B2RHN9 (SYR_PORG3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	PGN_0365

Organism

Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257) [Complete proteome] [HAMAP]

Taxonomic identifier

431947 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Porphyromonas

Protein attributes

Sequence length	597 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity. HAMAP MF_00123
Subcellular location	Cytoplasm By similarity HAMAP MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW arginine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 597	597	Arginine--tRNA ligase HAMAP MF_00123		PRO_1000095390
Regions
	Motif	125 – 135	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	B2RHN9 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 6E9378412B9D88DC	FASTA	597	67,522
	10 20 30 40 50 60 MSILQKLENS AAAAVKALYG TDPMEGQIQL QKTKREFKGH LTLVVFPFVK MSRKSPEATA 70 80 90 100 110 120 TEIGEWLLAN ESAVSAIEVV KGFLNLTIAP RVWLELLNEI RADINFGHKV ATEDSPLVMV 130 140 150 160 170 180 EYSSPNTNKP LHLGHVRNNL LGYSLSEIMK ANGYRVVKTN IVNDRGIHIC KSMLAWQKWG 190 200 210 220 230 240 DGVTPEKAGK KGDHLIGDFY VLFDKHYKAE LNSLMAEGKS KEEAEAASTL MAEAREMLRL 250 260 270 280 290 300 WEAGDEKVVD LWRTMNQWVY DGFEATYKMM GVDFDKIYYE SETYLVGKEE VLRGLEEGLF 310 320 330 340 350 360 VKHSDGSVWA DLTKDGLDEK LLLRADGTSV YMTQDIGTAK MRFNDYPINR MIYVVGNEQN 370 380 390 400 410 420 YHFQVLSILL DRLGFEFGKG LVHFSYGMVE LPEGKMKSRE GTVVDADDLM DEMIRTAAEI 430 440 450 460 470 480 AAEAGKAAEK DEEESREVAR IVGLGSLKYF ILKVDPRKNM TFNPKESIDF NGNTGSFVQY 490 500 510 520 530 540 TYARIRSLMR RAEAAGYDIP SQLPTDLPLS EKEEALIQKV SEYAEVVSEA GRSYSPALIA 550 560 570 580 590 NYIYDLVKEY NQFYHDFSVL KEEDERIRAF RLALSEVVAL TMRKGFALLG IEMPERM

References

[1]

"Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis." Naito M., Hirakawa H., Yamashita A., Ohara N., Shoji M., Yukitake H., Nakayama K., Toh H., Yoshimura F., Kuhara S., Hattori M., Hayashi T., Nakayama K. DNA Res. 15:215-225(2008) [PubMed: 18524787] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33277 / DSM 20709 / JCM 12257.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009380 Genomic DNA. Translation: BAG32884.1.
RefSeq	YP_001928481.1. NC_010729.1.
3D structure databases
ProteinModelPortal	B2RHN9.
ModBase	Search...
Protein-protein interaction databases
STRING	B2RHN9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6329945.
GenomeReviews	Gene locus PGN_0365 in contig AP009380_GR.
KEGG	pgn:PGN_0365.
PATRIC	22973666. VBIPorGin26334_0364.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG695395.
OMA	FHEEAEK.
ProtClustDB	PRK01611.
Family and domain databases
HAMAP	MF_00123. Arg_tRNA_synth. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01887.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. ArgS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_PORG3

Accession

Primary (citable) accession number: B2RHN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 1, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program