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Protein
Submitted name:

TLR7

Gene

TLR7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorSAAS annotationImported

Keywords - Biological processi

Immunity, Inflammatory responseSAAS annotation, Innate immunitySAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
TLR7Imported
Submitted name:
Toll-like receptor 7Imported
Submitted name:
cDNA, FLJ94489, Homo sapiens toll-like receptor 7 (TLR7), mRNAImported
Gene namesi
Name:TLR7Imported
ORF Names:hCG_1646600Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei840 – 865HelicalSequence analysisAdd BLAST26

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38008.

Expressioni

Gene expression databases

BgeeiENSG00000196664.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000370034.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini891 – 1036TIRInterPro annotationAdd BLAST146

Sequence similaritiesi

Belongs to the Toll-like receptor family.SAAS annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
HOVERGENiHBG018601.
KOiK05404.
OMAiSKNNMCI.
OrthoDBiEOG091G023M.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 5 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR026906. LRR_5.
IPR000157. TIR_dom.
IPR026880. TLR7.
[Graphical view]
PANTHERiPTHR24365:SF222. PTHR24365:SF222. 3 hits.
PfamiPF13306. LRR_5. 1 hit.
PF13855. LRR_8. 3 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 4 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 18 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2R9N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFPMWTLKR QILILFNIIL ISKLLGARWF PKTLPCDVTL DVPKNHVIVD
60 70 80 90 100
CTDKHLTEIP GGIPTNTTNL TLTINHIPDI SPASFHRLDH LVEIDFRCNC
110 120 130 140 150
VPIPLGSKNN MCIKRLQIKP RSFSGLTYLK SLYLDGNQLL EIPQGLPPSL
160 170 180 190 200
QLLSLEANNI FSIRKENLTE LANIEILYLG QNCYYRNPCY VSYSIEKDAF
210 220 230 240 250
LNLTKLKVLS LKDNNVTAVP TVLPSTLTEL YLYNNMIAKI QEDDFNNLNQ
260 270 280 290 300
LQILDLSGNC PRCYNAPFPC APCKNNSPLQ IPVNAFDALT ELKVLRLHSN
310 320 330 340 350
SLQHVPPRWF KNINKLQELD LSQNFLAKEI GDAKFLHFLP SLIQLDLSFN
360 370 380 390 400
FELQVYRASM NLSQAFSSLK SLKILRIRGY VFKELKSFNL SPLHNLQNLE
410 420 430 440 450
VLDLGTNFIK IANLSMFKQF KRLKVIDLSV NKISPSGDSS EVGFCSNART
460 470 480 490 500
SVESYEPQVL EQLHYFRYDK YARSCRFKNK EASFMSVNES CYKYGQTLDL
510 520 530 540 550
SKNSIFFVKS SDFQHLSFLK CLNLSGNLIS QTLNGSEFQP LAELRYLDFS
560 570 580 590 600
NNRLDLLHST AFEELHKLEV LDISSNSHYF QSEGITHMLN FTKNLKVLQK
610 620 630 640 650
LMMNDNDISS STSRTMESES LRTLEFRGNH LDVLWREGDN RYLQLFKNLL
660 670 680 690 700
KLEELDISKN SLSFLPSGVF DGMPPNLKNL SLAKNGLKSF SWKKLQCLKN
710 720 730 740 750
LETLDLSHNQ LTTVPERLSN CSRSLKNLIL KNNQIRSLTK YFLQDAFQLR
760 770 780 790 800
YLDLSSNKIQ MIQKTSFPEN VLNNLKMLLL HHNRFLCTCD AVWFVWWVNH
810 820 830 840 850
TEVTIPYLAT DVTCVGPGAH KGQSVISLDL YTCELDLTNL ILFSLSISVS
860 870 880 890 900
LFLMVMMTAS HLYFWDVWYI YHFCKAKIKG YQRLISPDCC YDAFIVYDTK
910 920 930 940 950
DPAVTEWVLA ELVAKLEDPR EKHFNLCLEE RDWLPGQPVL ENLSQSIQLS
960 970 980 990 1000
KKTVFVMTDK YAKTENFKIA FYLSHQRLMD EKVDVIILIF LEKPFQKSKF
1010 1020 1030 1040
LQLRKRLCGS SVLEWPTNPQ AHPYFWQCLK NALATDNHVA YSQVFKETV
Length:1,049
Mass (Da):120,922
Last modified:July 1, 2008 - v1
Checksum:i8C701E9E437F2721
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ022180 Genomic DNA. Translation: AAZ99021.1.
DQ022181 Genomic DNA. Translation: AAZ99022.1.
DQ022182 Genomic DNA. Translation: AAZ99023.1.
DQ022183 Genomic DNA. Translation: AAZ99024.1.
AK313858 mRNA. Translation: BAG36586.1.
AB445659 mRNA. Translation: BAG55056.1.
CH471074 Genomic DNA. Translation: EAW98807.1.
RefSeqiNP_057646.1. NM_016562.3.
UniGeneiHs.659215.

Genome annotation databases

GeneIDi51284.
KEGGihsa:51284.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ022180 Genomic DNA. Translation: AAZ99021.1.
DQ022181 Genomic DNA. Translation: AAZ99022.1.
DQ022182 Genomic DNA. Translation: AAZ99023.1.
DQ022183 Genomic DNA. Translation: AAZ99024.1.
AK313858 mRNA. Translation: BAG36586.1.
AB445659 mRNA. Translation: BAG55056.1.
CH471074 Genomic DNA. Translation: EAW98807.1.
RefSeqiNP_057646.1. NM_016562.3.
UniGeneiHs.659215.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000370034.

Protocols and materials databases

DNASUi51284.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi51284.
KEGGihsa:51284.

Organism-specific databases

CTDi51284.
PharmGKBiPA38008.

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
HOVERGENiHBG018601.
KOiK05404.
OMAiSKNNMCI.
OrthoDBiEOG091G023M.

Miscellaneous databases

ChiTaRSiTLR7. human.
GenomeRNAii51284.

Gene expression databases

BgeeiENSG00000196664.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 5 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR026906. LRR_5.
IPR000157. TIR_dom.
IPR026880. TLR7.
[Graphical view]
PANTHERiPTHR24365:SF222. PTHR24365:SF222. 3 hits.
PfamiPF13306. LRR_5. 1 hit.
PF13855. LRR_8. 3 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 4 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 18 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB2R9N9_HUMAN
AccessioniPrimary (citable) accession number: B2R9N9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: November 30, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.