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Protein
Submitted name:

Histone 1, H2bc, isoform CRA_a

Gene

HIST1H2BI

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. antibacterial humoral response Source: UniProtKB
  2. defense response to Gram-positive bacterium Source: UniProtKB
  3. innate immune response in mucosa Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Histone 1, H2bc, isoform CRA_aImported
Submitted name:
Histone 1, H2beImported
Submitted name:
Histone 1, H2bfImported
Submitted name:
Histone 1, H2bgImported
Submitted name:
Histone 1, H2biImported
Submitted name:
cDNA, FLJ92202, Homo sapiens histone 1, H2bg (HIST1H2BG), mRNAImported
Submitted name:
cDNA, FLJ92378, Homo sapiens histone 1, H2bc (HIST1H2BC), mRNAImported
Gene namesi
Name:HIST1H2BIImported
Synonyms:HIST1H2BCImported, HIST1H2BEImported, HIST1H2BFImported, HIST1H2BGImported
ORF Names:hCG_1640484Imported, hCG_1640985Imported, hCG_1641780Imported, hCG_1787353Imported, hCG_1787365Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Nucleus SAAS annotation. Chromosome SAAS annotation

GO - Cellular componenti

  1. extracellular space Source: UniProtKB
  2. nucleosome Source: UniProtKB-KW
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29132.

PTM / Processingi

Keywords - PTMi

Isopeptide bondSAAS annotation

Proteomic databases

PRIDEiB2R4S9.

Expressioni

Gene expression databases

BgeeiB2R4S9.
ExpressionAtlasiB2R4S9. baseline and differential.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB2R4S9.
SMRiB2R4S9. Positions 5-126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2B family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000231213.
HOVERGENiHBG007774.
KOiK11252.
OMAiFIHERHK.
PhylomeDBiB2R4S9.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR000558. Histone_H2B.
[Graphical view]
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00357. HISTONE_H2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2R4S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH
60 70 80 90 100
PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR
110 120
LLLPGELAKH AVSEGTKAVT KYTSSK
Length:126
Mass (Da):13,906
Last modified:June 30, 2008 - v1
Checksum:iFAE1479F44BE703D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311935 mRNA. Translation: BAG34876.1.
AK312096 mRNA. Translation: BAG35032.1.
CH471087 Genomic DNA. Translation: EAW55530.1.
CH471087 Genomic DNA. Translation: EAW55531.1.
CH471087 Genomic DNA. Translation: EAW55537.1.
CH471087 Genomic DNA. Translation: EAW55543.1.
CH471087 Genomic DNA. Translation: EAW55545.1.
CH471087 Genomic DNA. Translation: EAW55554.1.
RefSeqiNP_003509.1. NM_003518.3.
NP_003513.1. NM_003522.3.
NP_003514.2. NM_003523.2.
NP_003516.1. NM_003525.2.
NP_003517.2. NM_003526.2.
UniGeneiHs.182137.
Hs.534369.
Hs.553506.
Hs.591797.
Hs.591809.
Hs.658713.
Hs.726509.

Genome annotation databases

GeneIDi8339.
8343.
8344.
8346.
8347.
KEGGihsa:8339.
hsa:8343.
hsa:8344.
hsa:8346.
hsa:8347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311935 mRNA. Translation: BAG34876.1.
AK312096 mRNA. Translation: BAG35032.1.
CH471087 Genomic DNA. Translation: EAW55530.1.
CH471087 Genomic DNA. Translation: EAW55531.1.
CH471087 Genomic DNA. Translation: EAW55537.1.
CH471087 Genomic DNA. Translation: EAW55543.1.
CH471087 Genomic DNA. Translation: EAW55545.1.
CH471087 Genomic DNA. Translation: EAW55554.1.
RefSeqiNP_003509.1. NM_003518.3.
NP_003513.1. NM_003522.3.
NP_003514.2. NM_003523.2.
NP_003516.1. NM_003525.2.
NP_003517.2. NM_003526.2.
UniGeneiHs.182137.
Hs.534369.
Hs.553506.
Hs.591797.
Hs.591809.
Hs.658713.
Hs.726509.

3D structure databases

ProteinModelPortaliB2R4S9.
SMRiB2R4S9. Positions 5-126.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB2R4S9.

Protocols and materials databases

DNASUi8339.
8344.
8347.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8339.
8343.
8344.
8346.
8347.
KEGGihsa:8339.
hsa:8343.
hsa:8344.
hsa:8346.
hsa:8347.

Organism-specific databases

CTDi8339.
8343.
8344.
8346.
8347.
PharmGKBiPA29132.

Phylogenomic databases

HOGENOMiHOG000231213.
HOVERGENiHBG007774.
KOiK11252.
OMAiFIHERHK.
PhylomeDBiB2R4S9.

Miscellaneous databases

ChiTaRSiHIST1H2BC. human.
NextBioi31228.

Gene expression databases

BgeeiB2R4S9.
ExpressionAtlasiB2R4S9. baseline and differential.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR000558. Histone_H2B.
[Graphical view]
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00357. HISTONE_H2B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. "NEDO functional analysis of protein and research application project."
    Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiB2R4S9_HUMAN
AccessioniPrimary (citable) accession number: B2R4S9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 30, 2008
Last sequence update: June 30, 2008
Last modified: March 31, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.