B2RCU6 (B2RCU6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: cDNA, FLJ96299, highly similar to Homo sapiens p21 (CDKN1A)-activated kinase 3 (PAK3), mRNA EMBL BAG37693.1
Organism	Homo sapiens (Human) EMBL BAG37693.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	544 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein. SAAS SAAS000095
Sequence similarities	Contains 1 CRIB domain. SAAS SAAS000095 Contains 1 protein kinase domain. SAAS SAAS000095

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304 SAAS SAAS000095 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase SAAS SAAS000095 Transferase
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B2RCU6 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 25CAF45528B049E2	FASTA	544	60,675
	10 20 30 40 50 60 MSDGLDNEEK PPAPPLRMNS NNRDSSALNH SSKPLPMAPE EKNKKARLRS IFPGGGDKTN 70 80 90 100 110 120 KKKEKERPEI SLPSDFEHTI HVGFDAVTGE FTGIPEQWAR LLQTSNITKL EQKKNPQAVL 130 140 150 160 170 180 DVLKFYDSKE TVNNQKYMSF TSGDKSAHGY IAAHPSSTKT ASEPPLAPPV SEEEDEEEEE 190 200 210 220 230 240 EEDENEPPPV IAPRPEHTKS IYTRSVVESI ASPAVPNKEV TPPSAENANS STLYRNTDRQ 250 260 270 280 290 300 RKKSKMTDEE ILEKLRSIVS VGDPKKKYTR FEKIGQGASG TVYTALDIAT GQEVAIKQMN 310 320 330 340 350 360 LQQQPKKELI INEILVMREN KNPNIVNYLD SYLVGDELWV VMEYLAGGSL TDVVTETCMD 370 380 390 400 410 420 EGQIAAVCRE CLQALDFLHS NQVIHRDIKS DNILLGMDGS VKLTDFGFCA QITPEQSKRS 430 440 450 460 470 480 TIVGTPYWMA PEVVTRKAYG PKVDIWSLGI MAIEMVEGEP PYLNENPLRA LYLIATNGTP 490 500 510 520 530 540 ELQNPERLSA VFRDFLNRCL EMDVDRRGSA KELLQHPFLK LAKPLSSLTP LIIAAKEAIK NSSR

References

[1]

"NEDO functional analysis of protein and research application project." Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL BAG37693.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK315284 mRNA. Translation: BAG37693.1.
IPI	IPI00410084.
RefSeq	NP_001121638.1. NM_001128166.1.
UniGene	Hs.656789.
3D structure databases
ProteinModelPortal	B2RCU6.
SMR	B2RCU6. Positions 73-141, 247-538.
ModBase	Search...
Proteomic databases
PRIDE	B2RCU6.
Protocols and materials databases
DNASU	5063.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5063.
KEGG	hsa:5063.
Organism-specific databases
CTD	5063.
PharmGKB	PA32919.
Phylogenomic databases
HOGENOM	HOG000234202.
HOVERGEN	HBG108518.
KO	K05733.
Enzyme and pathway databases
SignaLink	B2RCU6.
Family and domain databases
Gene3D	3.90.810.10. 1 hit.
InterPro	IPR011009. Kinase-like_dom. IPR000095. PAK_box_Rho-bd. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00786. PBD. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00285. PBD. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50108. CRIB. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	5063.
NextBio	19502.

Entry information

Entry name

B2RCU6_HUMAN

Accession

Primary (citable) accession number: B2RCU6

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	May 29, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.