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Protein

Fructose-bisphosphate aldolase class 1

Gene

fda

Organism
Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (pfp)
  4. Fructose-bisphosphate aldolase class 1 (fda)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei176Proton acceptorUniRule annotation1
Active sitei211Schiff-base intermediate with dihydroxyacetone-PUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

BioCyciPGIN431947:G1G2V-1903-MONOMER
UniPathwayiUPA00109; UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1UniRule annotation (EC:4.1.2.13UniRule annotation)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolaseUniRule annotation
Gene namesi
Name:fdaUniRule annotation
Ordered Locus Names:PGN_1695
OrganismiPorphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)
Taxonomic identifieri431947 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
Proteomesi
  • UP000008842 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001327111 – 293Fructose-bisphosphate aldolase class 1Add BLAST293

Interactioni

Protein-protein interaction databases

STRINGi431947.PGN_1695

Structurei

3D structure databases

SMRiB2RLG9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I fructose-bisphosphate aldolase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105WYW Bacteria
COG3588 LUCA
HOGENOMiHOG000073502
KOiK01623
OMAiVFGTKER

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00729 FBP_aldolase_1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000741 FBA_I
IPR023014 FBA_I_Gram+-type
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit

Sequencei

Sequence statusi: Complete.

B2RLG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKEQLQQMR QAPGFVGALD QSGGSTPKAL KAYGIQPDAY QSEEEMFDLI
60 70 80 90 100
HQMRTRMITS PAFATGKIIG VILFERTMRG KIEGMPTADF LWEKRHIVPF
110 120 130 140 150
LKVDKGLQDE ANGVQLMKPF PELGKLCEEA VGYHVFGTKM RSVIKQANEQ
160 170 180 190 200
GIRDIVEQQF QWGKEILSHG LVPILEPEVD IHCPEKAKAE EILKRELLAQ
210 220 230 240 250
LDKMTEPVML KITIPTVDNF YKEIIEHPMM LRVVALSGGY SREQANELLS
260 270 280 290
RNHGVIASFS RALVEGLSVQ QTDAEFNAML EASIEDVYQA SIK
Length:293
Mass (Da):32,987
Last modified:July 1, 2008 - v1
Checksum:iCDBA3CFF649DCE91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009380 Genomic DNA Translation: BAG34214.1
RefSeqiWP_012458465.1, NZ_CP025930.1

Genome annotation databases

EnsemblBacteriaiBAG34214; BAG34214; PGN_1695
GeneIDi29256860
KEGGipgn:PGN_1695

Similar proteinsi

Entry informationi

Entry nameiALF1_PORG3
AccessioniPrimary (citable) accession number: B2RLG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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