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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:PGN_0624
OrganismiPorphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)
Taxonomic identifieri431947 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
Proteomesi
  • UP000008842 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalUniRule annotationAdd BLAST21
Transmembranei72 – 92HelicalUniRule annotationAdd BLAST21
Transmembranei99 – 119HelicalUniRule annotationAdd BLAST21
Transmembranei135 – 155HelicalUniRule annotationAdd BLAST21
Transmembranei208 – 228HelicalUniRule annotationAdd BLAST21
Transmembranei238 – 258HelicalUniRule annotationAdd BLAST21
Transmembranei278 – 298HelicalUniRule annotationAdd BLAST21
Transmembranei303 – 323HelicalUniRule annotationAdd BLAST21
Transmembranei328 – 348HelicalUniRule annotationAdd BLAST21
Transmembranei396 – 416HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000906561 – 419Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST419

Interactioni

Protein-protein interaction databases

STRINGi431947.PGN_0624.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B2RIE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYYLFDYLE KLQLPGARLF HYVSFRSAVA IILALLLATV IGNRIIERLR
60 70 80 90 100
KAQIGETIRD LGLEGQLSKK GTPTMGGLII IISILIPTLL LARLDNVYIL
110 120 130 140 150
LMIVTTLLLG SLGFLDDYIK VFRKKKEGLH GRYKIIGQVG LGFIIGIVLY
160 170 180 190 200
MNPAVVIKEN SEVLRDGQVE RVHFNKQEVK STKTTIPFVK NNNFDYADIL
210 220 230 240 250
PFEGKTKVLF GWILFVCVAV VVVTFISNCA NLTDGLDGLA TGSSAIIGVV
260 270 280 290 300
LAIFAYVSSH IEMASYLNIM FIPGAEELTI FAFAFVGATI GFLWYNAYPA
310 320 330 340 350
QVFMGDTGSL TLGGIIAVFA LIIRKEMLLP ILCFVFIIEG LSVMIQVFYF
360 370 380 390 400
KLTKRRTGEG RRIFKMTPLH HHFQKPGNAG IDAWLQKPMQ AIPESKITVR
410
FWLVGIIMAA ITIATLKMR
Length:419
Mass (Da):46,695
Last modified:July 1, 2008 - v1
Checksum:i5D91C69AF45441DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009380 Genomic DNA. Translation: BAG33143.1.
RefSeqiWP_012457656.1. NC_010729.1.

Genome annotation databases

EnsemblBacteriaiBAG33143; BAG33143; PGN_0624.
GeneIDi29255850.
KEGGipgn:PGN_0624.

Similar proteinsi

Entry informationi

Entry nameiMRAY_PORG3
AccessioniPrimary (citable) accession number: B2RIE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: June 7, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families