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B2RNN3

- C1T9B_HUMAN

UniProt

B2RNN3 - C1T9B_HUMAN

Protein

Complement C1q and tumor necrosis factor-related protein 9B

Gene

C1QTNF9B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Complement C1q and tumor necrosis factor-related protein 9B
    Alternative name(s):
    C1q/TNF-related protein 9B
    Short name:
    CTRP9B
    Complement C1q and tumor necrosis factor-related protein 9-like
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:34072. C1QTNF9B.

    Subcellular locationi

    Secreted 1 Publication
    Note: Heteromeric complex formation with CTRP9A or ADIPOQ is required for secretion, otherwise, it is retained in the endoplasmic reticulum.

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 333314Complement C1q and tumor necrosis factor-related protein 9BPRO_0000348424Add
    BLAST

    Proteomic databases

    MaxQBiB2RNN3.
    PaxDbiB2RNN3.
    PRIDEiB2RNN3.

    Expressioni

    Tissue specificityi

    Expressed at low levels. Not expressed in adipose tissues.1 Publication

    Gene expression databases

    BgeeiB2RNN3.
    GenevestigatoriB2RNN3.

    Interactioni

    Subunit structurei

    Interacts with CTRP9A and ADIPOQ. Forms heterotrimers and heterooligomeric complexes with CTRP9A.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliB2RNN3.
    SMRiB2RNN3. Positions 201-330.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 8259Collagen-like 1Add
    BLAST
    Domaini95 – 15460Collagen-like 2Add
    BLAST
    Domaini155 – 19137Collagen-like 3Add
    BLAST
    Domaini197 – 333137C1qPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C1q domain.PROSITE-ProRule annotation
    Contains 3 collagen-like domains.Curated

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG266951.
    HOGENOMiHOG000085653.
    HOVERGENiHBG108220.
    InParanoidiB2RNN3.
    OMAiLNHYNVA.
    OrthoDBiEOG7H4F0T.
    PhylomeDBiB2RNN3.
    TreeFamiTF334029.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00386. C1q. 1 hit.
    PF01391. Collagen. 1 hit.
    [Graphical view]
    PRINTSiPR00007. COMPLEMNTC1Q.
    SMARTiSM00110. C1Q. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS50871. C1Q. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: B2RNN3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRIWWLLLAI EICTGNINSQ DTCRQGHPGI PGNPGHNGLP GRDGRDGAKG    50
    DKGDAGEPGC PGSPGKDGTS GEKGERGADG KVEAKGIKGD QGSRGSPGKH 100
    GPKGLAGPMG EKGLRGETGP QGQKGNKGDV GPTGPEGPRG NIGPLGPTGL 150
    PGPMGPIGKP GPKGEAGPTG PQGEPGVRGI RGWKGDRGEK GKIGETLVLP 200
    KSAFTVGLTV LSKFPSSDVP IKFDKILYNE FNHYDTAVGK FTCHIAGVYY 250
    FTYHITVFSR NVQVSLVKNG VKILHTRDAY VSSEDQASGS IVLQLKLGDE 300
    MWLQVTGGER FNGLFADEDD DTTFTGFLLF SSQ 333
    Length:333
    Mass (Da):34,713
    Last modified:July 1, 2008 - v1
    Checksum:iA15F3F7546938A70
    GO
    Isoform 2 (identifier: B2RNN3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         89-99: GDQGSRGSPGK → EMFRCLWSKME
         100-333: Missing.

    Show »
    Length:99
    Mass (Da):10,418
    Checksum:i676CED8D67718D69
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei89 – 9911GDQGSRGSPGK → EMFRCLWSKME in isoform 2. 1 PublicationVSP_035153Add
    BLAST
    Alternative sequencei100 – 333234Missing in isoform 2. 1 PublicationVSP_035154Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445985 Genomic DNA. Translation: CAM20041.1.
    AL445985 Genomic DNA. Translation: CAM20042.1.
    BC110413 mRNA. Translation: AAI10414.1.
    BC137004 mRNA. Translation: AAI37005.1.
    BC137006 mRNA. Translation: AAI37007.1.
    CCDSiCCDS31947.1. [B2RNN3-1]
    RefSeqiNP_001007538.1. NM_001007537.2. [B2RNN3-1]
    UniGeneiHs.740810.

    Genome annotation databases

    EnsembliENST00000382137; ENSP00000371572; ENSG00000205863. [B2RNN3-1]
    ENST00000382140; ENSP00000371575; ENSG00000205863. [B2RNN3-1]
    ENST00000382145; ENSP00000371580; ENSG00000205863.
    GeneIDi387911.
    KEGGihsa:387911.
    UCSCiuc001uoz.1. human. [B2RNN3-2]
    uc010tcw.2. human. [B2RNN3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445985 Genomic DNA. Translation: CAM20041.1 .
    AL445985 Genomic DNA. Translation: CAM20042.1 .
    BC110413 mRNA. Translation: AAI10414.1 .
    BC137004 mRNA. Translation: AAI37005.1 .
    BC137006 mRNA. Translation: AAI37007.1 .
    CCDSi CCDS31947.1. [B2RNN3-1 ]
    RefSeqi NP_001007538.1. NM_001007537.2. [B2RNN3-1 ]
    UniGenei Hs.740810.

    3D structure databases

    ProteinModelPortali B2RNN3.
    SMRi B2RNN3. Positions 201-330.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    MaxQBi B2RNN3.
    PaxDbi B2RNN3.
    PRIDEi B2RNN3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382137 ; ENSP00000371572 ; ENSG00000205863 . [B2RNN3-1 ]
    ENST00000382140 ; ENSP00000371575 ; ENSG00000205863 . [B2RNN3-1 ]
    ENST00000382145 ; ENSP00000371580 ; ENSG00000205863 .
    GeneIDi 387911.
    KEGGi hsa:387911.
    UCSCi uc001uoz.1. human. [B2RNN3-2 ]
    uc010tcw.2. human. [B2RNN3-1 ]

    Organism-specific databases

    CTDi 387911.
    GeneCardsi GC13M024462.
    HGNCi HGNC:34072. C1QTNF9B.
    MIMi 614148. gene.
    neXtProti NX_B2RNN3.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG266951.
    HOGENOMi HOG000085653.
    HOVERGENi HBG108220.
    InParanoidi B2RNN3.
    OMAi LNHYNVA.
    OrthoDBi EOG7H4F0T.
    PhylomeDBi B2RNN3.
    TreeFami TF334029.

    Miscellaneous databases

    GenomeRNAii 387911.
    NextBioi 101721.
    PROi B2RNN3.
    SOURCEi Search...

    Gene expression databases

    Bgeei B2RNN3.
    Genevestigatori B2RNN3.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00386. C1q. 1 hit.
    PF01391. Collagen. 1 hit.
    [Graphical view ]
    PRINTSi PR00007. COMPLEMNTC1Q.
    SMARTi SM00110. C1Q. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS50871. C1Q. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Testis.
    3. "CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members."
      Peterson J.M., Wei Z., Wong G.W.
      Biochem. Biophys. Res. Commun. 388:360-365(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiC1T9B_HUMAN
    AccessioniPrimary (citable) accession number: B2RNN3
    Secondary accession number(s): A2A3T6
    , B9EH31, Q0VGC5, Q5VX65, Q5VX66, Q8IUU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3