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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic

Gene

accD

Organism
Guizotia abyssinica (Niger) (Ramtilla)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.UniRule annotation

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi223ZincUniRule annotation1
Metal bindingi226ZincUniRule annotation1
Metal bindingi242ZincUniRule annotation1
Metal bindingi245ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri223 – 245C4-typeUniRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplasticUniRule annotation (EC:6.4.1.2UniRule annotation)
Short name:
ACCase subunit betaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit betaUniRule annotation
Gene namesi
Name:accDUniRule annotation
Ordered Locus Names:GuabCp030
Encoded oniPlastid; Chloroplast
OrganismiGuizotia abyssinica (Niger) (Ramtilla)
Taxonomic identifieri4230 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsAsteralesAsteraceaeAsteroideaeHeliantheae allianceMillerieaeGuizotia

Subcellular locationi

  • Plastidchloroplast stroma UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003591421 – 483Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplasticAdd BLAST483

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein, biotin carboxylase and 2 subunits each of ACCase subunit alpha and ACCase plastid-coded subunit beta (accD).By similarity

Structurei

3D structure databases

SMRiB2LMK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini219 – 483CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST265

Sequence similaritiesi

Belongs to the AccD/PCCB family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri223 – 245C4-typeUniRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Family and domain databases

HAMAPiMF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00515. accD. 1 hit.
PROSITEiView protein in PROSITE
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

B2LMK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRWWFNSML FKKEFEHRCR LSKSTSSLGP IENAIESKDP NINDTDKNIQ
60 70 80 90 100
SWGGHDNYSN VDLFFGVKDI RNFISDDTFL VKDSNGDIYS IYFDIENHIF
110 120 130 140 150
EIDNDHSFCS ELESSFYRNS SYLNNGSKSK NPQHDPYMND TQYTWNNHIN
160 170 180 190 200
SCIDSYLQSQ ICIDSYIVSG SDNSSNNYIS SSICCESGNS SKNADARTSD
210 220 230 240 250
QIIRESSTDL DVTQKYRHLW VQCENCYGLN YKKFFKSKMN LCEQCGYHLK
260 270 280 290 300
MSSSDRIELS IDPGTWEPMD EDMVSLDPIE FHSEEEPYKN RIDSYQRKTG
310 320 330 340 350
LTEAVQTGIG QLDGINVAIA VMDFQFMGGS MGSVVGEKIT RLIEYATKEF
360 370 380 390 400
LPLIIVCASG GARMQEGSLS LMQMAKISSA LYDYQSNKKL FYVPILTSPT
410 420 430 440 450
TGGVTASFGM LGDIIIAEPN AYIAFAGKRV IEQTLNKTVP DGSQAAEYLF
460 470 480
QKGLFDLIVP RNPLKSVLSE LFQLHTFFPL NQN
Length:483
Mass (Da):54,723
Last modified:June 10, 2008 - v1
Checksum:i1B4F970B338A23FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU549769 Genomic DNA. Translation: ACB86536.1.
RefSeqiYP_001837369.1. NC_010601.1.

Genome annotation databases

GeneIDi6219076.

Similar proteinsi

Entry informationi

Entry nameiACCD_GUIAB
AccessioniPrimary (citable) accession number: B2LMK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: June 10, 2008
Last modified: May 10, 2017
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families