AGPLLARGPW ASTSRLPAPP ARTLHASLSR TGRSQVSLLG
710 720 730 740 750
PPPGGGARRL GPRGRPLSAS QPSLPQRATG DGSPRRKGSG SERLPPSGLL
760 770
AKPPGTVQPP RSSVPEPVTP RGPQISANM
Length:779
Mass (Da):86,641
Last modified:July 1, 2008 - v1
Checksum:iD4FF151F174DECAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC138319 mRNA Translation: AAI38320.1
BC138321 mRNA Translation: AAI38322.1
CH466547 Genomic DNA Translation: EDL15235.1
RefSeqiNP_032253.1, NM_008227.1
UniGeneiMm.389461
Mm.489362

Genome annotation databases

GeneIDi15168
KEGGimmu:15168

Similar proteinsi

Entry informationi

Entry nameiB2RRB5_MOUSE
AccessioniPrimary (citable) accession number: B2RRB5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: April 25, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health