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B2RQC2

- UBP42_MOUSE

UniProt

B2RQC2 - UBP42_MOUSE

Protein

Ubiquitin carboxyl-terminal hydrolase 42

Gene

Usp42

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme which may play an important role during spermatogenesis.1 Publication

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei119 – 1191NucleophilePROSITE-ProRule annotation
    Active sitei370 – 3701Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: MGI

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. protein deubiquitination Source: UniProtKB
    3. spermatogenesis Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Differentiation, Spermatogenesis, Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 42 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 42
    Ubiquitin thioesterase 42
    Ubiquitin-specific-processing protease 42
    Gene namesi
    Name:Usp42
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1924050. Usp42.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13241324Ubiquitin carboxyl-terminal hydrolase 42PRO_0000404199Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei858 – 8581PhosphoserineBy similarity
    Modified residuei1234 – 12341PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiB2RQC2.
    PRIDEiB2RQC2.

    PTM databases

    PhosphoSiteiB2RQC2.

    Expressioni

    Tissue specificityi

    Highest expression seen in the testis. Also expressed in brain, lung and thymus. The expression level gradually increases from 2 weeks after birth and then decreases from the pachytene spermatocyte (PS) stage during spermatogenesis.1 Publication

    Developmental stagei

    Expressed in the midbrain, forebrain, optic vesicles and eyes of embryos at E10.5 and a more pronounced expression is seen at E12.5.1 Publication

    Gene expression databases

    BgeeiB2RQC2.
    GenevestigatoriB2RQC2.

    Interactioni

    Protein-protein interaction databases

    BioGridi218324. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliB2RQC2.
    SMRiB2RQC2. Positions 110-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini110 – 411302USPAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1184 – 125471Lys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5533.
    GeneTreeiENSGT00750000117288.
    HOGENOMiHOG000236355.
    HOVERGENiHBG080724.
    InParanoidiB2RQC2.
    KOiK11855.
    OMAiGKLMPAP.
    OrthoDBiEOG72VH5K.
    PhylomeDBiB2RQC2.
    TreeFamiTF315281.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2RQC2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTIVDKTEPS DPSTCQNQPG SCEAVSPEDM DTGSASWGAV SSISDVSSHT     50
    LPLGPVPGAV VYSNSSVPEK SKPSPPKDQV LGDGIAPPQK VLFPSEKICL 100
    KWQQSHRVGA GLQNLGNTCF ANAALQCLTY TPPLANYMLS HEHSKTCHAE 150
    GFCMMCTMQT HITQALSNPG DVIKPMFVIN EMRRIARHFR FGNQEDAHEF 200
    LQYTVDAMQK ACLNGSNKLD RHTQATTLVC QIFGGYLRSR VKCLNCKGVS 250
    DTFDPYLDIT LEIKAAQSVT KALEQFVKPE QLDGENSYKC SKCKKMVPAS 300
    KRFTIHRSSN VLTISLKRFA NFTGGKIAKD VKYPEYLDIR PYMSQPNGEP 350
    IIYVLYAVLV HTGFNCHAGH YFCYIKASNG LWYQMNDSIV STSDIRAVLN 400
    QQAYVLFYIR SHDVKNGGES AHPAHSPGQS SPRPGVSQRV VNNKQVAPGF 450
    IGPQLPSHVM KNTPHLNGTT PVKDTPSSSV SSPNGNTSVN RASPATASTS 500
    VQNWSVTRPS VIPDHPKKQK ITISIHNKLP ARQGQAPLNN SLHGPCLEAP 550
    SKAAPSSTIT NPSAIQSTSN VPTTSTSPSE ACPKPMVNGK AKVGASVLVP 600
    YGAESSEESD EESKGLAKEN GVDMMAGTHS DRPEAAADDG AEASSHELQE 650
    PVLLNGANSA DSDSQENSLA FDSASCQVQP ELHTENLFSK LNGLPGKVTP 700
    APLQSVPEDR ILETFKLTNQ AKGPAGEESW TTTGGSSPKD PVSQLEPISD 750
    EPSPLEIPEA VTNGSTQTPS TTSPLEPTIS CTKEDSSVVV SAEPVEGLPS 800
    VPALCNSTGT ILGDTPVPEL CDPGDLTANP SQPTEAVKGD TAEKAQDSAM 850
    AEVVERLSPA PSVLTGDGCE QKLLLYLSAE GSEETEDSSR SSAVSADTMP 900
    PKPDRTTTSS CEGAAEQAAG DRGDGGHVGP KAQEPSPAKE KMSSLRKVDR 950
    GHYRSRRERS SSGEHVRDSR PRPEDHHHKK RHCYSRERPK QDRHPTNSYC 1000
    NGGQHLGHGD RASPERRSLS RYSHHHSRIR SGLEQDWSRY HHLENEHAWV 1050
    RERFYQDKLR WDKCRYYHDR YTPLYTARDA REWRPLHGRE HDRLVQSGRP 1100
    YKDSYWGRKG WELQSRGKER PHFNSPREAP SLAVPLERHL QEKAALSVQD 1150
    SSHSLPERFH EHKSVKSRKR RYETLENNDG RLEKKVHKSL EKDTLEEPRV 1200
    KKHKKSKKKK KSKDKHRDRE SRHQQESDFS GAYSDADLHR HRKKKKKKKR 1250
    HSRKSEDFIK DVEMRLPKLS SYEAGGHFRR TEGSFLLADG LPVEDSGPFR 1300
    EKTKHLRMES RPDRCRLSEY GQGD 1324
    Length:1,324
    Mass (Da):146,223
    Last modified:July 1, 2008 - v1
    Checksum:i5214E845D98C3288
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH466529 Genomic DNA. Translation: EDL19037.1.
    BC137852 mRNA. Translation: AAI37853.1.
    CCDSiCCDS39372.1.
    RefSeqiNP_084025.2. NM_029749.2.
    XP_006504817.1. XM_006504754.1.
    XP_006504818.1. XM_006504755.1.
    XP_006504819.1. XM_006504756.1.
    UniGeneiMm.259620.

    Genome annotation databases

    EnsembliENSMUST00000053287; ENSMUSP00000053955; ENSMUSG00000051306.
    GeneIDi76800.
    KEGGimmu:76800.
    UCSCiuc009akp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH466529 Genomic DNA. Translation: EDL19037.1 .
    BC137852 mRNA. Translation: AAI37853.1 .
    CCDSi CCDS39372.1.
    RefSeqi NP_084025.2. NM_029749.2.
    XP_006504817.1. XM_006504754.1.
    XP_006504818.1. XM_006504755.1.
    XP_006504819.1. XM_006504756.1.
    UniGenei Mm.259620.

    3D structure databases

    ProteinModelPortali B2RQC2.
    SMRi B2RQC2. Positions 110-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 218324. 1 interaction.

    PTM databases

    PhosphoSitei B2RQC2.

    Proteomic databases

    PaxDbi B2RQC2.
    PRIDEi B2RQC2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000053287 ; ENSMUSP00000053955 ; ENSMUSG00000051306 .
    GeneIDi 76800.
    KEGGi mmu:76800.
    UCSCi uc009akp.1. mouse.

    Organism-specific databases

    CTDi 84132.
    MGIi MGI:1924050. Usp42.

    Phylogenomic databases

    eggNOGi COG5533.
    GeneTreei ENSGT00750000117288.
    HOGENOMi HOG000236355.
    HOVERGENi HBG080724.
    InParanoidi B2RQC2.
    KOi K11855.
    OMAi GKLMPAP.
    OrthoDBi EOG72VH5K.
    PhylomeDBi B2RQC2.
    TreeFami TF315281.

    Miscellaneous databases

    NextBioi 345843.
    PROi B2RQC2.
    SOURCEi Search...

    Gene expression databases

    Bgeei B2RQC2.
    Genevestigatori B2RQC2.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "The expression of Usp42 during embryogenesis and spermatogenesis in mouse."
      Kim Y.K., Kim Y.S., Yoo K.J., Lee H.J., Lee D.R., Yeo C.Y., Baek K.H.
      Gene Expr. Patterns 7:143-148(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiUBP42_MOUSE
    AccessioniPrimary (citable) accession number: B2RQC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 8, 2011
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3