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B2R4R0

- B2R4R0_HUMAN

UniProt

B2R4R0 - B2R4R0_HUMAN

Protein

Histone H4

Gene

HIST1H4H

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. nucleosome assembly Source: InterPro

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone H4UniRule annotation
    Gene namesi
    Name:HIST1H4HImported
    Synonyms:HIST1H4JImported, HIST1H4LImported
    ORF Names:hCG_1640981Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    Nucleus SAAS annotation. Chromosome SAAS annotation

    GO - Cellular componenti

    1. nucleosome Source: UniProtKB-KW
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29169.

    Interactioni

    Subunit structurei

    The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotation

    Structurei

    3D structure databases

    SMRiB2R4R0. Positions 21-102.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone H4 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2036.
    HOVERGENiHBG051878.
    KOiK11254.
    OMAiYEEVRVV.
    PhylomeDBiB2R4R0.

    Family and domain databases

    Gene3Di1.10.20.10. 1 hit.
    InterProiIPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR001951. Histone_H4.
    IPR019809. Histone_H4_CS.
    [Graphical view]
    PfamiPF00125. Histone. 1 hit.
    [Graphical view]
    PRINTSiPR00623. HISTONEH4.
    SMARTiSM00417. H4. 1 hit.
    [Graphical view]
    SUPFAMiSSF47113. SSF47113. 1 hit.
    PROSITEiPS00047. HISTONE_H4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2R4R0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL    50
    IYEETRGVLK VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG 100
    FGG 103
    Length:103
    Mass (Da):11,367
    Last modified:July 1, 2008 - v1
    Checksum:iA9E5DFD3F8B97598
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei103 – 1031Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC148271 mRNA. Translation: AAI48272.1.
    AK311916 mRNA. Translation: BAG34857.1.
    AK312028 mRNA. Translation: BAG34965.1.
    AK312153 mRNA. Translation: BAG35087.1.
    AK316561 mRNA. Translation: BAG38150.1.
    AB451459 mRNA. Translation: BAG70273.1.
    CH471087 Genomic DNA. Translation: EAW55556.1.
    RefSeqiNP_001029249.1. NM_001034077.4.
    NP_003486.1. NM_003495.2.
    NP_003529.1. NM_003538.3.
    NP_003530.1. NM_003539.3.
    NP_003531.1. NM_003540.3.
    NP_003532.1. NM_003541.2.
    NP_003533.1. NM_003542.3.
    NP_003534.1. NM_003543.3.
    NP_003535.1. NM_003544.2.
    NP_003536.1. NM_003545.3.
    NP_003537.1. NM_003546.2.
    NP_003539.1. NM_003548.2.
    NP_068803.1. NM_021968.3.
    NP_778224.1. NM_175054.2.
    UniGeneiHs.143080.
    Hs.247816.
    Hs.248172.
    Hs.248178.
    Hs.248179.
    Hs.278483.
    Hs.46423.
    Hs.528055.
    Hs.533295.
    Hs.55468.
    Hs.591790.
    Hs.655235.
    Hs.662174.
    Hs.706635.
    Hs.745457.

    Genome annotation databases

    GeneIDi121504.
    554313.
    8294.
    8359.
    8360.
    8361.
    8362.
    8363.
    8364.
    8365.
    8366.
    8367.
    8368.
    8370.
    KEGGihsa:121504.
    hsa:554313.
    hsa:8294.
    hsa:8359.
    hsa:8360.
    hsa:8361.
    hsa:8362.
    hsa:8363.
    hsa:8364.
    hsa:8365.
    hsa:8366.
    hsa:8367.
    hsa:8368.
    hsa:8370.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC148271 mRNA. Translation: AAI48272.1 .
    AK311916 mRNA. Translation: BAG34857.1 .
    AK312028 mRNA. Translation: BAG34965.1 .
    AK312153 mRNA. Translation: BAG35087.1 .
    AK316561 mRNA. Translation: BAG38150.1 .
    AB451459 mRNA. Translation: BAG70273.1 .
    CH471087 Genomic DNA. Translation: EAW55556.1 .
    RefSeqi NP_001029249.1. NM_001034077.4.
    NP_003486.1. NM_003495.2.
    NP_003529.1. NM_003538.3.
    NP_003530.1. NM_003539.3.
    NP_003531.1. NM_003540.3.
    NP_003532.1. NM_003541.2.
    NP_003533.1. NM_003542.3.
    NP_003534.1. NM_003543.3.
    NP_003535.1. NM_003544.2.
    NP_003536.1. NM_003545.3.
    NP_003537.1. NM_003546.2.
    NP_003539.1. NM_003548.2.
    NP_068803.1. NM_021968.3.
    NP_778224.1. NM_175054.2.
    UniGenei Hs.143080.
    Hs.247816.
    Hs.248172.
    Hs.248178.
    Hs.248179.
    Hs.278483.
    Hs.46423.
    Hs.528055.
    Hs.533295.
    Hs.55468.
    Hs.591790.
    Hs.655235.
    Hs.662174.
    Hs.706635.
    Hs.745457.

    3D structure databases

    SMRi B2R4R0. Positions 21-102.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 8294.
    8360.
    8362.
    8363.
    8364.
    8365.
    8366.
    8367.
    8368.
    8370.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 121504.
    554313.
    8294.
    8359.
    8360.
    8361.
    8362.
    8363.
    8364.
    8365.
    8366.
    8367.
    8368.
    8370.
    KEGGi hsa:121504.
    hsa:554313.
    hsa:8294.
    hsa:8359.
    hsa:8360.
    hsa:8361.
    hsa:8362.
    hsa:8363.
    hsa:8364.
    hsa:8365.
    hsa:8366.
    hsa:8367.
    hsa:8368.
    hsa:8370.

    Organism-specific databases

    CTDi 121504.
    554313.
    8294.
    8359.
    8360.
    8361.
    8362.
    8363.
    8364.
    8365.
    8366.
    8367.
    8368.
    8370.
    PharmGKBi PA29169.

    Phylogenomic databases

    eggNOGi COG2036.
    HOVERGENi HBG051878.
    KOi K11254.
    OMAi YEEVRVV.
    PhylomeDBi B2R4R0.

    Miscellaneous databases

    NextBioi 31093.

    Family and domain databases

    Gene3Di 1.10.20.10. 1 hit.
    InterProi IPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR001951. Histone_H4.
    IPR019809. Histone_H4_CS.
    [Graphical view ]
    Pfami PF00125. Histone. 1 hit.
    [Graphical view ]
    PRINTSi PR00623. HISTONEH4.
    SMARTi SM00417. H4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47113. SSF47113. 1 hit.
    PROSITEi PS00047. HISTONE_H4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of the human genome."
      Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
      , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
      Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE.
    4. "NEDO functional analysis of protein and research application project."
      Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
      Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Corpus callosumImported, TongueImported and UterusImported.
    5. "NEDO functional analysis of protein and research application project."
      Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T.
      Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: EsophagusImported.
    6. "Human Protein Factory: an infrastructure to convert the human transcriptome into the in vitro-expressed human proteome of versatile utility."
      Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J.-I., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
      , Kenmochi K.-I., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J.-I., Watanabe S., Nomura N.
      Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiB2R4R0_HUMAN
    AccessioniPrimary (citable) accession number: B2R4R0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.