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B2RQC2 (UBP42_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 42

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 42
Ubiquitin thioesterase 42
Ubiquitin-specific-processing protease 42
Gene names
Name:Usp42
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1324 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Deubiquitinating enzyme which may play an important role during spermatogenesis. Ref.3

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Tissue specificity

Highest expression seen in the testis. Also expressed in brain, lung and thymus. The expression level gradually increases from 2 weeks after birth and then decreases from the pachytene spermatocyte (PS) stage during spermatogenesis. Ref.3

Developmental stage

Expressed in the midbrain, forebrain, optic vesicles and eyes of embryos at E10.5 and a more pronounced expression is seen at E12.5. Ref.3

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13241324Ubiquitin carboxyl-terminal hydrolase 42
PRO_0000404199

Regions

Domain110 – 411302USP
Compositional bias1184 – 125471Lys-rich

Sites

Active site1191Nucleophile By similarity
Active site3701Proton acceptor By similarity

Amino acid modifications

Modified residue8581Phosphoserine By similarity
Modified residue12341Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
B2RQC2 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 5214E845D98C3288

FASTA1,324146,223
        10         20         30         40         50         60 
MTIVDKTEPS DPSTCQNQPG SCEAVSPEDM DTGSASWGAV SSISDVSSHT LPLGPVPGAV 

        70         80         90        100        110        120 
VYSNSSVPEK SKPSPPKDQV LGDGIAPPQK VLFPSEKICL KWQQSHRVGA GLQNLGNTCF 

       130        140        150        160        170        180 
ANAALQCLTY TPPLANYMLS HEHSKTCHAE GFCMMCTMQT HITQALSNPG DVIKPMFVIN 

       190        200        210        220        230        240 
EMRRIARHFR FGNQEDAHEF LQYTVDAMQK ACLNGSNKLD RHTQATTLVC QIFGGYLRSR 

       250        260        270        280        290        300 
VKCLNCKGVS DTFDPYLDIT LEIKAAQSVT KALEQFVKPE QLDGENSYKC SKCKKMVPAS 

       310        320        330        340        350        360 
KRFTIHRSSN VLTISLKRFA NFTGGKIAKD VKYPEYLDIR PYMSQPNGEP IIYVLYAVLV 

       370        380        390        400        410        420 
HTGFNCHAGH YFCYIKASNG LWYQMNDSIV STSDIRAVLN QQAYVLFYIR SHDVKNGGES 

       430        440        450        460        470        480 
AHPAHSPGQS SPRPGVSQRV VNNKQVAPGF IGPQLPSHVM KNTPHLNGTT PVKDTPSSSV 

       490        500        510        520        530        540 
SSPNGNTSVN RASPATASTS VQNWSVTRPS VIPDHPKKQK ITISIHNKLP ARQGQAPLNN 

       550        560        570        580        590        600 
SLHGPCLEAP SKAAPSSTIT NPSAIQSTSN VPTTSTSPSE ACPKPMVNGK AKVGASVLVP 

       610        620        630        640        650        660 
YGAESSEESD EESKGLAKEN GVDMMAGTHS DRPEAAADDG AEASSHELQE PVLLNGANSA 

       670        680        690        700        710        720 
DSDSQENSLA FDSASCQVQP ELHTENLFSK LNGLPGKVTP APLQSVPEDR ILETFKLTNQ 

       730        740        750        760        770        780 
AKGPAGEESW TTTGGSSPKD PVSQLEPISD EPSPLEIPEA VTNGSTQTPS TTSPLEPTIS 

       790        800        810        820        830        840 
CTKEDSSVVV SAEPVEGLPS VPALCNSTGT ILGDTPVPEL CDPGDLTANP SQPTEAVKGD 

       850        860        870        880        890        900 
TAEKAQDSAM AEVVERLSPA PSVLTGDGCE QKLLLYLSAE GSEETEDSSR SSAVSADTMP 

       910        920        930        940        950        960 
PKPDRTTTSS CEGAAEQAAG DRGDGGHVGP KAQEPSPAKE KMSSLRKVDR GHYRSRRERS 

       970        980        990       1000       1010       1020 
SSGEHVRDSR PRPEDHHHKK RHCYSRERPK QDRHPTNSYC NGGQHLGHGD RASPERRSLS 

      1030       1040       1050       1060       1070       1080 
RYSHHHSRIR SGLEQDWSRY HHLENEHAWV RERFYQDKLR WDKCRYYHDR YTPLYTARDA 

      1090       1100       1110       1120       1130       1140 
REWRPLHGRE HDRLVQSGRP YKDSYWGRKG WELQSRGKER PHFNSPREAP SLAVPLERHL 

      1150       1160       1170       1180       1190       1200 
QEKAALSVQD SSHSLPERFH EHKSVKSRKR RYETLENNDG RLEKKVHKSL EKDTLEEPRV 

      1210       1220       1230       1240       1250       1260 
KKHKKSKKKK KSKDKHRDRE SRHQQESDFS GAYSDADLHR HRKKKKKKKR HSRKSEDFIK 

      1270       1280       1290       1300       1310       1320 
DVEMRLPKLS SYEAGGHFRR TEGSFLLADG LPVEDSGPFR EKTKHLRMES RPDRCRLSEY 


GQGD 

« Hide

References

« Hide 'large scale' references
[1]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The expression of Usp42 during embryogenesis and spermatogenesis in mouse."
Kim Y.K., Kim Y.S., Yoo K.J., Lee H.J., Lee D.R., Yeo C.Y., Baek K.H.
Gene Expr. Patterns 7:143-148(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH466529 Genomic DNA. Translation: EDL19037.1.
BC137852 mRNA. Translation: AAI37853.1.
CCDSCCDS39372.1.
RefSeqNP_084025.2. NM_029749.2.
XP_006504817.1. XM_006504754.1.
XP_006504818.1. XM_006504755.1.
XP_006504819.1. XM_006504756.1.
UniGeneMm.259620.

3D structure databases

ProteinModelPortalB2RQC2.
SMRB2RQC2. Positions 110-408.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid218324. 1 interaction.

PTM databases

PhosphoSiteB2RQC2.

Proteomic databases

PaxDbB2RQC2.
PRIDEB2RQC2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000053287; ENSMUSP00000053955; ENSMUSG00000051306.
GeneID76800.
KEGGmmu:76800.
UCSCuc009akp.1. mouse.

Organism-specific databases

CTD84132.
MGIMGI:1924050. Usp42.

Phylogenomic databases

eggNOGCOG5533.
GeneTreeENSGT00750000117288.
HOGENOMHOG000236355.
HOVERGENHBG080724.
InParanoidB2RQC2.
KOK11855.
OMAGKLMPAP.
OrthoDBEOG72VH5K.
PhylomeDBB2RQC2.
TreeFamTF315281.

Gene expression databases

BgeeB2RQC2.
GenevestigatorB2RQC2.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio345843.
PROB2RQC2.
SOURCESearch...

Entry information

Entry nameUBP42_MOUSE
AccessionPrimary (citable) accession number: B2RQC2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: July 1, 2008
Last modified: July 9, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot