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B2RC52

- B2RC52_HUMAN

UniProt

B2RC52 - B2RC52_HUMAN

Protein
Submitted name:

cDNA, FLJ95855, highly similar to Homo sapiens potassium inwardly-rectifying channel, subfamily J,member 11 (KCNJ11), mRNA

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP-activated inward rectifier potassium channel activity Source: Ensembl
    2. ATP binding Source: Ensembl

    GO - Biological processi

    1. cellular response to glucose stimulus Source: Ensembl
    2. cellular response to nicotine Source: Ensembl
    3. cellular response to tumor necrosis factor Source: Ensembl
    4. positive regulation of cation channel activity Source: Ensembl
    5. potassium ion import Source: Ensembl
    6. response to drug Source: Ensembl
    7. response to estradiol Source: Ensembl
    8. response to ischemia Source: Ensembl
    9. response to testosterone Source: Ensembl

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

    Keywords - Biological processi

    Ion transport, Potassium transportUniRule annotationSAAS annotation, Transport

    Keywords - Ligandi

    Potassium

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    cDNA, FLJ95855, highly similar to Homo sapiens potassium inwardly-rectifying channel, subfamily J,member 11 (KCNJ11), mRNAImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. ATP-sensitive potassium channel complex Source: Ensembl
    2. axolemma Source: Ensembl
    3. cell body fiber Source: Ensembl
    4. cytosol Source: Ensembl
    5. endoplasmic reticulum Source: Ensembl
    6. endosome Source: Ensembl
    7. intercalated disc Source: Ensembl
    8. mitochondrion Source: Ensembl
    9. myelin sheath Source: Ensembl
    10. neuronal cell body Source: Ensembl
    11. nuclear envelope Source: Ensembl
    12. T-tubule Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA217.

    PTM / Processingi

    Proteomic databases

    PRIDEiB2RC52.

    Expressioni

    Gene expression databases

    ArrayExpressiB2RC52.
    BgeeiB2RC52.

    Structurei

    3D structure databases

    ProteinModelPortaliB2RC52.
    SMRiB2RC52. Positions 33-357.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the inward rectifier-type potassium channel family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG006178.
    KOiK05004.
    OMAiHHQDLEI.
    PhylomeDBiB2RC52.

    Family and domain databases

    Gene3Di2.60.40.1400. 1 hit.
    InterProiIPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR003279. K_chnl_inward-rec_Kir6.2.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view]
    PANTHERiPTHR11767. PTHR11767. 1 hit.
    PfamiPF01007. IRK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005465. GIRK_kir. 1 hit.
    PRINTSiPR01332. KIR62CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMiSSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2RC52-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSRKGIIPE EYVLTRLAED PAKPRYRARQ RRARFVSKKG NCNVAHKNIR    50
    EQGRFLQDVF TTLVDLKWPH TLLIFTMSFL CSWLLFAMAW WLIAFAHGDL 100
    APSEGTAEPC VTSIHSFSSA FLFSIEVQVT IGFGGRMVTE ECPLAILILI 150
    VQNIVGLMIN AIMLGCIFMK TAQAHRRAET LIFSKHAVIA LRHGRLCFML 200
    RVGDLRKSMI ISATIHMQVV RKTTSPEGEV VPLHQVDIPM ENGVGGNSIF 250
    LVAPLIIYHV IDANSPLYDL APSDLHHHQD LEIIVILEGV VETTGITTQA 300
    RTSYLADEIL WGQRFVPIVA EEDGRYSVDY SKFGNTVKVP TPLCTARQLD 350
    EDHSLLEALT LASARGPLRK RSVPMAKAKP KFSISPDSLS 390
    Length:390
    Mass (Da):43,526
    Last modified:July 1, 2008 - v1
    Checksum:i00F4E7D94432F282
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK314943 mRNA. Translation: BAG37449.1.
    RefSeqiNP_000516.3. NM_000525.3.
    UniGeneiHs.248141.

    Genome annotation databases

    GeneIDi3767.
    KEGGihsa:3767.
    UCSCiuc001mna.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK314943 mRNA. Translation: BAG37449.1 .
    RefSeqi NP_000516.3. NM_000525.3.
    UniGenei Hs.248141.

    3D structure databases

    ProteinModelPortali B2RC52.
    SMRi B2RC52. Positions 33-357.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi B2RC52.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3767.
    KEGGi hsa:3767.
    UCSCi uc001mna.3. human.

    Organism-specific databases

    CTDi 3767.
    PharmGKBi PA217.

    Phylogenomic databases

    HOVERGENi HBG006178.
    KOi K05004.
    OMAi HHQDLEI.
    PhylomeDBi B2RC52.

    Miscellaneous databases

    GenomeRNAii 3767.
    NextBioi 14771.

    Gene expression databases

    ArrayExpressi B2RC52.
    Bgeei B2RC52.

    Family and domain databases

    Gene3Di 2.60.40.1400. 1 hit.
    InterProi IPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR003279. K_chnl_inward-rec_Kir6.2.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view ]
    PANTHERi PTHR11767. PTHR11767. 1 hit.
    Pfami PF01007. IRK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005465. GIRK_kir. 1 hit.
    PRINTSi PR01332. KIR62CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMi SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "NEDO functional analysis of protein and research application project."
      Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
      Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.

    Entry informationi

    Entry nameiB2RC52_HUMAN
    AccessioniPrimary (citable) accession number: B2RC52
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.