B2RLZ4 (EFG_PORG3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Elongation factor G
Short name=EF-G

Gene names

Name:	fusA
Ordered Locus Names:	PGN_1870

Organism

Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257) [Complete proteome] [HAMAP]

Taxonomic identifier

431947 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Porphyromonas

Protein attributes

Sequence length	707 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome By similarity. HAMAP MF_00054_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00054_B.
Sequence similarities	Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Elongation factor
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 707	707	Elongation factor G HAMAP MF_00054_B		PRO_1000091747
Regions
	Nucleotide binding	17 – 24	8	GTP By similarity
	Nucleotide binding	85 – 89	5	GTP By similarity
	Nucleotide binding	139 – 142	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2RLZ4 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 924792C58C512CC8	FASTA	707	78,326
	10 20 30 40 50 60 MAIDKELQFT RNIGIMAHID AGKTTTSERI LFYTGLTHKI GEVHDGAATM DWMEQEQERG 70 80 90 100 110 120 ITITSAATTA FWNYNNQKYK INLIDTPGHV DFTVEVERSL RILDGAVAAF CAVGGVEPQS 130 140 150 160 170 180 ETVWRQAEKY NVPRIGYVNK MDRSGANFFE VVRQLREVLG ANPCPIQIPI GAEETFKGVV 190 200 210 220 230 240 DLVSMKALVW NDETMGAKYD VEDIPAELVG EAEEWRDKML ETLADCDDTL MEKYFDDPST 250 260 270 280 290 300 ITEDEIIAAL RKGTLAMQIN PMLCGSSFKN KGVQTLLDAV CKFLPSPADT PTVEGTDPSD 310 320 330 340 350 360 PNKVIERKTS PNEPLCALAF KIATDPYVGR LCFFRVYSGE LPAGSYVYNA RSEKKERISR 370 380 390 400 410 420 LFQMHSNKQN PKEVIGCGDI GAGVGFKDIR TGDTLCDENH PIVLESMDFP DPVIGIAVEP 430 440 450 460 470 480 KTQKDLDRLG VGLAKLAEED PTFRVQTNED SGQTVISGMG ELHLDIIIDR LRREFKVECN 490 500 510 520 530 540 QGRPQVSYKE AINDPVELRE VYKKQTGGRG KFADIICRVE PADADFEGEL QFVDEVKGGN 550 560 570 580 590 600 IPKEFIPSIQ KGFQRAMKNG VLAGYPLDQL KVTVIDGSFH PVDSDQLSFE ICALQAFKNA 610 620 630 640 650 660 CEKAHPTLME PIMKLEVVTP EESMGDVIGD LNKRRGQVEG MESSRTGARI VKAKVPLAEM 670 680 690 700 FGYVTALRTI TSGRATSTMT FSHYSEVPST IAKQVLTEAQ GRVDLIK

References

[1]

"Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis." Naito M., Hirakawa H., Yamashita A., Ohara N., Shoji M., Yukitake H., Nakayama K., Toh H., Yoshimura F., Kuhara S., Hattori M., Hayashi T., Nakayama K. DNA Res. 15:215-225(2008) [PubMed: 18524787] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33277 / DSM 20709 / JCM 12257.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009380 Genomic DNA. Translation: BAG34389.1.
RefSeq	YP_001929986.1. NC_010729.1.
3D structure databases
ProteinModelPortal	B2RLZ4.
ModBase	Search...
Protein-protein interaction databases
STRING	B2RLZ4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6329136.
GenomeReviews	Gene locus PGN_1870 in contig AP009380_GR.
KEGG	pgn:PGN_1870.
PATRIC	22976701. VBIPorGin26334_1840.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG737692.
OMA	CNEWREK.
ProtClustDB	PRK12739.
Family and domain databases
HAMAP	MF_00054_B. EF-G_EF-2_B. [Tree]
InterPro	IPR009022. Elongation_fac_G/III/V. IPR000795. ProtSyn_GTP-bd. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR005225. Small_GTP-bd_dom. IPR004540. Transl_elong_EFG/EF2. IPR000640. Transl_elong_EFG/EF2_C. IPR005517. Transl_elong_EFG/EF2_IV. IPR004161. Transl_elong_EFTu/EF1A_2. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit. G3DSA:3.30.70.240. Transl_elong_EFG/EF2_C. 1 hit.
KO	K02355.
Pfam	PF00679. EFG_C. 1 hit. PF03764. EFG_IV. 1 hit. PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SMART	SM00838. EFG_C. 1 hit. SM00889. EFG_IV. 1 hit. [Graphical view]
SUPFAM	SSF54980. EFG_III_V. 2 hits. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit. SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR00484. EF-G. 1 hit. TIGR00231. Small_GTP. 1 hit.
PROSITE	PS00301. EFACTOR_GTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFG_PORG3

Accession

Primary (citable) accession number: B2RLZ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 1, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program