B2R5B3 (B2R5B3_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Recommended name: Histone H2A RuleBase RU003556
Organism	Homo sapiens (Human) EMBL BAG35060.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	130 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA By similarity. RuleBase RU003556
Subcellular location	Nucleus By similarity RuleBase RU000527.
Sequence similarities	Belongs to the histone H2A family. RuleBase RU003767

Ontologies

Keywords
Cellular component	Chromosome Nucleosome core RuleBase RU000527 SAAS SAAS002119 Nucleus RuleBase RU000527 SAAS SAAS002119
Ligand	DNA-binding
Gene Ontology (GO)
Biological_process	nucleosome assembly Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleosome Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B2R5B3 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: A90F473C6741C9A2	FASTA	130	14,111
	10 20 30 40 50 60 MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VRRLLRKGNY AERVGAGAPV YLAAVLEYLT 70 80 90 100 110 120 AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTIAQGGVLP NIQAVLLPKK 130 TESHHKAKGK

References

[1]	"NEDO functional analysis of protein and research application project." Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK312124 mRNA. Translation: BAG35060.1.
IPI	IPI00026272.
RefSeq	NP_066408.1. NM_021064.4.
UniGene	Hs.51011.
3D structure databases
ProteinModelPortal	B2R5B3.
SMR	B2R5B3. Positions 2-124.
ModBase	Search...
Protein-protein interaction databases
STRING	B2R5B3.
Proteomic databases
PRIDE	B2R5B3.
Protocols and materials databases
DNASU	8969.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8969.
KEGG	hsa:8969.
Organism-specific databases
CTD	8969.
PharmGKB	PA29114.
Phylogenomic databases
HOVERGEN	HBG009342.
KO	K11251.
Family and domain databases
Gene3D	1.10.20.10. 1 hit.
InterPro	IPR009072. Histone-fold. IPR007125. Histone_core_D. IPR002119. Histone_H2A. [Graphical view]
Pfam	PF00125. Histone. 1 hit. [Graphical view]
PRINTS	PR00620. HISTONEH2A.
SMART	SM00414. H2A. 1 hit. [Graphical view]
SUPFAM	SSF47113. Histone-fold. 1 hit.
PROSITE	PS00046. HISTONE_H2A. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	8969.
NextBio	33655.

Entry information

Entry name

B2R5B3_HUMAN

Accession

Primary (citable) accession number: B2R5B3

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	March 6, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.