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Protein

Non-specific serine/threonine protein kinase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiB2RCU6

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseSAAS annotation (EC:2.7.11.1SAAS annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32919

PTM / Processingi

Proteomic databases

PeptideAtlasiB2RCU6
PRIDEiB2RCU6

Expressioni

Gene expression databases

GenevisibleiB2RCU6 HS

Structurei

3D structure databases

ProteinModelPortaliB2RCU6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 83CRIBInterPro annotationAdd BLAST14
Domaini268 – 519Protein kinaseInterPro annotationAdd BLAST252

Phylogenomic databases

HOGENOMiHOG000234202
HOVERGENiHBG108518

Family and domain databases

CDDicd01093 CRIB_PAK_like, 1 hit
cd06656 STKc_PAK3, 1 hit
Gene3Di3.90.810.10, 1 hit
InterProiView protein in InterPro
IPR000095 CRIB_dom
IPR036936 CRIB_dom_sf
IPR011009 Kinase-like_dom_sf
IPR035065 PAK2/3
IPR033923 PAK_BD
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR035063 STK_PAK3
PANTHERiPTHR24361:SF250 PTHR24361:SF250, 1 hit
PfamiView protein in Pfam
PF00786 PBD, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

B2RCU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDGLDNEEK PPAPPLRMNS NNRDSSALNH SSKPLPMAPE EKNKKARLRS
60 70 80 90 100
IFPGGGDKTN KKKEKERPEI SLPSDFEHTI HVGFDAVTGE FTGIPEQWAR
110 120 130 140 150
LLQTSNITKL EQKKNPQAVL DVLKFYDSKE TVNNQKYMSF TSGDKSAHGY
160 170 180 190 200
IAAHPSSTKT ASEPPLAPPV SEEEDEEEEE EEDENEPPPV IAPRPEHTKS
210 220 230 240 250
IYTRSVVESI ASPAVPNKEV TPPSAENANS STLYRNTDRQ RKKSKMTDEE
260 270 280 290 300
ILEKLRSIVS VGDPKKKYTR FEKIGQGASG TVYTALDIAT GQEVAIKQMN
310 320 330 340 350
LQQQPKKELI INEILVMREN KNPNIVNYLD SYLVGDELWV VMEYLAGGSL
360 370 380 390 400
TDVVTETCMD EGQIAAVCRE CLQALDFLHS NQVIHRDIKS DNILLGMDGS
410 420 430 440 450
VKLTDFGFCA QITPEQSKRS TIVGTPYWMA PEVVTRKAYG PKVDIWSLGI
460 470 480 490 500
MAIEMVEGEP PYLNENPLRA LYLIATNGTP ELQNPERLSA VFRDFLNRCL
510 520 530 540
EMDVDRRGSA KELLQHPFLK LAKPLSSLTP LIIAAKEAIK NSSR
Length:544
Mass (Da):60,675
Last modified:July 1, 2008 - v1
Checksum:i25CAF45528B049E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315284 mRNA Translation: BAG37693.1
RefSeqiNP_001121638.1, NM_001128166.2
UniGeneiHs.593599
Hs.655757
Hs.656789

Genome annotation databases

GeneIDi5063

Similar proteinsi

Entry informationi

Entry nameiB2RCU6_HUMAN
AccessioniPrimary (citable) accession number: B2RCU6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: April 25, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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Main funding by: National Institutes of Health