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B2R5B3

- B2R5B3_HUMAN

UniProt

B2R5B3 - B2R5B3_HUMAN

Protein

Histone H2A

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. nucleosome assembly Source: InterPro

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone H2AUniRule annotation
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    Nucleus UniRule annotation
    Nucleus SAAS annotation. Chromosome SAAS annotation

    GO - Cellular componenti

    1. nucleosome Source: UniProtKB-KW
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29114.

    PTM / Processingi

    Proteomic databases

    PRIDEiB2R5B3.

    Interactioni

    Subunit structurei

    The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliB2R5B3.
    SMRiB2R5B3. Positions 2-124.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone H2A family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG009342.
    KOiK11251.

    Family and domain databases

    Gene3Di1.10.20.10. 1 hit.
    InterProiIPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR002119. Histone_H2A.
    [Graphical view]
    PfamiPF00125. Histone. 1 hit.
    [Graphical view]
    PRINTSiPR00620. HISTONEH2A.
    SMARTiSM00414. H2A. 1 hit.
    [Graphical view]
    SUPFAMiSSF47113. SSF47113. 1 hit.
    PROSITEiPS00046. HISTONE_H2A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2R5B3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VRRLLRKGNY AERVGAGAPV    50
    YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK 100
    VTIAQGGVLP NIQAVLLPKK TESHHKAKGK 130
    Length:130
    Mass (Da):14,111
    Last modified:July 1, 2008 - v1
    Checksum:iA90F473C6741C9A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK312124 mRNA. Translation: BAG35060.1.
    RefSeqiNP_066408.1. NM_021064.4.
    UniGeneiHs.51011.

    Genome annotation databases

    GeneIDi8969.
    KEGGihsa:8969.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK312124 mRNA. Translation: BAG35060.1 .
    RefSeqi NP_066408.1. NM_021064.4.
    UniGenei Hs.51011.

    3D structure databases

    ProteinModelPortali B2R5B3.
    SMRi B2R5B3. Positions 2-124.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi B2R5B3.

    Protocols and materials databases

    DNASUi 8969.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8969.
    KEGGi hsa:8969.

    Organism-specific databases

    CTDi 8969.
    PharmGKBi PA29114.

    Phylogenomic databases

    HOVERGENi HBG009342.
    KOi K11251.

    Miscellaneous databases

    GenomeRNAii 8969.
    NextBioi 33655.

    Family and domain databases

    Gene3Di 1.10.20.10. 1 hit.
    InterProi IPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR002119. Histone_H2A.
    [Graphical view ]
    Pfami PF00125. Histone. 1 hit.
    [Graphical view ]
    PRINTSi PR00620. HISTONEH2A.
    SMARTi SM00414. H2A. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47113. SSF47113. 1 hit.
    PROSITEi PS00046. HISTONE_H2A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NEDO functional analysis of protein and research application project."
      Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
      Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiB2R5B3_HUMAN
    AccessioniPrimary (citable) accession number: B2R5B3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.