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B2R4S9

- B2R4S9_HUMAN

UniProt

B2R4S9 - B2R4S9_HUMAN

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Protein
Histone H2B
Gene
HIST1H2BC, HIST1H2BE, HIST1H2BF, HIST1H2BG, HIST1H2BI, hCG_1640484, hCG_1640985, hCG_1641780, hCG_1787353, hCG_1787365
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. antibacterial humoral response Source: UniProt
  2. defense response to Gram-positive bacterium Source: UniProt
  3. innate immune response in mucosa Source: UniProt
  4. nucleosome assembly Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2BUniRule annotation
Gene namesi
Name:HIST1H2BCImported
Synonyms:HIST1H2BEImported, HIST1H2BFImported, HIST1H2BGImported, HIST1H2BIImported
ORF Names:hCG_1640484Imported, hCG_1640985Imported, hCG_1641780Imported, hCG_1787353Imported, hCG_1787365Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Nucleus. Chromosome By similarity SAAS annotations

GO - Cellular componenti

  1. extracellular space Source: UniProt
  2. nucleosome Source: UniProtKB-KW
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotations, NucleusUniRule annotationSAAS annotations

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29132.

PTM / Processingi

Keywords - PTMi

Isopeptide bondSAAS annotations

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2B family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000231213.
HOVERGENiHBG007774.
KOiK11252.
OMAiNETYSIY.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR000558. Histone_H2B.
[Graphical view]
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00357. HISTONE_H2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2R4S9-1 [UniParc]FASTAAdd to Basket

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MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH    50
PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR 100
LLLPGELAKH AVSEGTKAVT KYTSSK 126
Length:126
Mass (Da):13,906
Last modified:July 1, 2008 - v1
Checksum:iFAE1479F44BE703D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK311935 mRNA. Translation: BAG34876.1.
AK312096 mRNA. Translation: BAG35032.1.
CH471087 Genomic DNA. Translation: EAW55530.1.
CH471087 Genomic DNA. Translation: EAW55531.1.
CH471087 Genomic DNA. Translation: EAW55537.1.
CH471087 Genomic DNA. Translation: EAW55543.1.
CH471087 Genomic DNA. Translation: EAW55545.1.
CH471087 Genomic DNA. Translation: EAW55554.1.
RefSeqiNP_003509.1. NM_003518.3.
NP_003513.1. NM_003522.3.
NP_003514.2. NM_003523.2.
NP_003516.1. NM_003525.2.
NP_003517.2. NM_003526.2.
UniGeneiHs.182137.
Hs.534369.
Hs.553506.
Hs.591797.
Hs.591809.
Hs.658713.
Hs.726509.

Genome annotation databases

GeneIDi8339.
8343.
8344.
8346.
8347.
KEGGihsa:8339.
hsa:8343.
hsa:8344.
hsa:8346.
hsa:8347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK311935 mRNA. Translation: BAG34876.1 .
AK312096 mRNA. Translation: BAG35032.1 .
CH471087 Genomic DNA. Translation: EAW55530.1 .
CH471087 Genomic DNA. Translation: EAW55531.1 .
CH471087 Genomic DNA. Translation: EAW55537.1 .
CH471087 Genomic DNA. Translation: EAW55543.1 .
CH471087 Genomic DNA. Translation: EAW55545.1 .
CH471087 Genomic DNA. Translation: EAW55554.1 .
RefSeqi NP_003509.1. NM_003518.3.
NP_003513.1. NM_003522.3.
NP_003514.2. NM_003523.2.
NP_003516.1. NM_003525.2.
NP_003517.2. NM_003526.2.
UniGenei Hs.182137.
Hs.534369.
Hs.553506.
Hs.591797.
Hs.591809.
Hs.658713.
Hs.726509.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 8339.
8344.
8347.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8339.
8343.
8344.
8346.
8347.
KEGGi hsa:8339.
hsa:8343.
hsa:8344.
hsa:8346.
hsa:8347.

Organism-specific databases

CTDi 8339.
8343.
8344.
8346.
8347.
PharmGKBi PA29132.

Phylogenomic databases

HOGENOMi HOG000231213.
HOVERGENi HBG007774.
KOi K11252.
OMAi NETYSIY.

Miscellaneous databases

NextBioi 31228.

Family and domain databases

Gene3Di 1.10.20.10. 1 hit.
InterProi IPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR000558. Histone_H2B.
[Graphical view ]
PANTHERi PTHR23428. PTHR23428. 1 hit.
Pfami PF00125. Histone. 1 hit.
[Graphical view ]
PRINTSi PR00621. HISTONEH2B.
SMARTi SM00427. H2B. 1 hit.
[Graphical view ]
SUPFAMi SSF47113. SSF47113. 1 hit.
PROSITEi PS00357. HISTONE_H2B. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. "NEDO functional analysis of protein and research application project."
    Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiB2R4S9_HUMAN
AccessioniPrimary (citable) accession number: B2R4S9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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