B2RLG9 (ALF1_PORG3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fructose-bisphosphate aldolase class 1
EC=4.1.2.13

Alternative name(s):
Fructose-biphosphate aldolase class I
Short name=FBP aldolase

Gene names

Name:	fda
Ordered Locus Names:	PGN_1695

Organism

Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257) [Complete proteome] [HAMAP]

Taxonomic identifier

431947 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Porphyromonas

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. HAMAP MF_00729
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. HAMAP MF_00729
Sequence similarities	Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 293	293	Fructose-bisphosphate aldolase class 1 HAMAP MF_00729		PRO_1000132711
Sites
	Active site	176	1	Proton acceptor By similarity
	Active site	211	1	Schiff-base intermediate with dihydroxyacetone-P By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2RLG9 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: CDBA3CFF649DCE91	FASTA	293	32,987
	10 20 30 40 50 60 MNKEQLQQMR QAPGFVGALD QSGGSTPKAL KAYGIQPDAY QSEEEMFDLI HQMRTRMITS 70 80 90 100 110 120 PAFATGKIIG VILFERTMRG KIEGMPTADF LWEKRHIVPF LKVDKGLQDE ANGVQLMKPF 130 140 150 160 170 180 PELGKLCEEA VGYHVFGTKM RSVIKQANEQ GIRDIVEQQF QWGKEILSHG LVPILEPEVD 190 200 210 220 230 240 IHCPEKAKAE EILKRELLAQ LDKMTEPVML KITIPTVDNF YKEIIEHPMM LRVVALSGGY 250 260 270 280 290 SREQANELLS RNHGVIASFS RALVEGLSVQ QTDAEFNAML EASIEDVYQA SIK

References

[1]

"Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis." Naito M., Hirakawa H., Yamashita A., Ohara N., Shoji M., Yukitake H., Nakayama K., Toh H., Yoshimura F., Kuhara S., Hattori M., Hayashi T., Nakayama K. DNA Res. 15:215-225(2008) [PubMed: 18524787] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33277 / DSM 20709 / JCM 12257.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009380 Genomic DNA. Translation: BAG34214.1.
RefSeq	YP_001929811.1. NC_010729.1.
3D structure databases
ProteinModelPortal	B2RLG9.
ModBase	Search...
Protein-protein interaction databases
STRING	B2RLG9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6328797.
GenomeReviews	Gene locus PGN_1695 in contig AP009380_GR.
KEGG	pgn:PGN_1695.
PATRIC	22976359. VBIPorGin26334_1670.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG307137.
OMA	GTKMRSV.
ProtClustDB	PRK05377.
Family and domain databases
HAMAP	MF_00729. FBP_aldolase_1. [Tree]
InterPro	IPR000741. Aldolase_I. IPR013785. Aldolase_TIM. IPR023014. FBP_aldolase_I_bac. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01623.
Pfam	PF00274. Glycolytic. 1 hit. [Graphical view]
PROSITE	PS00158. ALDOLASE_CLASS_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALF1_PORG3

Accession

Primary (citable) accession number: B2RLG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 1, 2008
Last modified:	January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program