ID   B2RL82_PORG3            Unreviewed;       526 AA.
AC   B2RL82;
DT   01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   01-JUL-2008, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   OrderedLocusNames=PGN_1608 {ECO:0000313|EMBL:BAG34127.1};
OS   Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM
OS   12257 / NCTC 11834 / 2561).
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Porphyromonadaceae;
OC   Porphyromonas.
OX   NCBI_TaxID=431947 {ECO:0000313|EMBL:BAG34127.1, ECO:0000313|Proteomes:UP000008842};
RN   [1] {ECO:0000313|EMBL:BAG34127.1, ECO:0000313|Proteomes:UP000008842}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 /
RC   2561 {ECO:0000313|Proteomes:UP000008842};
RX   PubMed=18524787; DOI=10.1093/dnares/dsn013;
RA   Naito M., Hirakawa H., Yamashita A., Ohara N., Shoji M., Yukitake H.,
RA   Nakayama K., Toh H., Yoshimura F., Kuhara S., Hattori M., Hayashi T.,
RA   Nakayama K.;
RT   "Determination of the genome sequence of Porphyromonas gingivalis strain
RT   ATCC 33277 and genomic comparison with strain W83 revealed extensive genome
RT   rearrangements in P. gingivalis.";
RL   DNA Res. 15:215-225(2008).
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DR   EMBL; AP009380; BAG34127.1; -; Genomic_DNA.
DR   AlphaFoldDB; B2RL82; -.
DR   SMR; B2RL82; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   KEGG; pgn:PGN_1608; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_568428_0_0_10; -.
DR   BioCyc; PGIN431947:G1G2V-1809-MONOMER; -.
DR   Proteomes; UP000008842; Chromosome.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           31..526
FT                   /note="exo-alpha-sialidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5030165524"
FT   DOMAIN          222..499
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
SQ   SEQUENCE   526 AA;  58344 MW;  C1C9E793015B2F0F CRC64;
     MANNTLLAKT RRYVCLVVFC CLMAMMHLSG QEVTMWGDSH GVAPNQVRRT LVKVALSESL
     PPGAKQIRIG FSLPKETEEK VTALYLLVSD SLAVRDLPDY KGRVSYDSFP ISKEDRTTAL
     SADSVAGRCF FYLAADIGPV ASFSRSDTLT ARVEELAVDG RPLPLKELSP ASRRLYREYE
     ALFVPGDGGS RNYRIPSILK TANGTLIAMA DRRKYNQTDL PEDIDIVMRR STDGGKSWSD
     PRIIVQGEGR NHGFGDVALV QTQAGKLLMI FVGGVGLWQS TPDRPQRTYI SESRDEGLTW
     SPPRDITHFI FGKDCADPGR SRWLASFCAS GQGLVLPSGR VMFVAAIRES GQEYVLNNYV
     LYSDDEGGTW QLSDCAYHRG DEAKLSLMPD GRVLMSVRNQ GRQESRQRFF ALSSDDGLTW
     ERAKQFEGIH DPGCNGAMLQ VKRNGRNQML HSLPLGPDGR RDGAVYLFDH VSGRWSAPVV
     VNSGSSAYSD MTLLADGTIG YFVEEDDEIS LVFIRFVLDD LFDARQ
//