Skip Header

Contribute Send feedback
Read comments (?) or add your own

B2RJW4 (B2RJW4_PORG3) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE HAMAP MF_01208
Ordered Locus Names:PGN_1140
OrganismPorphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257) [Complete proteome] [HAMAP]
Taxonomic identifier431947 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Porphyromonas

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 SAAS SAAS004467

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 SAAS SAAS023031

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 SAAS SAAS023031

Subunit structure

Homodimer By similarity. HAMAP MF_01208 SAAS SAAS004467

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region123 – 13195-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site9715-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site10115-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site10315-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1271Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
B2RJW4 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 86E75962DF8C8215

FASTA21022,949
        10         20         30         40         50         60 
MKTLGKLIAS KLIEVKAIKL QPNNPFTWAS GWKAPIYCDN RKTLSYPQIR SLIKLELARV 

        70         80         90        100        110        120 
ISETFGDVEA IAGVATGAIA QGALVADLLG LPFVYVRSSP KDHGLENLVE GELKPNSKVV 

       130        140        150        160        170        180 
VIEDLISTGG SSLKAAEAIR NFGCEVLGMV AVYTHGFPMA EQNFEKAGVK LVTLTDYDQV 

       190        200        210 
IEEALRTGYI SAENVELLRE WRKSPETWGI

« Hide

References

[1]"Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis."
Naito M., Hirakawa H., Yamashita A., Ohara N., Shoji M., Yukitake H., Nakayama K., Toh H., Yoshimura F., Kuhara S., Hattori M., Hayashi T., Nakayama K.
DNA Res. 15:215-225(2008) [PubMed: 18524787] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33277 / DSM 20709 / JCM 12257.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009380 Genomic DNA. Translation: BAG33659.1.
RefSeqYP_001929256.1. NC_010729.1.

3D structure databases

ProteinModelPortalB2RJW4.
ModBaseSearch...

Protein-protein interaction databases

STRINGB2RJW4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6329858.
GenomeReviewsGene locus PGN_1140 in contig AP009380_GR.
KEGGpgn:PGN_1140.
PATRIC22975242. VBIPorGin26334_1131.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG404341.
OMALPMTYVR.
ProtClustDBPRK00455.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB2RJW4_PORG3
AccessionPrimary (citable) accession number: B2RJW4
Entry history
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info