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Protein

Histone H2B

Gene

HIST1H2BF

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • antibacterial humoral response Source: UniProtKB
  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • innate immune response in mucosa Source: UniProtKB

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2BUniRule annotation
Gene namesi
Name:HIST1H2BFImported
Synonyms:HIST1H2BCImported, HIST1H2BEImported, HIST1H2BGImported, HIST1H2BIImported
ORF Names:hCG_1640484Imported, hCG_1640985Imported, hCG_1641780Imported, hCG_1787353Imported, hCG_1787365Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000276410.2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29132.

Expressioni

Gene expression databases

BgeeiENSG00000276410.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotation

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 101HistoneInterPro annotationAdd BLAST92

Sequence similaritiesi

Belongs to the histone H2B family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
HOGENOMiHOG000231213.
HOVERGENiHBG007774.
KOiK11252.
OMAiTMAANDI.
OrthoDBiEOG091G0XGD.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PRINTSiPR00621. HISTONEH2B.
SMARTiView protein in SMART
SM00427. H2B. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiView protein in PROSITE
PS00357. HISTONE_H2B. 1 hit.

Sequencei

Sequence statusi: Complete.

B2R4S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH
60 70 80 90 100
PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR
110 120
LLLPGELAKH AVSEGTKAVT KYTSSK
Length:126
Mass (Da):13,906
Last modified:July 1, 2008 - v1
Checksum:iFAE1479F44BE703D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311935 mRNA. Translation: BAG34876.1.
AK312096 mRNA. Translation: BAG35032.1.
CH471087 Genomic DNA. Translation: EAW55530.1.
CH471087 Genomic DNA. Translation: EAW55531.1.
CH471087 Genomic DNA. Translation: EAW55537.1.
CH471087 Genomic DNA. Translation: EAW55543.1.
CH471087 Genomic DNA. Translation: EAW55545.1.
CH471087 Genomic DNA. Translation: EAW55554.1.
RefSeqiNP_003509.1. NM_003518.3.
NP_003513.1. NM_003522.3.
NP_003514.2. NM_003523.2.
NP_003516.1. NM_003525.2.
NP_003517.2. NM_003526.2.
UniGeneiHs.182137.
Hs.534369.
Hs.553506.
Hs.591797.
Hs.591809.
Hs.658713.
Hs.726509.

Genome annotation databases

GeneIDi8339.
8343.
8344.
8346.
8347.
KEGGihsa:8339.
hsa:8343.
hsa:8344.
hsa:8346.
hsa:8347.

Similar proteinsi

Entry informationi

Entry nameiB2R4S9_HUMAN
AccessioniPrimary (citable) accession number: B2R4S9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.