B2RCF3 (B2RCF3_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Recommended name: Glycylpeptide N-tetradecanoyltransferase RuleBase RU000586 EC=2.3.1.97 RuleBase RU000586
Organism	Homo sapiens (Human) EMBL BAG37550.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins By similarity. RuleBase RU000586
Catalytic activity	Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide. RuleBase RU000586
Sequence similarities	Belongs to the NMT family. RuleBase RU004178

Ontologies

Keywords
Molecular function	Acyltransferase RuleBase RU000586 Transferase
Gene Ontology (GO)
Biological_process	N-terminal protein myristoylation Inferred from electronic annotation. Source: InterPro
Molecular_function	glycylpeptide N-tetradecanoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B2RCF3 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: AE70F2A9012D6A8A	FASTA	498	56,908
	10 20 30 40 50 60 MAEDSESAAS QQSLELDDQD TCGIDGDNGE ETEHAKGSPG GYLGAKKKKK KQKRKKEKPN 70 80 90 100 110 120 SGGTKSDSAS DSQEIKIQQP SKNPSVPMQK LQDIQRAMEL LSACQGPARN IDEAAKHRYQ 130 140 150 160 170 180 FWDTQPVPKL DEVITSHGAI EPDKDNVRQE PYSLPQGFMW DTLDLSDAEV LKELYTLLNE 190 200 210 220 230 240 NYVEDDDNMF RFDYSPEFLL WALRPPGWLL QWHCGVRVSS NKKLVGFISA IPANIRIYDS 250 260 270 280 290 300 VKKMVEINFL CVHKKLRSKR VAPVLIREIT RRVNLEGIFQ AVYTAGVVLP KPIATCRYWH 310 320 330 340 350 360 RSLNPRKLVE VKFSHLSRNM TLQRTMKLYR LPDVTKTSGL RPMEPKDIKS VRELINTYLK 370 380 390 400 410 420 QFHLAPVMDE EEVAHWFLPR EHIIDTFVVE SPNGKLTDFL SFYTLPSTVM HHPAHKSLKA 430 440 450 460 470 480 AYSFYNIHTE TPLLDLMSDA LILAKSKGFD VFNALDLMEN KTFLEKLKFG IGDGNLQYYL 490 YNWRCPGTDS EKVGLVLQ

References

[1]

"NEDO functional analysis of protein and research application project." Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL BAG37550.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK315085 mRNA. Translation: BAG37550.1.
IPI	IPI00030223.
UniGene	Hs.60339.
3D structure databases
ProteinModelPortal	B2RCF3.
SMR	B2RCF3. Positions 157-498.
ModBase	Search...
Protein-protein interaction databases
STRING	B2RCF3.
Proteomic databases
PRIDE	B2RCF3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG003404.
Family and domain databases
Gene3D	3.40.630.30. 2 hits.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR000903. MyristoylCoA_TrFase. IPR022677. MyristoylCoA_TrFase_C. IPR022678. MyristoylCoA_TrFase_CS. IPR022676. MyristoylCoA_TrFase_N. [Graphical view]
PANTHER	PTHR11377. PTHR11377. 1 hit.
Pfam	PF01233. NMT. 1 hit. PF02799. NMT_C. 1 hit. [Graphical view]
PIRSF	PIRSF015892. N-myristl_transf. 1 hit.
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 2 hits.
PROSITE	PS00975. NMT_1. 1 hit. PS00976. NMT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35468164.

Entry information

Entry name

B2RCF3_HUMAN

Accession

Primary (citable) accession number: B2RCF3

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	April 3, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.