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Protein

Transporter

Gene

Slc6a5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

SymportUniRule annotationSAAS annotation, Transport

Enzyme and pathway databases

ReactomeiREACT_307956. Na+/Cl- dependent neurotransmitter transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
TransporterUniRule annotation
Gene namesi
Name:Slc6a5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:105090. Slc6a5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058699.

Family & Domainsi

Sequence similaritiesi

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118857.
HOVERGENiHBG071421.
KOiK05038.
OMAiGNALHCK.
OrthoDBiEOG793B71.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RQX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKQPANILE AAVPGHRDSP RAPRTSPEQD LPAEAPTATV QPPRVPRSAS
60 70 80 90 100
TGAQTFQSAD ARACEAQQSG VGFCNLSSPR AQATSAALRD LSEGHSAQAN
110 120 130 140 150
PPSGPAGAGN ALHCKIPALR GPEEDANVSV GKGTLEHNNT PAVGWVNMSQ
160 170 180 190 200
STVVLGTDGI ASVLPGSVAT TTIPEDEQGD ENKARGNWSS KLDFILSMVG
210 220 230 240 250
YAVGLGNVWR FPYLAFQNGG GAFLIPYLMM LALAGLPIFF LEVSLGQFAS
260 270 280 290 300
QGPVSVWKAI PALQGCGIAM LIISVLIAIY YNVIICYTLF YLFASFVSVL
310 320 330 340 350
PWGSCNNPWN TPECKDKTKL LLDSCVIGDH PKIQIKNSTF CMTAYPNLTM
360 370 380 390 400
VNFTSQTNKT FVSGSEEYFK YFVLKISAGI EYPGEIRWPL AFCLFLAWVI
410 420 430 440 450
VYASLAKGIK SSGKVVYFTA TFPYVVLVIL LIRGVTLPGA GAGIWYFITP
460 470 480 490 500
KWEKLTDATV WKDAATQIFF SLSAAWGGLI TLSSYNKFHN NCYRDTLIVT
510 520 530 540 550
CTNSATSIFA GFVIFSVIGF MANERKVNIE NVADQGPGIA FVVYPEALTR
560 570 580 590 600
LPLSPFWAII FFLMLLTLGL DTMFATIETI VTSISDEFPK YLRTHKPVFT
610 620 630 640 650
LGCCICFFIM GFPMITQGGI YMFQLVDTYA ASYALVIIAI FELVGISYVY
660 670 680 690 700
GLQRFCEDIE MMIGFKPNIF WKVCWAFVTP TILTFILCFS FYQWEPMTYG
710 720 730 740 750
SYRYPNWSMV LGWLMLACSV IWIPIMFVIK MYLAPGRFIE RLKLVCSPQP
760 770 780 790
DWGPFLAQHR GERYKNMIDP LGTSSLGLKL PVKDLELGTQ C
Length:791
Mass (Da):87,029
Last modified:July 1, 2008 - v1
Checksum:i3400501C93EC4421
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116694 Genomic DNA. No translation available.
AC135354 Genomic DNA. No translation available.
BC138125 mRNA. Translation: AAI38126.1.
BC138126 mRNA. Translation: AAI38127.1.
RefSeqiNP_001139485.1. NM_001146013.1.
NP_683733.2. NM_148931.3.
XP_006540610.1. XM_006540547.1.
UniGeneiMm.207053.

Genome annotation databases

EnsembliENSMUST00000056442; ENSMUSP00000058699; ENSMUSG00000039728.
ENSMUST00000107605; ENSMUSP00000103230; ENSMUSG00000039728.
GeneIDi104245.
KEGGimmu:104245.
UCSCiuc009hbv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116694 Genomic DNA. No translation available.
AC135354 Genomic DNA. No translation available.
BC138125 mRNA. Translation: AAI38126.1.
BC138126 mRNA. Translation: AAI38127.1.
RefSeqiNP_001139485.1. NM_001146013.1.
NP_683733.2. NM_148931.3.
XP_006540610.1. XM_006540547.1.
UniGeneiMm.207053.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058699.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056442; ENSMUSP00000058699; ENSMUSG00000039728.
ENSMUST00000107605; ENSMUSP00000103230; ENSMUSG00000039728.
GeneIDi104245.
KEGGimmu:104245.
UCSCiuc009hbv.2. mouse.

Organism-specific databases

CTDi9152.
MGIiMGI:105090. Slc6a5.

Phylogenomic databases

GeneTreeiENSGT00760000118857.
HOVERGENiHBG071421.
KOiK05038.
OMAiGNALHCK.
OrthoDBiEOG793B71.
TreeFamiTF343812.

Enzyme and pathway databases

ReactomeiREACT_307956. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

NextBioi356802.
SOURCEiSearch...

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB2RQX9_MOUSE
AccessioniPrimary (citable) accession number: B2RQX9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: June 24, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.