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B2RHB4 (HEMH_PORG3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:PGN_0240
OrganismPorphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257) [Complete proteome] [HAMAP]
Taxonomic identifier431947 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Porphyromonas

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345Ferrochelatase HAMAP MF_00323
PRO_1000116065

Sites

Metal binding1991Iron By similarity
Metal binding3021Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
B2RHB4 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: A2E7B7207FC8B37C

FASTA34539,594
        10         20         30         40         50         60 
MADRRRTDDN KGAREVVLLL NIGSPDSPEV KDVARYLNSF LTDRRIITLP FLLRQLLVRG 

        70         80         90        100        110        120 
IITPFRKKSS AQKYRTVWDE STRSFPLISH TKAIARALAH TGRDVHVAMR YGKPTVADVL 

       130        140        150        160        170        180 
KELPHGRSLV VLPLFPHYAM SSYETAVEHC KAEIRRLCPN LSFRVVQPFY AHEAYIRVLA 

       190        200        210        220        230        240 
DNIRPYLTKP FDKLILSYHG IPRDHLDKTT RQALDLRHPE GCCTEEDPTA NVCYRYQTYR 

       250        260        270        280        290        300 
TTALIREALC LAEEQVEQVF QSRVGHTEWL RPYLIERLSA WPQEETKRIL IACPSFVCDC 

       310        320        330        340 
LESLEEVADH GQSIFKKAGG ADFTYIPCLN SGANWIDALR NILEE

« Hide

References

[1]"Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis."
Naito M., Hirakawa H., Yamashita A., Ohara N., Shoji M., Yukitake H., Nakayama K., Toh H., Yoshimura F., Kuhara S., Hattori M., Hayashi T., Nakayama K.
DNA Res. 15:215-225(2008) [PubMed: 18524787] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33277 / DSM 20709 / JCM 12257.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009380 Genomic DNA. Translation: BAG32759.1.
RefSeqYP_001928356.1. NC_010729.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB2RHB4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6330063.
GenomeReviewsGene locus PGN_0240 in contig AP009380_GR.
KEGGpgn:PGN_0240.
PATRIC22973414. VBIPorGin26334_0238.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMATIEEIGM.
ProtClustDBCLSK2305817.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_PORG3
AccessionPrimary (citable) accession number: B2RHB4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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