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Protein

Complement C1q and tumor necrosis factor-related protein 9B

Gene

C1QTNF9B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q and tumor necrosis factor-related protein 9B
Alternative name(s):
C1q/TNF-related protein 9B
Short name:
CTRP9B
Complement C1q and tumor necrosis factor-related protein 9-like
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000205863.9
HGNCiHGNC:34072 C1QTNF9B
MIMi614148 gene
neXtProtiNX_B2RNN3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi387911
OpenTargetsiENSG00000205863

Polymorphism and mutation databases

BioMutaiC1QTNF9B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000034842420 – 333Complement C1q and tumor necrosis factor-related protein 9BAdd BLAST314

Proteomic databases

MaxQBiB2RNN3
PaxDbiB2RNN3
PRIDEiB2RNN3
ProteomicsDBi3442
3443 [B2RNN3-2]

PTM databases

iPTMnetiB2RNN3
PhosphoSitePlusiB2RNN3

Expressioni

Tissue specificityi

Expressed at low levels. Not expressed in adipose tissues.1 Publication

Gene expression databases

BgeeiENSG00000205863
ExpressionAtlasiB2RNN3 baseline and differential

Organism-specific databases

HPAiHPA056632

Interactioni

Subunit structurei

Interacts with CTRP9A and ADIPOQ. Forms heterotrimers and heterooligomeric complexes with CTRP9A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
C1QTNF9P0C8622EBI-10828035,EBI-5654640

Protein-protein interaction databases

BioGridi132501, 23 interactors
IntActiB2RNN3, 2 interactors
STRINGi9606.ENSP00000371572

Structurei

3D structure databases

ProteinModelPortaliB2RNN3
SMRiB2RNN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 82Collagen-like 1Add BLAST59
Domaini95 – 154Collagen-like 2Add BLAST60
Domaini155 – 191Collagen-like 3Add BLAST37
Domaini197 – 333C1qPROSITE-ProRule annotationAdd BLAST137

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IE67 Eukaryota
ENOG4112BCC LUCA
GeneTreeiENSGT00760000118830
HOGENOMiHOG000085653
HOVERGENiHBG108220
InParanoidiB2RNN3
OMAiCHIAGVC
OrthoDBiEOG091G0L3Y
PhylomeDBiB2RNN3
TreeFamiTF334029

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008160 Collagen
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00386 C1q, 1 hit
PF01391 Collagen, 1 hit
PRINTSiPR00007 COMPLEMNTC1Q
SMARTiView protein in SMART
SM00110 C1Q, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B2RNN3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRIWWLLLAI EICTGNINSQ DTCRQGHPGI PGNPGHNGLP GRDGRDGAKG
60 70 80 90 100
DKGDAGEPGC PGSPGKDGTS GEKGERGADG KVEAKGIKGD QGSRGSPGKH
110 120 130 140 150
GPKGLAGPMG EKGLRGETGP QGQKGNKGDV GPTGPEGPRG NIGPLGPTGL
160 170 180 190 200
PGPMGPIGKP GPKGEAGPTG PQGEPGVRGI RGWKGDRGEK GKIGETLVLP
210 220 230 240 250
KSAFTVGLTV LSKFPSSDVP IKFDKILYNE FNHYDTAVGK FTCHIAGVYY
260 270 280 290 300
FTYHITVFSR NVQVSLVKNG VKILHTRDAY VSSEDQASGS IVLQLKLGDE
310 320 330
MWLQVTGGER FNGLFADEDD DTTFTGFLLF SSQ
Length:333
Mass (Da):34,713
Last modified:July 1, 2008 - v1
Checksum:iA15F3F7546938A70
GO
Isoform 2 (identifier: B2RNN3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-99: GDQGSRGSPGK → EMFRCLWSKME
     100-333: Missing.

Show »
Length:99
Mass (Da):10,418
Checksum:i676CED8D67718D69
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03515389 – 99GDQGSRGSPGK → EMFRCLWSKME in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_035154100 – 333Missing in isoform 2. 1 PublicationAdd BLAST234

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445985 Genomic DNA No translation available.
BC110413 mRNA Translation: AAI10414.1
BC137004 mRNA Translation: AAI37005.1
BC137006 mRNA Translation: AAI37007.1
CCDSiCCDS31947.1 [B2RNN3-1]
RefSeqiNP_001007538.1, NM_001007537.2 [B2RNN3-1]
XP_011533372.1, XM_011535070.2 [B2RNN3-1]
UniGeneiHs.740810

Genome annotation databases

EnsembliENST00000382137; ENSP00000371572; ENSG00000205863 [B2RNN3-1]
ENST00000382140; ENSP00000371575; ENSG00000205863 [B2RNN3-1]
GeneIDi387911
KEGGihsa:387911
UCSCiuc001uoz.3 human [B2RNN3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiC1T9B_HUMAN
AccessioniPrimary (citable) accession number: B2RNN3
Secondary accession number(s): A2A3T6
, B9EH31, Q0VGC5, Q5VX65, Q5VX66, Q8IUU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 1, 2008
Last modified: June 20, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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