Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B2RME4 (PYRF_PORG3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:PGN_2021
OrganismPorphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257) [Complete proteome] [HAMAP]
Taxonomic identifier431947 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' UMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

'de novo' pyrimidine nucleobase biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionorotidine-5'-phosphate decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01215
PRO_1000138958

Sites

Active site961Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
B2RME4 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 626DD3BDDC3E168D

FASTA27630,558
        10         20         30         40         50         60 
MTTKELFDRI CRKRSFLCVG LDTDVKKIPP HLLNEDDPIL AFNKAIIDAT AEYCVAFKPN 

        70         80         90        100        110        120 
MAFYESMGSF GAHSFEKTIE YIRERYPDQF IIADAKRGDI GNTSDMYARS FFEHLKVDAL 

       130        140        150        160        170        180 
TVSPYMGEDS ISPFLSYAGK FTVLLALTSN KGSQDFQMMR DADGEYLFER VIRISQTWDN 

       190        200        210        220        230        240 
AGQLMYVVGA TQASMLKDIR EIVPDAFLLV PGVGAQGGSL EDVAEYGMNA HCGLLVNASR 

       250        260        270 
SIIYADNTEG FAAKAAGEAA AMQRQMEIAL RAKGLI 

« Hide

References

[1]"Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis."
Naito M., Hirakawa H., Yamashita A., Ohara N., Shoji M., Yukitake H., Nakayama K., Toh H., Yoshimura F., Kuhara S., Hattori M., Hayashi T., Nakayama K.
DNA Res. 15:215-225(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33277 / DSM 20709 / JCM 12257.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009380 Genomic DNA. Translation: BAG34539.1.
RefSeqYP_001930136.1. NC_010729.1.

3D structure databases

ProteinModelPortalB2RME4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING431947.PGN_2021.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAG34539; BAG34539; PGN_2021.
GeneID6330780.
KEGGpgn:PGN_2021.
PATRIC22976995. VBIPorGin26334_1985.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000245747.
KOK01591.
OMACRTSNAG.
OrthoDBEOG6DZF33.

Enzyme and pathway databases

BioCycPGIN431947:GC9J-2076-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01215. OMPdecase_type2.
InterProIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR02127. pyrF_sub2. 1 hit.
ProtoNetSearch...

Entry information

Entry namePYRF_PORG3
AccessionPrimary (citable) accession number: B2RME4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways