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B2RQC2

- UBP42_MOUSE

UniProt

B2RQC2 - UBP42_MOUSE

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Protein

Ubiquitin carboxyl-terminal hydrolase 42

Gene
Usp42
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Deubiquitinating enzyme which may play an important role during spermatogenesis.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei119 – 1191Nucleophile By similarity
Active sitei370 – 3701Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: MGI

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. protein deubiquitination Source: UniProtKB
  3. spermatogenesis Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Differentiation, Spermatogenesis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 42 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 42
Ubiquitin thioesterase 42
Ubiquitin-specific-processing protease 42
Gene namesi
Name:Usp42
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1924050. Usp42.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13241324Ubiquitin carboxyl-terminal hydrolase 42PRO_0000404199Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei858 – 8581Phosphoserine By similarity
Modified residuei1234 – 12341Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB2RQC2.
PRIDEiB2RQC2.

PTM databases

PhosphoSiteiB2RQC2.

Expressioni

Tissue specificityi

Highest expression seen in the testis. Also expressed in brain, lung and thymus. The expression level gradually increases from 2 weeks after birth and then decreases from the pachytene spermatocyte (PS) stage during spermatogenesis.1 Publication

Developmental stagei

Expressed in the midbrain, forebrain, optic vesicles and eyes of embryos at E10.5 and a more pronounced expression is seen at E12.5.1 Publication

Gene expression databases

BgeeiB2RQC2.
GenevestigatoriB2RQC2.

Interactioni

Protein-protein interaction databases

BioGridi218324. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliB2RQC2.
SMRiB2RQC2. Positions 110-408.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini110 – 411302USPAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1184 – 125471Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5533.
GeneTreeiENSGT00750000117288.
HOGENOMiHOG000236355.
HOVERGENiHBG080724.
InParanoidiB2RQC2.
KOiK11855.
OMAiGKLMPAP.
OrthoDBiEOG72VH5K.
PhylomeDBiB2RQC2.
TreeFamiTF315281.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RQC2-1 [UniParc]FASTAAdd to Basket

« Hide

MTIVDKTEPS DPSTCQNQPG SCEAVSPEDM DTGSASWGAV SSISDVSSHT     50
LPLGPVPGAV VYSNSSVPEK SKPSPPKDQV LGDGIAPPQK VLFPSEKICL 100
KWQQSHRVGA GLQNLGNTCF ANAALQCLTY TPPLANYMLS HEHSKTCHAE 150
GFCMMCTMQT HITQALSNPG DVIKPMFVIN EMRRIARHFR FGNQEDAHEF 200
LQYTVDAMQK ACLNGSNKLD RHTQATTLVC QIFGGYLRSR VKCLNCKGVS 250
DTFDPYLDIT LEIKAAQSVT KALEQFVKPE QLDGENSYKC SKCKKMVPAS 300
KRFTIHRSSN VLTISLKRFA NFTGGKIAKD VKYPEYLDIR PYMSQPNGEP 350
IIYVLYAVLV HTGFNCHAGH YFCYIKASNG LWYQMNDSIV STSDIRAVLN 400
QQAYVLFYIR SHDVKNGGES AHPAHSPGQS SPRPGVSQRV VNNKQVAPGF 450
IGPQLPSHVM KNTPHLNGTT PVKDTPSSSV SSPNGNTSVN RASPATASTS 500
VQNWSVTRPS VIPDHPKKQK ITISIHNKLP ARQGQAPLNN SLHGPCLEAP 550
SKAAPSSTIT NPSAIQSTSN VPTTSTSPSE ACPKPMVNGK AKVGASVLVP 600
YGAESSEESD EESKGLAKEN GVDMMAGTHS DRPEAAADDG AEASSHELQE 650
PVLLNGANSA DSDSQENSLA FDSASCQVQP ELHTENLFSK LNGLPGKVTP 700
APLQSVPEDR ILETFKLTNQ AKGPAGEESW TTTGGSSPKD PVSQLEPISD 750
EPSPLEIPEA VTNGSTQTPS TTSPLEPTIS CTKEDSSVVV SAEPVEGLPS 800
VPALCNSTGT ILGDTPVPEL CDPGDLTANP SQPTEAVKGD TAEKAQDSAM 850
AEVVERLSPA PSVLTGDGCE QKLLLYLSAE GSEETEDSSR SSAVSADTMP 900
PKPDRTTTSS CEGAAEQAAG DRGDGGHVGP KAQEPSPAKE KMSSLRKVDR 950
GHYRSRRERS SSGEHVRDSR PRPEDHHHKK RHCYSRERPK QDRHPTNSYC 1000
NGGQHLGHGD RASPERRSLS RYSHHHSRIR SGLEQDWSRY HHLENEHAWV 1050
RERFYQDKLR WDKCRYYHDR YTPLYTARDA REWRPLHGRE HDRLVQSGRP 1100
YKDSYWGRKG WELQSRGKER PHFNSPREAP SLAVPLERHL QEKAALSVQD 1150
SSHSLPERFH EHKSVKSRKR RYETLENNDG RLEKKVHKSL EKDTLEEPRV 1200
KKHKKSKKKK KSKDKHRDRE SRHQQESDFS GAYSDADLHR HRKKKKKKKR 1250
HSRKSEDFIK DVEMRLPKLS SYEAGGHFRR TEGSFLLADG LPVEDSGPFR 1300
EKTKHLRMES RPDRCRLSEY GQGD 1324
Length:1,324
Mass (Da):146,223
Last modified:July 1, 2008 - v1
Checksum:i5214E845D98C3288
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH466529 Genomic DNA. Translation: EDL19037.1.
BC137852 mRNA. Translation: AAI37853.1.
CCDSiCCDS39372.1.
RefSeqiNP_084025.2. NM_029749.2.
XP_006504817.1. XM_006504754.1.
XP_006504818.1. XM_006504755.1.
XP_006504819.1. XM_006504756.1.
UniGeneiMm.259620.

Genome annotation databases

EnsembliENSMUST00000053287; ENSMUSP00000053955; ENSMUSG00000051306.
GeneIDi76800.
KEGGimmu:76800.
UCSCiuc009akp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH466529 Genomic DNA. Translation: EDL19037.1 .
BC137852 mRNA. Translation: AAI37853.1 .
CCDSi CCDS39372.1.
RefSeqi NP_084025.2. NM_029749.2.
XP_006504817.1. XM_006504754.1.
XP_006504818.1. XM_006504755.1.
XP_006504819.1. XM_006504756.1.
UniGenei Mm.259620.

3D structure databases

ProteinModelPortali B2RQC2.
SMRi B2RQC2. Positions 110-408.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 218324. 1 interaction.

PTM databases

PhosphoSitei B2RQC2.

Proteomic databases

PaxDbi B2RQC2.
PRIDEi B2RQC2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000053287 ; ENSMUSP00000053955 ; ENSMUSG00000051306 .
GeneIDi 76800.
KEGGi mmu:76800.
UCSCi uc009akp.1. mouse.

Organism-specific databases

CTDi 84132.
MGIi MGI:1924050. Usp42.

Phylogenomic databases

eggNOGi COG5533.
GeneTreei ENSGT00750000117288.
HOGENOMi HOG000236355.
HOVERGENi HBG080724.
InParanoidi B2RQC2.
KOi K11855.
OMAi GKLMPAP.
OrthoDBi EOG72VH5K.
PhylomeDBi B2RQC2.
TreeFami TF315281.

Miscellaneous databases

NextBioi 345843.
PROi B2RQC2.
SOURCEi Search...

Gene expression databases

Bgeei B2RQC2.
Genevestigatori B2RQC2.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The expression of Usp42 during embryogenesis and spermatogenesis in mouse."
    Kim Y.K., Kim Y.S., Yoo K.J., Lee H.J., Lee D.R., Yeo C.Y., Baek K.H.
    Gene Expr. Patterns 7:143-148(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiUBP42_MOUSE
AccessioniPrimary (citable) accession number: B2RQC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: July 1, 2008
Last modified: July 9, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi