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Protein

Fructose-bisphosphate aldolase class 1

Gene

fda

Organism
Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotation

Pathway:iglycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi)
  3. no protein annotated in this organism
  4. Fructose-bisphosphate aldolase class 1 (fda)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei176 – 1761Proton acceptorUniRule annotation
Active sitei211 – 2111Schiff-base intermediate with dihydroxyacetone-PUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciPGIN431947:GC9J-1748-MONOMER.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1UniRule annotation (EC:4.1.2.13UniRule annotation)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolaseUniRule annotation
Gene namesi
Name:fdaUniRule annotation
Ordered Locus Names:PGN_1695
OrganismiPorphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257)
Taxonomic identifieri431947 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
ProteomesiUP000008842 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293Fructose-bisphosphate aldolase class 1PRO_1000132711Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi431947.PGN_1695.

Family & Domainsi

Sequence similaritiesi

Belongs to the class I fructose-bisphosphate aldolase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3588.
HOGENOMiHOG000073502.
KOiK01623.
OMAiEPEVDIH.
OrthoDBiEOG6M6JJT.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00729. FBP_aldolase_1.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
IPR023014. FBA_I_Gram+-type.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RLG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKEQLQQMR QAPGFVGALD QSGGSTPKAL KAYGIQPDAY QSEEEMFDLI
60 70 80 90 100
HQMRTRMITS PAFATGKIIG VILFERTMRG KIEGMPTADF LWEKRHIVPF
110 120 130 140 150
LKVDKGLQDE ANGVQLMKPF PELGKLCEEA VGYHVFGTKM RSVIKQANEQ
160 170 180 190 200
GIRDIVEQQF QWGKEILSHG LVPILEPEVD IHCPEKAKAE EILKRELLAQ
210 220 230 240 250
LDKMTEPVML KITIPTVDNF YKEIIEHPMM LRVVALSGGY SREQANELLS
260 270 280 290
RNHGVIASFS RALVEGLSVQ QTDAEFNAML EASIEDVYQA SIK
Length:293
Mass (Da):32,987
Last modified:July 1, 2008 - v1
Checksum:iCDBA3CFF649DCE91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009380 Genomic DNA. Translation: BAG34214.1.
RefSeqiWP_012458465.1. NC_010729.1.

Genome annotation databases

EnsemblBacteriaiBAG34214; BAG34214; PGN_1695.
KEGGipgn:PGN_1695.
PATRICi22976359. VBIPorGin26334_1670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009380 Genomic DNA. Translation: BAG34214.1.
RefSeqiWP_012458465.1. NC_010729.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi431947.PGN_1695.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG34214; BAG34214; PGN_1695.
KEGGipgn:PGN_1695.
PATRICi22976359. VBIPorGin26334_1670.

Phylogenomic databases

eggNOGiCOG3588.
HOGENOMiHOG000073502.
KOiK01623.
OMAiEPEVDIH.
OrthoDBiEOG6M6JJT.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.
BioCyciPGIN431947:GC9J-1748-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00729. FBP_aldolase_1.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
IPR023014. FBA_I_Gram+-type.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis."
    Naito M., Hirakawa H., Yamashita A., Ohara N., Shoji M., Yukitake H., Nakayama K., Toh H., Yoshimura F., Kuhara S., Hattori M., Hayashi T., Nakayama K.
    DNA Res. 15:215-225(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33277 / DSM 20709 / JCM 12257.

Entry informationi

Entry nameiALF1_PORG3
AccessioniPrimary (citable) accession number: B2RLG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: July 22, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.