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Protein

CENPB DNA-binding domain-containing protein 1

Gene

CENPBD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi40 – 6021H-T-H motifBy similarityAdd
BLAST
DNA bindingi111 – 14838H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CENPB DNA-binding domain-containing protein 1
Gene namesi
Name:CENPBD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:28272. CENPBD1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165449826.

Polymorphism and mutation databases

BioMutaiCENPBD1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 187187CENPB DNA-binding domain-containing protein 1PRO_0000394661Add
BLAST

Proteomic databases

PaxDbiB2RD01.
PRIDEiB2RD01.

PTM databases

iPTMnetiB2RD01.

Expressioni

Gene expression databases

BgeeiB2RD01.
GenevisibleiB2RD01. HS.

Organism-specific databases

HPAiHPA052759.
HPA060522.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000393854.

Structurei

3D structure databases

ProteinModelPortaliB2RD01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 6452HTH psq-typePROSITE-ProRule annotationAdd
BLAST
Domaini78 – 15578HTH CENPB-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3105. Eukaryota.
ENOG4110CDI. LUCA.
GeneTreeiENSGT00570000079532.
HOGENOMiHOG000202750.
InParanoidiB2RD01.
OMAiQTERFHA.
OrthoDBiEOG7KQ24B.
PhylomeDBiB2RD01.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RD01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGERPTDAT VIPSAKRERK AITLDLKLEV LRRFEAGEKL SQIAKALDLA
60 70 80 90 100
ISTVATIRDS KEKIKASSQI ATPLRASRLT RHRSAVMESM EQLLSLWLED
110 120 130 140 150
QSQPNATLSA AIVQEKAEFD DLQREHGEGS QTERFHASQG WLVRFKECHC
160 170 180
LPHFKMNSAA PSNKDMYTEM LKSIIEEGEY TPQVSLT
Length:187
Mass (Da):21,052
Last modified:July 1, 2008 - v1
Checksum:iAB2EC1EF82BED323
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti168 – 1681T → I in BC009263 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315352 mRNA. Translation: BAG37748.1.
AC092143 Genomic DNA. No translation available.
BC009263 mRNA. No translation available.
CCDSiCCDS45556.1.
RefSeqiNP_659476.2. NM_145039.3.
UniGeneiHs.513832.
Hs.733302.

Genome annotation databases

EnsembliENST00000314994; ENSP00000393854; ENSG00000177946.
GeneIDi92806.
KEGGihsa:92806.
UCSCiuc002fpr.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315352 mRNA. Translation: BAG37748.1.
AC092143 Genomic DNA. No translation available.
BC009263 mRNA. No translation available.
CCDSiCCDS45556.1.
RefSeqiNP_659476.2. NM_145039.3.
UniGeneiHs.513832.
Hs.733302.

3D structure databases

ProteinModelPortaliB2RD01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000393854.

PTM databases

iPTMnetiB2RD01.

Polymorphism and mutation databases

BioMutaiCENPBD1.

Proteomic databases

PaxDbiB2RD01.
PRIDEiB2RD01.

Protocols and materials databases

DNASUi92806.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314994; ENSP00000393854; ENSG00000177946.
GeneIDi92806.
KEGGihsa:92806.
UCSCiuc002fpr.4. human.

Organism-specific databases

CTDi92806.
GeneCardsiCENPBD1.
HGNCiHGNC:28272. CENPBD1.
HPAiHPA052759.
HPA060522.
neXtProtiNX_B2RD01.
PharmGKBiPA165449826.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3105. Eukaryota.
ENOG4110CDI. LUCA.
GeneTreeiENSGT00570000079532.
HOGENOMiHOG000202750.
InParanoidiB2RD01.
OMAiQTERFHA.
OrthoDBiEOG7KQ24B.
PhylomeDBiB2RD01.

Miscellaneous databases

ChiTaRSiCENPBD1. human.
GenomeRNAii92806.
PROiB2RD01.

Gene expression databases

BgeeiB2RD01.
GenevisibleiB2RD01. HS.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Neuroblastoma.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung carcinoma.

Entry informationi

Entry nameiCENP1_HUMAN
AccessioniPrimary (citable) accession number: B2RD01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 1, 2008
Last modified: June 8, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.