B2RNN3 (C1T9B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Complement C1q and tumor necrosis factor-related protein 9B

Alternative name(s):
C1q/TNF-related protein 9B
Short name=CTRP9B
Complement C1q and tumor necrosis factor-related protein 9-like

Gene names

Name:

C1QTNF9B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with CTRP9A and ADIPOQ. Forms heterotrimers and heterooligomeric complexes with CTRP9A. Ref.3
Subcellular location	Secreted. Note: Heteromeric complex formation with CTRP9A or ADIPOQ is required for secretion, otherwise, it is retained in the endoplasmic reticulum. Ref.3
Tissue specificity	Expressed at low levels. Not expressed in adipose tissues. Ref.3
Sequence similarities	Contains 1 C1q domain. Contains 3 collagen-like domains.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Collagen Repeat Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	collagen Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: B2RNN3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: B2RNN3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     89-99: GDQGSRGSPGK → EMFRCLWSKME
     100-333: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 333	314	Complement C1q and tumor necrosis factor-related protein 9B		PRO_0000348424
Regions
	Domain	24 – 82	59	Collagen-like 1
	Domain	95 – 154	60	Collagen-like 2
	Domain	155 – 191	37	Collagen-like 3
	Domain	197 – 333	137	C1q
Natural variations
	Alternative sequence	89 – 99	11	GDQGSRGSPGK → EMFRCLWSKME in isoform 2.		VSP_035153
	Alternative sequence	100 – 333	234	Missing in isoform 2.		VSP_035154

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: A15F3F7546938A70	FASTA	333	34,713
	10 20 30 40 50 60 MRIWWLLLAI EICTGNINSQ DTCRQGHPGI PGNPGHNGLP GRDGRDGAKG DKGDAGEPGC 70 80 90 100 110 120 PGSPGKDGTS GEKGERGADG KVEAKGIKGD QGSRGSPGKH GPKGLAGPMG EKGLRGETGP 130 140 150 160 170 180 QGQKGNKGDV GPTGPEGPRG NIGPLGPTGL PGPMGPIGKP GPKGEAGPTG PQGEPGVRGI 190 200 210 220 230 240 RGWKGDRGEK GKIGETLVLP KSAFTVGLTV LSKFPSSDVP IKFDKILYNE FNHYDTAVGK 250 260 270 280 290 300 FTCHIAGVYY FTYHITVFSR NVQVSLVKNG VKILHTRDAY VSSEDQASGS IVLQLKLGDE 310 320 330 MWLQVTGGER FNGLFADEDD DTTFTGFLLF SSQ
	Isoform 2 [UniParc]. Checksum: 676CED8D67718D69	FASTA	99	10,418
	10 20 30 40 50 60 MRIWWLLLAI EICTGNINSQ DTCRQGHPGI PGNPGHNGLP GRDGRDGAKG DKGDAGEPGC 70 80 90 PGSPGKDGTS GEKGERGADG KVEAKGIKEM FRCLWSKME

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Testis.
[3]	"CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members." Peterson J.M., Wei Z., Wong G.W. Biochem. Biophys. Res. Commun. 388:360-365(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Hippocampus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445985 Genomic DNA. Translation: CAM20041.1. AL445985 Genomic DNA. Translation: CAM20042.1. BC110413 mRNA. Translation: AAI10414.1. BC137004 mRNA. Translation: AAI37005.1. BC137006 mRNA. Translation: AAI37007.1.
IPI	IPI00550862. IPI00903064.
RefSeq	NP_001007538.1. NM_001007537.1.
UniGene	Hs.740810.
3D structure databases
ProteinModelPortal	B2RNN3.
ModBase	Search...
Proteomic databases
PaxDb	B2RNN3.
PRIDE	B2RNN3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000382057; ENSP00000371489; ENSG00000205863. ENST00000382137; ENSP00000371572; ENSG00000205863. ENST00000382140; ENSP00000371575; ENSG00000205863. ENST00000382145; ENSP00000371580; ENSG00000205863.
GeneID	387911.
KEGG	hsa:387911.
UCSC	uc001uoz.1. human. uc010tcw.2. human.
Organism-specific databases
CTD	387911.
GeneCards	GC13M024462.
HGNC	HGNC:34072. C1QTNF9B.
MIM	614148. gene.
neXtProt	NX_B2RNN3.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG266951.
HOGENOM	HOG000085653.
HOVERGEN	HBG108220.
InParanoid	B2RNN3.
OMA	CHIAGVC.
Gene expression databases
Bgee	B2RNN3.
Genevestigator	B2RNN3.
Family and domain databases
Gene3D	2.60.120.40. 1 hit.
InterPro	IPR001073. C1q. IPR008160. Collagen. IPR008983. Tumour_necrosis_fac-like_dom. [Graphical view]
Pfam	PF00386. C1q. 1 hit. PF01391. Collagen. 1 hit. [Graphical view]
PRINTS	PR00007. COMPLEMNTC1Q.
SMART	SM00110. C1Q. 1 hit. [Graphical view]
SUPFAM	SSF49842. TNF_like. 1 hit.
PROSITE	PS50871. C1Q. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	387911.
NextBio	101721.
SOURCE	Search...

Entry information

Entry name

C1T9B_HUMAN

Accession

Primary (citable) accession number: B2RNN3
Secondary accession number(s): A2A3T6 , B9EH31, Q0VGC5, Q5VX65, Q5VX66, Q8IUU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	July 1, 2008
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.