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Protein
Submitted name:

cDNA, FLJ95855, highly similar to Homo sapiens potassium inwardly-rectifying channel, subfamily J,member 11 (KCNJ11), mRNA

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei160 – 1601Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channelUniRule annotation

Keywords - Biological processi

Ion transport, Potassium transportUniRule annotation, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA, FLJ95855, highly similar to Homo sapiens potassium inwardly-rectifying channel, subfamily J,member 11 (KCNJ11), mRNAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei72 – 9322HelicalSequence analysisAdd
BLAST
Transmembranei144 – 16825HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA217.

PTM / Processingi

Proteomic databases

PaxDbiB2RC52.
PeptideAtlasiB2RC52.
PRIDEiB2RC52.

Expressioni

Gene expression databases

BgeeiENSG00000187486.
ExpressionAtlasiB2RC52. baseline and differential.
GenevisibleiB2RC52. HS.

Interactioni

Protein-protein interaction databases

IntActiB2RC52. 3 interactions.
STRINGi9606.ENSP00000345708.

Structurei

3D structure databases

ProteinModelPortaliB2RC52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3827. Eukaryota.
ENOG410XQ62. LUCA.
HOVERGENiHBG006178.
OMAiNGNCNVA.
OrthoDBiEOG091G08HC.
PhylomeDBiB2RC52.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003279. K_chnl_inward-rec_Kir6.2.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01332. KIR62CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

B2RC52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRKGIIPE EYVLTRLAED PAKPRYRARQ RRARFVSKKG NCNVAHKNIR
60 70 80 90 100
EQGRFLQDVF TTLVDLKWPH TLLIFTMSFL CSWLLFAMAW WLIAFAHGDL
110 120 130 140 150
APSEGTAEPC VTSIHSFSSA FLFSIEVQVT IGFGGRMVTE ECPLAILILI
160 170 180 190 200
VQNIVGLMIN AIMLGCIFMK TAQAHRRAET LIFSKHAVIA LRHGRLCFML
210 220 230 240 250
RVGDLRKSMI ISATIHMQVV RKTTSPEGEV VPLHQVDIPM ENGVGGNSIF
260 270 280 290 300
LVAPLIIYHV IDANSPLYDL APSDLHHHQD LEIIVILEGV VETTGITTQA
310 320 330 340 350
RTSYLADEIL WGQRFVPIVA EEDGRYSVDY SKFGNTVKVP TPLCTARQLD
360 370 380 390
EDHSLLEALT LASARGPLRK RSVPMAKAKP KFSISPDSLS
Length:390
Mass (Da):43,526
Last modified:July 1, 2008 - v1
Checksum:i00F4E7D94432F282
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK314943 mRNA. Translation: BAG37449.1.
RefSeqiNP_000516.3. NM_000525.3.
UniGeneiHs.248141.

Genome annotation databases

GeneIDi3767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK314943 mRNA. Translation: BAG37449.1.
RefSeqiNP_000516.3. NM_000525.3.
UniGeneiHs.248141.

3D structure databases

ProteinModelPortaliB2RC52.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB2RC52. 3 interactions.
STRINGi9606.ENSP00000345708.

Proteomic databases

PaxDbiB2RC52.
PeptideAtlasiB2RC52.
PRIDEiB2RC52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3767.

Organism-specific databases

CTDi3767.
PharmGKBiPA217.

Phylogenomic databases

eggNOGiKOG3827. Eukaryota.
ENOG410XQ62. LUCA.
HOVERGENiHBG006178.
OMAiNGNCNVA.
OrthoDBiEOG091G08HC.
PhylomeDBiB2RC52.

Miscellaneous databases

GenomeRNAii3767.

Gene expression databases

BgeeiENSG00000187486.
ExpressionAtlasiB2RC52. baseline and differential.
GenevisibleiB2RC52. HS.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003279. K_chnl_inward-rec_Kir6.2.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01332. KIR62CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB2RC52_HUMAN
AccessioniPrimary (citable) accession number: B2RC52
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.