Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B2R4S9

- B2R4S9_HUMAN

UniProt

B2R4S9 - B2R4S9_HUMAN

Protein

Histone H2B

Gene

HIST1H2BC

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. antibacterial humoral response Source: UniProt
    2. defense response to Gram-positive bacterium Source: UniProt
    3. innate immune response in mucosa Source: UniProt
    4. nucleosome assembly Source: InterPro

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone H2BUniRule annotation
    Gene namesi
    Name:HIST1H2BCImported
    Synonyms:HIST1H2BEImported, HIST1H2BFImported, HIST1H2BGImported, HIST1H2BIImported
    ORF Names:hCG_1640484Imported, hCG_1640985Imported, hCG_1641780Imported, hCG_1787353Imported, hCG_1787365Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    Nucleus UniRule annotation
    Nucleus SAAS annotation. Chromosome SAAS annotation

    GO - Cellular componenti

    1. extracellular space Source: UniProt
    2. nucleosome Source: UniProtKB-KW
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29132.

    PTM / Processingi

    Keywords - PTMi

    Isopeptide bondSAAS annotation

    Interactioni

    Subunit structurei

    The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotation

    Structurei

    3D structure databases

    SMRiB2R4S9. Positions 5-126.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone H2B family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000231213.
    HOVERGENiHBG007774.
    KOiK11252.
    OMAiNETYSIY.
    PhylomeDBiB2R4S9.

    Family and domain databases

    Gene3Di1.10.20.10. 1 hit.
    InterProiIPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR000558. Histone_H2B.
    [Graphical view]
    PANTHERiPTHR23428. PTHR23428. 1 hit.
    PfamiPF00125. Histone. 1 hit.
    [Graphical view]
    PRINTSiPR00621. HISTONEH2B.
    SMARTiSM00427. H2B. 1 hit.
    [Graphical view]
    SUPFAMiSSF47113. SSF47113. 1 hit.
    PROSITEiPS00357. HISTONE_H2B. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2R4S9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH    50
    PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR 100
    LLLPGELAKH AVSEGTKAVT KYTSSK 126
    Length:126
    Mass (Da):13,906
    Last modified:July 1, 2008 - v1
    Checksum:iFAE1479F44BE703D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK311935 mRNA. Translation: BAG34876.1.
    AK312096 mRNA. Translation: BAG35032.1.
    CH471087 Genomic DNA. Translation: EAW55530.1.
    CH471087 Genomic DNA. Translation: EAW55531.1.
    CH471087 Genomic DNA. Translation: EAW55537.1.
    CH471087 Genomic DNA. Translation: EAW55543.1.
    CH471087 Genomic DNA. Translation: EAW55545.1.
    CH471087 Genomic DNA. Translation: EAW55554.1.
    RefSeqiNP_003509.1. NM_003518.3.
    NP_003513.1. NM_003522.3.
    NP_003514.2. NM_003523.2.
    NP_003516.1. NM_003525.2.
    NP_003517.2. NM_003526.2.
    UniGeneiHs.182137.
    Hs.534369.
    Hs.553506.
    Hs.591797.
    Hs.591809.
    Hs.658713.
    Hs.726509.

    Genome annotation databases

    GeneIDi8339.
    8343.
    8344.
    8346.
    8347.
    KEGGihsa:8339.
    hsa:8343.
    hsa:8344.
    hsa:8346.
    hsa:8347.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK311935 mRNA. Translation: BAG34876.1 .
    AK312096 mRNA. Translation: BAG35032.1 .
    CH471087 Genomic DNA. Translation: EAW55530.1 .
    CH471087 Genomic DNA. Translation: EAW55531.1 .
    CH471087 Genomic DNA. Translation: EAW55537.1 .
    CH471087 Genomic DNA. Translation: EAW55543.1 .
    CH471087 Genomic DNA. Translation: EAW55545.1 .
    CH471087 Genomic DNA. Translation: EAW55554.1 .
    RefSeqi NP_003509.1. NM_003518.3.
    NP_003513.1. NM_003522.3.
    NP_003514.2. NM_003523.2.
    NP_003516.1. NM_003525.2.
    NP_003517.2. NM_003526.2.
    UniGenei Hs.182137.
    Hs.534369.
    Hs.553506.
    Hs.591797.
    Hs.591809.
    Hs.658713.
    Hs.726509.

    3D structure databases

    SMRi B2R4S9. Positions 5-126.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 8339.
    8344.
    8347.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8339.
    8343.
    8344.
    8346.
    8347.
    KEGGi hsa:8339.
    hsa:8343.
    hsa:8344.
    hsa:8346.
    hsa:8347.

    Organism-specific databases

    CTDi 8339.
    8343.
    8344.
    8346.
    8347.
    PharmGKBi PA29132.

    Phylogenomic databases

    HOGENOMi HOG000231213.
    HOVERGENi HBG007774.
    KOi K11252.
    OMAi NETYSIY.
    PhylomeDBi B2R4S9.

    Miscellaneous databases

    NextBioi 31228.

    Family and domain databases

    Gene3Di 1.10.20.10. 1 hit.
    InterProi IPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR000558. Histone_H2B.
    [Graphical view ]
    PANTHERi PTHR23428. PTHR23428. 1 hit.
    Pfami PF00125. Histone. 1 hit.
    [Graphical view ]
    PRINTSi PR00621. HISTONEH2B.
    SMARTi SM00427. H2B. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47113. SSF47113. 1 hit.
    PROSITEi PS00357. HISTONE_H2B. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of the human genome."
      Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
      , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
      Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Cited for: NUCLEOTIDE SEQUENCE.
    3. "NEDO functional analysis of protein and research application project."
      Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
      Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiB2R4S9_HUMAN
    AccessioniPrimary (citable) accession number: B2R4S9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.