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Protein
Submitted name:

GTPase KRas

Gene

Kras

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. GDP binding Source: Ensembl
  2. GMP binding Source: Ensembl
  3. GTPase activity Source: MGI
  4. GTP binding Source: UniProtKB-KW
  5. protein complex binding Source: MGI

GO - Biological processi

  1. actin cytoskeleton organization Source: MGI
  2. apoptotic process Source: Ensembl
  3. cell cycle arrest Source: Ensembl
  4. cellular senescence Source: Ensembl
  5. cytokine-mediated signaling pathway Source: Ensembl
  6. epithelial tube branching involved in lung morphogenesis Source: MGI
  7. homeostasis of number of cells within a tissue Source: MGI
  8. metabolic process Source: GOC
  9. mitotic cell cycle checkpoint Source: Ensembl
  10. negative regulation of cell differentiation Source: MGI
  11. negative regulation of cell proliferation Source: Ensembl
  12. negative regulation of gene expression Source: Ensembl
  13. negative regulation of neuron apoptotic process Source: MGI
  14. negative regulation of Rho GTPase activity Source: Ensembl
  15. positive regulation of actin cytoskeleton reorganization Source: Ensembl
  16. positive regulation of cell migration Source: Ensembl
  17. positive regulation of cell proliferation Source: MGI
  18. positive regulation of DNA replication Source: Ensembl
  19. positive regulation of epithelial cell proliferation Source: Ensembl
  20. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  21. positive regulation of gene expression Source: MGI
  22. positive regulation of JNK cascade Source: Ensembl
  23. positive regulation of MAP kinase activity Source: Ensembl
  24. positive regulation of miRNA metabolic process Source: Ensembl
  25. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  26. positive regulation of nitric-oxide synthase activity Source: Ensembl
  27. positive regulation of protein phosphorylation Source: MGI
  28. positive regulation of Rac GTPase activity Source: Ensembl
  29. positive regulation of Rac protein signal transduction Source: MGI
  30. positive regulation of ruffle assembly Source: Ensembl
  31. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  32. positive regulation of wound healing Source: Ensembl
  33. protein heterooligomerization Source: Ensembl
  34. Ras protein signal transduction Source: MGI
  35. regulation of long-term neuronal synaptic plasticity Source: MGI
  36. regulation of synaptic transmission, GABAergic Source: MGI
  37. response to glucocorticoid Source: Ensembl
  38. response to mineralocorticoid Source: Ensembl
  39. social behavior Source: Ensembl
  40. striated muscle cell differentiation Source: MGI
  41. visual learning Source: MGI
Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_275935. RAF phosphorylates MEK.
REACT_276076. SHC1 events in ERBB4 signaling.
REACT_278498. Downstream signal transduction.
REACT_285497. GRB2 events in EGFR signaling.
REACT_286571. SHC1 events in EGFR signaling.
REACT_288801. SOS-mediated signalling.
REACT_293097. Activation of RAS in B cells.
REACT_296095. p38MAPK events.
REACT_299722. VEGFR2 mediated cell proliferation.
REACT_301936. DAP12 signaling.
REACT_309034. MEK activation.
REACT_309710. RAF activation.
REACT_314186. FCERI mediated MAPK activation.
REACT_317270. Constitutive Signaling by EGFRvIII.
REACT_320246. Signalling to RAS.
REACT_321421. SHC-mediated cascade.
REACT_321592. SHC1 events in ERBB2 signaling.
REACT_325060. EGFR Transactivation by Gastrin.
REACT_326306. Signaling by FGFR mutants.
REACT_327089. GRB2 events in ERBB2 signaling.
REACT_327841. Signaling by SCF-KIT.
REACT_332809. FRS2-mediated cascade.
REACT_333309. SHC-mediated signalling.
REACT_339798. NCAM signaling for neurite out-growth.
REACT_341964. Tie2 Signaling.
REACT_344438. Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants.

Names & Taxonomyi

Protein namesi
Submitted name:
GTPase KRasImported
Gene namesi
Name:KrasImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96680. Kras.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular vesicular exosome Source: Ensembl
  3. extrinsic component of cytoplasmic side of plasma membrane Source: MGI
  4. focal adhesion Source: MGI
  5. Golgi apparatus Source: Ensembl
  6. membrane Source: MGI
  7. membrane raft Source: Ensembl
  8. mitochondrion Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiB2KGV5.
PRIDEiB2KGV5.

Expressioni

Gene expression databases

BgeeiB2KGV5.
ExpressionAtlasiB2KGV5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032397.

Structurei

3D structure databases

ProteinModelPortaliB2KGV5.
SMRiB2KGV5. Positions 1-34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00780000121849.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B2KGV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDP
Length:34
Mass (Da):3,693
Last modified:June 10, 2008 - v1
Checksum:i41D73D686A934F4F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei34 – 341Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC157091 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000155145; ENSMUSP00000118251; ENSMUSG00000030265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC157091 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliB2KGV5.
SMRiB2KGV5. Positions 1-34.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032397.

Proteomic databases

PaxDbiB2KGV5.
PRIDEiB2KGV5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000155145; ENSMUSP00000118251; ENSMUSG00000030265.

Organism-specific databases

MGIiMGI:96680. Kras.

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00780000121849.

Enzyme and pathway databases

ReactomeiREACT_275935. RAF phosphorylates MEK.
REACT_276076. SHC1 events in ERBB4 signaling.
REACT_278498. Downstream signal transduction.
REACT_285497. GRB2 events in EGFR signaling.
REACT_286571. SHC1 events in EGFR signaling.
REACT_288801. SOS-mediated signalling.
REACT_293097. Activation of RAS in B cells.
REACT_296095. p38MAPK events.
REACT_299722. VEGFR2 mediated cell proliferation.
REACT_301936. DAP12 signaling.
REACT_309034. MEK activation.
REACT_309710. RAF activation.
REACT_314186. FCERI mediated MAPK activation.
REACT_317270. Constitutive Signaling by EGFRvIII.
REACT_320246. Signalling to RAS.
REACT_321421. SHC-mediated cascade.
REACT_321592. SHC1 events in ERBB2 signaling.
REACT_325060. EGFR Transactivation by Gastrin.
REACT_326306. Signaling by FGFR mutants.
REACT_327089. GRB2 events in ERBB2 signaling.
REACT_327841. Signaling by SCF-KIT.
REACT_332809. FRS2-mediated cascade.
REACT_333309. SHC-mediated signalling.
REACT_339798. NCAM signaling for neurite out-growth.
REACT_341964. Tie2 Signaling.
REACT_344438. Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants.

Miscellaneous databases

ChiTaRSiKras. mouse.
NextBioi35546673.
SOURCEiSearch...

Gene expression databases

BgeeiB2KGV5.
ExpressionAtlasiB2KGV5. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB2KGV5_MOUSE
AccessioniPrimary (citable) accession number: B2KGV5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: April 1, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.