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Protein

Histone H2B

Gene

HIST1H2BF

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • antibacterial humoral response Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • innate immune response in mucosa Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2BUniRule annotation
Gene namesi
Name:HIST1H2BFImported
Synonyms:HIST1H2BBImported, HIST1H2BCImported, HIST1H2BEImported, HIST1H2BGImported, HIST1H2BIImported
ORF Names:hCG_1640484Imported, hCG_1640985Imported, hCG_1641780Imported, hCG_1787353Imported, hCG_1787365Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4751. HIST1H2BB.

Subcellular locationi

  • Chromosome SAAS annotation
  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

  • cytoplasm Source: HPA
  • extracellular space Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29132.

Expressioni

Gene expression databases

BgeeiENSG00000168242.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000366962.

Structurei

3D structure databases

SMRiB2R4S9. Positions 5-126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 10193HistoneInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the histone H2B family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
HOGENOMiHOG000231213.
HOVERGENiHBG007774.
KOiK11252.
OMAiKATHAFN.
OrthoDBiEOG091G0XGD.
PhylomeDBiB2R4S9.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00357. HISTONE_H2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2R4S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH
60 70 80 90 100
PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR
110 120
LLLPGELAKH AVSEGTKAVT KYTSSK
Length:126
Mass (Da):13,906
Last modified:July 1, 2008 - v1
Checksum:iFAE1479F44BE703D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91328 Genomic DNA. No translation available.
AK311935 mRNA. Translation: BAG34876.1.
AK312096 mRNA. Translation: BAG35032.1.
CH471087 Genomic DNA. Translation: EAW55530.1.
CH471087 Genomic DNA. Translation: EAW55531.1.
CH471087 Genomic DNA. Translation: EAW55537.1.
CH471087 Genomic DNA. Translation: EAW55543.1.
CH471087 Genomic DNA. Translation: EAW55545.1.
CH471087 Genomic DNA. Translation: EAW55554.1.
RefSeqiNP_003509.1. NM_003518.3.
NP_003513.1. NM_003522.3.
NP_003514.2. NM_003523.2.
NP_003516.1. NM_003525.2.
NP_003517.2. NM_003526.2.
UniGeneiHs.182137.
Hs.534369.
Hs.553506.
Hs.591797.
Hs.591809.
Hs.658713.
Hs.726509.

Genome annotation databases

EnsembliENST00000629531; ENSP00000486472; ENSG00000276410.
GeneIDi8339.
8343.
8344.
8346.
8347.
KEGGihsa:8339.
hsa:8343.
hsa:8344.
hsa:8346.
hsa:8347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91328 Genomic DNA. No translation available.
AK311935 mRNA. Translation: BAG34876.1.
AK312096 mRNA. Translation: BAG35032.1.
CH471087 Genomic DNA. Translation: EAW55530.1.
CH471087 Genomic DNA. Translation: EAW55531.1.
CH471087 Genomic DNA. Translation: EAW55537.1.
CH471087 Genomic DNA. Translation: EAW55543.1.
CH471087 Genomic DNA. Translation: EAW55545.1.
CH471087 Genomic DNA. Translation: EAW55554.1.
RefSeqiNP_003509.1. NM_003518.3.
NP_003513.1. NM_003522.3.
NP_003514.2. NM_003523.2.
NP_003516.1. NM_003525.2.
NP_003517.2. NM_003526.2.
UniGeneiHs.182137.
Hs.534369.
Hs.553506.
Hs.591797.
Hs.591809.
Hs.658713.
Hs.726509.

3D structure databases

SMRiB2R4S9. Positions 5-126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000366962.

Protocols and materials databases

DNASUi8339.
8344.
8347.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000629531; ENSP00000486472; ENSG00000276410.
GeneIDi8339.
8343.
8344.
8346.
8347.
KEGGihsa:8339.
hsa:8343.
hsa:8344.
hsa:8346.
hsa:8347.

Organism-specific databases

CTDi8339.
8343.
8344.
8346.
8347.
HGNCiHGNC:4751. HIST1H2BB.
PharmGKBiPA29132.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
HOGENOMiHOG000231213.
HOVERGENiHBG007774.
KOiK11252.
OMAiKATHAFN.
OrthoDBiEOG091G0XGD.
PhylomeDBiB2R4S9.

Miscellaneous databases

ChiTaRSiHIST1H2BC. human.

Gene expression databases

BgeeiENSG00000168242.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00357. HISTONE_H2B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB2R4S9_HUMAN
AccessioniPrimary (citable) accession number: B2R4S9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.