ID O11HC_HUMAN Reviewed; 326 AA. AC B2RN74; DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-2008, sequence version 1. DT 24-JAN-2024, entry version 106. DE RecName: Full=Olfactory receptor 11H12; GN Name=OR11H12; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Odorant receptor. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR11H12"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC136730; AAI36731.1; -; mRNA. DR EMBL; BC136731; AAI36732.1; -; mRNA. DR CCDS; CCDS32017.1; -. DR RefSeq; NP_001013372.1; NM_001013354.1. DR AlphaFoldDB; B2RN74; -. DR SMR; B2RN74; -. DR BioGRID; 136341; 3. DR STRING; 9606.ENSP00000449002; -. DR GlyCosmos; B2RN74; 3 sites, No reported glycans. DR GlyGen; B2RN74; 3 sites. DR BioMuta; OR11H12; -. DR PaxDb; 9606-ENSP00000449002; -. DR Antibodypedia; 52804; 30 antibodies from 14 providers. DR DNASU; 440153; -. DR Ensembl; ENST00000550708.2; ENSP00000449002.1; ENSG00000257115.2. DR GeneID; 440153; -. DR KEGG; hsa:440153; -. DR MANE-Select; ENST00000550708.2; ENSP00000449002.1; NM_001013354.1; NP_001013372.1. DR UCSC; uc010tkp.3; human. DR AGR; HGNC:30738; -. DR CTD; 440153; -. DR GeneCards; OR11H12; -. DR HGNC; HGNC:30738; OR11H12. DR HPA; ENSG00000257115; Not detected. DR neXtProt; NX_B2RN74; -. DR PharmGKB; PA142671220; -. DR VEuPathDB; HostDB:ENSG00000257115; -. DR eggNOG; ENOG502QVH7; Eukaryota. DR GeneTree; ENSGT00940000163479; -. DR HOGENOM; CLU_012526_1_0_1; -. DR InParanoid; B2RN74; -. DR OMA; VCALWCD; -. DR OrthoDB; 3040813at2759; -. DR PhylomeDB; B2RN74; -. DR PathwayCommons; B2RN74; -. DR SignaLink; B2RN74; -. DR BioGRID-ORCS; 440153; 16 hits in 619 CRISPR screens. DR GenomeRNAi; 440153; -. DR Pharos; B2RN74; Tdark. DR PRO; PR:B2RN74; -. DR Proteomes; UP000005640; Chromosome 14. DR RNAct; B2RN74; Protein. DR Bgee; ENSG00000257115; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 4 other cell types or tissues. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro. DR CDD; cd15913; 7tmA_OR11G-like; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR PANTHER; PTHR24242; G-PROTEIN COUPLED RECEPTOR; 1. DR PANTHER; PTHR24242:SF201; OLFACTORY RECEPTOR 11H1-RELATED; 1. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..326 FT /note="Olfactory receptor 11H12" FT /id="PRO_0000344798" FT TOPO_DOM 1..44 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 45..65 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 66..72 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 73..93 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 94..112 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 113..133 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 134..158 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 159..179 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 180..216 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 217..237 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 238..259 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 260..280 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 281..287 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 288..308 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 309..326 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 13 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 18 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 106 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 112..194 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" SQ SEQUENCE 326 AA; 36530 MW; F616037020AB0550 CRC64; MCPLTLQVTG LMNVSEPNSS FAFVNEFILQ GFTCEWTIQI FLFSLFTTTY ALTITGNGAI AFVLWCDWRL HTPMYMFLGN FSFLEIWYVS STVPKMLVNF LSEKKNISFA GCFLQFYFFF SLGTSECLLL TVMAFDQYLA ICRPLLYPNI MTGHLCAKLV ILCWVCGFLW FLIPIVLISQ MPFCGPNIID HVVCDPGPRF ALDCVSAPRI QLFCYTLSSL VIFGNFLFII GSYTLVLKAV LGMPSSTGRH KAFSTCGSHL AVVSLCYSSL MVMYVSPGLG HSTGMQKIET LFYAMVTPLF NPLIYSLQNK EIKAALRKVL GSSNII //