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B2RN74 (O11HC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 11H12
Gene names
Name:OR11H12
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Olfactory receptor 11H12
PRO_0000344798

Regions

Topological domain1 – 4444Extracellular Potential
Transmembrane45 – 6521Helical; Name=1; Potential
Topological domain66 – 727Cytoplasmic Potential
Transmembrane73 – 9321Helical; Name=2; Potential
Topological domain94 – 11219Extracellular Potential
Transmembrane113 – 13321Helical; Name=3; Potential
Topological domain134 – 15825Cytoplasmic Potential
Transmembrane159 – 17921Helical; Name=4; Potential
Topological domain180 – 21637Extracellular Potential
Transmembrane217 – 23721Helical; Name=5; Potential
Topological domain238 – 25922Cytoplasmic Potential
Transmembrane260 – 28021Helical; Name=6; Potential
Topological domain281 – 2877Extracellular Potential
Transmembrane288 – 30821Helical; Name=7; Potential
Topological domain309 – 32618Cytoplasmic Potential

Amino acid modifications

Glycosylation131N-linked (GlcNAc...) Potential
Glycosylation181N-linked (GlcNAc...) Potential
Glycosylation1061N-linked (GlcNAc...) Potential
Disulfide bond112 ↔ 194 By similarity

Sequences

Sequence LengthMass (Da)Tools
B2RN74 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: F616037020AB0550

FASTA32636,530
        10         20         30         40         50         60 
MCPLTLQVTG LMNVSEPNSS FAFVNEFILQ GFTCEWTIQI FLFSLFTTTY ALTITGNGAI 

        70         80         90        100        110        120 
AFVLWCDWRL HTPMYMFLGN FSFLEIWYVS STVPKMLVNF LSEKKNISFA GCFLQFYFFF 

       130        140        150        160        170        180 
SLGTSECLLL TVMAFDQYLA ICRPLLYPNI MTGHLCAKLV ILCWVCGFLW FLIPIVLISQ 

       190        200        210        220        230        240 
MPFCGPNIID HVVCDPGPRF ALDCVSAPRI QLFCYTLSSL VIFGNFLFII GSYTLVLKAV 

       250        260        270        280        290        300 
LGMPSSTGRH KAFSTCGSHL AVVSLCYSSL MVMYVSPGLG HSTGMQKIET LFYAMVTPLF 

       310        320 
NPLIYSLQNK EIKAALRKVL GSSNII 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC136730 mRNA. Translation: AAI36731.1.
BC136731 mRNA. Translation: AAI36732.1.
CCDSCCDS32017.1.
RefSeqNP_001013372.1. NM_001013354.1.
UniGeneHs.534880.

3D structure databases

ProteinModelPortalB2RN74.
SMRB2RN74. Positions 52-322.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000352724.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEB2RN74.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000550708; ENSP00000449002; ENSG00000257115.
GeneID440153.
KEGGhsa:440153.
UCSCuc010tkp.2. human.

Organism-specific databases

CTD440153.
GeneCardsGC14P019380.
HGNCHGNC:30738. OR11H12.
HPAHPA047370.
neXtProtNX_B2RN74.
PharmGKBPA142671220.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidB2RN74.
KOK04257.
OMAKLVIICW.
OrthoDBEOG7N0C51.
PhylomeDBB2RN74.

Gene expression databases

BgeeB2RN74.
CleanExHS_OR11H12.
GenevestigatorB2RN74.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi440153.
NextBio108999.
PROB2RN74.

Entry information

Entry nameO11HC_HUMAN
AccessionPrimary (citable) accession number: B2RN74
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 1, 2008
Last modified: July 9, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries