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Protein

Complement C1q and tumor necrosis factor-related protein 9B

Gene

C1QTNF9B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q and tumor necrosis factor-related protein 9B
Alternative name(s):
C1q/TNF-related protein 9B
Short name:
CTRP9B
Complement C1q and tumor necrosis factor-related protein 9-like
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:34072. C1QTNF9B.

Subcellular locationi

  • Secreted 1 Publication

  • Note: Heteromeric complex formation with CTRP9A or ADIPOQ is required for secretion, otherwise, it is retained in the endoplasmic reticulum.

GO - Cellular componenti

  • collagen trimer Source: UniProtKB-KW
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiC1QTNF9B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 333314Complement C1q and tumor necrosis factor-related protein 9BPRO_0000348424Add
BLAST

Proteomic databases

MaxQBiB2RNN3.
PaxDbiB2RNN3.
PRIDEiB2RNN3.

Expressioni

Tissue specificityi

Expressed at low levels. Not expressed in adipose tissues.1 Publication

Gene expression databases

BgeeiB2RNN3.

Organism-specific databases

HPAiHPA056632.

Interactioni

Subunit structurei

Interacts with CTRP9A and ADIPOQ. Forms heterotrimers and heterooligomeric complexes with CTRP9A.1 Publication

Protein-protein interaction databases

BioGridi132501. 1 interaction.
STRINGi9606.ENSP00000371572.

Structurei

3D structure databases

ProteinModelPortaliB2RNN3.
SMRiB2RNN3. Positions 201-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 8259Collagen-like 1Add
BLAST
Domaini95 – 15460Collagen-like 2Add
BLAST
Domaini155 – 19137Collagen-like 3Add
BLAST
Domaini197 – 333137C1qPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 3 collagen-like domains.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG266951.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiB2RNN3.
OMAiHNGMPGR.
OrthoDBiEOG7H4F0T.
PhylomeDBiB2RNN3.
TreeFamiTF334029.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B2RNN3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRIWWLLLAI EICTGNINSQ DTCRQGHPGI PGNPGHNGLP GRDGRDGAKG
60 70 80 90 100
DKGDAGEPGC PGSPGKDGTS GEKGERGADG KVEAKGIKGD QGSRGSPGKH
110 120 130 140 150
GPKGLAGPMG EKGLRGETGP QGQKGNKGDV GPTGPEGPRG NIGPLGPTGL
160 170 180 190 200
PGPMGPIGKP GPKGEAGPTG PQGEPGVRGI RGWKGDRGEK GKIGETLVLP
210 220 230 240 250
KSAFTVGLTV LSKFPSSDVP IKFDKILYNE FNHYDTAVGK FTCHIAGVYY
260 270 280 290 300
FTYHITVFSR NVQVSLVKNG VKILHTRDAY VSSEDQASGS IVLQLKLGDE
310 320 330
MWLQVTGGER FNGLFADEDD DTTFTGFLLF SSQ
Length:333
Mass (Da):34,713
Last modified:July 1, 2008 - v1
Checksum:iA15F3F7546938A70
GO
Isoform 2 (identifier: B2RNN3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-99: GDQGSRGSPGK → EMFRCLWSKME
     100-333: Missing.

Show »
Length:99
Mass (Da):10,418
Checksum:i676CED8D67718D69
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei89 – 9911GDQGSRGSPGK → EMFRCLWSKME in isoform 2. 1 PublicationVSP_035153Add
BLAST
Alternative sequencei100 – 333234Missing in isoform 2. 1 PublicationVSP_035154Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445985 Genomic DNA. Translation: CAM20041.1.
AL445985 Genomic DNA. Translation: CAM20042.1.
BC110413 mRNA. Translation: AAI10414.1.
BC137004 mRNA. Translation: AAI37005.1.
BC137006 mRNA. Translation: AAI37007.1.
CCDSiCCDS31947.1. [B2RNN3-1]
RefSeqiNP_001007538.1. NM_001007537.2. [B2RNN3-1]
UniGeneiHs.740810.

Genome annotation databases

EnsembliENST00000382137; ENSP00000371572; ENSG00000205863. [B2RNN3-1]
ENST00000382140; ENSP00000371575; ENSG00000205863. [B2RNN3-1]
GeneIDi387911.
KEGGihsa:387911.
UCSCiuc001uoz.1. human. [B2RNN3-2]
uc010tcw.2. human. [B2RNN3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445985 Genomic DNA. Translation: CAM20041.1.
AL445985 Genomic DNA. Translation: CAM20042.1.
BC110413 mRNA. Translation: AAI10414.1.
BC137004 mRNA. Translation: AAI37005.1.
BC137006 mRNA. Translation: AAI37007.1.
CCDSiCCDS31947.1. [B2RNN3-1]
RefSeqiNP_001007538.1. NM_001007537.2. [B2RNN3-1]
UniGeneiHs.740810.

3D structure databases

ProteinModelPortaliB2RNN3.
SMRiB2RNN3. Positions 201-330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132501. 1 interaction.
STRINGi9606.ENSP00000371572.

Polymorphism and mutation databases

BioMutaiC1QTNF9B.

Proteomic databases

MaxQBiB2RNN3.
PaxDbiB2RNN3.
PRIDEiB2RNN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382137; ENSP00000371572; ENSG00000205863. [B2RNN3-1]
ENST00000382140; ENSP00000371575; ENSG00000205863. [B2RNN3-1]
GeneIDi387911.
KEGGihsa:387911.
UCSCiuc001uoz.1. human. [B2RNN3-2]
uc010tcw.2. human. [B2RNN3-1]

Organism-specific databases

CTDi387911.
GeneCardsiGC13M024462.
HGNCiHGNC:34072. C1QTNF9B.
HPAiHPA056632.
MIMi614148. gene.
neXtProtiNX_B2RNN3.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG266951.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiB2RNN3.
OMAiHNGMPGR.
OrthoDBiEOG7H4F0T.
PhylomeDBiB2RNN3.
TreeFamiTF334029.

Miscellaneous databases

GenomeRNAii387911.
NextBioi101721.
PROiB2RNN3.
SOURCEiSearch...

Gene expression databases

BgeeiB2RNN3.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.
  3. "CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members."
    Peterson J.M., Wei Z., Wong G.W.
    Biochem. Biophys. Res. Commun. 388:360-365(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Hippocampus.

Entry informationi

Entry nameiC1T9B_HUMAN
AccessioniPrimary (citable) accession number: B2RNN3
Secondary accession number(s): A2A3T6
, B9EH31, Q0VGC5, Q5VX65, Q5VX66, Q8IUU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 1, 2008
Last modified: June 24, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.