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B2RCU6

- B2RCU6_HUMAN

UniProt

B2RCU6 - B2RCU6_HUMAN

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Protein
Submitted name: cDNA, FLJ96299, highly similar to Homo sapiens p21 (CDKN1A)-activated kinase 3 (PAK3), mRNA
Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinaseSAAS annotations, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiB2RCU6.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    cDNA, FLJ96299, highly similar to Homo sapiens p21 (CDKN1A)-activated kinase 3 (PAK3), mRNAImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32919.

    PTM / Processingi

    Proteomic databases

    PRIDEiB2RCU6.

    Structurei

    3D structure databases

    ProteinModelPortaliB2RCU6.
    SMRiB2RCU6. Positions 73-141, 247-538.

    Family & Domainsi

    Sequence similaritiesi

    Contains CRIB domain.SAAS annotations
    Contains protein kinase domain.SAAS annotations

    Phylogenomic databases

    HOGENOMiHOG000234202.
    HOVERGENiHBG108518.
    KOiK05733.

    Family and domain databases

    Gene3Di3.90.810.10. 1 hit.
    InterProiIPR000095. CRIB_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00786. PBD. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00285. PBD. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50108. CRIB. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2RCU6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDGLDNEEK PPAPPLRMNS NNRDSSALNH SSKPLPMAPE EKNKKARLRS    50
    IFPGGGDKTN KKKEKERPEI SLPSDFEHTI HVGFDAVTGE FTGIPEQWAR 100
    LLQTSNITKL EQKKNPQAVL DVLKFYDSKE TVNNQKYMSF TSGDKSAHGY 150
    IAAHPSSTKT ASEPPLAPPV SEEEDEEEEE EEDENEPPPV IAPRPEHTKS 200
    IYTRSVVESI ASPAVPNKEV TPPSAENANS STLYRNTDRQ RKKSKMTDEE 250
    ILEKLRSIVS VGDPKKKYTR FEKIGQGASG TVYTALDIAT GQEVAIKQMN 300
    LQQQPKKELI INEILVMREN KNPNIVNYLD SYLVGDELWV VMEYLAGGSL 350
    TDVVTETCMD EGQIAAVCRE CLQALDFLHS NQVIHRDIKS DNILLGMDGS 400
    VKLTDFGFCA QITPEQSKRS TIVGTPYWMA PEVVTRKAYG PKVDIWSLGI 450
    MAIEMVEGEP PYLNENPLRA LYLIATNGTP ELQNPERLSA VFRDFLNRCL 500
    EMDVDRRGSA KELLQHPFLK LAKPLSSLTP LIIAAKEAIK NSSR 544
    Length:544
    Mass (Da):60,675
    Last modified:July 1, 2008 - v1
    Checksum:i25CAF45528B049E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK315284 mRNA. Translation: BAG37693.1.
    RefSeqiNP_001121638.1. NM_001128166.1.
    UniGeneiHs.593599.
    Hs.656789.

    Genome annotation databases

    GeneIDi5063.
    KEGGihsa:5063.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK315284 mRNA. Translation: BAG37693.1 .
    RefSeqi NP_001121638.1. NM_001128166.1.
    UniGenei Hs.593599.
    Hs.656789.

    3D structure databases

    ProteinModelPortali B2RCU6.
    SMRi B2RCU6. Positions 73-141, 247-538.
    ModBasei Search...

    Proteomic databases

    PRIDEi B2RCU6.

    Protocols and materials databases

    DNASUi 5063.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5063.
    KEGGi hsa:5063.

    Organism-specific databases

    CTDi 5063.
    PharmGKBi PA32919.

    Phylogenomic databases

    HOGENOMi HOG000234202.
    HOVERGENi HBG108518.
    KOi K05733.

    Enzyme and pathway databases

    SignaLinki B2RCU6.

    Miscellaneous databases

    GenomeRNAii 5063.
    NextBioi 19502.

    Family and domain databases

    Gene3Di 3.90.810.10. 1 hit.
    InterProi IPR000095. CRIB_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00786. PBD. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00285. PBD. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50108. CRIB. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NEDO functional analysis of protein and research application project."
      Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
      Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.

    Entry informationi

    Entry nameiB2RCU6_HUMAN
    AccessioniPrimary (citable) accession number: B2RCU6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: March 19, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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