Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Short transient receptor potential channel 1

Gene

Trpc1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelSAAS annotation, ReceptorImported
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-3295583 TRP channels
R-MMU-5578775 Ion homeostasis
R-MMU-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Names & Taxonomyi

Protein namesi
Submitted name:
Short transient receptor potential channel 1Imported
Submitted name:
Transient receptor potential cation channel, subfamily C, member 1Imported
Submitted name:
Transient receptor potential cation channel, subfamily C, member 1, isoform CRA_aImported
Gene namesi
Name:Trpc1Imported
ORF Names:mCG_10244Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:109528 Trpc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Transmembranei435 – 453HelicalSequence analysisAdd BLAST19
Transmembranei473 – 492HelicalSequence analysisAdd BLAST20
Transmembranei512 – 533HelicalSequence analysisAdd BLAST22
Transmembranei553 – 575HelicalSequence analysisAdd BLAST23
Transmembranei603 – 624HelicalSequence analysisAdd BLAST22
Transmembranei636 – 658HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000032839

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 271TRP_2InterPro annotationAdd BLAST63
Domaini410 – 672Ion_transInterPro annotationAdd BLAST263

Sequence similaritiesi

Belongs to the transient receptor (TC 1.A.4) family. [View classification]SAAS annotation

Keywords - Domaini

ANK repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
GeneTreeiENSGT00760000119180
HOGENOMiHOG000020589
HOVERGENiHBG068337
KOiK04964
OMAiPKTICYL
OrthoDBiEOG091G029I
TreeFamiTF313147

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR013555 TRP_dom
IPR005457 TRPC1_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF56 PTHR10117:SF56, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01642 TRPCHANNEL1
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit

Sequencei

Sequence statusi: Complete.

B2RPS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAPPPSPGL PPSWAAMMAA LYPSTDLSGV SSSSLPSSPS SSSPNEVMAL
60 70 80 90 100
KDVREVKEEN TLNEKLFLLA CDKGDYYMVK KILEENSSGD LNINCVDVLG
110 120 130 140 150
RNAVTITIEN ESLDILQLLL DYGCQSADAL LVAIDSEVVG AVDILLNHRP
160 170 180 190 200
KRSSRPTIVK LMERIQNPEY STTMDVAPVI LAAHRNNYEI LTMLLKQDVS
210 220 230 240 250
LPKPHAVGCE CTLCSAKNKK DSLRHSRFRL DIYRCLASPA LIMLTEEDPI
260 270 280 290 300
LRAFELSADL KELSLVEVEF RNDYEELARQ CKMFAKDLLA QARNSRELEV
310 320 330 340 350
ILNHTSSDEP LDKRGLLEER MNLSRLKLAI KYNQKEFVSQ SNCQQFLNTV
360 370 380 390 400
WFGQMSGYRR KPTCKKIMTV LTVGIFWPVL SLCYLIAPKS QFGRIIHTPF
410 420 430 440 450
MKFIIHGASY FTFLLLLNLY SLVYNEDKKN TMGPALERID YLLILWIIGM
460 470 480 490 500
IWSDIKRLWY EGLEDFLEES RNQLSFVMNS LYLATFALKV VAHNKFHDFA
510 520 530 540 550
DRKDWDAFHP TLVAEGLFAF ANVLSYLRLF FMYTTSSILG PLQISMGQML
560 570 580 590 600
QDFGKFLGMF LLVLFSFTIG LTQLYDKGYT SKEQKDCVGI FCEQQSNDTF
610 620 630 640 650
HSFIGTCFAL FWYIFSLAHV AIFVTRFSYG EELQSFVGAV IVGTYNVVVV
660 670 680 690 700
IVLTKLLVAM LHKSFQLIAN HEDKEWKFAR AKLWLSYFDD KCTLPPPFNI
710 720 730 740 750
IPSPKTICYM ISSLSKWICS HTSKGKVKRQ NSLKEWRNLK QKRDENYQKV
760 770 780 790 800
MCCLVHRYLT SMRQKMQSTD QATVENLNEL RQDLSKFRNE IRDLLGFRTS

KYAMFYPRN
Length:809
Mass (Da):92,728
Last modified:July 1, 2008 - v1
Checksum:iDFD8377D5C538CDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091531 Genomic DNA No translation available.
AC157947 Genomic DNA No translation available.
BC137581 mRNA Translation: AAI37582.1
CH466560 Genomic DNA Translation: EDL20938.1
RefSeqiNP_035773.1, NM_011643.3
UniGeneiMm.149633
Mm.398522

Genome annotation databases

EnsembliENSMUST00000189137; ENSMUSP00000139672; ENSMUSG00000032839
GeneIDi22063
KEGGimmu:22063
UCSCiuc009rbh.1 mouse

Similar proteinsi

Entry informationi

Entry nameiB2RPS7_MOUSE
AccessioniPrimary (citable) accession number: B2RPS7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health