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Protein

Glucosylceramidase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotation, Hydrolase
Biological processLipid metabolism, Sphingolipid metabolismUniRule annotation

Protein family/group databases

CAZyiGH30 Glycoside Hydrolase Family 30

Names & Taxonomyi

Protein namesi
Recommended name:
GlucosylceramidaseUniRule annotation (EC:3.2.1.45UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Protein family/group databases

Allergomei8244 Hom s Glucocerebrosidase

PTM / Processingi

Proteomic databases

PeptideAtlasiB2R6A7
PRIDEiB2R6A7

Structurei

3D structure databases

ProteinModelPortaliB2R6A7
SMRiB2R6A7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 466Glyco_hydro_30InterPro annotationAdd BLAST350
Domaini469 – 531Glyco_hydro_30CInterPro annotationAdd BLAST63

Sequence similaritiesi

Belongs to the glycosyl hydrolase 30 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2566 Eukaryota
COG5520 LUCA
HOVERGENiHBG002285

Family and domain databases

Gene3Di2.60.40.1180, 2 hits
InterProiView protein in InterPro
IPR033452 GH30_C
IPR001139 Glyco_hydro_30
IPR033453 Glyco_hydro_30_TIM-barrel
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR11069 PTHR11069, 1 hit
PfamiView protein in Pfam
PF02055 Glyco_hydro_30, 1 hit
PF17189 Glyco_hydro_30C, 1 hit
PRINTSiPR00843 GLHYDRLASE30
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

B2R6A7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFSSPSREE CPKPLSRVSI MAGSLTGLLL LQAVSWASGA RPCIPKSFGY
60 70 80 90 100
SSVVCVCNAT YCDSFDPPTF PALGTFSRYE STRSGRRMEL SMGPIQANHT
110 120 130 140 150
GTGLLLTLQP EQKFQKVKGF GGAMTDAAAL NILALSPPAQ NLLLKSYFSE
160 170 180 190 200
EGIGYNIIRV PMASCDFSIR TYTYADTPDD FQLHNFSLPE EDTKLKIPLI
210 220 230 240 250
HRALQLAQRP VSLLASPWTS PTWLKTNGAV NGKGSLKGQP GDIYHQTWAR
260 270 280 290 300
YFVKFLDAYA EHKLQFWAVT AENEPSAGLL SGYPFQCLGF TPEHQRDFIA
310 320 330 340 350
RDLGPTLANS THHNVRLLML DDQRLLLPHW AKVVLTDPEA AKYVHGIAVH
360 370 380 390 400
WYLDFLAPAK ATLGETHRLF PNTMLFASEA CVGSKFWEQS VRLGSWDRGM
410 420 430 440 450
QYSHSIITNL LYHVVGWTDW NLALNPEGGP NWVRNFVDSP IIVDITKDTF
460 470 480 490 500
YKQPMFYHLG HFSKFIPEGS QRVGLVASQK NDLDAVALMH PDGSAVVVVL
510 520 530
NRSSKDVPLT IKDPAVGFLE TISPGYSIHT YLWHRQ
Length:536
Mass (Da):59,697
Last modified:July 1, 2008 - v1
Checksum:iFA1E00884344A0E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312502 mRNA Translation: BAG35404.1
UniGeneiHs.282997

Similar proteinsi

Entry informationi

Entry nameiB2R6A7_HUMAN
AccessioniPrimary (citable) accession number: B2R6A7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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