ID   B2RQS5_MOUSE            Unreviewed;       478 AA.
AC   B2RQS5;
DT   01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   01-JUL-2008, sequence version 1.
DT   27-MAR-2024, entry version 127.
DE   RecName: Full=D(1B) dopamine receptor {ECO:0000256|ARBA:ARBA00018627};
DE   AltName: Full=D(5) dopamine receptor {ECO:0000256|ARBA:ARBA00042808};
DE   AltName: Full=Dopamine D5 receptor {ECO:0000256|ARBA:ARBA00041538};
GN   Name=Drd5 {ECO:0000313|EMBL:AAI38061.1, ECO:0000313|MGI:MGI:94927};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI38061.1};
RN   [1] {ECO:0000313|EMBL:AAI38061.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000313|EMBL:AAI38061.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Dopamine receptor whose activity is mediated by G proteins
CC       which activate adenylyl cyclase. {ECO:0000256|ARBA:ARBA00002363}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|RuleBase:RU000688}.
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DR   EMBL; BC138059; AAI38060.1; -; mRNA.
DR   EMBL; BC138060; AAI38061.1; -; mRNA.
DR   RefSeq; NP_038531.1; NM_013503.3.
DR   AlphaFoldDB; B2RQS5; -.
DR   SMR; B2RQS5; -.
DR   PeptideAtlas; B2RQS5; -.
DR   Antibodypedia; 9652; 456 antibodies from 39 providers.
DR   DNASU; 13492; -.
DR   GeneID; 13492; -.
DR   KEGG; mmu:13492; -.
DR   AGR; MGI:94927; -.
DR   CTD; 1816; -.
DR   MGI; MGI:94927; Drd5.
DR   VEuPathDB; HostDB:ENSMUSG00000039358; -.
DR   HOGENOM; CLU_009579_11_0_1; -.
DR   OMA; HWHRDKA; -.
DR   OrthoDB; 2900736at2759; -.
DR   BioGRID-ORCS; 13492; 7 hits in 77 CRISPR screens.
DR   ExpressionAtlas; B2RQS5; baseline and differential.
DR   GO; GO:0060170; C:ciliary membrane; IEA:Ensembl.
DR   GO; GO:0097730; C:non-motile cilium; IEA:Ensembl.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0035240; F:dopamine binding; IEA:Ensembl.
DR   GO; GO:0004952; F:dopamine neurotransmitter receptor activity; IEA:Ensembl.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0007610; P:behavior; IEA:UniProt.
DR   GO; GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
DR   GO; GO:0065008; P:regulation of biological quality; IEA:UniProt.
DR   GO; GO:0001975; P:response to amphetamine; IEA:UniProt.
DR   GO; GO:0042220; P:response to cocaine; IEA:UniProt.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000497; Dopamine_D5_rcpt.
DR   InterPro; IPR000929; Dopamine_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24248:SF136; D(1B) DOPAMINE RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00566; DOPAMINED1BR.
DR   PRINTS; PR00242; DOPAMINER.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW   ECO:0000256|RuleBase:RU000688};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW   Transducer {ECO:0000256|RuleBase:RU000688};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000688};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        39..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        76..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        113..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        219..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          55..354
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
FT   REGION          416..446
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   478 AA;  53076 MW;  D39165BC558131DF CRC64;
     MLPPGRNGTA HRARLGLQRQ LAQVDAPGGS AAPLGPAQVV TAGLLTLLIV WTLLGNVLVC
     AAIVRSRHLR AKMTNIFIVS LAVSDLFVAL LVMPWKAVAE VAGYWPFGAF CDIWVAFDIM
     CSTASILNLC IISVDRYWAI SRPFRYERKM TQRVALVMVA LAWTLSILIS FIPVQLNWHR
     DKAGSQGREG LLSNETPWEE GWELDGRTEN CDSSLNRTYA ISSSLISFYI PVAIMIVTYT
     RIYRIAQVQI RRISSLERAA EHAQSCRSRG ACEPDPSLRA SIKKETKVFK TLSVIMGVFV
     CCWLPFFILN CMVPFCSSGD AQGPRTGFPC VSETTFDIFV WFGWANSSLN PIIYAFNADF
     RKVFAQLLGC SHLCFRTPVQ TVNISNELIS YNQDTVFHRE IAAAYVHMIP NAVSSGDREV
     GEEEEAEEEG PFDHMSQISP TTPDGDLAAE SVWELDCEEE VSLGKISPLT PNCFHKTA
//