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B2RN74

- O11HC_HUMAN

UniProt

B2RN74 - O11HC_HUMAN

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Protein
Olfactory receptor 11H12
Gene
OR11H12
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 11H12
    Gene namesi
    Name:OR11H12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:30738. OR11H12.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4444Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei45 – 6521Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini66 – 727Cytoplasmic Reviewed prediction
    Transmembranei73 – 9321Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini94 – 11219Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei113 – 13321Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini134 – 15825Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei159 – 17921Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini180 – 21637Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei217 – 23721Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini238 – 25922Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei260 – 28021Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini281 – 2877Extracellular Reviewed prediction
    Transmembranei288 – 30821Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini309 – 32618Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671220.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Olfactory receptor 11H12
    PRO_0000344798Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi13 – 131N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi18 – 181N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi106 – 1061N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi112 ↔ 194 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiB2RN74.

    Expressioni

    Gene expression databases

    BgeeiB2RN74.
    CleanExiHS_OR11H12.
    GenevestigatoriB2RN74.

    Organism-specific databases

    HPAiHPA047370.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000352724.

    Structurei

    3D structure databases

    ProteinModelPortaliB2RN74.
    SMRiB2RN74. Positions 52-322.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiB2RN74.
    KOiK04257.
    OMAiKLVIICW.
    OrthoDBiEOG7N0C51.
    PhylomeDBiB2RN74.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2RN74-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCPLTLQVTG LMNVSEPNSS FAFVNEFILQ GFTCEWTIQI FLFSLFTTTY    50
    ALTITGNGAI AFVLWCDWRL HTPMYMFLGN FSFLEIWYVS STVPKMLVNF 100
    LSEKKNISFA GCFLQFYFFF SLGTSECLLL TVMAFDQYLA ICRPLLYPNI 150
    MTGHLCAKLV ILCWVCGFLW FLIPIVLISQ MPFCGPNIID HVVCDPGPRF 200
    ALDCVSAPRI QLFCYTLSSL VIFGNFLFII GSYTLVLKAV LGMPSSTGRH 250
    KAFSTCGSHL AVVSLCYSSL MVMYVSPGLG HSTGMQKIET LFYAMVTPLF 300
    NPLIYSLQNK EIKAALRKVL GSSNII 326
    Length:326
    Mass (Da):36,530
    Last modified:July 1, 2008 - v1
    Checksum:iF616037020AB0550
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC136730 mRNA. Translation: AAI36731.1.
    BC136731 mRNA. Translation: AAI36732.1.
    CCDSiCCDS32017.1.
    RefSeqiNP_001013372.1. NM_001013354.1.
    UniGeneiHs.534880.

    Genome annotation databases

    EnsembliENST00000550708; ENSP00000449002; ENSG00000257115.
    GeneIDi440153.
    KEGGihsa:440153.
    UCSCiuc010tkp.2. human.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC136730 mRNA. Translation: AAI36731.1 .
    BC136731 mRNA. Translation: AAI36732.1 .
    CCDSi CCDS32017.1.
    RefSeqi NP_001013372.1. NM_001013354.1.
    UniGenei Hs.534880.

    3D structure databases

    ProteinModelPortali B2RN74.
    SMRi B2RN74. Positions 52-322.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000352724.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi B2RN74.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000550708 ; ENSP00000449002 ; ENSG00000257115 .
    GeneIDi 440153.
    KEGGi hsa:440153.
    UCSCi uc010tkp.2. human.

    Organism-specific databases

    CTDi 440153.
    GeneCardsi GC14P019380.
    HGNCi HGNC:30738. OR11H12.
    HPAi HPA047370.
    neXtProti NX_B2RN74.
    PharmGKBi PA142671220.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi B2RN74.
    KOi K04257.
    OMAi KLVIICW.
    OrthoDBi EOG7N0C51.
    PhylomeDBi B2RN74.

    Miscellaneous databases

    GenomeRNAii 440153.
    NextBioi 108999.
    PROi B2RN74.

    Gene expression databases

    Bgeei B2RN74.
    CleanExi HS_OR11H12.
    Genevestigatori B2RN74.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiO11HC_HUMAN
    AccessioniPrimary (citable) accession number: B2RN74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: July 1, 2008
    Last modified: July 9, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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