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Protein
Submitted name:

AIRE

Gene

Aire

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
AIREImported
Submitted name:
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy), isoform CRA_kImported
Submitted name:
Autoimmune regulator AIRE1aImported
Gene namesi
Name:AireImported
ORF Names:mCG_5980Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1338803 Aire

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000000731
ExpressionAtlasiB2MVU6 baseline and differential

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 106HSRInterPro annotationAdd BLAST106
Domaini182 – 282SANDInterPro annotationAdd BLAST101
Domaini298 – 345PHD-typeInterPro annotationAdd BLAST48

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IRE7 Eukaryota
ENOG410XQQA LUCA
HOGENOMiHOG000033872
HOVERGENiHBG014961
KOiK10603
OMAiLLSEHTF
OrthoDBiEOG091G055U

Family and domain databases

Gene3Di3.10.390.10, 1 hit
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR008087 AIRE
IPR004865 HSR_dom
IPR010919 SAND-like_dom_sf
IPR000770 SAND_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF03172 HSR, 1 hit
PF00628 PHD, 1 hit
PF01342 SAND, 1 hit
PRINTSiPR01711 AIREGULATOR
SMARTiView protein in SMART
SM00249 PHD, 2 hits
SM00258 SAND, 1 hit
SUPFAMiSSF57903 SSF57903, 2 hits
SSF63763 SSF63763, 1 hit
PROSITEiView protein in PROSITE
PS51414 HSR, 1 hit
PS50864 SAND, 1 hit
PS01359 ZF_PHD_1, 2 hits
PS50016 ZF_PHD_2, 1 hit

Sequencei

Sequence statusi: Complete.

B2MVU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGDGMLRR LLRLHRTEIA VAIDSAFPLL HALADHDVVP EDKFQETLRL
60 70 80 90 100
KEKEGCPQAF HALLSWLLTR DSGAILDFWR ILFKDYNLER YSRLHSILDG
110 120 130 140 150
FPKDVDLNQS RKGRKPLAGP KAAVLPPRPP TKRKALEEPR ATPPATLASK
160 170 180 190 200
SVSSPGSHLK TKPPKKPDGN LESQHLPLGN GIQTMAASVQ RAVTVASGDV
210 220 230 240 250
PGTRGAVEGI LIQQVFESGR SKKCIQVGGE FYTPNKFEDP SGNLKNKARS
260 270 280 290 300
GSSLKPVVRA KGAQVTIPGR DEQKVGQQCG VPPLPSLPSE PQVNQKNEDE
310 320 330 340 350
CAVCHDGGEL ICCDGCPRAF HLACLSPPLQ EIPSGLWRCS CCLQGRVQQN
360 370 380 390 400
LSQPEVSRPP ELPAETPILV GLRSASEKTR GPSRELKASS DAAVTYVNLL
410 420 430 440 450
APHPAAPLLE PSALCPLLSA GNEGRPGPAP SARCSVCGDG TEVLRCAHCA
460 470 480 490 500
AAFHWRCHFP TAAARPGTNL RCKSCSADST PTPGTPGEAV PTSGPRPAPG
510 520 530 540 550
LAKVGDDSAS HDPVLHRDDL ESLLNEHSFD GILQWAIQSM SRPLAETPPF

SS
Length:552
Mass (Da):59,042
Last modified:February 10, 2009 - v3
Checksum:iBF30F8F66B71239A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU625343 mRNA Translation: ACC85597.3
JF267399 mRNA Translation: ADZ48462.1
CH466553 Genomic DNA Translation: EDL31760.1
RefSeqiNP_033776.1, NM_009646.2
UniGeneiMm.35300

Genome annotation databases

GeneIDi11634
KEGGimmu:11634

Similar proteinsi

Entry informationi

Entry nameiB2MVU6_MOUSE
AccessioniPrimary (citable) accession number: B2MVU6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: February 10, 2009
Last modified: April 25, 2018
This is version 91 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health