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B2RC85

- R10B2_HUMAN

UniProt

B2RC85 - R10B2_HUMAN

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Protein

Radial spoke head 10 homolog B2

Gene
RSPH10B2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Radial spoke head 10 homolog B2
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:34385. RSPH10B2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162402247.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 870870Radial spoke head 10 homolog B2PRO_0000349254Add
BLAST

Proteomic databases

PaxDbiB2RC85.
PRIDEiB2RC85.

PTM databases

PhosphoSiteiB2RC85.

Expressioni

Gene expression databases

BgeeiB2RC85.
CleanExiHS_RSPH10B2.
GenevestigatoriB2RC85.

Organism-specific databases

HPAiHPA047076.
HPA049182.

Interactioni

Protein-protein interaction databases

BioGridi608628. 1 interaction.
STRINGi9606.ENSP00000297186.

Structurei

3D structure databases

ProteinModelPortaliB2RC85.
SMRiB2RC85. Positions 97-265, 288-341.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati86 – 10823MORN 1Add
BLAST
Repeati109 – 13123MORN 2Add
BLAST
Repeati132 – 15423MORN 3Add
BLAST
Repeati155 – 17723MORN 4Add
BLAST
Repeati179 – 20123MORN 5Add
BLAST
Repeati204 – 22623MORN 6Add
BLAST
Repeati227 – 24923MORN 7Add
BLAST
Repeati251 – 27323MORN 8Add
BLAST
Repeati284 – 30623MORN 9Add
BLAST
Repeati307 – 32923MORN 10Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili784 – 81128 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Contains 10 MORN repeats.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG4642.
HOGENOMiHOG000154057.
HOVERGENiHBG108420.
InParanoidiB2RC85.
OMAiLTTNQEY.
OrthoDBiEOG7DNNTG.
PhylomeDBiB2RC85.
TreeFamiTF328649.

Family and domain databases

InterProiIPR003409. MORN.
[Graphical view]
PfamiPF02493. MORN. 10 hits.
[Graphical view]
SMARTiSM00698. MORN. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: B2RC85-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVKEKKKADK KGEKSARSPS SLSDNLDFSK QDGNTTRQEM SPAGVPLLGM    50
QLNEVKPKKD RQNVQQNEDA SQYEESILTK LIVESYEGEK VRGLYEGEGF 100
AAFQGGCTYR GMFSEGLMHG QGTYIWADGL KYEGDFVKNV PMNHGVYTWP 150
DGSMYEGEVV NGMRNGFGMF KCSTQPVSYI GHWCNGKRHG KGSIYYNQEG 200
TCWYEGDWVQ NIKKGWGIRC YKSGNIYEGQ WEDNMRHGEG RMRWLTTNEE 250
YTGRWERGIQ NGFGTHTWFL KRIRSSQYPL RNEYIGEFVN GYRHGRGKFY 300
YASGAMYDGE WVSNKKHGMG RLTFKNGRVY EGAFSNDHIA GFPDLEVEFI 350
SCLDLSSGVA PRLSRSAELI RKLDGSESHS VLGSSIELDL NLLLDMYPET 400
VQPEEKKQVE YAVLRNITEL RRIYSFYSSL GCGHSLDNTF LMTKLHFWRF 450
LKDCKFHHHK LTLADMDRIL SANNDIPVEE IHSPFTTILL RTFLNYLLHL 500
AYHIYHEEFQ KRSPSLFLCF TKLMTENIRP NACQIKGNLF REQQRTLYSM 550
SYMNKCWEIY LAYCRPSAAP PHEPTMKMRH FLWMLKDFKM INKELTAATF 600
MEVIAEDNRF IYDGIDSNFE PELVFLEFFE ALLSFAFICV TDQMTKSYTN 650
VPADDVSGNK HETIYTILNQ DAQNKSPSAV MSHESDAAHS DSARSSSSKL 700
ELSPDVNKIR KSEPKIKKSV SHERVSKMNF KLTGKGITFF SSESKKYERP 750
KDDREEEFNT WVNNTYVFFV NTLFHAYKRE EAIKEKIRAD RLRSTAQAQQ 800
RKMEDDELEA RLNIFILREE EAKRHDYEVD ITVLKEPADV SSSHLILDPP 850
KEDVTVSPSS KTITSKKKKK 870
Length:870
Mass (Da):100,547
Last modified:September 2, 2008 - v2
Checksum:i7608F2CC07A70628
GO
Isoform 2 (identifier: B2RC85-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-234: Missing.
     511-514: KRSP → QFIP
     515-870: Missing.

Show »
Length:280
Mass (Da):32,772
Checksum:iBE38ADC76B396891
GO

Sequence cautioni

The sequence BAG37482.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti836 – 8361E → K.1 Publication
Corresponds to variant rs17855578 [ dbSNP | Ensembl ].
VAR_037357

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 234234Missing in isoform 2. VSP_035277Add
BLAST
Alternative sequencei511 – 5144KRSP → QFIP in isoform 2. VSP_035278
Alternative sequencei515 – 870356Missing in isoform 2. VSP_035279Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti148 – 1481T → M in AAI57865. 1 Publication
Sequence conflicti550 – 5501M → I in AAH34495. 1 Publication
Sequence conflicti619 – 6191F → L in BAG37482. 1 Publication
Sequence conflicti765 – 7651T → M in BAG37482. 1 Publication
Sequence conflicti765 – 7651T → M in AAH34495. 1 Publication
Sequence conflicti765 – 7651T → M in AAI57865. 1 Publication
Sequence conflicti765 – 7651T → M in AAI57872. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK314983 mRNA. Translation: BAG37482.1. Different initiation.
AC073343 Genomic DNA. No translation available.
BC034495 mRNA. Translation: AAH34495.2.
BC044242 mRNA. Translation: AAH44242.1.
BC157864 mRNA. Translation: AAI57865.1.
BC157871 mRNA. Translation: AAI57872.1.
CCDSiCCDS43552.1. [B2RC85-1]
RefSeqiNP_001093167.1. NM_001099697.1. [B2RC85-1]
NP_775836.3. NM_173565.3.
XP_005249887.1. XM_005249830.2. [B2RC85-1]
UniGeneiHs.442339.
Hs.710326.

Genome annotation databases

EnsembliENST00000297186; ENSP00000297186; ENSG00000169402. [B2RC85-1]
ENST00000359718; ENSP00000352749; ENSG00000169402. [B2RC85-2]
ENST00000403107; ENSP00000384766; ENSG00000169402. [B2RC85-1]
ENST00000404077; ENSP00000386102; ENSG00000169402. [B2RC85-1]
ENST00000433859; ENSP00000416710; ENSG00000169402. [B2RC85-1]
GeneIDi222967.
728194.
KEGGihsa:222967.
hsa:728194.
UCSCiuc010ktk.1. human. [B2RC85-1]
uc021zze.1. human. [B2RC85-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK314983 mRNA. Translation: BAG37482.1 . Different initiation.
AC073343 Genomic DNA. No translation available.
BC034495 mRNA. Translation: AAH34495.2 .
BC044242 mRNA. Translation: AAH44242.1 .
BC157864 mRNA. Translation: AAI57865.1 .
BC157871 mRNA. Translation: AAI57872.1 .
CCDSi CCDS43552.1. [B2RC85-1 ]
RefSeqi NP_001093167.1. NM_001099697.1. [B2RC85-1 ]
NP_775836.3. NM_173565.3.
XP_005249887.1. XM_005249830.2. [B2RC85-1 ]
UniGenei Hs.442339.
Hs.710326.

3D structure databases

ProteinModelPortali B2RC85.
SMRi B2RC85. Positions 97-265, 288-341.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 608628. 1 interaction.
STRINGi 9606.ENSP00000297186.

PTM databases

PhosphoSitei B2RC85.

Proteomic databases

PaxDbi B2RC85.
PRIDEi B2RC85.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000297186 ; ENSP00000297186 ; ENSG00000169402 . [B2RC85-1 ]
ENST00000359718 ; ENSP00000352749 ; ENSG00000169402 . [B2RC85-2 ]
ENST00000403107 ; ENSP00000384766 ; ENSG00000169402 . [B2RC85-1 ]
ENST00000404077 ; ENSP00000386102 ; ENSG00000169402 . [B2RC85-1 ]
ENST00000433859 ; ENSP00000416710 ; ENSG00000169402 . [B2RC85-1 ]
GeneIDi 222967.
728194.
KEGGi hsa:222967.
hsa:728194.
UCSCi uc010ktk.1. human. [B2RC85-1 ]
uc021zze.1. human. [B2RC85-2 ]

Organism-specific databases

CTDi 222967.
728194.
GeneCardsi GC07P006793.
HGNCi HGNC:34385. RSPH10B2.
HPAi HPA047076.
HPA049182.
neXtProti NX_B2RC85.
PharmGKBi PA162402247.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4642.
HOGENOMi HOG000154057.
HOVERGENi HBG108420.
InParanoidi B2RC85.
OMAi LTTNQEY.
OrthoDBi EOG7DNNTG.
PhylomeDBi B2RC85.
TreeFami TF328649.

Miscellaneous databases

GeneWikii RSPH10B.
NextBioi 91698.
PROi B2RC85.

Gene expression databases

Bgeei B2RC85.
CleanExi HS_RSPH10B2.
Genevestigatori B2RC85.

Family and domain databases

InterProi IPR003409. MORN.
[Graphical view ]
Pfami PF02493. MORN. 10 hits.
[Graphical view ]
SMARTi SM00698. MORN. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LYS-836.
    Tissue: Brain and Testis.

Entry informationi

Entry nameiR10B2_HUMAN
AccessioniPrimary (citable) accession number: B2RC85
Secondary accession number(s): A6NMW7
, B2RXI4, B2RXJ0, Q86ST9, Q8NE68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: July 9, 2014
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3