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B2RC85 (R10B2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Radial spoke head 10 homolog B2
Gene names
Name:RSPH10B2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length870 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 10 MORN repeats.

Sequence caution

The sequence BAG37482.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: B2RC85-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: B2RC85-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-234: Missing.
     511-514: KRSP → QFIP
     515-870: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 870870Radial spoke head 10 homolog B2
PRO_0000349254

Regions

Repeat86 – 10823MORN 1
Repeat109 – 13123MORN 2
Repeat132 – 15423MORN 3
Repeat155 – 17723MORN 4
Repeat179 – 20123MORN 5
Repeat204 – 22623MORN 6
Repeat227 – 24923MORN 7
Repeat251 – 27323MORN 8
Repeat284 – 30623MORN 9
Repeat307 – 32923MORN 10
Coiled coil784 – 81128 Potential

Natural variations

Alternative sequence1 – 234234Missing in isoform 2.
VSP_035277
Alternative sequence511 – 5144KRSP → QFIP in isoform 2.
VSP_035278
Alternative sequence515 – 870356Missing in isoform 2.
VSP_035279
Natural variant8361E → K. Ref.3
Corresponds to variant rs17855578 [ dbSNP | Ensembl ].
VAR_037357

Experimental info

Sequence conflict1481T → M in AAI57865. Ref.3
Sequence conflict5501M → I in AAH34495. Ref.3
Sequence conflict6191F → L in BAG37482. Ref.1
Sequence conflict7651T → M in BAG37482. Ref.1
Sequence conflict7651T → M in AAH34495. Ref.3
Sequence conflict7651T → M in AAI57865. Ref.3
Sequence conflict7651T → M in AAI57872. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 2, 2008. Version 2.
Checksum: 7608F2CC07A70628

FASTA870100,547
        10         20         30         40         50         60 
MVKEKKKADK KGEKSARSPS SLSDNLDFSK QDGNTTRQEM SPAGVPLLGM QLNEVKPKKD 

        70         80         90        100        110        120 
RQNVQQNEDA SQYEESILTK LIVESYEGEK VRGLYEGEGF AAFQGGCTYR GMFSEGLMHG 

       130        140        150        160        170        180 
QGTYIWADGL KYEGDFVKNV PMNHGVYTWP DGSMYEGEVV NGMRNGFGMF KCSTQPVSYI 

       190        200        210        220        230        240 
GHWCNGKRHG KGSIYYNQEG TCWYEGDWVQ NIKKGWGIRC YKSGNIYEGQ WEDNMRHGEG 

       250        260        270        280        290        300 
RMRWLTTNEE YTGRWERGIQ NGFGTHTWFL KRIRSSQYPL RNEYIGEFVN GYRHGRGKFY 

       310        320        330        340        350        360 
YASGAMYDGE WVSNKKHGMG RLTFKNGRVY EGAFSNDHIA GFPDLEVEFI SCLDLSSGVA 

       370        380        390        400        410        420 
PRLSRSAELI RKLDGSESHS VLGSSIELDL NLLLDMYPET VQPEEKKQVE YAVLRNITEL 

       430        440        450        460        470        480 
RRIYSFYSSL GCGHSLDNTF LMTKLHFWRF LKDCKFHHHK LTLADMDRIL SANNDIPVEE 

       490        500        510        520        530        540 
IHSPFTTILL RTFLNYLLHL AYHIYHEEFQ KRSPSLFLCF TKLMTENIRP NACQIKGNLF 

       550        560        570        580        590        600 
REQQRTLYSM SYMNKCWEIY LAYCRPSAAP PHEPTMKMRH FLWMLKDFKM INKELTAATF 

       610        620        630        640        650        660 
MEVIAEDNRF IYDGIDSNFE PELVFLEFFE ALLSFAFICV TDQMTKSYTN VPADDVSGNK 

       670        680        690        700        710        720 
HETIYTILNQ DAQNKSPSAV MSHESDAAHS DSARSSSSKL ELSPDVNKIR KSEPKIKKSV 

       730        740        750        760        770        780 
SHERVSKMNF KLTGKGITFF SSESKKYERP KDDREEEFNT WVNNTYVFFV NTLFHAYKRE 

       790        800        810        820        830        840 
EAIKEKIRAD RLRSTAQAQQ RKMEDDELEA RLNIFILREE EAKRHDYEVD ITVLKEPADV 

       850        860        870 
SSSHLILDPP KEDVTVSPSS KTITSKKKKK 

« Hide

Isoform 2 [UniParc].

Checksum: BE38ADC76B396891
Show »

FASTA28032,772

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LYS-836.
Tissue: Brain and Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK314983 mRNA. Translation: BAG37482.1. Different initiation.
AC073343 Genomic DNA. No translation available.
BC034495 mRNA. Translation: AAH34495.2.
BC044242 mRNA. Translation: AAH44242.1.
BC157864 mRNA. Translation: AAI57865.1.
BC157871 mRNA. Translation: AAI57872.1.
CCDSCCDS43552.1. [B2RC85-1]
RefSeqNP_001093167.1. NM_001099697.1. [B2RC85-1]
NP_775836.3. NM_173565.3.
XP_005249887.1. XM_005249830.2. [B2RC85-1]
UniGeneHs.442339.
Hs.710326.

3D structure databases

ProteinModelPortalB2RC85.
SMRB2RC85. Positions 97-265, 288-341.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid608628. 1 interaction.
STRING9606.ENSP00000297186.

PTM databases

PhosphoSiteB2RC85.

Proteomic databases

PaxDbB2RC85.
PRIDEB2RC85.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297186; ENSP00000297186; ENSG00000169402. [B2RC85-1]
ENST00000359718; ENSP00000352749; ENSG00000169402. [B2RC85-2]
ENST00000403107; ENSP00000384766; ENSG00000169402. [B2RC85-1]
ENST00000404077; ENSP00000386102; ENSG00000169402. [B2RC85-1]
ENST00000433859; ENSP00000416710; ENSG00000169402. [B2RC85-1]
GeneID222967.
728194.
KEGGhsa:222967.
hsa:728194.
UCSCuc010ktk.1. human. [B2RC85-1]
uc021zze.1. human. [B2RC85-2]

Organism-specific databases

CTD222967.
728194.
GeneCardsGC07P006793.
HGNCHGNC:34385. RSPH10B2.
HPAHPA047076.
HPA049182.
neXtProtNX_B2RC85.
PharmGKBPA162402247.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4642.
HOGENOMHOG000154057.
HOVERGENHBG108420.
InParanoidB2RC85.
OMALTTNQEY.
OrthoDBEOG7DNNTG.
PhylomeDBB2RC85.
TreeFamTF328649.

Gene expression databases

BgeeB2RC85.
CleanExHS_RSPH10B2.
GenevestigatorB2RC85.

Family and domain databases

InterProIPR003409. MORN.
[Graphical view]
PfamPF02493. MORN. 10 hits.
[Graphical view]
SMARTSM00698. MORN. 9 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiRSPH10B.
NextBio91698.
PROB2RC85.

Entry information

Entry nameR10B2_HUMAN
AccessionPrimary (citable) accession number: B2RC85
Secondary accession number(s): A6NMW7 expand/collapse secondary AC list , B2RXI4, B2RXJ0, Q86ST9, Q8NE68
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: July 9, 2014
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM