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Protein
Submitted name:

Itsn2 protein

Gene

Itsn2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Itsn2 proteinImported
Gene namesi
Name:Itsn2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1338049. Itsn2.

PTM / Processingi

Proteomic databases

PeptideAtlasiB2RR82.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052758.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 11089EHInterPro annotationAdd
BLAST
Domaini54 – 8936EF-handInterPro annotationAdd
BLAST
Domaini245 – 33490EHInterPro annotationAdd
BLAST
Domaini278 – 31336EF-handInterPro annotationAdd
BLAST
Domaini745 – 80662SH3InterPro annotationAdd
BLAST
Domaini879 – 93759SH3InterPro annotationAdd
BLAST
Domaini969 – 102759SH3InterPro annotationAdd
BLAST
Domaini1041 – 110565SH3InterPro annotationAdd
BLAST
Domaini1115 – 117460SH3InterPro annotationAdd
BLAST
Domaini1197 – 1383187DH (DBL-homology)InterPro annotationAdd
BLAST
Domaini1422 – 1532111PHInterPro annotationAdd
BLAST
Domaini1558 – 164083C2InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili369 – 46193Sequence analysisAdd
BLAST
Coiled coili510 – 55142Sequence analysisAdd
BLAST
Coiled coili586 – 62035Sequence analysisAdd
BLAST
Coiled coili706 – 74237Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 5 SH3 domains.UniRule annotation
Contains DH (DBL-homology) domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainUniRule annotation

Phylogenomic databases

eggNOGiKOG1029. Eukaryota.
KOG4305. Eukaryota.
COG5422. LUCA.
HOVERGENiHBG052159.
KOiK20045.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000219. DH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EH_dom.
IPR027029. Intersectin-2.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR11216:SF29. PTHR11216:SF29. 5 hits.
PfamiPF00168. C2. 1 hit.
PF12763. EF-hand_4. 2 hits.
PF16652. PH_13. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 2 hits.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF48065. SSF48065. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 5 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50010. DH_2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RR82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAQFPTAMN GGPNMWAITS EERTKHDKQF DNLKPSGGYI TGDQARTFFL
60 70 80 90 100
QSGLPAPVLA EIWALSDLNK DGKMDQQEFS IAMKLIKLKL QGQQLPVVLP
110 120 130 140 150
PIMKQPPMFS PLISARFGMG SMPNLSIHQP LPPVAPIATP LSSATSGTSI
160 170 180 190 200
PPLMMPAPLV PSVSTSSLPN GTASLIQPLS IPYSSSTLPH ASSYSLMMGG
210 220 230 240 250
FGGASIQKAQ SLIDLGSSSS TSSTASLSGN SPKTGTSEWA VPQPSRLKYR
260 270 280 290 300
QKFNSLDKGM SGYLSGFQAR NALLQSNLSQ TQLATIWTLA DIDGDGQLKA
310 320 330 340 350
EEFILAMHLT DMAKAGQPLP LTLPPELVPP SFRGGKQVDS VNGTLPSYQK
360 370 380 390 400
TQEEEPQKKL PVTFEDKRKA NYERGNMELE KRRQVLMEQQ QREAERKAQK
410 420 430 440 450
EKEEWERKQR ELQEQEWKKQ LELEKRLEKQ RELERQREEE RRKEIERREA
460 470 480 490 500
AKQELERQRR LEWERLRRQE LLSQKTREQE DIVRLSSRKK SLHLELEAVN
510 520 530 540 550
GKHQQISGRL QDVQIRKQTQ KTELEVLDKQ CDLEIMEIKQ LQQELKEYQN
560 570 580 590 600
KLIYLVPEKQ LLNERIKNMQ LSNTPDSGIS LLHKKSSEKE ELCQRLKEQL
610 620 630 640 650
DALEKETASK LSEMDSFNNQ LKCGSMDDCV LQCLLSLLSC LNNLFLLLKE
660 670 680 690 700
LRESYNTQQL ALEQLHKIKR DKLKEIERKR LEQIQKKKLE DEAARKAKQG
710 720 730 740 750
KENLWRESIR KEEEEKQKRL QEEKSQDKTQ EEERKAEAKQ SETASALVNY
760 770 780 790 800
RALYPFEARN HDEMSFSSGD IIQVDEKTVG EPGWLYGSFQ GKFGWFPCNY
810 820 830 840 850
VEKVLSSEKA LSPKKALLPP TVSLSATSTS SQPPASVTDY HNVSFSNLTV
860 870 880 890 900
NTTWQQKSAF TRTVSPGSVS PIHGQGQAVE NLKAQALCSW TAKKENHLNF
910 920 930 940 950
SKHDVITVLE QQENWWFGEV HGGRGWFPKS YVKLIPGNEV QRGEPEALYA
960 970 980 990 1000
AVTKKPTSTA YPVTSTAYPV GEDYIALYSY SSVEPGDLTF TEGEEILVTQ
1010 1020 1030 1040 1050
KDGEWWTGSI GERTGIFPSN YVRPKDQENF GNASKSGASN KKPEIAQVTS
1060 1070 1080 1090 1100
AYAASGTEQL SLAPGQLILI LKKNTSGWWQ GELQARGKKR QKGWFPASHV
1110 1120 1130 1140 1150
KLLGPSSERT MPTFHAVCQV IAMYDYMANN EDELNFSKGQ LINVMNKDDP
1160 1170 1180 1190 1200
DWWQGETNGL TGLFPSNYVK MTTDSDPSQQ WCADLQALDT MQPTERKRQG
1210 1220 1230 1240 1250
YIHELIQTEE RYMDDLQLVI EVFQKRMAES GFLTEADMAL IFVNWKELIM
1260 1270 1280 1290 1300
SNTKLLRALR VRKKTGGEKM PVQMIGDILA AELSHMQAYI RFCSCQLNGA
1310 1320 1330 1340 1350
TLLQQKTDED TDFKEFLKKL ASDPRCKGMP LSSFLLKPMQ RITRYPLLIR
1360 1370 1380 1390 1400
SILENTPQSH VDHSSLKLAL ERAEELCSQV NEGVREKENS DRLEWIQAHV
1410 1420 1430 1440 1450
QCEGLAEQLI FNSLTNCLGP RKLLHSGKLY KTKSNKELHA FLFNDFLLLT
1460 1470 1480 1490 1500
YLVRQFAAAS GHEKLFNSKS SAQFRMYKTP IFLNEVLVKL PTDPSSDEPV
1510 1520 1530 1540 1550
FHISHIDRVY TLRTDNINER TAWVQKIKGA SEQYIDTEKK KREKAYQARS
1560 1570 1580 1590 1600
QKTSGIGRLM VHVIEATELK ACKPNGKSNP YCEVSMGSQS YTTRTLQDTL
1610 1620 1630 1640 1650
NPKWNFNCQF FIKDLYQDVL CLTMFDRDQF SPDDFLGRTE VPVAKIRTEQ
1660 1670 1680
ESKGPTTRRL LLHEVPTGEV WVRFDLQLFE QKTLL
Length:1,685
Mass (Da):191,735
Last modified:July 1, 2008 - v1
Checksum:iCBB80A70F90C6A76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC138262 mRNA. Translation: AAI38263.1.
BC171950 mRNA. Translation: AAI71950.1.
RefSeqiNP_001185897.1. NM_001198968.2.
NP_001185898.1. NM_001198969.2.
NP_035495.2. NM_011365.4.
XP_006515086.1. XM_006515023.2.
XP_006515087.1. XM_006515024.2.
UniGeneiMm.341204.

Genome annotation databases

GeneIDi20403.
KEGGimmu:20403.
UCSCiuc007mxw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC138262 mRNA. Translation: AAI38263.1.
BC171950 mRNA. Translation: AAI71950.1.
RefSeqiNP_001185897.1. NM_001198968.2.
NP_001185898.1. NM_001198969.2.
NP_035495.2. NM_011365.4.
XP_006515086.1. XM_006515023.2.
XP_006515087.1. XM_006515024.2.
UniGeneiMm.341204.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052758.

Proteomic databases

PeptideAtlasiB2RR82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20403.
KEGGimmu:20403.
UCSCiuc007mxw.2. mouse.

Organism-specific databases

CTDi50618.
MGIiMGI:1338049. Itsn2.

Phylogenomic databases

eggNOGiKOG1029. Eukaryota.
KOG4305. Eukaryota.
COG5422. LUCA.
HOVERGENiHBG052159.
KOiK20045.

Miscellaneous databases

ChiTaRSiItsn2. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000219. DH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EH_dom.
IPR027029. Intersectin-2.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR11216:SF29. PTHR11216:SF29. 5 hits.
PfamiPF00168. C2. 1 hit.
PF12763. EF-hand_4. 2 hits.
PF16652. PH_13. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 2 hits.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF48065. SSF48065. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 5 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50010. DH_2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.

Entry informationi

Entry nameiB2RR82_MOUSE
AccessioniPrimary (citable) accession number: B2RR82
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: July 6, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.