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Protein

Histone H2B

Gene

HIST1H2BE

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • antibacterial humoral response Source: UniProtKB
  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • innate immune response in mucosa Source: UniProtKB

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2BUniRule annotation
Gene namesi
Name:HIST1H2BEImported
Synonyms:HIST1H2BCImported, HIST1H2BFImported, HIST1H2BGImported, HIST1H2BIImported
ORF Names:hCG_1640484Imported, hCG_1640985Imported, hCG_1641780Imported, hCG_1787353Imported, hCG_1787365Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000276410.2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29132

PTM / Processingi

Proteomic databases

PRIDEiB2R4S9

Expressioni

Gene expression databases

BgeeiENSG00000276410
ExpressionAtlasiB2R4S9 baseline and differential

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

SMRiB2R4S9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 101HistoneInterPro annotationAdd BLAST92

Sequence similaritiesi

Belongs to the histone H2B family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1744 Eukaryota
ENOG4111NV5 LUCA
HOGENOMiHOG000231213
HOVERGENiHBG007774
KOiK11252
OMAiTMAANDI
OrthoDBiEOG091G0XGD

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR000558 Histone_H2B
PANTHERiPTHR23428 PTHR23428, 1 hit
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PRINTSiPR00621 HISTONEH2B
SMARTiView protein in SMART
SM00427 H2B, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00357 HISTONE_H2B, 1 hit

Sequencei

Sequence statusi: Complete.

B2R4S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH
60 70 80 90 100
PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR
110 120
LLLPGELAKH AVSEGTKAVT KYTSSK
Length:126
Mass (Da):13,906
Last modified:July 1, 2008 - v1
Checksum:iFAE1479F44BE703D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311935 mRNA Translation: BAG34876.1
AK312096 mRNA Translation: BAG35032.1
CH471087 Genomic DNA Translation: EAW55530.1
CH471087 Genomic DNA Translation: EAW55531.1
CH471087 Genomic DNA Translation: EAW55537.1
CH471087 Genomic DNA Translation: EAW55543.1
CH471087 Genomic DNA Translation: EAW55545.1
CH471087 Genomic DNA Translation: EAW55554.1
RefSeqiNP_003509.1, NM_003518.3
NP_003513.1, NM_003522.3
NP_003514.2, NM_003523.2
NP_003516.1, NM_003525.2
NP_003517.2, NM_003526.2
UniGeneiHs.182137
Hs.534369
Hs.553506
Hs.591797
Hs.591809
Hs.658713
Hs.726509

Genome annotation databases

GeneIDi8339
8343
8344
8346
8347
KEGGihsa:8339
hsa:8343
hsa:8344
hsa:8346
hsa:8347

Similar proteinsi

Entry informationi

Entry nameiB2R4S9_HUMAN
AccessioniPrimary (citable) accession number: B2R4S9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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