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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:PGN_2021
OrganismiPorphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)
Taxonomic identifieri431947 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
Proteomesi
  • UP000008842 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001389581 – 276Orotidine 5'-phosphate decarboxylaseAdd BLAST276

Interactioni

Protein-protein interaction databases

STRINGi431947.PGN_2021

Structurei

3D structure databases

ProteinModelPortaliB2RME4
SMRiB2RME4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105SKN Bacteria
COG0284 LUCA
HOGENOMiHOG000245747
KOiK01591
OMAiQSAFFER

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01215 OMPdecase_type2, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011995 OMPdecase_type-2
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR43375 PTHR43375, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR02127 pyrF_sub2, 1 hit

Sequencei

Sequence statusi: Complete.

B2RME4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTKELFDRI CRKRSFLCVG LDTDVKKIPP HLLNEDDPIL AFNKAIIDAT
60 70 80 90 100
AEYCVAFKPN MAFYESMGSF GAHSFEKTIE YIRERYPDQF IIADAKRGDI
110 120 130 140 150
GNTSDMYARS FFEHLKVDAL TVSPYMGEDS ISPFLSYAGK FTVLLALTSN
160 170 180 190 200
KGSQDFQMMR DADGEYLFER VIRISQTWDN AGQLMYVVGA TQASMLKDIR
210 220 230 240 250
EIVPDAFLLV PGVGAQGGSL EDVAEYGMNA HCGLLVNASR SIIYADNTEG
260 270
FAAKAAGEAA AMQRQMEIAL RAKGLI
Length:276
Mass (Da):30,558
Last modified:July 1, 2008 - v1
Checksum:i626DD3BDDC3E168D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009380 Genomic DNA Translation: BAG34539.1
RefSeqiWP_012458691.1, NZ_CP025930.1

Genome annotation databases

EnsemblBacteriaiBAG34539; BAG34539; PGN_2021
GeneIDi29257157
KEGGipgn:PGN_2021

Similar proteinsi

Entry informationi

Entry nameiPYRF_PORG3
AccessioniPrimary (citable) accession number: B2RME4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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