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Protein

1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene

dxr

Organism
Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).UniRule annotation

Catalytic activityi

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Pathwayi: isopentenyl diphosphate biosynthesis via DXP pathway

This protein is involved in step 1 of the subpathway that synthesizes isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr)
  2. 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (ispD)
  3. 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (ispE)
  4. 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF)
  5. 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) (ispG)
  6. 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (PGN_0647)
This subpathway is part of the pathway isopentenyl diphosphate biosynthesis via DXP pathway, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate, the pathway isopentenyl diphosphate biosynthesis via DXP pathway and in Isoprenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei124SubstrateUniRule annotation1
Metal bindingi149Divalent metal cationUniRule annotation1
Metal bindingi151Divalent metal cationUniRule annotation1
Binding sitei151SubstrateUniRule annotation1
Binding sitei174SubstrateUniRule annotation1
Binding sitei197SubstrateUniRule annotation1
Metal bindingi219Divalent metal cationUniRule annotation1
Binding sitei219SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 37NADPUniRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIsoprene biosynthesis
LigandMetal-binding, NADP

Enzyme and pathway databases

UniPathwayiUPA00056; UER00092

Names & Taxonomyi

Protein namesi
Recommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomeraseUniRule annotation (EC:1.1.1.267UniRule annotation)
Short name:
DXP reductoisomeraseUniRule annotation
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomeraseUniRule annotation
2-C-methyl-D-erythritol 4-phosphate synthaseUniRule annotation
Gene namesi
Name:dxrUniRule annotation
Ordered Locus Names:PGN_1151
OrganismiPorphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)
Taxonomic identifieri431947 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
Proteomesi
  • UP000008842 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000985081 – 3851-deoxy-D-xylulose 5-phosphate reductoisomeraseAdd BLAST385

Interactioni

Protein-protein interaction databases

STRINGi431947.PGN_1151

Structurei

3D structure databases

ProteinModelPortaliB2RJX5
SMRiB2RJX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DXR family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEA Bacteria
COG0743 LUCA
HOGENOMiHOG000007221
KOiK00099
OMAiDSEHFGL

Family and domain databases

HAMAPiMF_00183 DXP_reductoisom, 1 hit
InterProiView protein in InterPro
IPR003821 DXP_reductoisomerase
IPR013644 DXP_reductoisomerase_C
IPR013512 DXP_reductoisomerase_N
IPR026877 DXPR_C
IPR036169 DXPR_C_sf
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR30525 PTHR30525, 1 hit
PfamiView protein in Pfam
PF08436 DXP_redisom_C, 1 hit
PF02670 DXP_reductoisom, 1 hit
PF13288 DXPR_C, 1 hit
PIRSFiPIRSF006205 Dxp_reductismrs, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF69055 SSF69055, 1 hit
TIGRFAMsiTIGR00243 Dxr, 1 hit

Sequencei

Sequence statusi: Complete.

B2RJX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKNIAILGS TGSIGTQTLD IIHLNPDLFD VYLLTANNNV DLLIRQAREY
60 70 80 90 100
RPEIVVIAND QKYHLIQEAL ADLPIKVWCG AEAIADAVTA PDIDMVVTAM
110 120 130 140 150
VGYSGLLPTI KAIEARKMIA LANKETLVVA GELIMRLAQD NQVPILPVDS
160 170 180 190 200
EHSAIFQALL GERQRPEKIL LTASGGPFLH LTAEELQHAT REQALRHPNW
210 220 230 240 250
NMGAKVTIDS ASLMNKGFEM IEAKWLFEMQ PDEIEILVHP QSIIHSMVQF
260 270 280 290 300
RDGSVKAQLG IPDMRLPISY ALGITHRIPN DYPRVDFTAT PLTFERPDLE
310 320 330 340 350
RFPNLSYAFD AIRLGGNAPC ALNAANEIAV TAFLRDEISF TDMSRLLYEV
360 370 380
MEKHELFREV SLPTFIETDS NTRRVAESLL PKFRR
Length:385
Mass (Da):43,104
Last modified:July 1, 2008 - v1
Checksum:iB656A6080FB243E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009380 Genomic DNA Translation: BAG33670.1
RefSeqiWP_005874315.1, NZ_CP025930.1

Genome annotation databases

EnsemblBacteriaiBAG33670; BAG33670; PGN_1151
GeneIDi29256357
KEGGipgn:PGN_1151

Similar proteinsi

Entry informationi

Entry nameiDXR_PORG3
AccessioniPrimary (citable) accession number: B2RJX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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