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Protein
Submitted name:

Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a

Gene

PRKAR1A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei202cAMP 1UniRule annotation1
Binding sitei211cAMP 1UniRule annotation1
Binding sitei326cAMP 2UniRule annotation1
Binding sitei335cAMP 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseImported, Transferase
LigandcAMP, cAMP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_aImported
Submitted name:
cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunitImported
Submitted name:
cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNAImported
Gene namesi
Name:PRKAR1AImported
ORF Names:hCG_28462Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000108946.14

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33754

PTM / Processingi

Proteomic databases

PRIDEiB2R5T5

Expressioni

Gene expression databases

BgeeiENSG00000108946
ExpressionAtlasiB2R5T5 baseline and differential

Structurei

3D structure databases

SMRiB2R5T5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini137 – 252Cyclic nucleotide-bindingInterPro annotationAdd BLAST116
Domaini255 – 376Cyclic nucleotide-bindingInterPro annotationAdd BLAST122

Phylogenomic databases

eggNOGiKOG1113 Eukaryota
COG0664 LUCA
HOVERGENiHBG002025
KOiK04739
OMAiVQLCTVR
OrthoDBiEOG091G0F1K

Family and domain databases

CDDicd00038 CAP_ED, 2 hits
Gene3Di2.60.120.10, 2 hits
InterProiView protein in InterPro
IPR012198 cAMP_dep_PK_reg_su
IPR003117 cAMP_dep_PK_reg_su_I/II_a/b
IPR018490 cNMP-bd-like
IPR018488 cNMP-bd_CS
IPR000595 cNMP-bd_dom
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027 cNMP_binding, 2 hits
PF02197 RIIa, 1 hit
PIRSFiPIRSF000548 PK_regulatory, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 2 hits
SM00394 RIIa, 1 hit
SUPFAMiSSF51206 SSF51206, 2 hits
PROSITEiView protein in PROSITE
PS00888 CNMP_BINDING_1, 2 hits
PS00889 CNMP_BINDING_2, 2 hits
PS50042 CNMP_BINDING_3, 2 hits

Sequencei

Sequence statusi: Complete.

B2R5T5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESGSTAASE EARSLRECEL YVQKHNIQAL LKDSIVQLCT ARPERPMAFL
60 70 80 90 100
REYFERLEKE EAKQIQNLQK AGTRTDSRED EISPPPPNPV VKGRRRRGAI
110 120 130 140 150
SAEVYTEEDA ASYVRKVIPK DYKTMAALAK AIEKNVLFSH LDDNERSDIF
160 170 180 190 200
DAMFSVSFIA GETVIQQGDE GDNFYVIDQG ETDVYVNNEW ATSVGEGGSF
210 220 230 240 250
GELALIYGTP RAATVKAKTN VKLWGIDRDS YRRILMGSTL RKRKMYEEFL
260 270 280 290 300
SKVSILESLD KWERLTVADA LEPVQFEDGQ KIVVQGEPGD EFFIILEGSA
310 320 330 340 350
AVLQRRSENE EFVEVGRLGP SDYFGEIALL MNRPRAATVV ARGPLKCVKL
360 370 380
DRPRFERVLG PCSDILKRNI QQYNSFVSLS V
Length:381
Mass (Da):42,982
Last modified:July 1, 2008 - v1
Checksum:i2D04F08CE8857A6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312307 mRNA Translation: BAG35232.1
AK097580 mRNA Translation: BAG53489.1
CH471099 Genomic DNA Translation: EAW89060.1
CH471099 Genomic DNA Translation: EAW89061.1
CH471099 Genomic DNA Translation: EAW89062.1
CH471099 Genomic DNA Translation: EAW89063.1
CH471099 Genomic DNA Translation: EAW89065.1
RefSeqiNP_001263218.1, NM_001276289.1
NP_001265362.1, NM_001278433.1
NP_002725.1, NM_002734.4
NP_997636.1, NM_212471.2
NP_997637.1, NM_212472.2
XP_011523285.1, XM_011524983.2
XP_011523286.1, XM_011524984.2
XP_011523287.1, XM_011524985.2
UniGeneiHs.280342
Hs.745160

Genome annotation databases

GeneIDi5573
KEGGihsa:5573

Similar proteinsi

Entry informationi

Entry nameiB2R5T5_HUMAN
AccessioniPrimary (citable) accession number: B2R5T5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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