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Protein

Olfactory receptor 11H12

Gene

OR11H12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-31369-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 11H12
Gene namesi
Name:OR11H12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:30738. OR11H12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 65Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini66 – 72CytoplasmicSequence analysis7
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 112ExtracellularSequence analysisAdd BLAST19
Transmembranei113 – 133Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini134 – 158CytoplasmicSequence analysisAdd BLAST25
Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini180 – 216ExtracellularSequence analysisAdd BLAST37
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 259CytoplasmicSequence analysisAdd BLAST22
Transmembranei260 – 280Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini281 – 287ExtracellularSequence analysis7
Transmembranei288 – 308Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini309 – 326CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000257115.
PharmGKBiPA142671220.

Polymorphism and mutation databases

BioMutaiOR11H12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003447981 – 326Olfactory receptor 11H12Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi13N-linked (GlcNAc...)Sequence analysis1
Glycosylationi18N-linked (GlcNAc...)Sequence analysis1
Glycosylationi106N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi112 ↔ 194PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiB2RN74.
PRIDEiB2RN74.

Expressioni

Gene expression databases

CleanExiHS_OR11H12.

Organism-specific databases

HPAiHPA047370.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000449002.

Structurei

3D structure databases

ProteinModelPortaliB2RN74.
SMRiB2RN74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFEZ. Eukaryota.
ENOG411183S. LUCA.
GeneTreeiENSGT00840000129709.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiB2RN74.
KOiK04257.
OMAiKLVIICW.
OrthoDBiEOG091G0AZH.
PhylomeDBiB2RN74.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RN74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPLTLQVTG LMNVSEPNSS FAFVNEFILQ GFTCEWTIQI FLFSLFTTTY
60 70 80 90 100
ALTITGNGAI AFVLWCDWRL HTPMYMFLGN FSFLEIWYVS STVPKMLVNF
110 120 130 140 150
LSEKKNISFA GCFLQFYFFF SLGTSECLLL TVMAFDQYLA ICRPLLYPNI
160 170 180 190 200
MTGHLCAKLV ILCWVCGFLW FLIPIVLISQ MPFCGPNIID HVVCDPGPRF
210 220 230 240 250
ALDCVSAPRI QLFCYTLSSL VIFGNFLFII GSYTLVLKAV LGMPSSTGRH
260 270 280 290 300
KAFSTCGSHL AVVSLCYSSL MVMYVSPGLG HSTGMQKIET LFYAMVTPLF
310 320
NPLIYSLQNK EIKAALRKVL GSSNII
Length:326
Mass (Da):36,530
Last modified:July 1, 2008 - v1
Checksum:iF616037020AB0550
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC136730 mRNA. Translation: AAI36731.1.
BC136731 mRNA. Translation: AAI36732.1.
CCDSiCCDS32017.1.
RefSeqiNP_001013372.1. NM_001013354.1.
UniGeneiHs.534880.

Genome annotation databases

EnsembliENST00000550708; ENSP00000449002; ENSG00000257115.
GeneIDi440153.
KEGGihsa:440153.
UCSCiuc010tkp.3. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC136730 mRNA. Translation: AAI36731.1.
BC136731 mRNA. Translation: AAI36732.1.
CCDSiCCDS32017.1.
RefSeqiNP_001013372.1. NM_001013354.1.
UniGeneiHs.534880.

3D structure databases

ProteinModelPortaliB2RN74.
SMRiB2RN74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000449002.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR11H12.

Proteomic databases

PaxDbiB2RN74.
PRIDEiB2RN74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000550708; ENSP00000449002; ENSG00000257115.
GeneIDi440153.
KEGGihsa:440153.
UCSCiuc010tkp.3. human.

Organism-specific databases

CTDi440153.
GeneCardsiOR11H12.
HGNCiHGNC:30738. OR11H12.
HPAiHPA047370.
neXtProtiNX_B2RN74.
OpenTargetsiENSG00000257115.
PharmGKBiPA142671220.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFEZ. Eukaryota.
ENOG411183S. LUCA.
GeneTreeiENSGT00840000129709.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiB2RN74.
KOiK04257.
OMAiKLVIICW.
OrthoDBiEOG091G0AZH.
PhylomeDBiB2RN74.

Enzyme and pathway databases

BioCyciZFISH:G66-31369-MONOMER.

Miscellaneous databases

GenomeRNAii440153.
PROiB2RN74.

Gene expression databases

CleanExiHS_OR11H12.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO11HC_HUMAN
AccessioniPrimary (citable) accession number: B2RN74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 1, 2008
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.