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Protein

NAD kinase

Gene

nadK

Organism
Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73Proton acceptorUniRule annotation1
Binding sitei78NADUniRule annotation1
Binding sitei174NADUniRule annotation1
Binding sitei209NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi73 – 74NADUniRule annotation2
Nucleotide bindingi144 – 145NADUniRule annotation2
Nucleotide bindingi185 – 190NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPGIN431947:G1G2V-736-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:PGN_0670
OrganismiPorphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)
Taxonomic identifieri431947 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
Proteomesi
  • UP000008842 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001208761 – 288NAD kinaseAdd BLAST288

Interactioni

Protein-protein interaction databases

STRINGi431947.PGN_0670

Structurei

3D structure databases

SMRiB2RIJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG

Family and domain databases

Gene3Di2.60.200.301 hit
3.40.50.103302 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

B2RIJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIAIFGSR HKSEQGASIK ALILKLEEAG TPLYIERKFL SFLEQDLDFH
60 70 80 90 100
PAICGVIDTL PEHIDYVICM GGDGTFLRTA HQIGVSQIPV LGVNTGRLGF
110 120 130 140 150
LTDVDCHEAS ELITRLLDGD FTIETRSLLE VTEDNGSSPS YALNEAAILK
160 170 180 190 200
RETGSMIRVN ACLNDDYLAA YDADGLVVAT PSGSTAYSLS GNGPIIMPAC
210 220 230 240 250
RNFVLTPIAP HSLNMRPLVV PDDTAIRLEV DSRSRNYLLV LDGRTRTLPC
260 270 280
DTSILLKRAP HTLRMIRLRP HSFAETLRRK LMWGAAVR
Length:288
Mass (Da):31,704
Last modified:July 1, 2008 - v1
Checksum:iB0F6CF5819D0420A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009380 Genomic DNA Translation: BAG33189.1
RefSeqiWP_012457686.1, NC_010729.1

Genome annotation databases

EnsemblBacteriaiBAG33189; BAG33189; PGN_0670
GeneIDi29255893
KEGGipgn:PGN_0670

Similar proteinsi

Entry informationi

Entry nameiNADK_PORG3
AccessioniPrimary (citable) accession number: B2RIJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: February 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome