ID   B2R7S3_HUMAN            Unreviewed;       425 AA.
AC   B2R7S3;
DT   01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   01-JUL-2008, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=cDNA, FLJ93580, highly similar to Homo sapiens TRAF family member-associated NFKB activator (TANK), transcript variant 1, mRNA {ECO:0000313|EMBL:BAG35920.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG35920.1};
RN   [1] {ECO:0000313|EMBL:BAG35920.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Thalamus {ECO:0000313|EMBL:BAG35920.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y.,
RA   Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R.,
RA   Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N.,
RA   Isogai T.;
RT   "NEDO functional analysis of protein and research application project.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK313096; BAG35920.1; -; mRNA.
DR   RefSeq; NP_001186064.1; NM_001199135.1.
DR   AlphaFoldDB; B2R7S3; -.
DR   PeptideAtlas; B2R7S3; -.
DR   DNASU; 10010; -.
DR   GeneID; 10010; -.
DR   KEGG; hsa:10010; -.
DR   CTD; 10010; -.
DR   OrthoDB; 5358337at2759; -.
DR   BioGRID-ORCS; 10010; 22 hits in 1158 CRISPR screens.
DR   GenomeRNAi; 10010; -.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007249; P:canonical NF-kappaB signal transduction; IEA:InterPro.
DR   InterPro; IPR041641; CALCOCO1/2_Zn_UBZ1.
DR   InterPro; IPR039669; TANK.
DR   InterPro; IPR024581; TBD.
DR   PANTHER; PTHR15249; TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR; 1.
DR   PANTHER; PTHR15249:SF0; TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR; 1.
DR   Pfam; PF12845; TBD; 1.
DR   PROSITE; PS51905; ZF_UBZ1; 1.
DR   Genevisible; B2R7S3; HS.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01253}.
FT   DOMAIN          393..420
FT                   /note="UBZ1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51905"
FT   COILED          27..61
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   425 AA;  47786 MW;  7D3BEBAE06BA62EE CRC64;
     MDKNIGEQLN KAYEAFRQAC MDRDSAVKEL QQKTENYEQR IREQQEQLSL QQTIIDKLKS
     QLLLVNSTQD NNYGCVPLLE DSETRKNNLT LDQPQDKVIS GIAREKLPKV RRQEVSSPRK
     ETSARSLGSP LLHERGNIEK AFWDLKEEFH KICMLAKAQK DHLSKLNIPD TATETQCSVP
     IQCTDKTDKQ EALFKPQAKD DINRGAPSIT SVTPRGLCRD EEDTSFESLS KFNVKFPPMD
     NDSTFLHSTP ERPGILSPAT SEAVCQEKFN MEFRDNPGNF VKTEETLFEI QGIDPIASAI
     QNLKTTDKTK PSNLVNTCIR TTLDRAACLP PGDHNALYVN SFPLLDPSDA PFPSLDSPGK
     AIRGPQQPIW KPFPNQDSDS VVLSGTDSEL HIPRVCEFCQ AVFPPSITSR GDFLRHLNSH
     FNGET
//