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B2KGV5

- B2KGV5_MOUSE

UniProt

B2KGV5 - B2KGV5_MOUSE

Protein
Submitted name:

GTPase KRas

Gene

Kras

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. GDP binding Source: Ensembl
    2. GMP binding Source: Ensembl
    3. GTPase activity Source: MGI
    4. GTP binding Source: UniProtKB-KW
    5. protein complex binding Source: MGI

    GO - Biological processi

    1. actin cytoskeleton organization Source: MGI
    2. apoptotic process Source: Ensembl
    3. cell cycle arrest Source: Ensembl
    4. cellular senescence Source: Ensembl
    5. cytokine-mediated signaling pathway Source: Ensembl
    6. epithelial tube branching involved in lung morphogenesis Source: MGI
    7. mitotic cell cycle checkpoint Source: Ensembl
    8. negative regulation of cell differentiation Source: MGI
    9. negative regulation of cell proliferation Source: Ensembl
    10. negative regulation of gene expression Source: Ensembl
    11. negative regulation of neuron apoptotic process Source: MGI
    12. negative regulation of Rho GTPase activity Source: Ensembl
    13. positive regulation of actin cytoskeleton reorganization Source: Ensembl
    14. positive regulation of cell migration Source: Ensembl
    15. positive regulation of cell proliferation Source: MGI
    16. positive regulation of DNA replication Source: Ensembl
    17. positive regulation of epithelial cell proliferation Source: Ensembl
    18. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    19. positive regulation of JNK cascade Source: Ensembl
    20. positive regulation of MAP kinase activity Source: Ensembl
    21. positive regulation of miRNA metabolic process Source: Ensembl
    22. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
    23. positive regulation of nitric-oxide synthase activity Source: Ensembl
    24. positive regulation of Rac GTPase activity Source: Ensembl
    25. positive regulation of Rac protein signal transduction Source: MGI
    26. positive regulation of ruffle assembly Source: Ensembl
    27. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    28. positive regulation of wound healing Source: Ensembl
    29. protein heterooligomerization Source: Ensembl
    30. Ras protein signal transduction Source: MGI
    31. regulation of long-term neuronal synaptic plasticity Source: MGI
    32. regulation of synaptic transmission, GABAergic Source: MGI
    33. response to glucocorticoid Source: Ensembl
    34. response to mineralocorticoid Source: Ensembl
    35. social behavior Source: Ensembl
    36. striated muscle cell differentiation Source: MGI
    37. visual learning Source: MGI

    Keywords - Ligandi

    GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_188185. DAP12 signaling.
    REACT_188528. GRB2 events in ERBB2 signaling.
    REACT_188530. FCERI mediated MAPK activation.
    REACT_188574. SHC1 events in ERBB2 signaling.
    REACT_188578. Signaling by SCF-KIT.
    REACT_188580. SHC1 events in ERBB4 signaling.
    REACT_196455. Signaling by FGFR mutants.
    REACT_198350. EGFR Transactivation by Gastrin.
    REACT_199122. Activation of RAS in B cells.
    REACT_199123. Signaling by constitutively active EGFR.
    REACT_207601. p38MAPK events.
    REACT_211860. Tie2 Signaling.
    REACT_94437. SHC-mediated cascade.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    GTPase KRasImported
    Gene namesi
    Name:KrasImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:96680. Kras.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: Ensembl
    2. membrane Source: MGI
    3. membrane raft Source: Ensembl
    4. mitochondrion Source: Ensembl
    5. plasma membrane Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PaxDbiB2KGV5.
    PRIDEiB2KGV5.

    Expressioni

    Gene expression databases

    ArrayExpressiB2KGV5.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000032397.

    Structurei

    3D structure databases

    ProteinModelPortaliB2KGV5.
    SMRiB2KGV5. Positions 1-34.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00750000117221.
    InParanoidiB2KGV5.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view]
    PANTHERiPTHR24070. PTHR24070. 1 hit.
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51421. RAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    B2KGV5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDP                    34
    Length:34
    Mass (Da):3,693
    Last modified:June 10, 2008 - v1
    Checksum:i41D73D686A934F4F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei34 – 341Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC157091 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000155145; ENSMUSP00000118251; ENSMUSG00000030265.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC157091 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali B2KGV5.
    SMRi B2KGV5. Positions 1-34.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000032397.

    Proteomic databases

    PaxDbi B2KGV5.
    PRIDEi B2KGV5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000155145 ; ENSMUSP00000118251 ; ENSMUSG00000030265 .

    Organism-specific databases

    MGIi MGI:96680. Kras.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00750000117221.
    InParanoidi B2KGV5.

    Enzyme and pathway databases

    Reactomei REACT_188185. DAP12 signaling.
    REACT_188528. GRB2 events in ERBB2 signaling.
    REACT_188530. FCERI mediated MAPK activation.
    REACT_188574. SHC1 events in ERBB2 signaling.
    REACT_188578. Signaling by SCF-KIT.
    REACT_188580. SHC1 events in ERBB4 signaling.
    REACT_196455. Signaling by FGFR mutants.
    REACT_198350. EGFR Transactivation by Gastrin.
    REACT_199122. Activation of RAS in B cells.
    REACT_199123. Signaling by constitutively active EGFR.
    REACT_207601. p38MAPK events.
    REACT_211860. Tie2 Signaling.
    REACT_94437. SHC-mediated cascade.

    Miscellaneous databases

    ChiTaRSi KRAS. mouse.
    NextBioi 35546673.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi B2KGV5.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view ]
    PANTHERi PTHR24070. PTHR24070. 1 hit.
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51421. RAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiB2KGV5_MOUSE
    AccessioniPrimary (citable) accession number: B2KGV5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 10, 2008
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3