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B2RC85

- R10B2_HUMAN

UniProt

B2RC85 - R10B2_HUMAN

Protein

Radial spoke head 10 homolog B2

Gene

RSPH10B2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 2 (02 Sep 2008)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Radial spoke head 10 homolog B2
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:34385. RSPH10B2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162402247.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 870870Radial spoke head 10 homolog B2PRO_0000349254Add
    BLAST

    Proteomic databases

    PaxDbiB2RC85.
    PRIDEiB2RC85.

    PTM databases

    PhosphoSiteiB2RC85.

    Expressioni

    Gene expression databases

    BgeeiB2RC85.
    CleanExiHS_RSPH10B2.
    GenevestigatoriB2RC85.

    Organism-specific databases

    HPAiHPA047076.
    HPA049182.

    Interactioni

    Protein-protein interaction databases

    BioGridi608628. 1 interaction.
    STRINGi9606.ENSP00000297186.

    Structurei

    3D structure databases

    ProteinModelPortaliB2RC85.
    SMRiB2RC85. Positions 97-265, 288-341.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati86 – 10823MORN 1Add
    BLAST
    Repeati109 – 13123MORN 2Add
    BLAST
    Repeati132 – 15423MORN 3Add
    BLAST
    Repeati155 – 17723MORN 4Add
    BLAST
    Repeati179 – 20123MORN 5Add
    BLAST
    Repeati204 – 22623MORN 6Add
    BLAST
    Repeati227 – 24923MORN 7Add
    BLAST
    Repeati251 – 27323MORN 8Add
    BLAST
    Repeati284 – 30623MORN 9Add
    BLAST
    Repeati307 – 32923MORN 10Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili784 – 81128Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 10 MORN repeats.Curated

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG4642.
    HOGENOMiHOG000154057.
    HOVERGENiHBG108420.
    InParanoidiB2RC85.
    OMAiLTTNQEY.
    OrthoDBiEOG7DNNTG.
    PhylomeDBiB2RC85.
    TreeFamiTF328649.

    Family and domain databases

    InterProiIPR003409. MORN.
    [Graphical view]
    PfamiPF02493. MORN. 10 hits.
    [Graphical view]
    SMARTiSM00698. MORN. 9 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: B2RC85-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVKEKKKADK KGEKSARSPS SLSDNLDFSK QDGNTTRQEM SPAGVPLLGM    50
    QLNEVKPKKD RQNVQQNEDA SQYEESILTK LIVESYEGEK VRGLYEGEGF 100
    AAFQGGCTYR GMFSEGLMHG QGTYIWADGL KYEGDFVKNV PMNHGVYTWP 150
    DGSMYEGEVV NGMRNGFGMF KCSTQPVSYI GHWCNGKRHG KGSIYYNQEG 200
    TCWYEGDWVQ NIKKGWGIRC YKSGNIYEGQ WEDNMRHGEG RMRWLTTNEE 250
    YTGRWERGIQ NGFGTHTWFL KRIRSSQYPL RNEYIGEFVN GYRHGRGKFY 300
    YASGAMYDGE WVSNKKHGMG RLTFKNGRVY EGAFSNDHIA GFPDLEVEFI 350
    SCLDLSSGVA PRLSRSAELI RKLDGSESHS VLGSSIELDL NLLLDMYPET 400
    VQPEEKKQVE YAVLRNITEL RRIYSFYSSL GCGHSLDNTF LMTKLHFWRF 450
    LKDCKFHHHK LTLADMDRIL SANNDIPVEE IHSPFTTILL RTFLNYLLHL 500
    AYHIYHEEFQ KRSPSLFLCF TKLMTENIRP NACQIKGNLF REQQRTLYSM 550
    SYMNKCWEIY LAYCRPSAAP PHEPTMKMRH FLWMLKDFKM INKELTAATF 600
    MEVIAEDNRF IYDGIDSNFE PELVFLEFFE ALLSFAFICV TDQMTKSYTN 650
    VPADDVSGNK HETIYTILNQ DAQNKSPSAV MSHESDAAHS DSARSSSSKL 700
    ELSPDVNKIR KSEPKIKKSV SHERVSKMNF KLTGKGITFF SSESKKYERP 750
    KDDREEEFNT WVNNTYVFFV NTLFHAYKRE EAIKEKIRAD RLRSTAQAQQ 800
    RKMEDDELEA RLNIFILREE EAKRHDYEVD ITVLKEPADV SSSHLILDPP 850
    KEDVTVSPSS KTITSKKKKK 870
    Length:870
    Mass (Da):100,547
    Last modified:September 2, 2008 - v2
    Checksum:i7608F2CC07A70628
    GO
    Isoform 2 (identifier: B2RC85-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-234: Missing.
         511-514: KRSP → QFIP
         515-870: Missing.

    Show »
    Length:280
    Mass (Da):32,772
    Checksum:iBE38ADC76B396891
    GO

    Sequence cautioni

    The sequence BAG37482.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti148 – 1481T → M in AAI57865. (PubMed:15489334)Curated
    Sequence conflicti550 – 5501M → I in AAH34495. (PubMed:15489334)Curated
    Sequence conflicti619 – 6191F → L in BAG37482. (PubMed:14702039)Curated
    Sequence conflicti765 – 7651T → M in BAG37482. (PubMed:14702039)Curated
    Sequence conflicti765 – 7651T → M in AAH34495. (PubMed:15489334)Curated
    Sequence conflicti765 – 7651T → M in AAI57865. (PubMed:15489334)Curated
    Sequence conflicti765 – 7651T → M in AAI57872. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti836 – 8361E → K.1 Publication
    Corresponds to variant rs17855578 [ dbSNP | Ensembl ].
    VAR_037357

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 234234Missing in isoform 2. 1 PublicationVSP_035277Add
    BLAST
    Alternative sequencei511 – 5144KRSP → QFIP in isoform 2. 1 PublicationVSP_035278
    Alternative sequencei515 – 870356Missing in isoform 2. 1 PublicationVSP_035279Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK314983 mRNA. Translation: BAG37482.1. Different initiation.
    AC073343 Genomic DNA. No translation available.
    BC034495 mRNA. Translation: AAH34495.2.
    BC044242 mRNA. Translation: AAH44242.1.
    BC157864 mRNA. Translation: AAI57865.1.
    BC157871 mRNA. Translation: AAI57872.1.
    CCDSiCCDS43552.1. [B2RC85-1]
    RefSeqiNP_001093167.1. NM_001099697.1. [B2RC85-1]
    NP_775836.3. NM_173565.3.
    XP_005249887.1. XM_005249830.2. [B2RC85-1]
    UniGeneiHs.442339.
    Hs.710326.

    Genome annotation databases

    EnsembliENST00000297186; ENSP00000297186; ENSG00000169402. [B2RC85-1]
    ENST00000403107; ENSP00000384766; ENSG00000169402. [B2RC85-1]
    ENST00000404077; ENSP00000386102; ENSG00000169402. [B2RC85-1]
    GeneIDi222967.
    728194.
    KEGGihsa:222967.
    hsa:728194.
    UCSCiuc010ktk.1. human. [B2RC85-1]
    uc021zze.1. human. [B2RC85-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK314983 mRNA. Translation: BAG37482.1 . Different initiation.
    AC073343 Genomic DNA. No translation available.
    BC034495 mRNA. Translation: AAH34495.2 .
    BC044242 mRNA. Translation: AAH44242.1 .
    BC157864 mRNA. Translation: AAI57865.1 .
    BC157871 mRNA. Translation: AAI57872.1 .
    CCDSi CCDS43552.1. [B2RC85-1 ]
    RefSeqi NP_001093167.1. NM_001099697.1. [B2RC85-1 ]
    NP_775836.3. NM_173565.3.
    XP_005249887.1. XM_005249830.2. [B2RC85-1 ]
    UniGenei Hs.442339.
    Hs.710326.

    3D structure databases

    ProteinModelPortali B2RC85.
    SMRi B2RC85. Positions 97-265, 288-341.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 608628. 1 interaction.
    STRINGi 9606.ENSP00000297186.

    PTM databases

    PhosphoSitei B2RC85.

    Proteomic databases

    PaxDbi B2RC85.
    PRIDEi B2RC85.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297186 ; ENSP00000297186 ; ENSG00000169402 . [B2RC85-1 ]
    ENST00000403107 ; ENSP00000384766 ; ENSG00000169402 . [B2RC85-1 ]
    ENST00000404077 ; ENSP00000386102 ; ENSG00000169402 . [B2RC85-1 ]
    GeneIDi 222967.
    728194.
    KEGGi hsa:222967.
    hsa:728194.
    UCSCi uc010ktk.1. human. [B2RC85-1 ]
    uc021zze.1. human. [B2RC85-2 ]

    Organism-specific databases

    CTDi 222967.
    728194.
    GeneCardsi GC07P006793.
    HGNCi HGNC:34385. RSPH10B2.
    HPAi HPA047076.
    HPA049182.
    neXtProti NX_B2RC85.
    PharmGKBi PA162402247.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4642.
    HOGENOMi HOG000154057.
    HOVERGENi HBG108420.
    InParanoidi B2RC85.
    OMAi LTTNQEY.
    OrthoDBi EOG7DNNTG.
    PhylomeDBi B2RC85.
    TreeFami TF328649.

    Miscellaneous databases

    GeneWikii RSPH10B.
    NextBioi 91698.
    PROi B2RC85.

    Gene expression databases

    Bgeei B2RC85.
    CleanExi HS_RSPH10B2.
    Genevestigatori B2RC85.

    Family and domain databases

    InterProi IPR003409. MORN.
    [Graphical view ]
    Pfami PF02493. MORN. 10 hits.
    [Graphical view ]
    SMARTi SM00698. MORN. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LYS-836.
      Tissue: Brain and Testis.

    Entry informationi

    Entry nameiR10B2_HUMAN
    AccessioniPrimary (citable) accession number: B2RC85
    Secondary accession number(s): A6NMW7
    , B2RXI4, B2RXJ0, Q86ST9, Q8NE68
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 52 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3