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B2RC52

- B2RC52_HUMAN

UniProt

B2RC52 - B2RC52_HUMAN

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Protein
Submitted name:

cDNA, FLJ95855, highly similar to Homo sapiens potassium inwardly-rectifying channel, subfamily J,member 11 (KCNJ11), mRNA

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP-activated inward rectifier potassium channel activity Source: Ensembl
  2. ATP binding Source: Ensembl

GO - Biological processi

  1. cellular response to glucose stimulus Source: Ensembl
  2. cellular response to nicotine Source: Ensembl
  3. cellular response to tumor necrosis factor Source: Ensembl
  4. positive regulation of cation channel activity Source: Ensembl
  5. potassium ion import Source: Ensembl
  6. response to drug Source: Ensembl
  7. response to estradiol Source: Ensembl
  8. response to ischemia Source: Ensembl
  9. response to testosterone Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Potassium transportUniRule annotationSAAS annotation, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA, FLJ95855, highly similar to Homo sapiens potassium inwardly-rectifying channel, subfamily J,member 11 (KCNJ11), mRNAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. ATP-sensitive potassium channel complex Source: Ensembl
  2. axolemma Source: Ensembl
  3. cell body fiber Source: Ensembl
  4. cytosol Source: Ensembl
  5. endoplasmic reticulum Source: Ensembl
  6. endosome Source: Ensembl
  7. intercalated disc Source: Ensembl
  8. mitochondrion Source: Ensembl
  9. myelin sheath Source: Ensembl
  10. neuronal cell body Source: Ensembl
  11. nuclear envelope Source: Ensembl
  12. T-tubule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA217.

PTM / Processingi

Proteomic databases

PRIDEiB2RC52.

Expressioni

Gene expression databases

BgeeiB2RC52.
ExpressionAtlasiB2RC52. baseline.

Interactioni

Protein-protein interaction databases

IntActiB2RC52. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliB2RC52.
SMRiB2RC52. Positions 33-357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the inward rectifier-type potassium channel family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118842.
HOVERGENiHBG006178.
KOiK05004.
OMAiHHQDLEI.
PhylomeDBiB2RC52.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003279. K_chnl_inward-rec_Kir6.2.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01332. KIR62CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

B2RC52-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSRKGIIPE EYVLTRLAED PAKPRYRARQ RRARFVSKKG NCNVAHKNIR
60 70 80 90 100
EQGRFLQDVF TTLVDLKWPH TLLIFTMSFL CSWLLFAMAW WLIAFAHGDL
110 120 130 140 150
APSEGTAEPC VTSIHSFSSA FLFSIEVQVT IGFGGRMVTE ECPLAILILI
160 170 180 190 200
VQNIVGLMIN AIMLGCIFMK TAQAHRRAET LIFSKHAVIA LRHGRLCFML
210 220 230 240 250
RVGDLRKSMI ISATIHMQVV RKTTSPEGEV VPLHQVDIPM ENGVGGNSIF
260 270 280 290 300
LVAPLIIYHV IDANSPLYDL APSDLHHHQD LEIIVILEGV VETTGITTQA
310 320 330 340 350
RTSYLADEIL WGQRFVPIVA EEDGRYSVDY SKFGNTVKVP TPLCTARQLD
360 370 380 390
EDHSLLEALT LASARGPLRK RSVPMAKAKP KFSISPDSLS
Length:390
Mass (Da):43,526
Last modified:July 1, 2008 - v1
Checksum:i00F4E7D94432F282
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK314943 mRNA. Translation: BAG37449.1.
RefSeqiNP_000516.3. NM_000525.3.
UniGeneiHs.248141.

Genome annotation databases

GeneIDi3767.
KEGGihsa:3767.
UCSCiuc001mna.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK314943 mRNA. Translation: BAG37449.1 .
RefSeqi NP_000516.3. NM_000525.3.
UniGenei Hs.248141.

3D structure databases

ProteinModelPortali B2RC52.
SMRi B2RC52. Positions 33-357.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi B2RC52. 3 interactions.

Proteomic databases

PRIDEi B2RC52.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3767.
KEGGi hsa:3767.
UCSCi uc001mna.3. human.

Organism-specific databases

CTDi 3767.
PharmGKBi PA217.

Phylogenomic databases

GeneTreei ENSGT00760000118842.
HOVERGENi HBG006178.
KOi K05004.
OMAi HHQDLEI.
PhylomeDBi B2RC52.

Miscellaneous databases

GenomeRNAii 3767.
NextBioi 14771.

Gene expression databases

Bgeei B2RC52.
ExpressionAtlasi B2RC52. baseline.

Family and domain databases

Gene3Di 2.60.40.1400. 1 hit.
InterProi IPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003279. K_chnl_inward-rec_Kir6.2.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view ]
PANTHERi PTHR11767. PTHR11767. 1 hit.
Pfami PF01007. IRK. 1 hit.
[Graphical view ]
PIRSFi PIRSF005465. GIRK_kir. 1 hit.
PRINTSi PR01332. KIR62CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMi SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "NEDO functional analysis of protein and research application project."
    Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiB2RC52_HUMAN
AccessioniPrimary (citable) accession number: B2RC52
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.