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Protein
Submitted name:

AIRE

Gene

Aire

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
AIREImported
Submitted name:
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy), isoform CRA_kImported
Submitted name:
Autoimmune regulator AIRE1aImported
Gene namesi
Name:AireImported
ORF Names:mCG_5980Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1338803. Aire.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000114904.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 106106HSRInterPro annotationAdd
BLAST
Domaini182 – 282101SANDInterPro annotationAdd
BLAST
Domaini298 – 34548PHD-typeInterPro annotationAdd
BLAST

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiENOG410IRE7. Eukaryota.
ENOG410XQQA. LUCA.
HOGENOMiHOG000033872.
HOVERGENiHBG014961.
KOiK10603.
OMAiLLSEHTF.

Family and domain databases

Gene3Di3.10.390.10. 1 hit.
3.30.40.10. 2 hits.
InterProiIPR008087. AIRE.
IPR004865. HSR_dom.
IPR000770. SAND_dom.
IPR010919. SAND_dom-like.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
PF01342. SAND. 1 hit.
PF03172. Sp100. 1 hit.
[Graphical view]
PRINTSiPR01711. AIREGULATOR.
SMARTiSM00249. PHD. 2 hits.
SM00258. SAND. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 2 hits.
SSF63763. SSF63763. 1 hit.
PROSITEiPS51414. HSR. 1 hit.
PS50864. SAND. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2MVU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGDGMLRR LLRLHRTEIA VAIDSAFPLL HALADHDVVP EDKFQETLRL
60 70 80 90 100
KEKEGCPQAF HALLSWLLTR DSGAILDFWR ILFKDYNLER YSRLHSILDG
110 120 130 140 150
FPKDVDLNQS RKGRKPLAGP KAAVLPPRPP TKRKALEEPR ATPPATLASK
160 170 180 190 200
SVSSPGSHLK TKPPKKPDGN LESQHLPLGN GIQTMAASVQ RAVTVASGDV
210 220 230 240 250
PGTRGAVEGI LIQQVFESGR SKKCIQVGGE FYTPNKFEDP SGNLKNKARS
260 270 280 290 300
GSSLKPVVRA KGAQVTIPGR DEQKVGQQCG VPPLPSLPSE PQVNQKNEDE
310 320 330 340 350
CAVCHDGGEL ICCDGCPRAF HLACLSPPLQ EIPSGLWRCS CCLQGRVQQN
360 370 380 390 400
LSQPEVSRPP ELPAETPILV GLRSASEKTR GPSRELKASS DAAVTYVNLL
410 420 430 440 450
APHPAAPLLE PSALCPLLSA GNEGRPGPAP SARCSVCGDG TEVLRCAHCA
460 470 480 490 500
AAFHWRCHFP TAAARPGTNL RCKSCSADST PTPGTPGEAV PTSGPRPAPG
510 520 530 540 550
LAKVGDDSAS HDPVLHRDDL ESLLNEHSFD GILQWAIQSM SRPLAETPPF

SS
Length:552
Mass (Da):59,042
Last modified:February 10, 2009 - v3
Checksum:iBF30F8F66B71239A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU625343 mRNA. Translation: ACC85597.3.
JF267399 mRNA. Translation: ADZ48462.1.
CH466553 Genomic DNA. Translation: EDL31760.1.
RefSeqiNP_033776.1. NM_009646.2.
UniGeneiMm.35300.

Genome annotation databases

GeneIDi11634.
KEGGimmu:11634.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU625343 mRNA. Translation: ACC85597.3.
JF267399 mRNA. Translation: ADZ48462.1.
CH466553 Genomic DNA. Translation: EDL31760.1.
RefSeqiNP_033776.1. NM_009646.2.
UniGeneiMm.35300.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000114904.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11634.
KEGGimmu:11634.

Organism-specific databases

CTDi326.
MGIiMGI:1338803. Aire.

Phylogenomic databases

eggNOGiENOG410IRE7. Eukaryota.
ENOG410XQQA. LUCA.
HOGENOMiHOG000033872.
HOVERGENiHBG014961.
KOiK10603.
OMAiLLSEHTF.

Miscellaneous databases

ChiTaRSiAire. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di3.10.390.10. 1 hit.
3.30.40.10. 2 hits.
InterProiIPR008087. AIRE.
IPR004865. HSR_dom.
IPR000770. SAND_dom.
IPR010919. SAND_dom-like.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
PF01342. SAND. 1 hit.
PF03172. Sp100. 1 hit.
[Graphical view]
PRINTSiPR01711. AIREGULATOR.
SMARTiSM00249. PHD. 2 hits.
SM00258. SAND. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 2 hits.
SSF63763. SSF63763. 1 hit.
PROSITEiPS51414. HSR. 1 hit.
PS50864. SAND. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. "AIRE1a is expressed in testicular germline and its introduction into the oocyte by spermatozoa during fertilization correlates with cyclin B2 breakdown."
    Brahmaraju M., Shiny T., Sebastian A., Laloraya M., Kumar P.G.
    Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Swiss AlbinoImported.
    Tissue: TestisImported.
  4. "AIRE expression during embryo implantation in mouse uteri."
    Renjini A.P., Soumya V., Laloraya M.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Swiss AlbinoImported.

Entry informationi

Entry nameiB2MVU6_MOUSE
AccessioniPrimary (citable) accession number: B2MVU6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: February 10, 2009
Last modified: July 6, 2016
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.