Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Non-specific serine/threonine protein kinase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiB2RCU6.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseSAAS annotation (EC:2.7.11.1SAAS annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32919.

PTM / Processingi

Proteomic databases

PRIDEiB2RCU6.

Expressioni

Gene expression databases

GenevisibleiB2RCU6. HS.

Structurei

3D structure databases

ProteinModelPortaliB2RCU6.
SMRiB2RCU6. Positions 73-141, 247-538.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains CRIB domain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000234202.
HOVERGENiHBG108518.
KOiK05733.

Family and domain databases

Gene3Di3.90.810.10. 1 hit.
InterProiIPR000095. CRIB_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00786. PBD. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50108. CRIB. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RCU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDGLDNEEK PPAPPLRMNS NNRDSSALNH SSKPLPMAPE EKNKKARLRS
60 70 80 90 100
IFPGGGDKTN KKKEKERPEI SLPSDFEHTI HVGFDAVTGE FTGIPEQWAR
110 120 130 140 150
LLQTSNITKL EQKKNPQAVL DVLKFYDSKE TVNNQKYMSF TSGDKSAHGY
160 170 180 190 200
IAAHPSSTKT ASEPPLAPPV SEEEDEEEEE EEDENEPPPV IAPRPEHTKS
210 220 230 240 250
IYTRSVVESI ASPAVPNKEV TPPSAENANS STLYRNTDRQ RKKSKMTDEE
260 270 280 290 300
ILEKLRSIVS VGDPKKKYTR FEKIGQGASG TVYTALDIAT GQEVAIKQMN
310 320 330 340 350
LQQQPKKELI INEILVMREN KNPNIVNYLD SYLVGDELWV VMEYLAGGSL
360 370 380 390 400
TDVVTETCMD EGQIAAVCRE CLQALDFLHS NQVIHRDIKS DNILLGMDGS
410 420 430 440 450
VKLTDFGFCA QITPEQSKRS TIVGTPYWMA PEVVTRKAYG PKVDIWSLGI
460 470 480 490 500
MAIEMVEGEP PYLNENPLRA LYLIATNGTP ELQNPERLSA VFRDFLNRCL
510 520 530 540
EMDVDRRGSA KELLQHPFLK LAKPLSSLTP LIIAAKEAIK NSSR
Length:544
Mass (Da):60,675
Last modified:July 1, 2008 - v1
Checksum:i25CAF45528B049E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315284 mRNA. Translation: BAG37693.1.
RefSeqiNP_001121638.1. NM_001128166.1.
UniGeneiHs.593599.
Hs.656789.

Genome annotation databases

GeneIDi5063.
KEGGihsa:5063.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315284 mRNA. Translation: BAG37693.1.
RefSeqiNP_001121638.1. NM_001128166.1.
UniGeneiHs.593599.
Hs.656789.

3D structure databases

ProteinModelPortaliB2RCU6.
SMRiB2RCU6. Positions 73-141, 247-538.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB2RCU6.

Protocols and materials databases

DNASUi5063.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5063.
KEGGihsa:5063.

Organism-specific databases

CTDi5063.
PharmGKBiPA32919.

Phylogenomic databases

HOGENOMiHOG000234202.
HOVERGENiHBG108518.
KOiK05733.

Enzyme and pathway databases

SignaLinkiB2RCU6.

Miscellaneous databases

GenomeRNAii5063.
NextBioi19502.

Gene expression databases

GenevisibleiB2RCU6. HS.

Family and domain databases

Gene3Di3.90.810.10. 1 hit.
InterProiIPR000095. CRIB_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00786. PBD. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50108. CRIB. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "NEDO functional analysis of protein and research application project."
    Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiB2RCU6_HUMAN
AccessioniPrimary (citable) accession number: B2RCU6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: July 22, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.