B2RH80 (B2RH80_PORG3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative lipid A disaccharide synthase EMBL BAG32725.1

Gene names

Ordered Locus Names:

PGN_0206

Organism

Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257) [Complete proteome] [HAMAP]

Taxonomic identifier

431947 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Porphyromonas

Protein attributes

Sequence length	383 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B2RH80 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: C0B77F91BDE5C9D1	FASTA	383	42,998
	10 20 30 40 50 60 MRYFIVAGEA SGDLHASNLV RALKEHDPEA VFAFMGGDFL SEATGERPIF HYREVAFMGF 70 80 90 100 110 120 IPVLTHLGVI RRAGEHVQEQ MRAFNPDVVI AVDYPGFNMR YVLPFVREEL GKPIVYYISP 130 140 150 160 170 180 KVWAWKSWRI KTLKKYVDLM LCILPFEKDF FAGHDFPVIY VGNPCYDAVK QHMRPTIEEQ 190 200 210 220 230 240 ERSAKDSRQV ALLCGSRLLE VKENLPVMLR VMKQFPDYRP VIAGAPGLTI QDYTPFLPDD 250 260 270 280 290 300 SIPVVFGRTY EILRESKAAL VTSGTATLET ALIGTPQVVC YYIRGGRLTN LIFKYCFGTP 310 320 330 340 350 360 FISLTNLIAG RAVVPELFGA LFTEKRLAAS LSPLLDASSA ERQAQLSGYD SIRKSIGTDN 370 380 TSDKAARHII ARFAKDNVRP SSL

References

[1]

"Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis." Naito M., Hirakawa H., Yamashita A., Ohara N., Shoji M., Yukitake H., Nakayama K., Toh H., Yoshimura F., Kuhara S., Hattori M., Hayashi T., Nakayama K. DNA Res. 15:215-225(2008) [PubMed: 18524787] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33277 / DSM 20709 / JCM 12257.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009380 Genomic DNA. Translation: BAG32725.1.
RefSeq	YP_001928322.1. NC_010729.1.
3D structure databases
ProteinModelPortal	B2RH80.
ModBase	Search...
Protein-protein interaction databases
STRING	B2RH80.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6330097.
GenomeReviews	Gene locus PGN_0206 in contig AP009380_GR.
KEGG	pgn:PGN_0206.
PATRIC	22973330. VBIPorGin26334_0201.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG584837.
OMA	AEFAFIC.
ProtClustDB	CLSK2306189.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B2RH80_PORG3

Accession

Primary (citable) accession number: B2RH80

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)