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B2RNN3 (C1T9B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Complement C1q and tumor necrosis factor-related protein 9B
Alternative name(s):
C1q/TNF-related protein 9B
Short name=CTRP9B
Complement C1q and tumor necrosis factor-related protein 9-like
Gene names
Name:C1QTNF9B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with CTRP9A and ADIPOQ. Forms heterotrimers and heterooligomeric complexes with CTRP9A. Ref.3

Subcellular location

Secreted. Note: Heteromeric complex formation with CTRP9A or ADIPOQ is required for secretion, otherwise, it is retained in the endoplasmic reticulum. Ref.3

Tissue specificity

Expressed at low levels. Not expressed in adipose tissues. Ref.3

Sequence similarities

Contains 1 C1q domain.

Contains 3 collagen-like domains.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainCollagen
Repeat
Signal
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcollagen

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: B2RNN3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: B2RNN3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     89-99: GDQGSRGSPGK → EMFRCLWSKME
     100-333: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 333314Complement C1q and tumor necrosis factor-related protein 9B
PRO_0000348424

Regions

Domain24 – 8259Collagen-like 1
Domain95 – 15460Collagen-like 2
Domain155 – 19137Collagen-like 3
Domain197 – 333137C1q

Natural variations

Alternative sequence89 – 9911GDQGSRGSPGK → EMFRCLWSKME in isoform 2.
VSP_035153
Alternative sequence100 – 333234Missing in isoform 2.
VSP_035154

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: A15F3F7546938A70

FASTA33334,713
        10         20         30         40         50         60 
MRIWWLLLAI EICTGNINSQ DTCRQGHPGI PGNPGHNGLP GRDGRDGAKG DKGDAGEPGC 

        70         80         90        100        110        120 
PGSPGKDGTS GEKGERGADG KVEAKGIKGD QGSRGSPGKH GPKGLAGPMG EKGLRGETGP 

       130        140        150        160        170        180 
QGQKGNKGDV GPTGPEGPRG NIGPLGPTGL PGPMGPIGKP GPKGEAGPTG PQGEPGVRGI 

       190        200        210        220        230        240 
RGWKGDRGEK GKIGETLVLP KSAFTVGLTV LSKFPSSDVP IKFDKILYNE FNHYDTAVGK 

       250        260        270        280        290        300 
FTCHIAGVYY FTYHITVFSR NVQVSLVKNG VKILHTRDAY VSSEDQASGS IVLQLKLGDE 

       310        320        330 
MWLQVTGGER FNGLFADEDD DTTFTGFLLF SSQ 

« Hide

Isoform 2 [UniParc].

Checksum: 676CED8D67718D69
Show »

FASTA9910,418

References

« Hide 'large scale' references
[1]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Testis.
[3]"CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members."
Peterson J.M., Wei Z., Wong G.W.
Biochem. Biophys. Res. Commun. 388:360-365(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Hippocampus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL445985 Genomic DNA. Translation: CAM20041.1.
AL445985 Genomic DNA. Translation: CAM20042.1.
BC110413 mRNA. Translation: AAI10414.1.
BC137004 mRNA. Translation: AAI37005.1.
BC137006 mRNA. Translation: AAI37007.1.
RefSeqNP_001007538.1. NM_001007537.2.
UniGeneHs.740810.

3D structure databases

ProteinModelPortalB2RNN3.
SMRB2RNN3. Positions 201-330.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbB2RNN3.
PRIDEB2RNN3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000382057; ENSP00000371489; ENSG00000205863.
ENST00000382137; ENSP00000371572; ENSG00000205863. [B2RNN3-1]
ENST00000382140; ENSP00000371575; ENSG00000205863. [B2RNN3-1]
ENST00000382145; ENSP00000371580; ENSG00000205863.
GeneID387911.
KEGGhsa:387911.
UCSCuc001uoz.1. human. [B2RNN3-2]
uc010tcw.2. human. [B2RNN3-1]

Organism-specific databases

CTD387911.
GeneCardsGC13M024462.
HGNCHGNC:34072. C1QTNF9B.
MIM614148. gene.
neXtProtNX_B2RNN3.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG266951.
HOGENOMHOG000085653.
HOVERGENHBG108220.
InParanoidB2RNN3.
OMAHKGNIGY.
OrthoDBEOG7H4F0T.
PhylomeDBB2RNN3.
TreeFamTF334029.

Gene expression databases

BgeeB2RNN3.
GenevestigatorB2RNN3.

Family and domain databases

Gene3D2.60.120.40. 1 hit.
InterProIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSPR00007. COMPLEMNTC1Q.
SMARTSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi387911.
NextBio101721.
PROB2RNN3.
SOURCESearch...

Entry information

Entry nameC1T9B_HUMAN
AccessionPrimary (citable) accession number: B2RNN3
Secondary accession number(s): A2A3T6 expand/collapse secondary AC list , B9EH31, Q0VGC5, Q5VX65, Q5VX66, Q8IUU4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 1, 2008
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM