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Protein
Submitted name:

Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a

Gene

PRKAR1A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei202cAMP 1UniRule annotation1
Binding sitei211cAMP 1UniRule annotation1
Binding sitei326cAMP 2UniRule annotation1
Binding sitei335cAMP 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Keywords - Ligandi

cAMP, cAMP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_aImported
Submitted name:
cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunitImported
Submitted name:
cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNAImported
Gene namesi
Name:PRKAR1AImported
ORF Names:hCG_28462Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33754.

Expressioni

Gene expression databases

BgeeiENSG00000108946.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000351410.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini137 – 252Cyclic nucleotide-bindingInterPro annotationAdd BLAST116
Domaini255 – 376Cyclic nucleotide-bindingInterPro annotationAdd BLAST122

Phylogenomic databases

eggNOGiKOG1113. Eukaryota.
COG0664. LUCA.
HOVERGENiHBG002025.
KOiK04739.
OMAiFDAMFPC.
OrthoDBiEOG091G0F1K.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR012198. cAMP_dep_PK_reg_su.
IPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF02197. RIIa. 1 hit.
[Graphical view]
PIRSFiPIRSF000548. PK_regulatory. 1 hit.
SMARTiSM00100. cNMP. 2 hits.
SM00394. RIIa. 1 hit.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.
SSF51206. SSF51206. 2 hits.
PROSITEiPS00888. CNMP_BINDING_1. 2 hits.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2R5T5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESGSTAASE EARSLRECEL YVQKHNIQAL LKDSIVQLCT ARPERPMAFL
60 70 80 90 100
REYFERLEKE EAKQIQNLQK AGTRTDSRED EISPPPPNPV VKGRRRRGAI
110 120 130 140 150
SAEVYTEEDA ASYVRKVIPK DYKTMAALAK AIEKNVLFSH LDDNERSDIF
160 170 180 190 200
DAMFSVSFIA GETVIQQGDE GDNFYVIDQG ETDVYVNNEW ATSVGEGGSF
210 220 230 240 250
GELALIYGTP RAATVKAKTN VKLWGIDRDS YRRILMGSTL RKRKMYEEFL
260 270 280 290 300
SKVSILESLD KWERLTVADA LEPVQFEDGQ KIVVQGEPGD EFFIILEGSA
310 320 330 340 350
AVLQRRSENE EFVEVGRLGP SDYFGEIALL MNRPRAATVV ARGPLKCVKL
360 370 380
DRPRFERVLG PCSDILKRNI QQYNSFVSLS V
Length:381
Mass (Da):42,982
Last modified:July 1, 2008 - v1
Checksum:i2D04F08CE8857A6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312307 mRNA. Translation: BAG35232.1.
AK097580 mRNA. Translation: BAG53489.1.
CH471099 Genomic DNA. Translation: EAW89060.1.
CH471099 Genomic DNA. Translation: EAW89061.1.
CH471099 Genomic DNA. Translation: EAW89062.1.
CH471099 Genomic DNA. Translation: EAW89063.1.
CH471099 Genomic DNA. Translation: EAW89065.1.
RefSeqiNP_001263218.1. NM_001276289.1.
NP_001265362.1. NM_001278433.1.
NP_002725.1. NM_002734.4.
NP_997636.1. NM_212471.2.
NP_997637.1. NM_212472.2.
XP_011523285.1. XM_011524983.2.
XP_011523286.1. XM_011524984.2.
XP_011523287.1. XM_011524985.2.
UniGeneiHs.280342.
Hs.745160.

Genome annotation databases

GeneIDi5573.
KEGGihsa:5573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312307 mRNA. Translation: BAG35232.1.
AK097580 mRNA. Translation: BAG53489.1.
CH471099 Genomic DNA. Translation: EAW89060.1.
CH471099 Genomic DNA. Translation: EAW89061.1.
CH471099 Genomic DNA. Translation: EAW89062.1.
CH471099 Genomic DNA. Translation: EAW89063.1.
CH471099 Genomic DNA. Translation: EAW89065.1.
RefSeqiNP_001263218.1. NM_001276289.1.
NP_001265362.1. NM_001278433.1.
NP_002725.1. NM_002734.4.
NP_997636.1. NM_212471.2.
NP_997637.1. NM_212472.2.
XP_011523285.1. XM_011524983.2.
XP_011523286.1. XM_011524984.2.
XP_011523287.1. XM_011524985.2.
UniGeneiHs.280342.
Hs.745160.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000351410.

Protocols and materials databases

DNASUi5573.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5573.
KEGGihsa:5573.

Organism-specific databases

CTDi5573.
PharmGKBiPA33754.

Phylogenomic databases

eggNOGiKOG1113. Eukaryota.
COG0664. LUCA.
HOVERGENiHBG002025.
KOiK04739.
OMAiFDAMFPC.
OrthoDBiEOG091G0F1K.

Miscellaneous databases

ChiTaRSiPRKAR1A. human.
GenomeRNAii5573.

Gene expression databases

BgeeiENSG00000108946.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR012198. cAMP_dep_PK_reg_su.
IPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF02197. RIIa. 1 hit.
[Graphical view]
PIRSFiPIRSF000548. PK_regulatory. 1 hit.
SMARTiSM00100. cNMP. 2 hits.
SM00394. RIIa. 1 hit.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.
SSF51206. SSF51206. 2 hits.
PROSITEiPS00888. CNMP_BINDING_1. 2 hits.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB2R5T5_HUMAN
AccessioniPrimary (citable) accession number: B2R5T5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: November 30, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.