ID   R10B2_HUMAN             Reviewed;         870 AA.
AC   B2RC85; A6NMW7; B2RXI4; B2RXJ0; Q86ST9; Q8NE68;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   27-MAR-2024, entry version 105.
DE   RecName: Full=Radial spoke head 10 homolog B2;
GN   Name=RSPH10B2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP   LYS-836.
RC   TISSUE=Brain, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May function as part of the axonemal radial spoke complex 3
CC       (RS3). Radial spoke complexes are important for ciliary motility.
CC       {ECO:0000250|UniProtKB:E9PYQ0}.
CC   -!- SUBUNIT: Interacts with RSPH6A. Does not appear to be part of the
CC       axonemal radial spoke complexes 1 or 2. {ECO:0000250|UniProtKB:E9PYQ0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:E9PYQ0}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=B2RC85-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=B2RC85-2; Sequence=VSP_035277, VSP_035278, VSP_035279;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAG37482.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AK314983; BAG37482.1; ALT_INIT; mRNA.
DR   EMBL; AC073343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC034495; AAH34495.2; -; mRNA.
DR   EMBL; BC044242; AAH44242.1; -; mRNA.
DR   EMBL; BC157864; AAI57865.1; -; mRNA.
DR   EMBL; BC157871; AAI57872.1; -; mRNA.
DR   CCDS; CCDS43552.1; -. [B2RC85-1]
DR   RefSeq; NP_001093167.1; NM_001099697.1. [B2RC85-1]
DR   RefSeq; NP_775836.3; NM_173565.3.
DR   AlphaFoldDB; B2RC85; -.
DR   SMR; B2RC85; -.
DR   BioGRID; 128823; 3.
DR   BioGRID; 608628; 8.
DR   IntAct; B2RC85; 1.
DR   STRING; 9606.ENSP00000384766; -.
DR   iPTMnet; B2RC85; -.
DR   PhosphoSitePlus; B2RC85; -.
DR   BioMuta; RSPH10B2; -.
DR   MassIVE; B2RC85; -.
DR   PaxDb; 9606-ENSP00000384766; -.
DR   PeptideAtlas; B2RC85; -.
DR   ProteomicsDB; 3422; -. [B2RC85-1]
DR   Antibodypedia; 76939; 4 antibodies from 2 providers.
DR   DNASU; 222967; -.
DR   DNASU; 728194; -.
DR   Ensembl; ENST00000297186.7; ENSP00000297186.3; ENSG00000169402.16. [B2RC85-1]
DR   Ensembl; ENST00000403107.5; ENSP00000384766.1; ENSG00000169402.16. [B2RC85-1]
DR   Ensembl; ENST00000404077.6; ENSP00000386102.1; ENSG00000169402.16. [B2RC85-1]
DR   GeneID; 222967; -.
DR   GeneID; 728194; -.
DR   KEGG; hsa:222967; -.
DR   KEGG; hsa:728194; -.
DR   MANE-Select; ENST00000404077.6; ENSP00000386102.1; NM_001099697.2; NP_001093167.1.
DR   UCSC; uc003sqw.1; human. [B2RC85-1]
DR   AGR; HGNC:27362; -.
DR   AGR; HGNC:34385; -.
DR   GeneCards; RSPH10B2; -.
DR   HGNC; HGNC:34385; RSPH10B2.
DR   HPA; ENSG00000169402; Tissue enhanced (fallopian tube, testis).
DR   neXtProt; NX_B2RC85; -.
DR   OpenTargets; ENSG00000155026; -.
DR   OpenTargets; ENSG00000169402; -.
DR   PharmGKB; PA162402247; -.
DR   VEuPathDB; HostDB:ENSG00000169402; -.
DR   eggNOG; KOG0231; Eukaryota.
DR   GeneTree; ENSGT00940000159899; -.
DR   HOGENOM; CLU_012108_1_0_1; -.
DR   InParanoid; B2RC85; -.
DR   OMA; IPMNHGM; -.
DR   OrthoDB; 102983at2759; -.
DR   PhylomeDB; B2RC85; -.
DR   TreeFam; TF328649; -.
DR   PathwayCommons; B2RC85; -.
DR   SignaLink; B2RC85; -.
DR   BioGRID-ORCS; 222967; 22 hits in 997 CRISPR screens.
DR   BioGRID-ORCS; 728194; 58 hits in 1030 CRISPR screens.
DR   ChiTaRS; RSPH10B2; human.
DR   GeneWiki; RSPH10B; -.
DR   Pharos; B2RC85; Tdark.
DR   PRO; PR:B2RC85; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; B2RC85; Protein.
DR   Bgee; ENSG00000169402; Expressed in right uterine tube and 96 other cell types or tissues.
DR   ExpressionAtlas; B2RC85; baseline and differential.
DR   GO; GO:0097729; C:9+2 motile cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 3.
DR   InterPro; IPR003409; MORN.
DR   PANTHER; PTHR46613; RADIAL SPOKE HEAD 10 HOMOLOG B-RELATED; 1.
DR   PANTHER; PTHR46613:SF1; RADIAL SPOKE HEAD 10 HOMOLOG B-RELATED; 1.
DR   Pfam; PF02493; MORN; 10.
DR   SMART; SM00698; MORN; 9.
DR   SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 3.
DR   Genevisible; B2RC85; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell projection; Coiled coil; Cytoplasm;
KW   Cytoskeleton; Reference proteome; Repeat.
FT   CHAIN           1..870
FT                   /note="Radial spoke head 10 homolog B2"
FT                   /id="PRO_0000349254"
FT   REPEAT          86..108
FT                   /note="MORN 1"
FT   REPEAT          109..131
FT                   /note="MORN 2"
FT   REPEAT          132..154
FT                   /note="MORN 3"
FT   REPEAT          155..177
FT                   /note="MORN 4"
FT   REPEAT          179..201
FT                   /note="MORN 5"
FT   REPEAT          204..226
FT                   /note="MORN 6"
FT   REPEAT          227..249
FT                   /note="MORN 7"
FT   REPEAT          251..273
FT                   /note="MORN 8"
FT   REPEAT          284..306
FT                   /note="MORN 9"
FT   REPEAT          307..329
FT                   /note="MORN 10"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          674..704
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          840..870
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          784..811
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..17
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        674..703
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..234
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_035277"
FT   VAR_SEQ         511..514
FT                   /note="KRSP -> QFIP (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_035278"
FT   VAR_SEQ         515..870
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_035279"
FT   VARIANT         836
FT                   /note="E -> K (in dbSNP:rs17855578)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_037357"
FT   CONFLICT        148
FT                   /note="T -> M (in Ref. 3; AAI57865)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        550
FT                   /note="M -> I (in Ref. 3; AAH34495)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        619
FT                   /note="F -> L (in Ref. 1; BAG37482)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        765
FT                   /note="T -> M (in Ref. 1; BAG37482 and 3;
FT                   AAH34495/AAI57865/AAI57872)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   870 AA;  100547 MW;  7608F2CC07A70628 CRC64;
     MVKEKKKADK KGEKSARSPS SLSDNLDFSK QDGNTTRQEM SPAGVPLLGM QLNEVKPKKD
     RQNVQQNEDA SQYEESILTK LIVESYEGEK VRGLYEGEGF AAFQGGCTYR GMFSEGLMHG
     QGTYIWADGL KYEGDFVKNV PMNHGVYTWP DGSMYEGEVV NGMRNGFGMF KCSTQPVSYI
     GHWCNGKRHG KGSIYYNQEG TCWYEGDWVQ NIKKGWGIRC YKSGNIYEGQ WEDNMRHGEG
     RMRWLTTNEE YTGRWERGIQ NGFGTHTWFL KRIRSSQYPL RNEYIGEFVN GYRHGRGKFY
     YASGAMYDGE WVSNKKHGMG RLTFKNGRVY EGAFSNDHIA GFPDLEVEFI SCLDLSSGVA
     PRLSRSAELI RKLDGSESHS VLGSSIELDL NLLLDMYPET VQPEEKKQVE YAVLRNITEL
     RRIYSFYSSL GCGHSLDNTF LMTKLHFWRF LKDCKFHHHK LTLADMDRIL SANNDIPVEE
     IHSPFTTILL RTFLNYLLHL AYHIYHEEFQ KRSPSLFLCF TKLMTENIRP NACQIKGNLF
     REQQRTLYSM SYMNKCWEIY LAYCRPSAAP PHEPTMKMRH FLWMLKDFKM INKELTAATF
     MEVIAEDNRF IYDGIDSNFE PELVFLEFFE ALLSFAFICV TDQMTKSYTN VPADDVSGNK
     HETIYTILNQ DAQNKSPSAV MSHESDAAHS DSARSSSSKL ELSPDVNKIR KSEPKIKKSV
     SHERVSKMNF KLTGKGITFF SSESKKYERP KDDREEEFNT WVNNTYVFFV NTLFHAYKRE
     EAIKEKIRAD RLRSTAQAQQ RKMEDDELEA RLNIFILREE EAKRHDYEVD ITVLKEPADV
     SSSHLILDPP KEDVTVSPSS KTITSKKKKK
//