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B2R5B3

- B2R5B3_HUMAN

UniProt

B2R5B3 - B2R5B3_HUMAN

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Protein

Histone H2A

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. nucleosome assembly Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2AUniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Nucleus By similarity UniRule annotation
Nucleus. Chromosome By similarity SAAS annotations

GO - Cellular componenti

  1. nucleosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotations, NucleusUniRule annotationSAAS annotations

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29114.

PTM / Processingi

Proteomic databases

PRIDEiB2R5B3.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB2R5B3.
SMRiB2R5B3. Positions 2-124.

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG009342.
KOiK11251.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR002119. Histone_H2A.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2R5B3-1 [UniParc]FASTAAdd to Basket

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MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VRRLLRKGNY AERVGAGAPV    50
YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK 100
VTIAQGGVLP NIQAVLLPKK TESHHKAKGK 130
Length:130
Mass (Da):14,111
Last modified:July 1, 2008 - v1
Checksum:iA90F473C6741C9A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK312124 mRNA. Translation: BAG35060.1.
RefSeqiNP_066408.1. NM_021064.4.
UniGeneiHs.51011.

Genome annotation databases

GeneIDi8969.
KEGGihsa:8969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK312124 mRNA. Translation: BAG35060.1 .
RefSeqi NP_066408.1. NM_021064.4.
UniGenei Hs.51011.

3D structure databases

ProteinModelPortali B2R5B3.
SMRi B2R5B3. Positions 2-124.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi B2R5B3.

Protocols and materials databases

DNASUi 8969.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8969.
KEGGi hsa:8969.

Organism-specific databases

CTDi 8969.
PharmGKBi PA29114.

Phylogenomic databases

HOVERGENi HBG009342.
KOi K11251.

Miscellaneous databases

GenomeRNAii 8969.
NextBioi 33655.

Family and domain databases

Gene3Di 1.10.20.10. 1 hit.
InterProi IPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR002119. Histone_H2A.
[Graphical view ]
Pfami PF00125. Histone. 1 hit.
[Graphical view ]
PRINTSi PR00620. HISTONEH2A.
SMARTi SM00414. H2A. 1 hit.
[Graphical view ]
SUPFAMi SSF47113. SSF47113. 1 hit.
PROSITEi PS00046. HISTONE_H2A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "NEDO functional analysis of protein and research application project."
    Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiB2R5B3_HUMAN
AccessioniPrimary (citable) accession number: B2R5B3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: June 11, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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