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B2RIZ3

- SYL_PORG3

UniProt

B2RIZ3 - SYL_PORG3

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Protein
Leucine--tRNA ligase
Gene
leuS, PGN_0819
Organism
Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei703 – 7031ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPGIN431947:GC9J-846-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:PGN_0819
OrganismiPorphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257)
Taxonomic identifieri431947 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
ProteomesiUP000008842: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 925925Leucine--tRNA ligaseUniRule annotation
PRO_1000091343Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi431947.PGN_0819.

Structurei

3D structure databases

ProteinModelPortaliB2RIZ3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotation
Add
BLAST
Motifi700 – 7045"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RIZ3-1 [UniParc]FASTAAdd to Basket

« Hide

MEYNFQEIEK RVQGQWRKDK VYRVAEDTSK KPFYVLDMFP YPSGAGLHVG    50
HPLGYIASDI FSRYKRLRGF NVLHPMGYDA FGLPAEQYAI QTGQHPEKTT 100
EENTARYREQ LDKIGFSYDW EREIRTCDPN YYKWTQWAFL KMFDSYYCNQ 150
AQQARPISEL IEVFARQGNE GLNVACGEGV RFTAEEWTAM SEKEQQEILM 200
NYRLAYLGDT MVNWCPALGT VLANDEVKDG VSERGGHPVE QKKMRQWCLR 250
VSAYAERLLH DLETLDWTES LKETQRNWIG RSEGAEMEFR LAGKDCTFTI 300
FTTRADTIFG VTFMVLAPES ELVEEVTTEE QRAAVETYLT ETKRRTERER 350
ISDKRVSGVF SGSYAINPLT GKEIPIWISD YVLAGYGTGA IMAVPAHDTR 400
DFAFARHFDL PIVQVVVPEG ETATDPATWE DAKDSKSGIM VNSDFLNGLS 450
VEDAIAQTKE YIREKHLGCV KVNYRLRDAI FSRQRYWGEP FPIYYKEGMP 500
HALDEDRLPL RLPEVDKFLP TESGEPPLGR ATGWHTAEGY PYELSTMPGF 550
AGSSAYYLRY MDPQNDTALV SRSANEYWRH VDLYIGGTEH ATGHLIYSRF 600
WNKFLFDLGI VCEAEPFRKL VNQGMIQGRS NFVYRIKNTN TFVSYGLREQ 650
YEVTPLHVDV NIVSNDQLDI DRFRAWRPEY ASAEFILEDG KYICGWAIEK 700
MSKSMFNVVN PDDIIARYGA DTLRLYEMFL GPLEQSKPWD TNGIDGVHRF 750
LKKFWALYYN ADGIRVTDTA PTKEELKSLH KLIKKVGQDI ESFSFNTSIP 800
AFMICVNELT AAKTTSRAIL CPLLTVLSPF APHITEWLWQ ELGVEGSIVT 850
ATWPEYNEEY LVESCVRYPV SFNGKVRFNI ELPADMSKKD VEQAALTAPE 900
AARWLEGKSP KKVIVVPGRI VNVVV 925
Length:925
Mass (Da):106,051
Last modified:July 1, 2008 - v1
Checksum:iD1E774CE15ABA339
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009380 Genomic DNA. Translation: BAG33338.1.
RefSeqiWP_012457800.1. NC_010729.1.
YP_001928935.1. NC_010729.1.

Genome annotation databases

EnsemblBacteriaiBAG33338; BAG33338; PGN_0819.
GeneIDi6329348.
KEGGipgn:PGN_0819.
PATRICi22974582. VBIPorGin26334_0808.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009380 Genomic DNA. Translation: BAG33338.1 .
RefSeqi WP_012457800.1. NC_010729.1.
YP_001928935.1. NC_010729.1.

3D structure databases

ProteinModelPortali B2RIZ3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 431947.PGN_0819.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG33338 ; BAG33338 ; PGN_0819 .
GeneIDi 6329348.
KEGGi pgn:PGN_0819.
PATRICi 22974582. VBIPorGin26334_0808.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PGIN431947:GC9J-846-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis."
    Naito M., Hirakawa H., Yamashita A., Ohara N., Shoji M., Yukitake H., Nakayama K., Toh H., Yoshimura F., Kuhara S., Hattori M., Hayashi T., Nakayama K.
    DNA Res. 15:215-225(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33277 / DSM 20709 / JCM 12257.

Entry informationi

Entry nameiSYL_PORG3
AccessioniPrimary (citable) accession number: B2RIZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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