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Protein

Olfactory receptor 11H12

Gene

OR11H12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 11H12
Gene namesi
Name:OR11H12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:30738. OR11H12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444ExtracellularSequence AnalysisAdd
BLAST
Transmembranei45 – 6521Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini66 – 727CytoplasmicSequence Analysis
Transmembranei73 – 9321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini94 – 11219ExtracellularSequence AnalysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini134 – 15825CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei159 – 17921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini180 – 21637ExtracellularSequence AnalysisAdd
BLAST
Transmembranei217 – 23721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini238 – 25922CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei260 – 28021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini281 – 2877ExtracellularSequence Analysis
Transmembranei288 – 30821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini309 – 32618CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671220.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Olfactory receptor 11H12PRO_0000344798Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi112 ↔ 194PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiB2RN74.

Expressioni

Gene expression databases

BgeeiB2RN74.
CleanExiHS_OR11H12.
GenevestigatoriB2RN74.

Organism-specific databases

HPAiHPA047370.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352724.

Structurei

3D structure databases

ProteinModelPortaliB2RN74.
SMRiB2RN74. Positions 52-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119087.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiB2RN74.
KOiK04257.
OMAiKLVIICW.
OrthoDBiEOG7N0C51.
PhylomeDBiB2RN74.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RN74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPLTLQVTG LMNVSEPNSS FAFVNEFILQ GFTCEWTIQI FLFSLFTTTY
60 70 80 90 100
ALTITGNGAI AFVLWCDWRL HTPMYMFLGN FSFLEIWYVS STVPKMLVNF
110 120 130 140 150
LSEKKNISFA GCFLQFYFFF SLGTSECLLL TVMAFDQYLA ICRPLLYPNI
160 170 180 190 200
MTGHLCAKLV ILCWVCGFLW FLIPIVLISQ MPFCGPNIID HVVCDPGPRF
210 220 230 240 250
ALDCVSAPRI QLFCYTLSSL VIFGNFLFII GSYTLVLKAV LGMPSSTGRH
260 270 280 290 300
KAFSTCGSHL AVVSLCYSSL MVMYVSPGLG HSTGMQKIET LFYAMVTPLF
310 320
NPLIYSLQNK EIKAALRKVL GSSNII
Length:326
Mass (Da):36,530
Last modified:July 1, 2008 - v1
Checksum:iF616037020AB0550
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC136730 mRNA. Translation: AAI36731.1.
BC136731 mRNA. Translation: AAI36732.1.
CCDSiCCDS32017.1.
RefSeqiNP_001013372.1. NM_001013354.1.
UniGeneiHs.534880.

Genome annotation databases

EnsembliENST00000550708; ENSP00000449002; ENSG00000257115.
GeneIDi440153.
KEGGihsa:440153.
UCSCiuc010tkp.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC136730 mRNA. Translation: AAI36731.1.
BC136731 mRNA. Translation: AAI36732.1.
CCDSiCCDS32017.1.
RefSeqiNP_001013372.1. NM_001013354.1.
UniGeneiHs.534880.

3D structure databases

ProteinModelPortaliB2RN74.
SMRiB2RN74. Positions 52-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000352724.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiB2RN74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000550708; ENSP00000449002; ENSG00000257115.
GeneIDi440153.
KEGGihsa:440153.
UCSCiuc010tkp.2. human.

Organism-specific databases

CTDi440153.
GeneCardsiGC14P019380.
HGNCiHGNC:30738. OR11H12.
HPAiHPA047370.
neXtProtiNX_B2RN74.
PharmGKBiPA142671220.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119087.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiB2RN74.
KOiK04257.
OMAiKLVIICW.
OrthoDBiEOG7N0C51.
PhylomeDBiB2RN74.

Miscellaneous databases

GenomeRNAii440153.
NextBioi108999.
PROiB2RN74.

Gene expression databases

BgeeiB2RN74.
CleanExiHS_OR11H12.
GenevestigatoriB2RN74.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiO11HC_HUMAN
AccessioniPrimary (citable) accession number: B2RN74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 1, 2008
Last modified: January 7, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.