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Protein

CENPB DNA-binding domain-containing protein 1

Gene

CENPBD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi40 – 60H-T-H motifBy similarityAdd BLAST21
DNA bindingi111 – 148H-T-H motifBy similarityAdd BLAST38

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-32510-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
CENPB DNA-binding domain-containing protein 1
Gene namesi
Name:CENPBD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:28272. CENPBD1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177946.
PharmGKBiPA165449826.

Polymorphism and mutation databases

BioMutaiCENPBD1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003946611 – 187CENPB DNA-binding domain-containing protein 1Add BLAST187

Proteomic databases

PaxDbiB2RD01.
PRIDEiB2RD01.

PTM databases

iPTMnetiB2RD01.
PhosphoSitePlusiB2RD01.

Expressioni

Gene expression databases

BgeeiENSG00000177946.
GenevisibleiB2RD01. HS.

Organism-specific databases

HPAiHPA052759.
HPA060522.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000393854.

Structurei

3D structure databases

ProteinModelPortaliB2RD01.
SMRiB2RD01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 64HTH psq-typePROSITE-ProRule annotationAdd BLAST52
Domaini78 – 155HTH CENPB-typePROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3105. Eukaryota.
ENOG4110CDI. LUCA.
GeneTreeiENSGT00570000079532.
HOGENOMiHOG000202750.
InParanoidiB2RD01.
OMAiRTIITME.
OrthoDBiEOG091G07CP.
PhylomeDBiB2RD01.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RD01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGERPTDAT VIPSAKRERK AITLDLKLEV LRRFEAGEKL SQIAKALDLA
60 70 80 90 100
ISTVATIRDS KEKIKASSQI ATPLRASRLT RHRSAVMESM EQLLSLWLED
110 120 130 140 150
QSQPNATLSA AIVQEKAEFD DLQREHGEGS QTERFHASQG WLVRFKECHC
160 170 180
LPHFKMNSAA PSNKDMYTEM LKSIIEEGEY TPQVSLT
Length:187
Mass (Da):21,052
Last modified:July 1, 2008 - v1
Checksum:iAB2EC1EF82BED323
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168T → I in BC009263 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315352 mRNA. Translation: BAG37748.1.
AC092143 Genomic DNA. No translation available.
BC009263 mRNA. No translation available.
CCDSiCCDS45556.1.
RefSeqiNP_659476.2. NM_145039.3.
UniGeneiHs.513832.
Hs.733302.

Genome annotation databases

EnsembliENST00000314994; ENSP00000393854; ENSG00000177946.
GeneIDi92806.
KEGGihsa:92806.
UCSCiuc002fpr.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315352 mRNA. Translation: BAG37748.1.
AC092143 Genomic DNA. No translation available.
BC009263 mRNA. No translation available.
CCDSiCCDS45556.1.
RefSeqiNP_659476.2. NM_145039.3.
UniGeneiHs.513832.
Hs.733302.

3D structure databases

ProteinModelPortaliB2RD01.
SMRiB2RD01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000393854.

PTM databases

iPTMnetiB2RD01.
PhosphoSitePlusiB2RD01.

Polymorphism and mutation databases

BioMutaiCENPBD1.

Proteomic databases

PaxDbiB2RD01.
PRIDEiB2RD01.

Protocols and materials databases

DNASUi92806.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314994; ENSP00000393854; ENSG00000177946.
GeneIDi92806.
KEGGihsa:92806.
UCSCiuc002fpr.4. human.

Organism-specific databases

CTDi92806.
GeneCardsiCENPBD1.
HGNCiHGNC:28272. CENPBD1.
HPAiHPA052759.
HPA060522.
neXtProtiNX_B2RD01.
OpenTargetsiENSG00000177946.
PharmGKBiPA165449826.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3105. Eukaryota.
ENOG4110CDI. LUCA.
GeneTreeiENSGT00570000079532.
HOGENOMiHOG000202750.
InParanoidiB2RD01.
OMAiRTIITME.
OrthoDBiEOG091G07CP.
PhylomeDBiB2RD01.

Enzyme and pathway databases

BioCyciZFISH:G66-32510-MONOMER.

Miscellaneous databases

ChiTaRSiCENPBD1. human.
GenomeRNAii92806.
PROiB2RD01.

Gene expression databases

BgeeiENSG00000177946.
GenevisibleiB2RD01. HS.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCENP1_HUMAN
AccessioniPrimary (citable) accession number: B2RD01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 1, 2008
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.