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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei265ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPGIN431947:G1G2V-588-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:PGN_0543
OrganismiPorphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)
Taxonomic identifieri431947 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
Proteomesi
  • UP000008842 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000900961 – 507Glutamate--tRNA ligaseAdd BLAST507

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi431947.PGN_0543

Structurei

3D structure databases

SMRiB2RI67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi14 – 24"HIGH" regionUniRule annotationAdd BLAST11
Motifi262 – 266"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
KOiK01885
OMAiAYYAFDT

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B2RI67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTINRRIRV RFAPSPTGPL HIGGVRTALY NYLFARQHGG DMILRIEDTD
60 70 80 90 100
SNRFVPGAEA YIIEALEWLG IKFDEGVGYG GRFGPYRQSE RRDIYRTYVR
110 120 130 140 150
QLLDSGRAYI AFDTPEELEA RRAEVPNFQY DATTRGQMRN SLTLPAEEVE
160 170 180 190 200
RLVAEGTQYV VRFLVEPNVD VEVNDLIRGR VVIDSSILDD KVLYKSADDL
210 220 230 240 250
PTYHLANIVD DHLMEVSHVI RGEEWLPSAP LHVLLYRAFG WEDTMPRFAH
260 270 280 290 300
LALLLKPEGN GKLSKRDGDR LGFPVFPLEW KDPQTGDISK GYRESGYLPE
310 320 330 340 350
AVVNFLALLG WNPGNDQDVM SMDELIRLFD IEKCSKAGAK FDYEKGRWFN
360 370 380 390 400
HQYIQRKDNA ELAELFRPIL RENGVVATDE KTAHVISLVK ERVNFIGELW
410 420 430 440 450
EQAGFFFIAP LSYDEKTVKK RWKEDTAKQL GELAELLDSH RSFAAEATEP
460 470 480 490 500
TVKNWIETNG YHLGNIMNAT RLALVGESKG PHIFDIMEVL GREETVGRIR

RAIEILG
Length:507
Mass (Da):57,908
Last modified:July 1, 2008 - v1
Checksum:iB0025C1C2451FE81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009380 Genomic DNA Translation: BAG33062.1
RefSeqiWP_012457588.1, NZ_CP025930.1

Genome annotation databases

EnsemblBacteriaiBAG33062; BAG33062; PGN_0543
GeneIDi29255772
KEGGipgn:PGN_0543

Similar proteinsi

Entry informationi

Entry nameiSYE_PORG3
AccessioniPrimary (citable) accession number: B2RI67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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