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B2L109

- B2L109_HORSE

UniProt

B2L109 - B2L109_HORSE

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Protein
Submitted name: Glycogen synthase
Gene
GYS1
Organism
Equus caballus (Horse)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. glycogen (starch) synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycogen biosynthetic process Source: InterPro
  2. heart development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseImported, Transferase

Protein family/group databases

CAZyiGT3. Glycosyltransferase Family 3.

Names & Taxonomyi

Protein namesi
Submitted name:
Glycogen synthaseImported
Submitted name:
Glycogen synthase 1 (Muscle)Imported (EC:2.4.1.11Imported)
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:GYS1Imported
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281: Chromosome 10

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. inclusion body Source: Ensembl
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000018612.
HOGENOMiHOG000160890.
HOVERGENiHBG001960.
KOiK00693.
OMAiFAMKRHG.
OrthoDBiEOG741Z1N.
TreeFamiTF300306.

Family and domain databases

InterProiIPR008631. Glycogen_synth.
[Graphical view]
PANTHERiPTHR10176. PTHR10176. 1 hit.
PfamiPF05693. Glycogen_syn. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2L109-1 [UniParc]FASTAAdd to Basket

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MPLNRTLSMS SLPGLDDWED EFDLENTVLF EVAWEVANKV GGIYTVLQTK    50
AKVTGDEWGD NYYLVGPYTE QGVRTQVELL EPPTPALKRT LDSMNSKGCK 100
VYFGRWLIEG GPLVVLLDVG ASAWALERWK GELWDTCNIG VPWYDREAND 150
AVLFGFLTTW FLGEFLAQSE EKPHVVAHFH EWLAGIGLCL CRARRLPVAT 200
IFTTHATLLG RYLCAGAVDF YNNLENFNVD KEAGERQIYH RYCMERAAAH 250
CTHVFTTVSQ ITAIEAQHLL KRKPDIVTPN GLNVKKFSAM HEFQNLHAQS 300
KARIQEFVRG HFYGHLDFNL DKTLYFFIAG RYEFSNKGAD VFLEALARLN 350
YLLRVNGSEQ TVVAFFIMPA RTNNFNVETL KGQAVRKQLW DTANTVKEKF 400
GRKLYESLLV GSLPDMNKML DKEDFTMMKR AIFATQRQSF PPVCTHNMLD 450
DSSDPILTTI RRIGLFNSSA DRVKVIFHPE FLSSTSPLLP VDYEEFVRGC 500
HLGVFPSYYE PWGYTPAECT VMGIPSISTN LSGFGCFMEE HIADPSAYGI 550
YILDRRFRSL DDSCSQLTSF LYSFCQQSRR QRIIQRNRTE RLSDLLDWKY 600
LGRYYMSARH MALAKAFPEH FTYEPREADA TQGYRYPRPA SVPPSPSLSR 650
HSSPHQSEDE EEPRDVPPDE DSERYDEDEE AAKDRRNIRA PEWPRRASCT 700
SSTSGSKRGS VDTGPSSSLS TPSEPLSPAS SLGEERN 737
Length:737
Mass (Da):83,896
Last modified:June 10, 2008 - v1
Checksum:i5F01E0C31E482363
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU373801 mRNA. Translation: ACB14276.1.
AB522619 mRNA. Translation: BAI79302.1.
RefSeqiNP_001119597.2. NM_001126125.2.
UniGeneiEca.16827.

Genome annotation databases

EnsembliENSECAT00000023453; ENSECAP00000019426; ENSECAG00000021428.
GeneIDi100054723.
KEGGiecb:100054723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU373801 mRNA. Translation: ACB14276.1 .
AB522619 mRNA. Translation: BAI79302.1 .
RefSeqi NP_001119597.2. NM_001126125.2.
UniGenei Eca.16827.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT3. Glycosyltransferase Family 3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSECAT00000023453 ; ENSECAP00000019426 ; ENSECAG00000021428 .
GeneIDi 100054723.
KEGGi ecb:100054723.

Organism-specific databases

CTDi 2997.

Phylogenomic databases

GeneTreei ENSGT00390000018612.
HOGENOMi HOG000160890.
HOVERGENi HBG001960.
KOi K00693.
OMAi FAMKRHG.
OrthoDBi EOG741Z1N.
TreeFami TF300306.

Family and domain databases

InterProi IPR008631. Glycogen_synth.
[Graphical view ]
PANTHERi PTHR10176. PTHR10176. 1 hit.
Pfami PF05693. Glycogen_syn. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Glycogen synthase (GYS1) mutation causes a novel skeletal muscle glycogenosis."
    McCue M.E., Valberg S.J., Miller M.B., Wade C., DiMauro S., Akman H.O., Mickelson J.R.
    Genomics 91:458-466(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Genome sequence, comparative analysis, and population genetics of the domestic horse."
    Broad Institute Genome Sequencing Platform, Broad Institute Whole Genome Assembly Team
    Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.
    , Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.
    Science 326:865-867(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ThoroughbredImported.
  3. "Molecular characterization of glycogen synthase 1 and its tissue expression profile with type II hexokinase and muscle-type phosphofructokinase in horses."
    Echigoya Y., Okabe H., Itou T., Endo H., Sakai T.
    Mol. Biol. Rep. 38:461-469(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Skeletal muscleImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: ThoroughbredImported.

Entry informationi

Entry nameiB2L109_HORSE
AccessioniPrimary (citable) accession number: B2L109
Entry historyi
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: February 19, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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