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B2L109

- B2L109_HORSE

UniProt

B2L109 - B2L109_HORSE

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Protein
Submitted name:

Glycogen synthase

Gene

GYS1

Organism
Equus caballus (Horse)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. glycogen (starch) synthase activity Source: UniProtKB-EC
  2. glycogen synthase activity, transferring glucose-1-phosphate Source: Ensembl

GO - Biological processi

  1. glycogen biosynthetic process Source: InterPro
  2. heart development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseImported, Transferase

Protein family/group databases

CAZyiGT3. Glycosyltransferase Family 3.

Names & Taxonomyi

Protein namesi
Submitted name:
Glycogen synthaseImported
Submitted name:
Glycogen synthase 1 (Muscle)Imported (EC:2.4.1.11Imported)
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:GYS1Imported
OrganismiEquus caballus (Horse)Imported
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281: Chromosome 10

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. inclusion body Source: Ensembl
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000018612.
HOGENOMiHOG000160890.
HOVERGENiHBG001960.
InParanoidiB2L109.
KOiK00693.
OMAiFAMKRHG.
OrthoDBiEOG741Z1N.
TreeFamiTF300306.

Family and domain databases

InterProiIPR008631. Glycogen_synth.
[Graphical view]
PANTHERiPTHR10176. PTHR10176. 1 hit.
PfamiPF05693. Glycogen_syn. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2L109-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLNRTLSMS SLPGLDDWED EFDLENTVLF EVAWEVANKV GGIYTVLQTK
60 70 80 90 100
AKVTGDEWGD NYYLVGPYTE QGVRTQVELL EPPTPALKRT LDSMNSKGCK
110 120 130 140 150
VYFGRWLIEG GPLVVLLDVG ASAWALERWK GELWDTCNIG VPWYDREAND
160 170 180 190 200
AVLFGFLTTW FLGEFLAQSE EKPHVVAHFH EWLAGIGLCL CRARRLPVAT
210 220 230 240 250
IFTTHATLLG RYLCAGAVDF YNNLENFNVD KEAGERQIYH RYCMERAAAH
260 270 280 290 300
CTHVFTTVSQ ITAIEAQHLL KRKPDIVTPN GLNVKKFSAM HEFQNLHAQS
310 320 330 340 350
KARIQEFVRG HFYGHLDFNL DKTLYFFIAG RYEFSNKGAD VFLEALARLN
360 370 380 390 400
YLLRVNGSEQ TVVAFFIMPA RTNNFNVETL KGQAVRKQLW DTANTVKEKF
410 420 430 440 450
GRKLYESLLV GSLPDMNKML DKEDFTMMKR AIFATQRQSF PPVCTHNMLD
460 470 480 490 500
DSSDPILTTI RRIGLFNSSA DRVKVIFHPE FLSSTSPLLP VDYEEFVRGC
510 520 530 540 550
HLGVFPSYYE PWGYTPAECT VMGIPSISTN LSGFGCFMEE HIADPSAYGI
560 570 580 590 600
YILDRRFRSL DDSCSQLTSF LYSFCQQSRR QRIIQRNRTE RLSDLLDWKY
610 620 630 640 650
LGRYYMSARH MALAKAFPEH FTYEPREADA TQGYRYPRPA SVPPSPSLSR
660 670 680 690 700
HSSPHQSEDE EEPRDVPPDE DSERYDEDEE AAKDRRNIRA PEWPRRASCT
710 720 730
SSTSGSKRGS VDTGPSSSLS TPSEPLSPAS SLGEERN
Length:737
Mass (Da):83,896
Last modified:June 10, 2008 - v1
Checksum:i5F01E0C31E482363
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU373801 mRNA. Translation: ACB14276.1.
AB522619 mRNA. Translation: BAI79302.1.
RefSeqiNP_001119597.2. NM_001126125.2.
UniGeneiEca.16827.

Genome annotation databases

EnsembliENSECAT00000023453; ENSECAP00000019426; ENSECAG00000021428.
GeneIDi100054723.
KEGGiecb:100054723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU373801 mRNA. Translation: ACB14276.1 .
AB522619 mRNA. Translation: BAI79302.1 .
RefSeqi NP_001119597.2. NM_001126125.2.
UniGenei Eca.16827.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT3. Glycosyltransferase Family 3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSECAT00000023453 ; ENSECAP00000019426 ; ENSECAG00000021428 .
GeneIDi 100054723.
KEGGi ecb:100054723.

Organism-specific databases

CTDi 2997.

Phylogenomic databases

GeneTreei ENSGT00390000018612.
HOGENOMi HOG000160890.
HOVERGENi HBG001960.
InParanoidi B2L109.
KOi K00693.
OMAi FAMKRHG.
OrthoDBi EOG741Z1N.
TreeFami TF300306.

Family and domain databases

InterProi IPR008631. Glycogen_synth.
[Graphical view ]
PANTHERi PTHR10176. PTHR10176. 1 hit.
Pfami PF05693. Glycogen_syn. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Glycogen synthase (GYS1) mutation causes a novel skeletal muscle glycogenosis."
    McCue M.E., Valberg S.J., Miller M.B., Wade C., DiMauro S., Akman H.O., Mickelson J.R.
    Genomics 91:458-466(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Genome sequence, comparative analysis, and population genetics of the domestic horse."
    Broad Institute Genome Sequencing Platform, Broad Institute Whole Genome Assembly Team
    Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.
    , Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.
    Science 326:865-867(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ThoroughbredImported.
  3. "Molecular characterization of glycogen synthase 1 and its tissue expression profile with type II hexokinase and muscle-type phosphofructokinase in horses."
    Echigoya Y., Okabe H., Itou T., Endo H., Sakai T.
    Mol. Biol. Rep. 38:461-469(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Skeletal muscleImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: ThoroughbredImported.

Entry informationi

Entry nameiB2L109_HORSE
AccessioniPrimary (citable) accession number: B2L109
Entry historyi
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: October 29, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3