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B2KGV5

- B2KGV5_MOUSE

UniProt

B2KGV5 - B2KGV5_MOUSE

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Protein
Submitted name:

GTPase KRas

Gene

Kras

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. GDP binding Source: Ensembl
  2. GMP binding Source: Ensembl
  3. GTPase activity Source: MGI
  4. GTP binding Source: UniProtKB-KW
  5. protein complex binding Source: MGI

GO - Biological processi

  1. actin cytoskeleton organization Source: MGI
  2. apoptotic process Source: Ensembl
  3. cell cycle arrest Source: Ensembl
  4. cellular senescence Source: Ensembl
  5. cytokine-mediated signaling pathway Source: Ensembl
  6. epithelial tube branching involved in lung morphogenesis Source: MGI
  7. mitotic cell cycle checkpoint Source: Ensembl
  8. negative regulation of cell differentiation Source: MGI
  9. negative regulation of cell proliferation Source: Ensembl
  10. negative regulation of gene expression Source: Ensembl
  11. negative regulation of neuron apoptotic process Source: MGI
  12. negative regulation of Rho GTPase activity Source: Ensembl
  13. positive regulation of actin cytoskeleton reorganization Source: Ensembl
  14. positive regulation of cell migration Source: Ensembl
  15. positive regulation of cell proliferation Source: MGI
  16. positive regulation of DNA replication Source: Ensembl
  17. positive regulation of epithelial cell proliferation Source: Ensembl
  18. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  19. positive regulation of JNK cascade Source: Ensembl
  20. positive regulation of MAP kinase activity Source: Ensembl
  21. positive regulation of miRNA metabolic process Source: Ensembl
  22. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  23. positive regulation of nitric-oxide synthase activity Source: Ensembl
  24. positive regulation of Rac GTPase activity Source: Ensembl
  25. positive regulation of Rac protein signal transduction Source: MGI
  26. positive regulation of ruffle assembly Source: Ensembl
  27. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  28. positive regulation of wound healing Source: Ensembl
  29. protein heterooligomerization Source: Ensembl
  30. Ras protein signal transduction Source: MGI
  31. regulation of long-term neuronal synaptic plasticity Source: MGI
  32. regulation of synaptic transmission, GABAergic Source: MGI
  33. response to glucocorticoid Source: Ensembl
  34. response to mineralocorticoid Source: Ensembl
  35. social behavior Source: Ensembl
  36. striated muscle cell differentiation Source: MGI
  37. visual learning Source: MGI
Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_188185. DAP12 signaling.
REACT_188528. GRB2 events in ERBB2 signaling.
REACT_188530. FCERI mediated MAPK activation.
REACT_188574. SHC1 events in ERBB2 signaling.
REACT_188578. Signaling by SCF-KIT.
REACT_188580. SHC1 events in ERBB4 signaling.
REACT_196455. Signaling by FGFR mutants.
REACT_198350. EGFR Transactivation by Gastrin.
REACT_199122. Activation of RAS in B cells.
REACT_199123. Signaling by constitutively active EGFR.
REACT_207601. p38MAPK events.
REACT_211860. Tie2 Signaling.
REACT_230639. Downstream signal transduction.
REACT_234357. FRS2-mediated cascade.
REACT_237640. RAF activation.
REACT_237796. NCAM signaling for neurite out-growth.
REACT_239466. SHC-mediated signalling.
REACT_239722. Signalling to RAS.
REACT_241824. SOS-mediated signalling.
REACT_245086. VEGFR2 mediated cell proliferation.
REACT_245103. GRB2 events in EGFR signaling.
REACT_247566. MEK activation.
REACT_257146. RAF phosphorylates MEK.
REACT_260286. SHC1 events in EGFR signaling.
REACT_94437. SHC-mediated cascade.

Names & Taxonomyi

Protein namesi
Submitted name:
GTPase KRasImported
Gene namesi
Name:KrasImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:96680. Kras.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. Golgi apparatus Source: Ensembl
  3. membrane Source: MGI
  4. membrane raft Source: Ensembl
  5. mitochondrion Source: Ensembl
  6. plasma membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiB2KGV5.
PRIDEiB2KGV5.

Expressioni

Gene expression databases

ExpressionAtlasiB2KGV5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032397.

Structurei

3D structure databases

ProteinModelPortaliB2KGV5.
SMRiB2KGV5. Positions 1-34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00770000120468.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B2KGV5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30 
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDP
Length:34
Mass (Da):3,693
Last modified:June 10, 2008 - v1
Checksum:i41D73D686A934F4F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei34 – 341Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC157091 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000155145; ENSMUSP00000118251; ENSMUSG00000030265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC157091 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali B2KGV5.
SMRi B2KGV5. Positions 1-34.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000032397.

Proteomic databases

PaxDbi B2KGV5.
PRIDEi B2KGV5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000155145 ; ENSMUSP00000118251 ; ENSMUSG00000030265 .

Organism-specific databases

MGIi MGI:96680. Kras.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00770000120468.

Enzyme and pathway databases

Reactomei REACT_188185. DAP12 signaling.
REACT_188528. GRB2 events in ERBB2 signaling.
REACT_188530. FCERI mediated MAPK activation.
REACT_188574. SHC1 events in ERBB2 signaling.
REACT_188578. Signaling by SCF-KIT.
REACT_188580. SHC1 events in ERBB4 signaling.
REACT_196455. Signaling by FGFR mutants.
REACT_198350. EGFR Transactivation by Gastrin.
REACT_199122. Activation of RAS in B cells.
REACT_199123. Signaling by constitutively active EGFR.
REACT_207601. p38MAPK events.
REACT_211860. Tie2 Signaling.
REACT_230639. Downstream signal transduction.
REACT_234357. FRS2-mediated cascade.
REACT_237640. RAF activation.
REACT_237796. NCAM signaling for neurite out-growth.
REACT_239466. SHC-mediated signalling.
REACT_239722. Signalling to RAS.
REACT_241824. SOS-mediated signalling.
REACT_245086. VEGFR2 mediated cell proliferation.
REACT_245103. GRB2 events in EGFR signaling.
REACT_247566. MEK activation.
REACT_257146. RAF phosphorylates MEK.
REACT_260286. SHC1 events in EGFR signaling.
REACT_94437. SHC-mediated cascade.

Miscellaneous databases

ChiTaRSi Kras. mouse.
NextBioi 35546673.
SOURCEi Search...

Gene expression databases

ExpressionAtlasi B2KGV5. baseline and differential.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view ]
PANTHERi PTHR24070. PTHR24070. 1 hit.
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51421. RAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB2KGV5_MOUSE
AccessioniPrimary (citable) accession number: B2KGV5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 26, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3