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Protein

CENPB DNA-binding domain-containing protein 1

Gene

CENPBD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi40 – 60H-T-H motifBy similarityAdd BLAST21
DNA bindingi111 – 148H-T-H motifBy similarityAdd BLAST38

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CENPB DNA-binding domain-containing protein 1
Gene namesi
Name:CENPBD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000177946.5
HGNCiHGNC:28272 CENPBD1
neXtProtiNX_B2RD01

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177946
PharmGKBiPA165449826

Polymorphism and mutation databases

BioMutaiCENPBD1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003946611 – 187CENPB DNA-binding domain-containing protein 1Add BLAST187

Proteomic databases

PaxDbiB2RD01
PRIDEiB2RD01

PTM databases

iPTMnetiB2RD01
PhosphoSitePlusiB2RD01

Expressioni

Gene expression databases

BgeeiENSG00000177946
GenevisibleiB2RD01 HS

Organism-specific databases

HPAiHPA052759
HPA060522

Structurei

3D structure databases

ProteinModelPortaliB2RD01
SMRiB2RD01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 64HTH psq-typePROSITE-ProRule annotationAdd BLAST52
Domaini78 – 155HTH CENPB-typePROSITE-ProRule annotationAdd BLAST78

Phylogenomic databases

eggNOGiKOG3105 Eukaryota
ENOG4110CDI LUCA
GeneTreeiENSGT00890000139742
HOGENOMiHOG000202750
InParanoidiB2RD01
OMAiMICEKAR
OrthoDBiEOG091G07CP
PhylomeDBiB2RD01

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR006600 HTH_CenpB_DNA-bd_dom
IPR007889 HTH_Psq
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF04218 CENP-B_N, 1 hit
PF03221 HTH_Tnp_Tc5, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51253 HTH_CENPB, 1 hit
PS50960 HTH_PSQ, 1 hit

Sequencei

Sequence statusi: Complete.

B2RD01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGERPTDAT VIPSAKRERK AITLDLKLEV LRRFEAGEKL SQIAKALDLA
60 70 80 90 100
ISTVATIRDS KEKIKASSQI ATPLRASRLT RHRSAVMESM EQLLSLWLED
110 120 130 140 150
QSQPNATLSA AIVQEKAEFD DLQREHGEGS QTERFHASQG WLVRFKECHC
160 170 180
LPHFKMNSAA PSNKDMYTEM LKSIIEEGEY TPQVSLT
Length:187
Mass (Da):21,052
Last modified:July 1, 2008 - v1
Checksum:iAB2EC1EF82BED323
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168T → I in BC009263 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315352 mRNA Translation: BAG37748.1
AC092143 Genomic DNA No translation available.
BC009263 mRNA No translation available.
CCDSiCCDS45556.1
RefSeqiNP_659476.2, NM_145039.3
UniGeneiHs.513832
Hs.733302

Genome annotation databases

EnsembliENST00000314994; ENSP00000393854; ENSG00000177946
GeneIDi92806
KEGGihsa:92806
UCSCiuc002fpr.4 human

Similar proteinsi

Entry informationi

Entry nameiCENP1_HUMAN
AccessioniPrimary (citable) accession number: B2RD01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 1, 2008
Last modified: April 25, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM

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