B2PNE9 (B2PNE9_ECO57) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolase PIRNR PIRNR001361
EC=2.5.1.54 PIRNR PIRNR001361

Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase PIRNR PIRNR001361
DAHP synthase PIRNR PIRNR001361
Phospho-2-keto-3-deoxyheptonate aldolase PIRNR PIRNR001361

Gene names

Name:	aroH EMBL EDU69310.1
ORF Names:	ECH7EC4076_4435 EMBL EDU69310.1

Organism

Escherichia coli O157:H7 str. EC4076 EMBL EDU69310.1

Taxonomic identifier

444453 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) By similarity. PIRNR PIRNR001361
Catalytic activity	Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. PIRNR PIRNR001361
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7. PIRNR PIRNR001361
Sequence similarities	Belongs to the class-I DAHP synthase family. PIRNR PIRNR001361

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis PIRNR PIRNR001361
Molecular function	Transferase PIRNR PIRNR001361 EMBL EDU69310.1
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B2PNE9 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: AAB751FA13EB47C1	FASTA	348	38,719
	10 20 30 40 50 60 MNRTDELRTA RIESLVTPAE LALRYPVTPG VATHVTDSRR RIEKILNGED KRLLVIIGPC 70 80 90 100 110 120 SIHDLTAAME YATRLQSLRN QYQSRLEIVM RTYFEKPRTV VGWKGLISDP DLNGSYRINH 130 140 150 160 170 180 GLELARKLLL QVNELGVPTA TEFLDMVTGQ FIADLISWGA IGARTTESQI HREMASALSC 190 200 210 220 230 240 PVGFKNGTDG NTRIAVDAIR AARASHMFLS PDKNGQMTIY QTSGNPYGHI IMRGGKKPNY 250 260 270 280 290 300 HADDIAAACD TLHEFDLPEH LVVDFSHGNC QKQHRRQLEV CEDICQQIRN GSTAIAGIMA 310 320 330 340 ESFLREGTQK IVGGQPLTYG QSITDPCLGW EDTERLVEKL ASAVDTRF

References

[1]	"Annotation of Escherichia coli O157:H7 str. EC4076." Eppinger M., Ravel J., Mammel M.K., LeClerc J.E., Cebula T.A., Sebastian Y. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: EC4076 EMBL EDU69310.1.
[2]	Rosovitz M.J., Ravel J. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: EC4076 EMBL EDU69310.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ABHQ01000013 Genomic DNA. Translation: EDU69310.1.
3D structure databases
ProteinModelPortal	B2PNE9.
SMR	B2PNE9. Positions 2-347.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	26588635. VBIEscCol87564_3504.
Phylogenomic databases
OMA	ELFIVMR.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006219. DHAP_synth_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR21225. AroFGH. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
PIRSF	PIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMs	TIGR00034. AroFGH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B2PNE9_ECO57

Accession

Primary (citable) accession number: B2PNE9

Entry history

Integrated into UniProtKB/TrEMBL:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)