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B2RNN3

- C1T9B_HUMAN

UniProt

B2RNN3 - C1T9B_HUMAN

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Protein

Complement C1q and tumor necrosis factor-related protein 9B

Gene

C1QTNF9B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q and tumor necrosis factor-related protein 9B
Alternative name(s):
C1q/TNF-related protein 9B
Short name:
CTRP9B
Complement C1q and tumor necrosis factor-related protein 9-like
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:34072. C1QTNF9B.

Subcellular locationi

Secreted 1 Publication
Note: Heteromeric complex formation with CTRP9A or ADIPOQ is required for secretion, otherwise, it is retained in the endoplasmic reticulum.

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 333314Complement C1q and tumor necrosis factor-related protein 9BPRO_0000348424Add
BLAST

Proteomic databases

MaxQBiB2RNN3.
PaxDbiB2RNN3.
PRIDEiB2RNN3.

Expressioni

Tissue specificityi

Expressed at low levels. Not expressed in adipose tissues.1 Publication

Gene expression databases

BgeeiB2RNN3.
GenevestigatoriB2RNN3.

Interactioni

Subunit structurei

Interacts with CTRP9A and ADIPOQ. Forms heterotrimers and heterooligomeric complexes with CTRP9A.1 Publication

Protein-protein interaction databases

BioGridi132501. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliB2RNN3.
SMRiB2RNN3. Positions 201-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 8259Collagen-like 1Add
BLAST
Domaini95 – 15460Collagen-like 2Add
BLAST
Domaini155 – 19137Collagen-like 3Add
BLAST
Domaini197 – 333137C1qPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 3 collagen-like domains.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG266951.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiB2RNN3.
OMAiLNHYNVA.
OrthoDBiEOG7H4F0T.
PhylomeDBiB2RNN3.
TreeFamiTF334029.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: B2RNN3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRIWWLLLAI EICTGNINSQ DTCRQGHPGI PGNPGHNGLP GRDGRDGAKG
60 70 80 90 100
DKGDAGEPGC PGSPGKDGTS GEKGERGADG KVEAKGIKGD QGSRGSPGKH
110 120 130 140 150
GPKGLAGPMG EKGLRGETGP QGQKGNKGDV GPTGPEGPRG NIGPLGPTGL
160 170 180 190 200
PGPMGPIGKP GPKGEAGPTG PQGEPGVRGI RGWKGDRGEK GKIGETLVLP
210 220 230 240 250
KSAFTVGLTV LSKFPSSDVP IKFDKILYNE FNHYDTAVGK FTCHIAGVYY
260 270 280 290 300
FTYHITVFSR NVQVSLVKNG VKILHTRDAY VSSEDQASGS IVLQLKLGDE
310 320 330
MWLQVTGGER FNGLFADEDD DTTFTGFLLF SSQ
Length:333
Mass (Da):34,713
Last modified:July 1, 2008 - v1
Checksum:iA15F3F7546938A70
GO
Isoform 2 (identifier: B2RNN3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-99: GDQGSRGSPGK → EMFRCLWSKME
     100-333: Missing.

Show »
Length:99
Mass (Da):10,418
Checksum:i676CED8D67718D69
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei89 – 9911GDQGSRGSPGK → EMFRCLWSKME in isoform 2. 1 PublicationVSP_035153Add
BLAST
Alternative sequencei100 – 333234Missing in isoform 2. 1 PublicationVSP_035154Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445985 Genomic DNA. Translation: CAM20041.1.
AL445985 Genomic DNA. Translation: CAM20042.1.
BC110413 mRNA. Translation: AAI10414.1.
BC137004 mRNA. Translation: AAI37005.1.
BC137006 mRNA. Translation: AAI37007.1.
CCDSiCCDS31947.1. [B2RNN3-1]
RefSeqiNP_001007538.1. NM_001007537.2. [B2RNN3-1]
UniGeneiHs.740810.

Genome annotation databases

EnsembliENST00000382137; ENSP00000371572; ENSG00000205863. [B2RNN3-1]
ENST00000382140; ENSP00000371575; ENSG00000205863. [B2RNN3-1]
ENST00000382145; ENSP00000371580; ENSG00000205863.
GeneIDi387911.
KEGGihsa:387911.
UCSCiuc001uoz.1. human. [B2RNN3-2]
uc010tcw.2. human. [B2RNN3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445985 Genomic DNA. Translation: CAM20041.1 .
AL445985 Genomic DNA. Translation: CAM20042.1 .
BC110413 mRNA. Translation: AAI10414.1 .
BC137004 mRNA. Translation: AAI37005.1 .
BC137006 mRNA. Translation: AAI37007.1 .
CCDSi CCDS31947.1. [B2RNN3-1 ]
RefSeqi NP_001007538.1. NM_001007537.2. [B2RNN3-1 ]
UniGenei Hs.740810.

3D structure databases

ProteinModelPortali B2RNN3.
SMRi B2RNN3. Positions 201-330.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 132501. 1 interaction.

Proteomic databases

MaxQBi B2RNN3.
PaxDbi B2RNN3.
PRIDEi B2RNN3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382137 ; ENSP00000371572 ; ENSG00000205863 . [B2RNN3-1 ]
ENST00000382140 ; ENSP00000371575 ; ENSG00000205863 . [B2RNN3-1 ]
ENST00000382145 ; ENSP00000371580 ; ENSG00000205863 .
GeneIDi 387911.
KEGGi hsa:387911.
UCSCi uc001uoz.1. human. [B2RNN3-2 ]
uc010tcw.2. human. [B2RNN3-1 ]

Organism-specific databases

CTDi 387911.
GeneCardsi GC13M024462.
HGNCi HGNC:34072. C1QTNF9B.
MIMi 614148. gene.
neXtProti NX_B2RNN3.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG266951.
GeneTreei ENSGT00760000118830.
HOGENOMi HOG000085653.
HOVERGENi HBG108220.
InParanoidi B2RNN3.
OMAi LNHYNVA.
OrthoDBi EOG7H4F0T.
PhylomeDBi B2RNN3.
TreeFami TF334029.

Miscellaneous databases

GenomeRNAii 387911.
NextBioi 101721.
PROi B2RNN3.
SOURCEi Search...

Gene expression databases

Bgeei B2RNN3.
Genevestigatori B2RNN3.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view ]
PRINTSi PR00007. COMPLEMNTC1Q.
SMARTi SM00110. C1Q. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS50871. C1Q. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.
  3. "CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members."
    Peterson J.M., Wei Z., Wong G.W.
    Biochem. Biophys. Res. Commun. 388:360-365(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Hippocampus.

Entry informationi

Entry nameiC1T9B_HUMAN
AccessioniPrimary (citable) accession number: B2RNN3
Secondary accession number(s): A2A3T6
, B9EH31, Q0VGC5, Q5VX65, Q5VX66, Q8IUU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3